ATE524471T1 - Pyrazolonaphthyridinderivat - Google Patents

Pyrazolonaphthyridinderivat

Info

Publication number: ATE524471T1
Authority: AT; Austria
Prior art keywords: group; copd; prophylactic; cyano; nitro
Prior art date: 2002-11-06

Application number

AT03810609T

Other languages

English (en)

Inventor

Hashime Kanazawa

Tomoji Aotsuka

Kentarou Kumazawa

Kouki Ishitani

Takashi Nose

Original Assignee

Aska Pharm Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-06

Filing date

2003-11-05

Publication date

2011-09-15

2003-11-05 Application filed by Aska Pharm Co Ltd filed Critical Aska Pharm Co Ltd

2011-09-15 Application granted granted Critical

2011-09-15 Publication of ATE524471T1 publication Critical patent/ATE524471T1/de

Links

VMPCBEQFWHYVIV-UHFFFAOYSA-N C1=CC=N[C]2N[C]3C=NN=C3C=C21 Chemical class C1=CC=N[C]2N[C]3C=NN=C3C=C21 VMPCBEQFWHYVIV-UHFFFAOYSA-N 0.000 title 1
-1 1-oxypyridyl Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
230000001088 anti-asthma Effects 0.000 abstract 2
239000000924 antiasthmatic agent Substances 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000002587 phosphodiesterase IV inhibitor Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
229940043274 prophylactic drug Drugs 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940126585 therapeutic drug Drugs 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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AT03810609T 2002-11-06 2003-11-05 Pyrazolonaphthyridinderivat ATE524471T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2002322000		2002-11-06
PCT/JP2003/014119 WO2004041819A1 (ja)	2002-11-06	2003-11-05	ピラゾロナフチリジン誘導体

Publications (1)

Publication Number	Publication Date
ATE524471T1 true ATE524471T1 (de)	2011-09-15

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ID=32310378

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03810609T ATE524471T1 (de)	2002-11-06	2003-11-05	Pyrazolonaphthyridinderivat

Country Status (10)

Country	Link
US (2)	US7608716B2 (de)
EP (1)	EP1559716B1 (de)
JP (2)	JP4700965B2 (de)
KR (1)	KR101064227B1 (de)
CN (1)	CN100572381C (de)
AT (1)	ATE524471T1 (de)
AU (1)	AU2003277562B2 (de)
CA (1)	CA2504820C (de)
ES (1)	ES2372600T3 (de)
WO (1)	WO2004041819A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003277562B2 (en) *	2002-11-06	2009-03-26	Aska Pharmaceutical Co., Ltd.	Pyrazolonaphthyridine derivative
WO2007032466A1 (ja)	2005-09-15	2007-03-22	Aska Pharmaceutical Co., Ltd.	複素環化合物、その製造方法並びに用途
US20110294799A1 (en) *	2007-08-14	2011-12-01	Novartis Ag	Organic Compounds
US8193177B2 (en) *	2007-11-13	2012-06-05	Angion Biomedica Corp.	Hepatocyte growth factor pathway activators in fibrotic connective tissue diseases
WO2016090382A1 (en) *	2014-12-06	2016-06-09	Intra-Cellular Therapies, Inc.	Organic compounds
BR112017012007B1 (pt)	2014-12-06	2022-11-01	Intra-Cellular Therapies, Inc	Compostos orgânicos inibitórios de pde2, composições farmacêuticas compreendendo os ditos compostos e uso dos mesmos no tratamento de um distúrbio mediado por pde2
JP6610056B2 (ja) *	2015-07-28	2019-11-27	株式会社Ｓｕｍｃｏ	エピタキシャルシリコンウェーハの製造方法
TWI680973B (zh) *	2018-11-09	2020-01-01	長庚學校財團法人長庚科技大學	嗜中性白血球發炎抑制劑及其用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH05132484A (ja)	1991-04-26	1993-05-28	Otsuka Pharmaceut Factory Inc	ピラゾロキノリン及びピラゾロナフチリジン誘導体
JPH05194515A (ja) *	1991-07-31	1993-08-03	Kyowa Hakko Kogyo Co Ltd	縮合ナフチリジン誘導体
US5281610A (en) *	1991-07-31	1994-01-25	Kyowa Hakko Kogyo Co., Ltd.	Condensed naphthyridine derivatives
JPH06100561A (ja)	1992-07-13	1994-04-12	Otsuka Pharmaceut Factory Inc	ナフチリジン及びピリドピラジン誘導体
JPH0710875A (ja) *	1993-06-21	1995-01-13	Green Cross Corp:The	選択的ホスホジエステラーゼｉｖ阻害剤
WO1996006843A1 (en) *	1994-08-29	1996-03-07	Yamanouchi Pharmaceutical Co., Ltd.	Novel naphthyridine derivative and medicinal composition thereof
US6325989B1 (en) *	1995-06-01	2001-12-04	Dana-Farber Cancer Institute, Inc.	Form of dipeptidylpeptidase IV (CD26) found in human serum
ATE237589T1 (de)	1995-06-07	2003-05-15	Pfizer	Catecholdiether-derivate verwendbar als pharmazeutische mittel
GB9526558D0 (en) *	1995-12-27	1996-02-28	Fujisawa Pharmaceutical Co	Heterobicyclic derivatives
JP3237109B2 (ja)	1996-12-13	2001-12-10	田辺製薬株式会社	医薬組成物
CA2295598A1 (en)	1997-07-10	1999-01-21	Otsuka Pharmaceutical Factory, Inc.	Naphthyridine derivatives
ES2137113B1 (es)	1997-07-29	2000-09-16	Almirall Prodesfarma Sa	Nuevos derivados de triazolo-piridazinas heterociclicos.
JPH11106385A (ja)	1997-08-06	1999-04-20	Suntory Ltd	Ｉｖ型ホスホジエステラーゼ阻害作用を有する１−アリール−１，８−ナフチリジン−４−オン誘導体
JPH11209350A (ja)	1998-01-26	1999-08-03	Eisai Co Ltd	含窒素複素環誘導体およびその医薬
CA2285352A1 (en)	1998-01-29	1999-08-05	Suntory Limited	1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phosphodiesterase iv inhibitory activity
JP2000119271A (ja) *	1998-08-12	2000-04-25	Hokuriku Seiyaku Co Ltd	１ｈ―イミダゾピリジン誘導体
IT1303272B1 (it) *	1998-10-29	2000-11-06	Zambon Spa	Derivati triciclici inibitori della fosfodiesterasi 4
EP1145714A4 (de)	1998-11-27	2004-12-15	Takeda Chemical Industries Ltd	Arzneimittel
FR2792938B1 (fr) *	1999-04-28	2001-07-06	Warner Lambert Co	NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
ATE261445T1 (de) *	1999-12-08	2004-03-15	Grelan Pharmaceutical Co	Neue 1,8-naphtyridin-2(1h)-on-derivate
JP2001354655A (ja)	2000-04-12	2001-12-25	Dainippon Pharmaceut Co Ltd	２，３−ジ置換ピリジン誘導体からなる医薬
JP2002138089A (ja)	2000-08-23	2002-05-14	Otsuka Pharmaceut Factory Inc	ナフチリジン誘導体
AU2003277562B2 (en) *	2002-11-06	2009-03-26	Aska Pharmaceutical Co., Ltd.	Pyrazolonaphthyridine derivative
US20050281610A1 (en) *	2004-06-04	2005-12-22	Maclean Barry L	Composite link

2003
- 2003-11-05 AU AU2003277562A patent/AU2003277562B2/en not_active Ceased
- 2003-11-05 KR KR1020057007856A patent/KR101064227B1/ko not_active Expired - Fee Related
- 2003-11-05 US US10/533,806 patent/US7608716B2/en not_active Expired - Fee Related
- 2003-11-05 CA CA2504820A patent/CA2504820C/en not_active Expired - Fee Related
- 2003-11-05 AT AT03810609T patent/ATE524471T1/de not_active IP Right Cessation
- 2003-11-05 WO PCT/JP2003/014119 patent/WO2004041819A1/ja not_active Ceased
- 2003-11-05 EP EP03810609A patent/EP1559716B1/de not_active Expired - Lifetime
- 2003-11-05 CN CNB2003801040701A patent/CN100572381C/zh not_active Expired - Fee Related
- 2003-11-05 ES ES03810609T patent/ES2372600T3/es not_active Expired - Lifetime
- 2003-11-05 JP JP2004549617A patent/JP4700965B2/ja not_active Expired - Fee Related
2009
- 2009-09-15 US US12/585,430 patent/US20100093782A1/en not_active Abandoned
2010
- 2010-12-24 JP JP2010288284A patent/JP2011088923A/ja active Pending

Also Published As

Publication number	Publication date
CA2504820C (en)	2011-08-23
ES2372600T3 (es)	2012-01-24
CA2504820A1 (en)	2004-05-21
JP4700965B2 (ja)	2011-06-15
WO2004041819A1 (ja)	2004-05-21
JPWO2004041819A1 (ja)	2006-03-09
AU2003277562A1 (en)	2004-06-07
CN1717409A (zh)	2006-01-04
CN100572381C (zh)	2009-12-23
US7608716B2 (en)	2009-10-27
EP1559716B1 (de)	2011-09-14
KR20050084649A (ko)	2005-08-26
KR101064227B1 (ko)	2011-09-14
JP2011088923A (ja)	2011-05-06
US20060040972A1 (en)	2006-02-23
EP1559716A4 (de)	2008-04-23
EP1559716A1 (de)	2005-08-03
AU2003277562B2 (en)	2009-03-26
US20100093782A1 (en)	2010-04-15

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Date	Code	Title	Description
2012-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
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DE60317326D1 (de)	2007-12-20	Phenylalkansäure- und phenyloxyalkansäure-derivate als hppar aktivatore
EP1642880A4 (de)	2006-11-15	Proteininhibitoren der hsp90-familie
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GB0308201D0 (en)	2003-05-14	Novel compounds
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DK1603917T3 (da)	2011-02-28	Immunmodulerende heterocycliske forbindelser
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WO2009028387A1 (ja)	2009-03-05	プロテアーゼ阻害剤耐性を有する癌の治療薬
MX2025003324A (es)	2025-05-02	Inhibidores de sik heterociclicos