ATE526416T1 - Verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht - Google Patents

Verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht

Info

Publication number: ATE526416T1
Authority: AT; Austria
Prior art keywords: solution; hyaluronic acid; salt; molecular weight; high molecular
Prior art date: 2006-07-06

Application number

AT07859586T

Other languages

English (en)

Inventor

Vidhya Rangaswamy

Vyas Santosh

Jain Dharmendra

Vedapuri Nataraj

Harshad Velankar

Arnab Kapat

Original Assignee

Reliance Life Sciences Pvt Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-06

Filing date

2007-07-06

Publication date

2011-10-15

2007-07-06 Application filed by Reliance Life Sciences Pvt Ltd filed Critical Reliance Life Sciences Pvt Ltd

2011-10-15 Application granted granted Critical

2011-10-15 Publication of ATE526416T1 publication Critical patent/ATE526416T1/de

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 11
229920002674 hyaluronan Polymers 0.000 title abstract 8
229960003160 hyaluronic acid Drugs 0.000 title abstract 8
238000004519 manufacturing process Methods 0.000 title 1
239000000243 solution Substances 0.000 abstract 4
239000012266 salt solution Substances 0.000 abstract 3
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
238000000855 fermentation Methods 0.000 abstract 2
230000004151 fermentation Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000000741 silica gel Substances 0.000 abstract 2
229910002027 silica gel Inorganic materials 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
230000001580 bacterial effect Effects 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
239000003599 detergent Substances 0.000 abstract 1
238000007865 diluting Methods 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
230000001376 precipitating effect Effects 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Materials Engineering (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Zoology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Sustainable Development (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT07859586T 2006-07-06 2007-07-06 Verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht ATE526416T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IN1065MU2006		2006-07-06
IN1874MU2006		2006-11-13
PCT/IN2007/000289 WO2008035372A2 (en)	2006-07-06	2007-07-06	Efficient process for purification of high molecular weight hyaluronic acid

Publications (1)

Publication Number	Publication Date
ATE526416T1 true ATE526416T1 (de)	2011-10-15

Family

ID=39197232

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07859586T ATE526416T1 (de)	2006-07-06	2007-07-06	Verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht

Country Status (10)

Country	Link
US (1)	US20080138865A1 (de)
EP (2)	EP2216412B1 (de)
CN (2)	CN101512006B (de)
AT (1)	ATE526416T1 (de)
AU (1)	AU2007298454B2 (de)
BR (1)	BRPI0713215A2 (de)
CA (1)	CA2657162A1 (de)
ES (2)	ES2396955T3 (de)
IL (1)	IL196371A (de)
WO (1)	WO2008035372A2 (de)

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DE102009037514A1 (de)	2009-08-17	2011-03-10	Dirk-Henning Dr. Menz	Wasserlösliche Polysaccharidether und ihre Verwendung
CN102021213B (zh) *	2009-09-17	2014-07-09	上海佰加壹医药有限公司	一种发酵生产透明质酸发酵液的方法
JP2011195604A (ja) *	2010-03-17	2011-10-06	Denki Kagaku Kogyo Kk	ヒアルロン酸及び／又はその塩の含有液中の異物除去方法
KR101627014B1 (ko) *	2010-03-17	2016-06-03	덴카 주식회사	히알루론산의 정제 방법
JP2011195611A (ja) *	2010-03-17	2011-10-06	Denki Kagaku Kogyo Kk	ヒアルロン酸及び／又はその塩の精製法
JP2011195608A (ja) *	2010-03-17	2011-10-06	Denki Kagaku Kogyo Kk	ヒアルロン酸及び／又はその塩の精製法
CN102093206B (zh) *	2010-12-02	2013-04-24	浙江科技学院	硅胶负载硫酸镍催化水解蔗糖制备乙酰丙酸的方法
CN102154402A (zh) *	2010-12-22	2011-08-17	东辰控股集团有限公司	一种透明质酸钠发酵前种子培养的方法及投放工艺
CN102154403A (zh) *	2010-12-22	2011-08-17	东辰控股集团有限公司	一种粗品透明质酸钠的溶解方法及工艺
CN102504047A (zh) *	2011-11-30	2012-06-20	上海景峰制药有限公司	一种玻璃酸钠发酵液的超滤方法
ITMI20121184A1 (it) *	2012-07-05	2014-01-06	Altergon Italia Srl	Processo per la produzione industriale di ialuronato di sodio (hana) altamente purificato a peso molecolare controllato
FR3016637B1 (fr) *	2014-01-23	2020-11-27	Centre Nat Rech Scient	Procede de production in vivo de glycosaminoglycane
WO2016174683A1 (en) *	2015-04-28	2016-11-03	Biological E Limited	Method for separation of protein and other impurities from microbial capsular polysaccharides
CN105564682B (zh) *	2015-12-24	2018-02-02	浙江景嘉医疗科技有限公司	一种减少医用透明质酸钠凝胶气泡的方法
IT201700081449A1 (it) *	2017-07-18	2019-01-18	Fidia Farm Spa	Procedimento di purificazione dell'acido ialuronico
EP3441919A1 (de)	2017-08-11	2019-02-13	Schneider Electric Industries SAS	Verfahren zum austausch von daten zwischen engineering-tools eines engineering-systems sowie engineering-system zur durchführung des verfahrens
CN107586810A (zh) *	2017-10-31	2018-01-16	成都远泓生物科技有限公司	一种透明质酸的生物发酵生产工艺
CN110029064B (zh) *	2019-04-28	2021-11-23	陕西科技大学	一种水体微生物菌种分离与纯化的方法和采样装置
RU2719140C1 (ru)	2019-07-26	2020-04-17	Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех"	Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии
CN110511972A (zh) *	2019-09-22	2019-11-29	山东众山生物科技有限公司	一种透明质酸钠链球菌的培养基及培养方法
WO2021215440A1 (ja) *	2020-04-22	2021-10-28	株式会社資生堂	ヒアルロン酸産生促進剤
CN112592849A (zh) *	2020-12-14	2021-04-02	宁夏泰胜生物科技有限公司	利用兽疫链霉菌发酵生产高分子量透明质酸的培养基和培养方法
CN113045773B (zh) *	2021-03-16	2022-05-31	南京林业大学	一种在兽疫链球菌发酵过程中原位诱导纳米纤维素凝胶化的方法
CN115215949B (zh) *	2022-06-09	2024-01-05	浙江驭远生物科技有限公司	透明质酸钠及其提纯方法
TR2023014027A1 (tr) *	2023-10-30	2025-05-21	Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi	Hyalüroni̇k asi̇tleri̇ni̇n üreti̇mi̇ esnasinda kullanima uygun bi̇r saflaştirma yöntemi̇ ve bu saflaştirma yöntemi̇nde kullanilan membran
WO2025141008A1 (en) *	2023-12-29	2025-07-03	Hyspinlab Sa	Process for purifying high molecular weight hyaluronic acid
CN118580393B (zh) *	2024-04-22	2025-04-11	株洲市中建科密添加剂有限公司	一种透明质酸固体原料的制备方法

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US4141973A (en) *	1975-10-17	1979-02-27	Biotrics, Inc.	Ultrapure hyaluronic acid and the use thereof
US4780414A (en) *	1985-01-18	1988-10-25	Bio-Technology General Corp.	Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
US4784990A (en)	1985-01-18	1988-11-15	Bio-Technology General Corporation	High molecular weight sodium hyaluronate
JPS62215397A (ja)	1986-03-17	1987-09-22	Nippon Kayaku Co Ltd	ヒアルロン酸の製造方法
JPH0630603B2 (ja)	1986-05-02	1994-04-27	生化学工業株式会社	ヒアルロン酸の製造法
JPS62289198A (ja)	1986-06-09	1987-12-16	Nippon Kayaku Co Ltd	ヒアルロン酸の新規製造方法
US4946780A (en)	1988-10-12	1990-08-07	Denkl Kagaku Kogyo Kabushiki Kaisha	Method for producing sodium hyaluronate by fermentation method
JPH0638783B2 (ja)	1988-12-26	1994-05-25	孝一郎中間	二重蓋の開閉装置
US4897349A (en)	1989-04-28	1990-01-30	Medchem Products, Inc.	Biosynthesis of hyaluronic acid
GB9024223D0 (en)	1990-11-07	1990-12-19	Fermentech Ltd	Production of hyaluronic acid
JPH0753117B2 (ja)	1992-10-26	1995-06-07	チッソ株式会社	ヒアルロン酸の製造法
JPH06319579A (ja)	1993-05-17	1994-11-22	Kyowa Hakko Kogyo Co Ltd	ヒアルロン酸の製造法
RU2074863C1 (ru) *	1993-08-23	1997-03-10	Научно-производственная фирма "Нарт"	Способ получения гиалуроновой кислоты
IT1271001B (it)	1994-07-26	1997-05-26	Poli Ind Chimica Spa	Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus
CH692919A5 (fr)	1999-01-28	2002-12-13	Trb Chemedica S A	Procédé de purification de l'acide hyaluronique à poids moléculaire élevé.
AU2003252566A1 (en) *	2002-08-19	2004-03-03	Kolon Ind. Inc.	Microorganism producing hyaluronic acid and purification method of hyaluronic acid
JP2005169008A (ja) *	2003-12-15	2005-06-30	Nipro Corp	生体適合性材料の滅菌方法
US7002007B2 (en)	2004-05-28	2006-02-21	Calcigen Corporation	Production of high molecular weight hyaluronates
CN1786180A (zh) *	2005-11-23	2006-06-14	江南大学	一种提高发酵法生产透明质酸产量及分子量的方法

2007
- 2007-07-06 US US11/774,037 patent/US20080138865A1/en not_active Abandoned
- 2007-07-06 EP EP10005542A patent/EP2216412B1/de not_active Not-in-force
- 2007-07-06 WO PCT/IN2007/000289 patent/WO2008035372A2/en not_active Ceased
- 2007-07-06 CA CA002657162A patent/CA2657162A1/en not_active Abandoned
- 2007-07-06 CN CN200780033000XA patent/CN101512006B/zh not_active Expired - Fee Related
- 2007-07-06 EP EP07859586A patent/EP2046969B1/de not_active Not-in-force
- 2007-07-06 CN CN201210027481.6A patent/CN102617754B/zh not_active Expired - Fee Related
- 2007-07-06 AU AU2007298454A patent/AU2007298454B2/en not_active Ceased
- 2007-07-06 BR BRPI0713215-8A patent/BRPI0713215A2/pt not_active IP Right Cessation
- 2007-07-06 AT AT07859586T patent/ATE526416T1/de not_active IP Right Cessation
- 2007-07-06 ES ES10005542T patent/ES2396955T3/es active Active
- 2007-07-06 ES ES07859586T patent/ES2374512T3/es active Active
2009
- 2009-01-06 IL IL196371A patent/IL196371A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP2216412A3 (de)	2010-11-24
ES2374512T3 (es)	2012-02-17
EP2046969B1 (de)	2011-09-28
EP2216412A2 (de)	2010-08-11
EP2046969A2 (de)	2009-04-15
IL196371A0 (en)	2011-08-01
AU2007298454B2 (en)	2014-01-16
AU2007298454A1 (en)	2008-03-27
CA2657162A1 (en)	2008-03-27
IL196371A (en)	2015-03-31
US20080138865A1 (en)	2008-06-12
BRPI0713215A2 (pt)	2012-04-17
ES2396955T3 (es)	2013-03-01
CN101512006B (zh)	2012-04-11
CN101512006A (zh)	2009-08-19
EP2216412B1 (de)	2012-10-03
CN102617754B (zh)	2015-09-16
CN102617754A (zh)	2012-08-01
WO2008035372A2 (en)	2008-03-27
WO2008035372A3 (en)	2008-12-31

Legal Events

Date	Code	Title	Description
2012-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE526416T1 (de)	2011-10-15	Verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht
ATE240348T1 (de)	2003-05-15	Verfahren zur herstellung eines proteins
DE50104019D1 (de)	2004-11-11	Verfahren zur agglomeration dispergierter kautschuke
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DE60222734D1 (de)	2007-11-15	Mikropartikel und Verfahren zur deren Herstellung
ITMI20121184A1 (it)	2014-01-06	Processo per la produzione industriale di ialuronato di sodio (hana) altamente purificato a peso molecolare controllato
CN108057348A (zh)	2018-05-22	一种亲水性杀菌抗污染反渗透膜及其制法
CY1107082T1 (el)	2012-10-24	Μεθοδος καθαρισμου αλβουμινης η οποια περιλαμβανει ενα σταδιο νανοδιηθησης, διαλυμα και συνθεση για θεραπευτικη χρηση που περιεχουν την ιδια
ATE486949T1 (de)	2010-11-15	Verfahren zur herstellung von n- acetylneuraminsäure
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DE60003282D1 (de)	2003-07-17	Verfahren zur reinigung von hyaluronsäure mit hohem molekulargewicht
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