ATE529103T1 - Modulation der apolipoprotein c-iii expression - Google Patents

Modulation der apolipoprotein c-iii expression

Info

Publication number: ATE529103T1
Authority: AT; Austria
Prior art keywords: apolipoprotein; iii; modulation; expression; iii expression
Prior art date: 2003-04-16

Application number

AT04749914T

Other languages

English (en)

Inventor

Rosanne Crooke

Mark Graham

Tarbet Kristina Lemonidis

Kenneth Dobie

Original Assignee

Isis Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-16

Filing date

2004-04-15

Publication date

2011-11-15

2004-04-15 Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc

2011-11-15 Application granted granted Critical

2011-11-15 Publication of ATE529103T1 publication Critical patent/ATE529103T1/de

Links

102000030169 Apolipoprotein C-III Human genes 0.000 title abstract 5
108010056301 Apolipoprotein C-III Proteins 0.000 title abstract 5
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1

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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
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- C12N2310/3341—5-Methylcytosine
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
- C12N2330/31—Libraries, arrays

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Diabetes (AREA)
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Heart & Thoracic Surgery (AREA)
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Child & Adolescent Psychology (AREA)
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Vascular Medicine (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT04749914T 2003-04-16 2004-04-15 Modulation der apolipoprotein c-iii expression ATE529103T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10/418,780 US7598227B2 (en)	2003-04-16	2003-04-16	Modulation of apolipoprotein C-III expression
PCT/US2004/010946 WO2004093783A2 (en)	2003-04-16	2004-04-15	Modulation of apolipoprotein c-iii expression

Publications (1)

Publication Number	Publication Date
ATE529103T1 true ATE529103T1 (de)	2011-11-15

Family

ID=33159181

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04749914T ATE529103T1 (de)	2003-04-16	2004-04-15	Modulation der apolipoprotein c-iii expression

Country Status (13)

Country	Link
US (6)	US7598227B2 (de)
EP (4)	EP3002007B1 (de)
AT (1)	ATE529103T1 (de)
AU (2)	AU2004231550B2 (de)
CA (2)	CA2958943A1 (de)
CY (1)	CY1117030T1 (de)
DK (2)	DK2441449T3 (de)
ES (3)	ES2373101T3 (de)
HU (1)	HUE027411T2 (de)
PL (1)	PL2441449T3 (de)
PT (1)	PT2441449E (de)
SI (1)	SI2441449T1 (de)
WO (1)	WO2004093783A2 (de)

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2003
- 2003-04-16 US US10/418,780 patent/US7598227B2/en not_active Expired - Lifetime
2004
- 2004-04-15 PL PL11185507T patent/PL2441449T3/pl unknown
- 2004-04-15 SI SI200432281T patent/SI2441449T1/sl unknown
- 2004-04-15 EP EP15189401.1A patent/EP3002007B1/de not_active Expired - Lifetime
- 2004-04-15 AU AU2004231550A patent/AU2004231550B2/en not_active Expired
- 2004-04-15 EP EP18162847.0A patent/EP3412284A1/de not_active Withdrawn
- 2004-04-15 EP EP04749914A patent/EP1622597B1/de not_active Expired - Lifetime
- 2004-04-15 ES ES04749914T patent/ES2373101T3/es not_active Expired - Lifetime
- 2004-04-15 CA CA2958943A patent/CA2958943A1/en not_active Abandoned
- 2004-04-15 EP EP11185507.8A patent/EP2441449B1/de not_active Expired - Lifetime
- 2004-04-15 DK DK11185507.8T patent/DK2441449T3/en active
- 2004-04-15 CA CA2522560A patent/CA2522560C/en not_active Expired - Fee Related
- 2004-04-15 ES ES11185507.8T patent/ES2558949T3/es not_active Expired - Lifetime
- 2004-04-15 US US10/553,722 patent/US7750141B2/en not_active Expired - Lifetime
- 2004-04-15 AT AT04749914T patent/ATE529103T1/de not_active IP Right Cessation
- 2004-04-15 DK DK04749914.0T patent/DK1622597T3/da active
- 2004-04-15 ES ES15189401.1T patent/ES2666405T3/es not_active Expired - Lifetime
- 2004-04-15 PT PT111855078T patent/PT2441449E/pt unknown
- 2004-04-15 WO PCT/US2004/010946 patent/WO2004093783A2/en not_active Ceased
- 2004-04-15 HU HUE11185507A patent/HUE027411T2/hu unknown
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- 2010-01-28 AU AU2010200324A patent/AU2010200324B2/en not_active Expired
- 2010-05-17 US US12/781,479 patent/US8530439B2/en not_active Expired - Fee Related
2013
- 2013-08-07 US US13/961,646 patent/US9365848B2/en not_active Expired - Fee Related
2015
- 2015-12-07 CY CY20151101109T patent/CY1117030T1/el unknown
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- 2016-04-29 US US15/143,222 patent/US9624496B2/en not_active Expired - Fee Related
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- 2017-03-03 US US15/449,444 patent/US20170275620A1/en not_active Abandoned

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Publication number	Publication date
US20040208856A1 (en)	2004-10-21
AU2004231550A1 (en)	2004-11-04
WO2004093783A2 (en)	2004-11-04
US8530439B2 (en)	2013-09-10
CA2522560C (en)	2017-04-11
US9624496B2 (en)	2017-04-18
US20170275620A1 (en)	2017-09-28
US20160237434A1 (en)	2016-08-18
HUE027411T2 (hu)	2016-10-28
CA2522560A1 (en)	2004-11-04
US20060264395A1 (en)	2006-11-23
US7598227B2 (en)	2009-10-06
EP3412284A1 (de)	2018-12-12
ES2666405T3 (es)	2018-05-04
PL2441449T3 (pl)	2016-04-29
EP2441449A1 (de)	2012-04-18
WO2004093783A3 (en)	2006-05-04
DK1622597T3 (da)	2012-01-30
EP3002007A1 (de)	2016-04-06
CY1117030T1 (el)	2017-04-05
ES2373101T3 (es)	2012-01-31
SI2441449T1 (sl)	2015-12-31
AU2004231550B2 (en)	2009-10-29
AU2010200324B2 (en)	2013-10-10
ES2558949T3 (es)	2016-02-09
US20110060030A1 (en)	2011-03-10
AU2010200324A1 (en)	2010-02-18
EP1622597B1 (de)	2011-10-19
US9365848B2 (en)	2016-06-14
EP2441449B1 (de)	2015-10-14
US20130317085A1 (en)	2013-11-28
DK2441449T3 (en)	2015-11-16
PT2441449E (pt)	2015-11-26
EP3002007B1 (de)	2018-03-21
EP1622597A4 (de)	2009-01-28
CA2958943A1 (en)	2004-11-04
HK1169609A1 (en)	2013-02-01
US7750141B2 (en)	2010-07-06
EP1622597A2 (de)	2006-02-08

Legal Events

Date	Code	Title	Description
2012-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE529103T1 (de)	2011-11-15	Modulation der apolipoprotein c-iii expression
ATE512222T1 (de)	2011-06-15	Modulation der expression von diacylglycerin- acyltransferase 2
EP1633302A4 (de)	2006-12-06	Modulation der apolipoprotein (a) expression
EP1629084A4 (de)	2008-01-16	Modulation der expression von c-reaktivem protein
EP1581656A4 (de)	2007-02-07	MODULATION DER EXPRESSION VON HIF1a UND HIF2a
ATE395426T1 (de)	2008-05-15	Antisense inhibierung der ptp1b expression.
DE60143901D1 (de)	2011-03-03	Antisense-modulation der clusterinexpression
NO20081884L (no)	2008-06-12	Modulasjon av glukagonreseptorekspresjon
WO2004096016A3 (en)	2005-08-11	Modulation of glucagon receptor expression
WO2004055162A3 (en)	2004-10-07	Modulation of endothelial lipase expression
WO2004096996A3 (en)	2006-11-02	Modulation of glucagon receptor expression
WO2004009024A3 (en)	2004-08-12	Modulation of protein kinase c-iota expression
WO2005006958A8 (en)	2005-06-23	Modulation of ceacam1 expression
WO2004047741A3 (en)	2005-09-22	Modulation of iap-like expression
EP1570082A4 (de)	2006-04-26	Modulation der notch2-expression
WO2004047731A8 (en)	2004-09-16	Modulation of notch3 expression
WO2004043398A3 (en)	2006-03-30	Modulation of jumonji expression
WO2004048601A3 (en)	2004-11-25	Modulation of b7h expression
WO2004048325A3 (en)	2005-03-31	Modulation of jagged 1 expression
WO2004048524A3 (en)	2005-04-28	Modulation of stat2 expression
WO2005007825A3 (en)	2005-10-27	Modulation of aminopeptidase n expression
EP1441740A4 (de)	2006-12-13	Antisense-modulation der matrix-metalloproteinase-1-expression
WO2004047736A3 (en)	2004-12-09	Modulation of bcl2-associated athanogene expression
WO2005028633A3 (en)	2008-11-06	Modulation of rankl expression
WO2004052301A3 (en)	2005-04-07	Modulation of matrix metalloproteinase 11 expression