ATE529103T1 - Modulation der apolipoprotein c-iii expression - Google Patents

Modulation der apolipoprotein c-iii expression

Info

Publication number: ATE529103T1
Authority: AT; Austria
Prior art keywords: apolipoprotein; iii; modulation; expression; iii expression
Prior art date: 2003-04-16

Application number

AT04749914T

Other languages

English (en)

Inventor

Rosanne Crooke

Mark Graham

Tarbet Kristina Lemonidis

Kenneth Dobie

Original Assignee

Isis Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-16

Filing date

2004-04-15

Publication date

2011-11-15

2004-04-15 Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc

2011-11-15 Application granted granted Critical

2011-11-15 Publication of ATE529103T1 publication Critical patent/ATE529103T1/de

Links

102000030169 Apolipoprotein C-III Human genes 0.000 title abstract 5
108010056301 Apolipoprotein C-III Proteins 0.000 title abstract 5
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
- C12N2330/31—Libraries, arrays

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Genetics & Genomics (AREA)
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General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Pharmacology & Pharmacy (AREA)
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Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
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Molecular Biology (AREA)
Obesity (AREA)
Hematology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT04749914T 2003-04-16 2004-04-15 Modulation der apolipoprotein c-iii expression ATE529103T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10/418,780 US7598227B2 (en)	2003-04-16	2003-04-16	Modulation of apolipoprotein C-III expression
PCT/US2004/010946 WO2004093783A2 (en)	2003-04-16	2004-04-15	Modulation of apolipoprotein c-iii expression

Publications (1)

Publication Number	Publication Date
ATE529103T1 true ATE529103T1 (de)	2011-11-15

Family

ID=33159181

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04749914T ATE529103T1 (de)	2003-04-16	2004-04-15	Modulation der apolipoprotein c-iii expression

Country Status (13)

Country	Link
US (6)	US7598227B2 (de)
EP (4)	EP3002007B1 (de)
AT (1)	ATE529103T1 (de)
AU (2)	AU2004231550B2 (de)
CA (2)	CA2958943A1 (de)
CY (1)	CY1117030T1 (de)
DK (2)	DK2441449T3 (de)
ES (3)	ES2558949T3 (de)
HU (1)	HUE027411T2 (de)
PL (1)	PL2441449T3 (de)
PT (1)	PT2441449E (de)
SI (1)	SI2441449T1 (de)
WO (1)	WO2004093783A2 (de)

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CN107233337A (zh)	2009-04-29	2017-10-10	阿马里纳药物爱尔兰有限公司	含有epa和心血管剂的药物组合物以及使用其的方法
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WO2013080784A1 (ja)	2011-11-30	2013-06-06	シャープ株式会社	メモリ回路とその駆動方法、及び、これを用いた不揮発性記憶装置、並びに、液晶表示装置
US9400902B2 (en)	2012-05-22	2016-07-26	Trimble Navigation Limited	Multi-modal entity tracking and display

2003
- 2003-04-16 US US10/418,780 patent/US7598227B2/en not_active Expired - Lifetime
2004
- 2004-04-15 CA CA2958943A patent/CA2958943A1/en not_active Abandoned
- 2004-04-15 PL PL11185507T patent/PL2441449T3/pl unknown
- 2004-04-15 DK DK11185507.8T patent/DK2441449T3/en active
- 2004-04-15 SI SI200432281T patent/SI2441449T1/sl unknown
- 2004-04-15 CA CA2522560A patent/CA2522560C/en not_active Expired - Fee Related
- 2004-04-15 AT AT04749914T patent/ATE529103T1/de not_active IP Right Cessation
- 2004-04-15 ES ES11185507.8T patent/ES2558949T3/es not_active Expired - Lifetime
- 2004-04-15 AU AU2004231550A patent/AU2004231550B2/en not_active Expired
- 2004-04-15 US US10/553,722 patent/US7750141B2/en not_active Expired - Lifetime
- 2004-04-15 EP EP15189401.1A patent/EP3002007B1/de not_active Expired - Lifetime
- 2004-04-15 HU HUE11185507A patent/HUE027411T2/hu unknown
- 2004-04-15 EP EP11185507.8A patent/EP2441449B1/de not_active Expired - Lifetime
- 2004-04-15 EP EP18162847.0A patent/EP3412284A1/de not_active Withdrawn
- 2004-04-15 DK DK04749914.0T patent/DK1622597T3/da active
- 2004-04-15 EP EP04749914A patent/EP1622597B1/de not_active Expired - Lifetime
- 2004-04-15 ES ES15189401.1T patent/ES2666405T3/es not_active Expired - Lifetime
- 2004-04-15 ES ES04749914T patent/ES2373101T3/es not_active Expired - Lifetime
- 2004-04-15 WO PCT/US2004/010946 patent/WO2004093783A2/en not_active Ceased
- 2004-04-15 PT PT111855078T patent/PT2441449E/pt unknown
2010
- 2010-01-28 AU AU2010200324A patent/AU2010200324B2/en not_active Expired
- 2010-05-17 US US12/781,479 patent/US8530439B2/en not_active Expired - Fee Related
2013
- 2013-08-07 US US13/961,646 patent/US9365848B2/en not_active Expired - Fee Related
2015
- 2015-12-07 CY CY20151101109T patent/CY1117030T1/el unknown
2016
- 2016-04-29 US US15/143,222 patent/US9624496B2/en not_active Expired - Fee Related
2017
- 2017-03-03 US US15/449,444 patent/US20170275620A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US8530439B2 (en)	2013-09-10
US20110060030A1 (en)	2011-03-10
EP3002007A1 (de)	2016-04-06
US20170275620A1 (en)	2017-09-28
US20040208856A1 (en)	2004-10-21
ES2558949T3 (es)	2016-02-09
EP2441449A1 (de)	2012-04-18
EP3002007B1 (de)	2018-03-21
CA2522560A1 (en)	2004-11-04
PT2441449E (pt)	2015-11-26
EP2441449B1 (de)	2015-10-14
US9624496B2 (en)	2017-04-18
US7750141B2 (en)	2010-07-06
CY1117030T1 (el)	2017-04-05
US20160237434A1 (en)	2016-08-18
HUE027411T2 (hu)	2016-10-28
SI2441449T1 (sl)	2015-12-31
WO2004093783A3 (en)	2006-05-04
US20130317085A1 (en)	2013-11-28
AU2004231550B2 (en)	2009-10-29
HK1169609A1 (en)	2013-02-01
EP1622597A4 (de)	2009-01-28
EP3412284A1 (de)	2018-12-12
ES2666405T3 (es)	2018-05-04
AU2004231550A1 (en)	2004-11-04
AU2010200324A1 (en)	2010-02-18
PL2441449T3 (pl)	2016-04-29
AU2010200324B2 (en)	2013-10-10
CA2522560C (en)	2017-04-11
DK1622597T3 (da)	2012-01-30
US9365848B2 (en)	2016-06-14
ES2373101T3 (es)	2012-01-31
CA2958943A1 (en)	2004-11-04
US20060264395A1 (en)	2006-11-23
US7598227B2 (en)	2009-10-06
EP1622597B1 (de)	2011-10-19
EP1622597A2 (de)	2006-02-08
WO2004093783A2 (en)	2004-11-04
DK2441449T3 (en)	2015-11-16

Legal Events

Date	Code	Title	Description
2012-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
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WO2004047741A3 (en)	2005-09-22	Modulation of iap-like expression
EP1570082A4 (de)	2006-04-26	Modulation der notch2-expression
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WO2004047736A3 (en)	2004-12-09	Modulation of bcl2-associated athanogene expression
WO2005028633A3 (en)	2008-11-06	Modulation of rankl expression
WO2004052301A3 (en)	2005-04-07	Modulation of matrix metalloproteinase 11 expression