ATE529504T1 - Optimierte mikroorganismenstämme für nadph verbrauchende biosynthesewege - Google Patents
Optimierte mikroorganismenstämme für nadph verbrauchende biosynthesewegeInfo
- Publication number
- ATE529504T1 ATE529504T1 AT04805397T AT04805397T ATE529504T1 AT E529504 T1 ATE529504 T1 AT E529504T1 AT 04805397 T AT04805397 T AT 04805397T AT 04805397 T AT04805397 T AT 04805397T AT E529504 T1 ATE529504 T1 AT E529504T1
- Authority
- AT
- Austria
- Prior art keywords
- nadph
- microorganization
- consumpting
- strains
- optimized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/12—Acting on D ring
- C12P33/16—Acting at 17 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0313056A FR2862068B1 (fr) | 2003-11-06 | 2003-11-06 | Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph |
| PCT/FR2004/002848 WO2005047498A1 (fr) | 2003-11-06 | 2004-11-05 | Souches de microorganismes optimisees pour des voies de biosynthese consommatrices de nadph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE529504T1 true ATE529504T1 (de) | 2011-11-15 |
Family
ID=34508307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04805397T ATE529504T1 (de) | 2003-11-06 | 2004-11-05 | Optimierte mikroorganismenstämme für nadph verbrauchende biosynthesewege |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8088620B2 (de) |
| EP (1) | EP1680504B1 (de) |
| JP (1) | JP5553956B2 (de) |
| KR (1) | KR101149566B1 (de) |
| CN (2) | CN1875096A (de) |
| AT (1) | ATE529504T1 (de) |
| AU (1) | AU2004289859B2 (de) |
| BR (1) | BRPI0415774B1 (de) |
| CA (1) | CA2544507A1 (de) |
| DK (1) | DK1680504T3 (de) |
| ES (1) | ES2371648T3 (de) |
| FR (1) | FR2862068B1 (de) |
| IL (1) | IL174890A0 (de) |
| RU (1) | RU2006119625A (de) |
| WO (1) | WO2005047498A1 (de) |
| ZA (1) | ZA200603590B (de) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0514201B1 (pt) * | 2004-08-10 | 2020-09-15 | Ajinomoto Co., Inc | Bactéria, e, método para produzir um metabólito útil |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| WO2007140816A1 (en) | 2006-06-09 | 2007-12-13 | Metabolic Explorer | Glycolic acid production by fermentation from renewable resources |
| US20080293101A1 (en) * | 2006-07-27 | 2008-11-27 | Peters Matthew W | Engineered microorganisms for increasing product yield in biotransformations, related methods and systems |
| CA2675026A1 (en) * | 2007-01-12 | 2008-07-24 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms |
| US8673601B2 (en) * | 2007-01-22 | 2014-03-18 | Genomatica, Inc. | Methods and organisms for growth-coupled production of 3-hydroxypropionic acid |
| EP2215243A2 (de) * | 2007-10-31 | 2010-08-11 | GEVO, Inc. | Verfahren zur wirtschaftlichen herstellung eines biokraftstoffvorläufers, der auch ein biokraftstoff aus biomasse ist |
| US8048624B1 (en) | 2007-12-04 | 2011-11-01 | Opx Biotechnologies, Inc. | Compositions and methods for 3-hydroxypropionate bio-production from biomass |
| CA2712779C (en) | 2008-01-22 | 2021-03-16 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| DK2262901T3 (en) | 2008-03-05 | 2019-01-21 | Genomatica Inc | ORGANISMS PRODUCING PRIMARY ALCOHOL |
| WO2009135074A2 (en) | 2008-05-01 | 2009-11-05 | Genomatica, Inc. | Microorganisms for the production of methacrylic acid |
| WO2010022763A1 (en) * | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| CA2737112A1 (en) * | 2008-10-27 | 2010-06-03 | Butamax Advanced Biofuels Llc | Carbon pathway optimized production hosts for the production of isobutanol |
| CA2779262C (en) * | 2008-10-31 | 2021-09-07 | Gevo, Inc. | Engineered microorganisms capable of converting pyruvate to isobutanol under anaerobic conditions |
| BRPI0923748B1 (pt) | 2008-12-31 | 2019-04-09 | Metabolic Explorer | Método para a preparação de dióis |
| BRPI1013505A2 (pt) | 2009-04-30 | 2018-02-14 | Genomatica Inc | organismos para a produção de isopropanol, n-butanol, e isobutanol |
| MY176050A (en) | 2009-04-30 | 2020-07-22 | Genomatica Inc | Organisms for the production of 1,3-butanediol |
| EP3190174A1 (de) | 2009-08-05 | 2017-07-12 | Genomatica, Inc. | Aus muconsäureproduzierenden mikroorganismen gewonnene halbsynthetische terephthalsäure |
| MX2012003604A (es) | 2009-09-27 | 2012-09-12 | Opx Biotechnologies Inc | Metodo para producir acido 3-hidroxipropionico y otros productos. |
| US8809027B1 (en) | 2009-09-27 | 2014-08-19 | Opx Biotechnologies, Inc. | Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase |
| KR20180014240A (ko) | 2009-10-23 | 2018-02-07 | 게노마티카 인코포레이티드 | 아닐린의 제조를 위한 미생물 |
| JPWO2011052482A1 (ja) * | 2009-10-29 | 2013-03-21 | 三井化学株式会社 | イソプロピルアルコール生産細菌及びイソプロピルアルコール生産方法 |
| US20110125118A1 (en) * | 2009-11-20 | 2011-05-26 | Opx Biotechnologies, Inc. | Production of an Organic Acid and/or Related Chemicals |
| JP2013517796A (ja) | 2010-01-29 | 2013-05-20 | ジェノマティカ・インコーポレイテッド | ｐ−トルイル酸およびテレフタル酸を生合成するための方法および微生物 |
| CN103189513A (zh) * | 2010-03-31 | 2013-07-03 | 纳幕尔杜邦公司 | 上调磷酸戊糖途径以提高转基因微生物中受关注的非天然产物的产量 |
| US9023636B2 (en) | 2010-04-30 | 2015-05-05 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of propylene |
| EP2588598B1 (de) | 2010-07-02 | 2016-03-09 | Metabolic Explorer | Verfahren zur herstellung von hydroxysäuren |
| TWI500768B (zh) | 2010-07-05 | 2015-09-21 | Metabolic Explorer Sa | 由蔗糖製備１，３－丙二醇之方法 |
| PH12013500158A1 (en) | 2010-07-26 | 2013-03-11 | Genomatica Inc | Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene |
| AR083468A1 (es) * | 2010-10-25 | 2013-02-27 | Metabolic Explorer Sa | Aumento de la disponibilidad de nadph para la produccion de metionina |
| KR20120108538A (ko) * | 2011-03-24 | 2012-10-05 | 삼성전자주식회사 | 말로닉 세미알데히드 환원 경로를 이용한 3-하이드록시프로피온산의 생산방법 |
| US20120247066A1 (en) | 2011-04-01 | 2012-10-04 | Ice House America, Llc | Ice bagging apparatus and methods |
| US9169486B2 (en) | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
| EP2540834A1 (de) | 2011-06-29 | 2013-01-02 | Metabolic Explorer | Verfahren zur Herstellung von 1,3-Propandiol |
| ES2599482T3 (es) | 2011-07-29 | 2017-02-01 | Mitsui Chemicals, Inc. | Microorganismo que tiene un ciclo de fijación de dióxido de carbono introducido en el mismo |
| EP2766492B1 (de) | 2011-10-11 | 2018-06-06 | Metabolic Explorer | Fermentative Herstellung von Prenol |
| EP2647718A3 (de) | 2012-04-06 | 2014-12-24 | Metabolic Explorer | Verfahren zur Herstellung von 5-Aminopentanoat unter Verwendung eines rekombinanten Mikroorganismus |
| US9181568B2 (en) | 2012-04-23 | 2015-11-10 | Exxonmobil Research And Engineering Company | Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases |
| MX2015001780A (es) | 2012-08-10 | 2015-09-28 | Opx Biotechnologies Inc | Microorganismos y métodos para la producción de ácidos grasos y productos derivados de ácidos grasos. |
| WO2014049382A2 (en) | 2012-09-26 | 2014-04-03 | Metabolic Explorer | Ethylenediamine fermentative production by a recombinant microorganism |
| US10480016B2 (en) | 2012-10-15 | 2019-11-19 | Calysta, Inc. | Genetically engineered microorganisms for biological oxidation of hydrocarbons |
| US9828618B2 (en) | 2013-01-24 | 2017-11-28 | Mitsui Chemicals, Inc. | Microorganism having carbon dioxide fixation cycle introduced thereinto |
| US20150119601A1 (en) | 2013-03-15 | 2015-04-30 | Opx Biotechnologies, Inc. | Monofunctional mcr + 3-hp dehydrogenase |
| EP2976141A4 (de) | 2013-03-15 | 2016-10-05 | Cargill Inc | Blitzverdampfung für produktionsreinigung und rückgewinnung |
| CN103205391A (zh) * | 2013-04-12 | 2013-07-17 | 浙江大学 | 一种基因工程菌及其应用 |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| EP3022310B1 (de) | 2013-07-19 | 2019-10-16 | Cargill, Incorporated | Mikroorganismen und verfahren zur herstellung von fettsäuren und aus fettsäuren gewonnenen produkten |
| AU2014306074B2 (en) * | 2013-08-05 | 2018-08-30 | Greenlight Biosciences, Inc. | Engineered proteins with a protease cleavage site |
| CN103710396A (zh) * | 2013-12-30 | 2014-04-09 | 南京工业大学 | 一种提高厌氧发酵目标产物转化率的方法 |
| CN106559997B (zh) | 2014-05-12 | 2021-04-09 | 代谢探索者公司 | 基于nadph依赖型丙酮醇还原酶和改进的nadph供给用于生产1,2-丙二醇的新微生物和方法 |
| EP2993228B1 (de) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Herstellung von fettsäureestern |
| EP3050970B1 (de) | 2015-01-28 | 2019-09-18 | Metabolic Explorer | Modifizierter Mikroorganismus zur optimierten Herstellung von 1,4-Butandiol |
| ES2811337T3 (es) | 2015-04-07 | 2021-03-11 | Metabolic Explorer Sa | Microorganismo modificado para la producción optimizada de 2,4-dihidroxibutirato con eflujo de 2,4- dihidroxibutirato aumentado |
| CN107690482B (zh) | 2015-04-07 | 2022-11-29 | 代谢探索者公司 | 用于2,4-二羟基丁酸的优化生产的经修饰的微生物 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2017042602A1 (en) | 2015-09-10 | 2017-03-16 | Metabolic Explorer | New lactaldehyde reductases for the production of 1,2-propanediol |
| CN106086082B (zh) * | 2016-06-01 | 2019-11-15 | 苏州华赛生物工程技术有限公司 | 一种改良重组大肠杆菌生产9-癸烯醇的方法 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| EP3342873A1 (de) | 2016-12-29 | 2018-07-04 | Metabolic Explorer | Umsetzung von methylglyoxal zu hydroxyaceton unter verwendung von enzymen sowie ihre anwendungen |
| US11345938B2 (en) | 2017-02-02 | 2022-05-31 | Cargill, Incorporated | Genetically modified cells that produce C6-C10 fatty acid derivatives |
| EP3428282A1 (de) * | 2017-07-11 | 2019-01-16 | Alderys | Ectoine-herstellende hefe |
| KR101894984B1 (ko) * | 2017-07-14 | 2018-09-05 | 한국과학기술원 | 환원력이 증가된 캔디다 속 변이 균주 및 이의 용도 |
| IL297008A (en) * | 2020-04-03 | 2022-12-01 | Univ Duke | Methods and compositions for the production of xylitol from xylose utilizing dynamic metabolic control |
| CN115747240B (zh) * | 2022-08-05 | 2025-04-22 | 华熙生物科技股份有限公司 | 一种生产雌马酚的重组大肠杆菌工程菌株及应用 |
| CN117487681A (zh) * | 2023-11-16 | 2024-02-02 | 湖南农业大学 | 一种生产角鲨烯的酵母工程菌及其应用 |
| WO2025252176A1 (zh) * | 2024-06-05 | 2025-12-11 | 杭州明德生物医药技术有限公司 | 表达载体及其用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9614618D0 (en) * | 1996-07-11 | 1996-09-04 | Animal Health Inst | Vaccine compositions |
| JP4380029B2 (ja) * | 2000-07-05 | 2009-12-09 | 味の素株式会社 | 微生物を利用した物質の製造法 |
-
2003
- 2003-11-06 FR FR0313056A patent/FR2862068B1/fr not_active Expired - Fee Related
-
2004
- 2004-11-05 ES ES04805397T patent/ES2371648T3/es not_active Expired - Lifetime
- 2004-11-05 AU AU2004289859A patent/AU2004289859B2/en not_active Ceased
- 2004-11-05 EP EP04805397A patent/EP1680504B1/de not_active Expired - Lifetime
- 2004-11-05 DK DK04805397.9T patent/DK1680504T3/da active
- 2004-11-05 US US10/577,084 patent/US8088620B2/en not_active Expired - Fee Related
- 2004-11-05 CN CNA2004800319806A patent/CN1875096A/zh active Pending
- 2004-11-05 KR KR1020067008922A patent/KR101149566B1/ko not_active Expired - Fee Related
- 2004-11-05 WO PCT/FR2004/002848 patent/WO2005047498A1/fr not_active Ceased
- 2004-11-05 CA CA002544507A patent/CA2544507A1/fr not_active Abandoned
- 2004-11-05 RU RU2006119625/13A patent/RU2006119625A/ru not_active Application Discontinuation
- 2004-11-05 CN CN201410119033.8A patent/CN103952335B/zh not_active Expired - Fee Related
- 2004-11-05 AT AT04805397T patent/ATE529504T1/de not_active IP Right Cessation
- 2004-11-05 JP JP2006537373A patent/JP5553956B2/ja not_active Expired - Fee Related
- 2004-11-05 BR BRPI0415774A patent/BRPI0415774B1/pt not_active IP Right Cessation
-
2006
- 2006-04-10 IL IL174890A patent/IL174890A0/en unknown
- 2006-05-05 ZA ZA200603590A patent/ZA200603590B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1680504T3 (da) | 2011-11-21 |
| FR2862068B1 (fr) | 2007-10-12 |
| US20070087403A1 (en) | 2007-04-19 |
| KR101149566B1 (ko) | 2012-07-05 |
| JP2007510411A (ja) | 2007-04-26 |
| CN1875096A (zh) | 2006-12-06 |
| ZA200603590B (en) | 2007-07-25 |
| IL174890A0 (en) | 2006-08-20 |
| KR20060132577A (ko) | 2006-12-21 |
| ES2371648T3 (es) | 2012-01-05 |
| CN103952335B (zh) | 2016-08-31 |
| WO2005047498A1 (fr) | 2005-05-26 |
| CA2544507A1 (fr) | 2005-05-26 |
| FR2862068A1 (fr) | 2005-05-13 |
| JP5553956B2 (ja) | 2014-07-23 |
| RU2006119625A (ru) | 2007-12-27 |
| US8088620B2 (en) | 2012-01-03 |
| BRPI0415774B1 (pt) | 2019-12-31 |
| CN103952335A (zh) | 2014-07-30 |
| EP1680504B1 (de) | 2011-10-19 |
| BRPI0415774A (pt) | 2006-12-26 |
| AU2004289859A1 (en) | 2005-05-26 |
| EP1680504A1 (de) | 2006-07-19 |
| AU2004289859B2 (en) | 2009-03-26 |
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