ATE534465T1 - Kartusche, system und verfahren für automatisierte medizinische diagnosen - Google Patents

Kartusche, system und verfahren für automatisierte medizinische diagnosen

Info

Publication number
ATE534465T1
ATE534465T1 AT06765771T AT06765771T ATE534465T1 AT E534465 T1 ATE534465 T1 AT E534465T1 AT 06765771 T AT06765771 T AT 06765771T AT 06765771 T AT06765771 T AT 06765771T AT E534465 T1 ATE534465 T1 AT E534465T1
Authority
AT
Austria
Prior art keywords
cartridge
absence
sample
medical diagnosis
detection
Prior art date
Application number
AT06765771T
Other languages
English (en)
Inventor
Haag Chris Van
Michiel Jongerius
Danny Schaefer
Den Bijgaart Adrianus Van
Gier Ronald De
Jong Michiel De
Gerhard Pross
Johannes Bacher
Andreas Boos
Gerd Luedke
Jens-Peter Seher
Original Assignee
Biocartis Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37188981&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE534465(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biocartis Sa filed Critical Biocartis Sa
Application granted granted Critical
Publication of ATE534465T1 publication Critical patent/ATE534465T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/54Labware with identification means
    • B01L3/545Labware with identification means for laboratory containers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/028Modular arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087Multiple sequential chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements
    • G01N2035/00158Elements containing microarrays, i.e. "biochip"

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT06765771T 2005-06-23 2006-06-16 Kartusche, system und verfahren für automatisierte medizinische diagnosen ATE534465T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05105608 2005-06-23
PCT/IB2006/051941 WO2006136990A2 (en) 2005-06-23 2006-06-16 Cartridge, system and method for automated medical diagnostics

Publications (1)

Publication Number Publication Date
ATE534465T1 true ATE534465T1 (de) 2011-12-15

Family

ID=37188981

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06765771T ATE534465T1 (de) 2005-06-23 2006-06-16 Kartusche, system und verfahren für automatisierte medizinische diagnosen

Country Status (8)

Country Link
US (2) US9568424B2 (de)
EP (2) EP1896180B1 (de)
JP (1) JP5086250B2 (de)
CN (2) CN101203312B (de)
AT (1) ATE534465T1 (de)
ES (2) ES2689172T3 (de)
RU (1) RU2432205C2 (de)
WO (1) WO2006136990A2 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009531118A (ja) * 2006-03-29 2009-09-03 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 流体処理及び体積決定システム
WO2008012550A2 (en) 2006-07-28 2008-01-31 Diagnostics For The Real World, Ltd. Device, system and method for processing a sample
US9707556B2 (en) 2007-08-17 2017-07-18 Diagnostics For The Real World, Ltd. Device, system and method for processing a sample
JP2009240296A (ja) * 2007-12-14 2009-10-22 Ngk Insulators Ltd 流体収容カートリッジ及びその利用
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
CA2756463C (en) 2009-03-24 2019-01-22 University Of Chicago Slip chip device and methods
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
AU2010237530B2 (en) 2009-04-14 2016-04-21 Biocartis Nv HIFU induced cavitation with reduced power threshold
EP2419220B1 (de) 2009-04-15 2018-06-06 Biocartis NV Schutz von kammern für biologische proben
WO2010118541A1 (en) 2009-04-15 2010-10-21 Biocartis Sa OPTICAL DETECTION SYSTEM FOR MONITORING rtPCR REACTION
EP2427270B1 (de) 2009-05-06 2015-04-01 Biocartis NV Vorrichtung zum schneiden eines probenträgers
CA3016967C (en) 2010-04-16 2021-08-31 Opko Diagnostics, Llc Systems and devices for analysis of samples
US9387476B2 (en) 2010-10-27 2016-07-12 Illumina, Inc. Flow cells for biological or chemical analysis
EP2632593B1 (de) * 2010-10-27 2021-09-29 Illumina, Inc. Durchflusszellen zur biologischen oder chemischen analyse
US9689029B2 (en) * 2011-12-02 2017-06-27 Caliper Life Sciences, Inc. Systems and methods for sampling of amplification products
BR112015008268A2 (pt) 2012-10-22 2017-11-28 Bayer Cropscience Ag composição de material, kit, dispositivo, cartucho e métodos para a amplificação de ácidos nucleicos
EP3427830B1 (de) * 2012-10-24 2021-06-23 Genmark Diagnostics Inc. Integrierte multiplex-zielanalyse
EP3674406A1 (de) 2013-02-25 2020-07-01 Biocartis N.V. Isolierung von nukleinsäuren
DE102013222283B3 (de) * 2013-11-04 2015-01-15 Robert Bosch Gmbh Vorrichtung und Verfahren zur Handhabung von Reagenzien
DE202014104510U1 (de) 2014-09-22 2016-01-04 Robert Bosch Gmbh Vorrichtung zum Vorlagern eines Fluids in einem mikrofluidischen System
EP2905079A1 (de) 2014-02-10 2015-08-12 Robert Bosch Gmbh Vorrichtung zum Vorlagern eines Fluids in einem mikrofluidischen System, Verfahren zum Betreiben und Verfahren zum Herstellen einer solchen Vorrichtung
DE102014202342A1 (de) 2014-02-10 2015-08-13 Robert Bosch Gmbh Vorrichtung zum Vorlagern eines Fluids in einem mikrofluidischen System, Verfahren zum Betreiben und Verfahren zum Herstellen einer solchen Vorrichtung
CN104946510B (zh) * 2014-03-31 2017-06-06 博奥生物集团有限公司 集核酸扩增和微阵列检测于一体的微流控装置
DE102015205906B4 (de) 2015-04-01 2024-05-23 Robert Bosch Gmbh Bevorratungseinheit, Verfahren zum Herstellen einer Bevorratungseinheit und Verfahren zum Freisetzen eines in einer Bevorratungseinheit gelagerten Fluids
CA2981940A1 (en) 2015-06-10 2016-12-15 Biocartis N.V. Improved detection of methylated dna
CN107922941A (zh) * 2015-06-15 2018-04-17 塞弗德公司 在自动化反应盒中DNA甲基化的整合的纯化和测量以及突变和/或mRNA表达水平的共同测量
GB201511129D0 (en) * 2015-06-24 2015-08-05 Linea Ab Q Method of determining antimicrobial susceptibility of a microorganism
KR102648647B1 (ko) 2015-09-22 2024-03-18 비오까르띠 엔브이 짧은 호모폴리머릭 반복서열의 개선된 검출법
CA3046636A1 (en) 2016-12-12 2018-06-21 Cepheid Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge
CN110291206A (zh) 2017-02-13 2019-09-27 基美健有限公司 用于评估前列腺癌晚期临床终点的算法和方法
WO2018213550A1 (en) 2017-05-18 2018-11-22 Genomic Health, Inc. Dna methylation and mutational analysis methods for bladder cancer surveillance
GB201716883D0 (en) 2017-10-13 2017-11-29 Q-Linea Ab Method for determining the concentration of intact microorganisms in a sample
CA3087887A1 (en) 2018-01-23 2019-08-01 Biocartis Nv Methods for the analysis of dissociation melt curve data
ES2785149T3 (es) 2018-01-23 2020-10-06 Biocartis Nv Panel de biomarcadores y métodos para detectar la inestabilidad de los microsatélites en cánceres
US11713488B2 (en) 2018-01-23 2023-08-01 Biocartis Nv Biomarker panel and methods for detecting microsatellite instability in cancers
CN109082375B (zh) * 2018-09-14 2024-06-14 深圳市伟创力拓实业发展有限公司 一种样品检测的系统
WO2020104390A2 (en) 2018-11-19 2020-05-28 Biocartis Nv Enhanced detection of low-copy-number nucleic acids in an integrated workflow
WO2020165180A1 (en) 2019-02-12 2020-08-20 Biocartis Nv Protocols and kits for multiplex amplification and ngs-specific tagging
EP3997246A1 (de) 2019-07-11 2022-05-18 Biocartis NV Verfahren und genetische signatur zur erkennung einer erhöhten tumormutationslast
CA3149690A1 (en) 2019-08-08 2021-02-11 Biocartis Nv Novel nucleic acid purification chemistry
AU2021270457A1 (en) * 2020-05-13 2022-12-15 Quidel Corporation System and cartridge for sample testing
ES3034761T3 (en) 2020-10-29 2025-08-22 Biocartis Nv Generic cartridge and method for multiplex nucleic acid detection
WO2022098747A1 (en) * 2020-11-03 2022-05-12 Single Helix Genomics, Inc. Nucleic acid synthesis device and methods of use
CN115418311A (zh) * 2022-07-29 2022-12-02 东莞市李群自动化技术有限公司 一种样本预处理装置及方法
NL2034698B1 (en) 2023-04-26 2024-11-04 Biocartis Nv Semi-solid phase extraction of nucleic acids using a quaternary salt and cation mixture in alkaline conditions
WO2024240872A1 (en) 2023-05-23 2024-11-28 Biocartis Nv Cartridges comprising tablets

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US37164A (en) * 1862-12-16 Improvement in locks for mail-bags
US3476515A (en) * 1966-04-26 1969-11-04 Du Pont Analytical test pack and process for analysis
US4479760A (en) 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
US4828545A (en) 1984-02-08 1989-05-09 Omni-Flow, Inc. Pressure responsive multiple input infusion system
EP0206411A3 (de) * 1985-06-17 1988-10-05 The Board Of Trustees Of The University Of Illinois Umkehrphasenchromatographie zur Sequenzierung von Oligonukleotiden
US4940527A (en) 1987-06-01 1990-07-10 Abbott Laboratories Two-part test cartridge for centrifuge
US5133937A (en) 1989-06-01 1992-07-28 Iniziative Marittime, 1991 S.R.L. Analysis system having a removable reaction cartridge and temperature control
DE59104604D1 (de) * 1990-11-26 1995-03-23 Ciba Geigy Ag Detektorzelle.
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
USD351913S (en) 1993-02-25 1994-10-25 Diametrics Medical, Inc. Disposable electrochemical measurement cartridge for a portable medical analyzer
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
JP2000500331A (ja) 1995-11-03 2000-01-18 サーノフ コーポレイション アッセイシステムおよびアッセイを実施する方法
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
SE9602610D0 (sv) * 1996-07-01 1996-07-01 Pharmacia & Upjohn Ab Delivery device and method for its operation
JP3834357B2 (ja) 1996-07-10 2006-10-18 オリンパス株式会社 小型分析装置及びその駆動方法
US5882903A (en) 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
DK2333520T3 (da) 1997-02-28 2014-09-29 Cepheid Varmevekslende, forespurgt indretning til kemisk reaktion
US5958349A (en) 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
DK1017848T3 (da) * 1997-07-28 2003-02-10 Medical Biosystems Ltd Nucleinsyresekvensanalyse
ATE400358T1 (de) 1997-12-24 2008-07-15 Cepheid Vorrichtung und verfahren zur lyse
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US6416293B1 (en) 1999-07-20 2002-07-09 Deka Products Limited Partnership Pumping cartridge including a bypass valve and method for directing flow in a pumping cartridge
US6382923B1 (en) 1999-07-20 2002-05-07 Deka Products Ltd. Partnership Pump chamber having at least one spacer for inhibiting the pumping of a gas
JP2001194373A (ja) * 2000-01-06 2001-07-19 Olympus Optical Co Ltd 超小型化学操作装置
DE60110976T2 (de) * 2000-07-10 2006-04-27 Océ-Technologies B.V. Pulverbildübertragungssystem mit Wärmetauscher
FR2812306B1 (fr) * 2000-07-28 2005-01-14 Gabriel Festoc Systeme d'amplification en chaine par polymerse de sequences nucleiques cibles
SE0004297D0 (sv) 2000-11-23 2000-11-23 Gyros Ab Device for thermal cycling
US7051831B2 (en) * 2001-08-24 2006-05-30 Ford Global Technologies, Llc Method and apparatus for maintaining a connection between a vehicle and a fuel source
DE10149684B4 (de) * 2001-10-09 2005-02-17 Clondiag Chip Technologies Gmbh Vorrichtung zur Halterung eines Substanzbibliothekenträgers
US20030073089A1 (en) * 2001-10-16 2003-04-17 Mauze Ganapati R. Companion cartridge for disposable diagnostic sensing platforms
US7338760B2 (en) 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US20030224506A1 (en) * 2002-05-30 2003-12-04 Biomicroarrays Inc Tiled biochips and the methods of making the same
US6789355B2 (en) * 2002-07-29 2004-09-14 The Pride Group, Inc. Planter having an integral water tray
US6743634B2 (en) * 2002-08-23 2004-06-01 Coulter International Corp. Method and apparatus for differentiating blood cells using back-scatter
US7217542B2 (en) * 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
US7390457B2 (en) 2002-10-31 2008-06-24 Agilent Technologies, Inc. Integrated microfluidic array device
US7364896B2 (en) 2002-10-31 2008-04-29 Agilent Technologies, Inc. Test strips including flexible array substrates and method of hybridization
DE10251313B4 (de) * 2002-11-04 2007-05-03 Advanced Micro Devices, Inc., Sunnyvale Gemeinsame Benutzung eines Schaltkreises für Frequenz- und Phasenfehlerkorrektur
JP2004212326A (ja) * 2003-01-08 2004-07-29 Matsushita Electric Ind Co Ltd マイクロポンプと試料処理チップ、及びシートコネクタ
JP4069747B2 (ja) * 2003-01-20 2008-04-02 横河電機株式会社 分離可能型バイオチップ
JP4632262B2 (ja) * 2003-02-05 2011-02-16 アイキューム,インク. サンプルの処理
JP2004309145A (ja) * 2003-04-02 2004-11-04 Hitachi High-Technologies Corp 化学分析装置及び化学分析用構造体
US20040228765A1 (en) * 2003-05-14 2004-11-18 Witty Thomas R. Point of care diagnostic platform
US7781226B2 (en) * 2004-02-27 2010-08-24 The Board Of Regents Of The University Of Texas System Particle on membrane assay system
WO2005121963A2 (en) * 2004-06-07 2005-12-22 Iquum, Inc. Sample multiprocessing
JPWO2006123578A1 (ja) * 2005-05-19 2008-12-25 コニカミノルタエムジー株式会社 検体中の標的物質を分析するための検査チップおよびマイクロ総合分析システム

Also Published As

Publication number Publication date
EP2409767A1 (de) 2012-01-25
CN101203312A (zh) 2008-06-18
WO2006136990A2 (en) 2006-12-28
JP5086250B2 (ja) 2012-11-28
US9568424B2 (en) 2017-02-14
EP2409767B1 (de) 2018-08-08
ES2373686T3 (es) 2012-02-07
CN101203312B (zh) 2011-08-17
WO2006136990A3 (en) 2007-03-08
RU2432205C2 (ru) 2011-10-27
US20100047774A1 (en) 2010-02-25
CN102268367A (zh) 2011-12-07
EP1896180A2 (de) 2008-03-12
ES2689172T3 (es) 2018-11-08
RU2008102386A (ru) 2009-07-27
EP1896180B1 (de) 2011-11-23
JP2008546401A (ja) 2008-12-25
US20170100719A1 (en) 2017-04-13

Similar Documents

Publication Publication Date Title
WO2006136990A3 (en) Cartridge, system and method for automated medical diagnostics
ATE521948T1 (de) System und verfahren zur nukleinsäuresequenzierung
ATE469247T1 (de) Verfahren zum nachweis von egfr-mutationen in blutproben
ATE478342T1 (de) Kompakte vorrichtung, zusammensetzungen und verfahren zur reinigung von nukleinsäuren
WO2009076485A3 (en) Sequencing of nucleic acids
MX2019006628A (es) Purificacion y medicion integradas de metilacion de adn y co-medicion de mutaciones y/o niveles de expresion de arnm en un cartucho de reaccion automatizado.
DE602004029391D1 (de) Ein auf computerverwendung basiertes verfahren zur identifizierung von dna-sequenzen, die für als "drug targets" nutzbare proteine codieren
DE602006003012D1 (de) Verfahren und Nukleinsäuren für die Analyse von zellulären Proliferationsstörungen
AU2014204426B2 (en) Integrated nucleic acid analysis
DE602005020011D1 (de) Verfahren zur nukleinsäureanalyse
ATE384803T1 (de) Verfahren zur schnellen bestimmung von mikrobieller dns/rns, kit dafür und verwendung des verfahrens
EP2134861A4 (de) Primer für die schmelzanalyse
DE60331979D1 (de) Verfahren zur Diagnose von Tuberkulose mittels Abstrichmikroskopie, Kultur und Polymerasekettenreaktion unter Verwendung prozessierter klinischer Proben und Kit davon
ATE515498T1 (de) Verfahren zur aufreinigung von montelukast und dessen aminsalzen
ATE362530T1 (de) Verfahren und vorrichtung zur reinigung von nukleinsäuren
ATE510029T1 (de) Verfahren zur analyse von nukleinsäuren
ATE485372T1 (de) Nukleinsäurenachweisverfahren und system dafür
ATE537191T1 (de) Protein, verfahren zur proteinimmobilisierung, struktur, biosensor, nukleinsäure, vektor und kit für den nachweis einer zielsubstanz
ATE462803T1 (de) Kit und verfahren zum nachweis von urothelkarzinom
GB2445529A (en) Method for isothermal amplification of nucleic acids and method for detecting nucleic acids using simultaneous isothermal amplification of nucleic acids
DE602008004702D1 (de) Verfahren zur Amplifikation von Nukleinsäure
ATE528395T1 (de) In an den 5'-terminus eines primers zur verwendung bei einer nukleinsäureamplifikationsreaktion gebundener form verwendetes dna-fragment und verwendung davon
ATE547520T1 (de) Verfahren zum nachweis und zur quantifizierung von endogener weizen-dna-sequenz
DE60324819D1 (de) Verfahren zur amplifikation von nukleinsäure, kit zur amplifikation von nukleinsäure, verfahren zum nachweis von einzelnukleotid-polymorphismus und reagentienkit zum nachweis von einzelnukleotid-polymorphismus
ATE477340T1 (de) Mittel und verfahren zur diagnose und behandlung von krebs auf basis des frmd3-gens