ATE534465T1 - Kartusche, system und verfahren für automatisierte medizinische diagnosen - Google Patents

Kartusche, system und verfahren für automatisierte medizinische diagnosen

Info

Publication number
ATE534465T1
ATE534465T1 AT06765771T AT06765771T ATE534465T1 AT E534465 T1 ATE534465 T1 AT E534465T1 AT 06765771 T AT06765771 T AT 06765771T AT 06765771 T AT06765771 T AT 06765771T AT E534465 T1 ATE534465 T1 AT E534465T1
Authority
AT
Austria
Prior art keywords
cartridge
absence
sample
medical diagnosis
detection
Prior art date
Application number
AT06765771T
Other languages
English (en)
Inventor
Haag Chris Van
Michiel Jongerius
Danny Schaefer
Den Bijgaart Adrianus Van
Gier Ronald De
Jong Michiel De
Gerhard Pross
Johannes Bacher
Andreas Boos
Gerd Luedke
Jens-Peter Seher
Original Assignee
Biocartis Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37188981&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE534465(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biocartis Sa filed Critical Biocartis Sa
Application granted granted Critical
Publication of ATE534465T1 publication Critical patent/ATE534465T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/54Labware with identification means
    • B01L3/545Labware with identification means for laboratory containers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/028Modular arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087Multiple sequential chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements
    • G01N2035/00158Elements containing microarrays, i.e. "biochip"

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT06765771T 2005-06-23 2006-06-16 Kartusche, system und verfahren für automatisierte medizinische diagnosen ATE534465T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05105608 2005-06-23
PCT/IB2006/051941 WO2006136990A2 (en) 2005-06-23 2006-06-16 Cartridge, system and method for automated medical diagnostics

Publications (1)

Publication Number Publication Date
ATE534465T1 true ATE534465T1 (de) 2011-12-15

Family

ID=37188981

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06765771T ATE534465T1 (de) 2005-06-23 2006-06-16 Kartusche, system und verfahren für automatisierte medizinische diagnosen

Country Status (8)

Country Link
US (2) US9568424B2 (de)
EP (2) EP1896180B1 (de)
JP (1) JP5086250B2 (de)
CN (2) CN101203312B (de)
AT (1) ATE534465T1 (de)
ES (2) ES2689172T3 (de)
RU (1) RU2432205C2 (de)
WO (1) WO2006136990A2 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007110825A2 (en) * 2006-03-29 2007-10-04 Koninklijke Philips Electronics N.V. Fluid processing and volume determination system
ES2688281T3 (es) 2006-07-28 2018-10-31 Diagnostics For The Real World, Ltd Dispositivo, sistema y método para procesar una muestra
GB2456079B (en) 2007-08-17 2010-07-14 Diagnostics For The Real World Device, system and method for processing a sample
JP2009240296A (ja) * 2007-12-14 2009-10-22 Ngk Insulators Ltd 流体収容カートリッジ及びその利用
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
JP5766178B2 (ja) 2009-03-24 2015-08-19 ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago SlipChip装置および方法
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
BRPI1014469A2 (pt) 2009-04-14 2017-06-27 Biocartis Sa cavitação induzida hifu com limiar de energia reduzido
KR20120030361A (ko) 2009-04-15 2012-03-28 비오까르띠 에스아 바이오분석 샘플 챔버의 보호
EP2419743B1 (de) 2009-04-15 2020-08-05 Biocartis NV OPTISCHES ERKENNUNGSSYSTEM ZUR ÜBERWACHUNG DER rtPCR-REAKTION
WO2010127464A1 (en) 2009-05-06 2010-11-11 Biocartis Sa Device for cutting a sample carrier
CA3016967C (en) 2010-04-16 2021-08-31 Opko Diagnostics, Llc Systems and devices for analysis of samples
EP2632593B1 (de) 2010-10-27 2021-09-29 Illumina, Inc. Durchflusszellen zur biologischen oder chemischen analyse
US9387476B2 (en) 2010-10-27 2016-07-12 Illumina, Inc. Flow cells for biological or chemical analysis
US9689029B2 (en) * 2011-12-02 2017-06-27 Caliper Life Sciences, Inc. Systems and methods for sampling of amplification products
WO2014064002A1 (en) 2012-10-22 2014-05-01 Bayer Cropscience Nv Methods, compositions and devices for amplification of nucleic acids
AU2013334189B2 (en) * 2012-10-24 2018-08-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
WO2014128129A1 (en) 2013-02-25 2014-08-28 Biocartis N.V. Isolation of nucleic acids
DE102013222283B3 (de) 2013-11-04 2015-01-15 Robert Bosch Gmbh Vorrichtung und Verfahren zur Handhabung von Reagenzien
DE202014104510U1 (de) 2014-09-22 2016-01-04 Robert Bosch Gmbh Vorrichtung zum Vorlagern eines Fluids in einem mikrofluidischen System
DE102014202342A1 (de) 2014-02-10 2015-08-13 Robert Bosch Gmbh Vorrichtung zum Vorlagern eines Fluids in einem mikrofluidischen System, Verfahren zum Betreiben und Verfahren zum Herstellen einer solchen Vorrichtung
EP2905079A1 (de) 2014-02-10 2015-08-12 Robert Bosch Gmbh Vorrichtung zum Vorlagern eines Fluids in einem mikrofluidischen System, Verfahren zum Betreiben und Verfahren zum Herstellen einer solchen Vorrichtung
CN204727866U (zh) 2014-03-31 2015-10-28 博奥生物集团有限公司 一种集核酸扩增和微阵列检测于一体的微流控装置
DE102015205906B4 (de) 2015-04-01 2024-05-23 Robert Bosch Gmbh Bevorratungseinheit, Verfahren zum Herstellen einer Bevorratungseinheit und Verfahren zum Freisetzen eines in einer Bevorratungseinheit gelagerten Fluids
ES2815684T3 (es) 2015-06-10 2021-03-30 Biocartis N V Detección mejorada de ADN metilado
EP3307885B1 (de) * 2015-06-15 2020-10-21 Cepheid Integrierte reinigung und messung der dna-methylierung und ko-messung von mutationen und/oder mrna-expressionsniveaus in einer automatisierten reaktionskartusche
GB201511129D0 (en) * 2015-06-24 2015-08-05 Linea Ab Q Method of determining antimicrobial susceptibility of a microorganism
EP4299763A2 (de) 2015-09-22 2024-01-03 Biocartis NV Verbesserte detektion von kurzen homopolymeren wiederholungen
AU2017376118B2 (en) 2016-12-12 2022-09-01 Cepheid Integrated purification and measurement of DNA methylation and co-measurement of mutations and/or mRNA expression levels in an automated reaction cartridge
MX2019009027A (es) 2017-02-13 2020-01-27 Genomic Health Inc Algoritmos y metodos para evaluar criterios de valoracion tardios en cancer de prostata.
SG10201912359XA (en) 2017-05-18 2020-02-27 Genomic Health Inc Dna methylation and mutational analysis methods for bladder cancer surveillance
GB201716883D0 (en) 2017-10-13 2017-11-29 Q-Linea Ab Method for determining the concentration of intact microorganisms in a sample
WO2019145306A1 (en) 2018-01-23 2019-08-01 Biocartis Nv Biomarker panel and methods for detecting microsatellite instability in cancers
EP3514247B1 (de) 2018-01-23 2020-03-11 Biocartis NV Biomarkertafel und verfahren zur detektion von mikrosatelliteninstabilität bei tumoren
WO2019145303A1 (en) 2018-01-23 2019-08-01 Biocartis Nv Methods for the analysis of dissociation melt curve data
CN109082375B (zh) * 2018-09-14 2024-06-14 深圳市伟创力拓实业发展有限公司 一种样品检测的系统
JP2022513079A (ja) 2018-11-19 2022-02-07 バイオカルティス エン フェー 統合ワークフローでの低コピー数の核酸の強化された検出
US20220195510A1 (en) 2019-02-12 2022-06-23 Biocartis Nv Protocols and kits for multiplex amplification and ngs-specific tagging
CN114207152A (zh) 2019-07-11 2022-03-18 拜奥卡蒂斯生物股份有限公司 检测肿瘤突变负荷增加的方法和遗传特征
EP4010488A1 (de) 2019-08-08 2022-06-15 Biocartis NV Neuartige chemische formulierungen zur nukleinsäurereinigung
CA3178543A1 (en) * 2020-05-13 2021-11-18 Johannes KEHLE System and cartridge for sample testing
KR20230098259A (ko) 2020-10-29 2023-07-03 비오까르띠 엔브이 멀티플렉스 핵산 검출을 위한 제네릭 카트리지 및 방법
WO2022098747A1 (en) * 2020-11-03 2022-05-12 Single Helix Genomics, Inc. Nucleic acid synthesis device and methods of use
CN115418311A (zh) * 2022-07-29 2022-12-02 东莞市李群自动化技术有限公司 一种样本预处理装置及方法
NL2034698B1 (en) 2023-04-26 2024-11-04 Biocartis Nv Semi-solid phase extraction of nucleic acids using a quaternary salt and cation mixture in alkaline conditions
WO2024240872A1 (en) 2023-05-23 2024-11-28 Biocartis Nv Cartridges comprising tablets

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US37164A (en) * 1862-12-16 Improvement in locks for mail-bags
US3476515A (en) * 1966-04-26 1969-11-04 Du Pont Analytical test pack and process for analysis
US4479760A (en) 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
US4828545A (en) 1984-02-08 1989-05-09 Omni-Flow, Inc. Pressure responsive multiple input infusion system
EP0206411A3 (de) * 1985-06-17 1988-10-05 The Board Of Trustees Of The University Of Illinois Umkehrphasenchromatographie zur Sequenzierung von Oligonukleotiden
US4940527A (en) * 1987-06-01 1990-07-10 Abbott Laboratories Two-part test cartridge for centrifuge
US5133937A (en) * 1989-06-01 1992-07-28 Iniziative Marittime, 1991 S.R.L. Analysis system having a removable reaction cartridge and temperature control
DE59104604D1 (de) * 1990-11-26 1995-03-23 Ciba Geigy Ag Detektorzelle.
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
USD351913S (en) 1993-02-25 1994-10-25 Diametrics Medical, Inc. Disposable electrochemical measurement cartridge for a portable medical analyzer
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
EP0862647A1 (de) 1995-11-03 1998-09-09 Sarnoff Corporation Testsystem und verfahren zur ausführung von testverfahren
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
SE9602610D0 (sv) * 1996-07-01 1996-07-01 Pharmacia & Upjohn Ab Delivery device and method for its operation
JP3834357B2 (ja) 1996-07-10 2006-10-18 オリンパス株式会社 小型分析装置及びその駆動方法
US5882903A (en) * 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
EP0963545B1 (de) 1997-02-28 2011-05-11 Cepheid Chemischer reaktor mit wärmetauscher und optischem detektor, und reaktionsbehälter
US5958349A (en) * 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
JP2001511358A (ja) * 1997-07-28 2001-08-14 メディカル・バイオシステムズ・リミテッド 核酸配列の解析
EP1179585B1 (de) * 1997-12-24 2008-07-09 Cepheid Vorrichtung und Verfahren zur Lyse
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US6382923B1 (en) * 1999-07-20 2002-05-07 Deka Products Ltd. Partnership Pump chamber having at least one spacer for inhibiting the pumping of a gas
US6416293B1 (en) 1999-07-20 2002-07-09 Deka Products Limited Partnership Pumping cartridge including a bypass valve and method for directing flow in a pumping cartridge
JP2001194373A (ja) * 2000-01-06 2001-07-19 Olympus Optical Co Ltd 超小型化学操作装置
DE60110976T2 (de) * 2000-07-10 2006-04-27 Océ-Technologies B.V. Pulverbildübertragungssystem mit Wärmetauscher
FR2812306B1 (fr) 2000-07-28 2005-01-14 Gabriel Festoc Systeme d'amplification en chaine par polymerse de sequences nucleiques cibles
SE0004297D0 (sv) 2000-11-23 2000-11-23 Gyros Ab Device for thermal cycling
US7051831B2 (en) * 2001-08-24 2006-05-30 Ford Global Technologies, Llc Method and apparatus for maintaining a connection between a vehicle and a fuel source
DE10149684B4 (de) * 2001-10-09 2005-02-17 Clondiag Chip Technologies Gmbh Vorrichtung zur Halterung eines Substanzbibliothekenträgers
US20030073089A1 (en) * 2001-10-16 2003-04-17 Mauze Ganapati R. Companion cartridge for disposable diagnostic sensing platforms
US7338760B2 (en) * 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US20030224506A1 (en) * 2002-05-30 2003-12-04 Biomicroarrays Inc Tiled biochips and the methods of making the same
US6789355B2 (en) * 2002-07-29 2004-09-14 The Pride Group, Inc. Planter having an integral water tray
US6743634B2 (en) * 2002-08-23 2004-06-01 Coulter International Corp. Method and apparatus for differentiating blood cells using back-scatter
US7390457B2 (en) * 2002-10-31 2008-06-24 Agilent Technologies, Inc. Integrated microfluidic array device
US7364896B2 (en) 2002-10-31 2008-04-29 Agilent Technologies, Inc. Test strips including flexible array substrates and method of hybridization
US7217542B2 (en) 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
DE10251313B4 (de) * 2002-11-04 2007-05-03 Advanced Micro Devices, Inc., Sunnyvale Gemeinsame Benutzung eines Schaltkreises für Frequenz- und Phasenfehlerkorrektur
JP2004212326A (ja) * 2003-01-08 2004-07-29 Matsushita Electric Ind Co Ltd マイクロポンプと試料処理チップ、及びシートコネクタ
JP4069747B2 (ja) * 2003-01-20 2008-04-02 横河電機株式会社 分離可能型バイオチップ
CA2515075C (en) * 2003-02-05 2012-10-02 Iquum, Inc. Sample processing
JP2004309145A (ja) * 2003-04-02 2004-11-04 Hitachi High-Technologies Corp 化学分析装置及び化学分析用構造体
US20040228765A1 (en) * 2003-05-14 2004-11-18 Witty Thomas R. Point of care diagnostic platform
US7781226B2 (en) * 2004-02-27 2010-08-24 The Board Of Regents Of The University Of Texas System Particle on membrane assay system
JP2008505346A (ja) * 2004-06-07 2008-02-21 アイキューム, インク. サンプルマルチ処理
EP1882950A4 (de) * 2005-05-19 2012-08-15 Konica Minolta Med & Graphic Testchip zur analyse einer in einem analyten enthaltenen zielsubstanz und umfangreiches mikroskopisches analysesystem

Also Published As

Publication number Publication date
JP2008546401A (ja) 2008-12-25
EP1896180B1 (de) 2011-11-23
ES2689172T3 (es) 2018-11-08
EP2409767A1 (de) 2012-01-25
RU2008102386A (ru) 2009-07-27
CN101203312A (zh) 2008-06-18
EP2409767B1 (de) 2018-08-08
WO2006136990A3 (en) 2007-03-08
US9568424B2 (en) 2017-02-14
EP1896180A2 (de) 2008-03-12
ES2373686T3 (es) 2012-02-07
US20100047774A1 (en) 2010-02-25
WO2006136990A2 (en) 2006-12-28
CN102268367A (zh) 2011-12-07
JP5086250B2 (ja) 2012-11-28
US20170100719A1 (en) 2017-04-13
RU2432205C2 (ru) 2011-10-27
CN101203312B (zh) 2011-08-17

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