ATE541214T1 - Zusammensetzungen und verfahren zum nachweis von präkanzerösen bedingungen in zell- und gewebeproben unter anwendung von 5,10,15,20- tetrakis(carbophenyl)porphin - Google Patents

Zusammensetzungen und verfahren zum nachweis von präkanzerösen bedingungen in zell- und gewebeproben unter anwendung von 5,10,15,20- tetrakis(carbophenyl)porphin

Info

Publication number
ATE541214T1
ATE541214T1 AT01987011T AT01987011T ATE541214T1 AT E541214 T1 ATE541214 T1 AT E541214T1 AT 01987011 T AT01987011 T AT 01987011T AT 01987011 T AT01987011 T AT 01987011T AT E541214 T1 ATE541214 T1 AT E541214T1
Authority
AT
Austria
Prior art keywords
tcpp
porphine
tetrakis
tissue samples
sample
Prior art date
Application number
AT01987011T
Other languages
English (en)
Inventor
Jeffrey Garwin
Original Assignee
Biomoda Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomoda Inc filed Critical Biomoda Inc
Application granted granted Critical
Publication of ATE541214T1 publication Critical patent/ATE541214T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
AT01987011T 2000-11-17 2001-11-19 Zusammensetzungen und verfahren zum nachweis von präkanzerösen bedingungen in zell- und gewebeproben unter anwendung von 5,10,15,20- tetrakis(carbophenyl)porphin ATE541214T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24950500P 2000-11-17 2000-11-17
PCT/US2001/043238 WO2002042267A2 (en) 2000-11-17 2001-11-19 Compositions and methods for detecting pre-cancerous conditions in cell and tissue samples using 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine

Publications (1)

Publication Number Publication Date
ATE541214T1 true ATE541214T1 (de) 2012-01-15

Family

ID=22943735

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01987011T ATE541214T1 (de) 2000-11-17 2001-11-19 Zusammensetzungen und verfahren zum nachweis von präkanzerösen bedingungen in zell- und gewebeproben unter anwendung von 5,10,15,20- tetrakis(carbophenyl)porphin

Country Status (11)

Country Link
US (8) US6838248B2 (de)
EP (2) EP1364044B1 (de)
JP (3) JP4307070B2 (de)
CN (1) CN1545557A (de)
AT (1) ATE541214T1 (de)
AU (2) AU3926902A (de)
CA (2) CA2725716C (de)
DK (2) DK2372361T3 (de)
ES (2) ES2380261T3 (de)
MX (1) MXPA03004406A (de)
WO (1) WO2002042267A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4307070B2 (ja) * 2000-11-17 2009-08-05 バイオモーダ・インコーポレーテツド ５，１０，１５，２０−テトラキス（カルボキシフェニル）ポルフィンを使用する、細胞および組織サンプルにおける前がん症状を検出するための組成物および方法
US8213005B2 (en) 2003-07-22 2012-07-03 King Saud University Method for discriminating between benign and malignant prostate tumors
US7869033B2 (en) * 2003-12-24 2011-01-11 Vadivel Masilamani Cancer detection by optical analysis of body fluids
US8208142B2 (en) * 2003-12-24 2012-06-26 King Salid University Lung cancer detection by optical analysis of body fluids
EP2270712A1 (de) * 2009-06-30 2011-01-05 Koninklijke Philips Electronics N.V. Qualitätserkennungsverfahren und Vorrichtung für Zell- und Gewebsproben
CN103168234B (zh) * 2009-07-17 2015-11-25 保爱菲技术公司 用于分析被5，10，15，20四(4-羧基苯基)卟吩(tcpp)标记的样品的系统和方法
WO2012065004A2 (en) * 2010-11-12 2012-05-18 Incelldx, Inc. Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (cin) lesion from a suspension sample of cervical cells
US9779283B2 (en) 2011-01-05 2017-10-03 The Board Of Trustees Of The University Of Illinois Automated prostate tissue referencing for cancer detection and diagnosis
US9230063B2 (en) * 2011-01-05 2016-01-05 The Board Of Trustees Of The University Of Illinois Automated prostate tissue referencing for cancer detection and diagnosis
US9933341B2 (en) 2012-04-05 2018-04-03 Becton, Dickinson And Company Sample preparation for flow cytometry
AU2013243378B2 (en) * 2012-04-05 2019-04-11 Becton, Dickinson And Company Sample preparation for flow cytometry
JP6294352B2 (ja) * 2013-01-07 2018-03-14 ブリガム・ヤング・ユニバーシティＢｒｉｇｈａｍ Ｙｏｕｎｇ Ｕｎｉｖｅｒｓｉｔｙ 細胞増殖を減少させ、ある特定の疾患を治療する方法
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
WO2014151411A1 (en) 2013-03-15 2014-09-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
CN105143882B (zh) 2013-04-11 2018-10-26 塞托克尔公司 使用细胞学和免疫学的生物学样本评估方法
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
EP3471774A4 (de) 2016-06-16 2020-04-15 Oncoselect Therapeutics, LLC Porphyrinverbindungen und zusammensetzungen zur behandlung von krebs
MX2020010825A (es) * 2018-04-13 2021-01-15 Bioaffinity Tech Inc Sistema y metodo para determinar la salud pulmonar.
US12186328B2 (en) 2019-05-23 2025-01-07 Brigham Young University Use of CSA compounds to stimulate stem cells and hair growth
US20240118284A1 (en) * 2019-10-18 2024-04-11 The Regents Of The University Of California Compositions and methods for detecting plxdc1 and plxcd2 in human tissues
KR20220087497A (ko) 2019-10-18 2022-06-24 더 리전츠 오브 더 유니버시티 오브 캘리포니아 병원성 혈관을 표적화하기 위한 화합물 및 방법
US12590298B2 (en) 2019-10-18 2026-03-31 The Regents Of The University Of California Ex vivo tumor angiogenesis model
CN110927369A (zh) * 2019-12-11 2020-03-27 安徽安龙基因科技有限公司 一种利用tcpp联合cep探针鉴定循环肿瘤细胞的试剂盒及应用
MX2024007563A (es) 2021-12-17 2024-08-27 Bioaffinity Tech Inc Detección de cáncer de pulmón en etapa temprana en esputo utilizando citometría de flujo automatizada y aprendizaje automático.

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485086A (en) 1983-04-11 1984-11-27 Wong Dennis W Radiolabeled tumor imaging agent and method of preparation
US4930516B1 (en) 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US4783529A (en) 1985-12-03 1988-11-08 Research Corporation Technologies Rapid synthesis of radiolabeled porphyrin complexes for medical application
US5162231A (en) * 1989-10-25 1992-11-10 Cole Dean A Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung
US4857300A (en) 1987-07-27 1989-08-15 Cytocorp, Inc. Cytological and histological fixative formulation and methods for using same
US5004811A (en) 1987-12-24 1991-04-02 Nippon Petrochemicals Company, Ltd. Tetrapyrrole aminocarboxylic acids
CA2093361C (en) * 1990-10-05 2002-04-23 Michel Ringuet Porphyrin derivative
DE59009561D1 (de) 1990-12-20 1995-09-28 Siemens Ag Beatmungsgerät mit vom Patientengasfluss abhängiger Triggerempfindlichkeit.
US5837865A (en) * 1993-10-15 1998-11-17 Trustees Of The University Of Pennsylvania Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen
DE19503163A1 (de) * 1995-02-01 1996-08-08 Bayer Ag Verfahren zur Reinigung von 4-Hydroxybenzaldehyd enthaltenden Reaktionsgemischen
US6706473B1 (en) 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
US6274086B1 (en) * 1996-12-16 2001-08-14 The Trustees Of The University Of Pennsylvania Apparatus for non-invasive imaging oxygen distribution in multi-dimensions
US6316215B1 (en) * 1999-12-27 2001-11-13 Edwin L. Adair Methods of cancer screening utilizing fluorescence detection techniques and selectable imager charge integration periods
JP3753866B2 (ja) 1998-07-01 2006-03-08 株式会社日立製作所 自己救済型光ネットワーク
US7904139B2 (en) * 1999-08-26 2011-03-08 Non-Invasive Technology Inc. Optical examination of biological tissue using non-contact irradiation and detection
US6750037B2 (en) * 1999-12-27 2004-06-15 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
US6984498B2 (en) * 1999-12-27 2006-01-10 Adair Edwin L Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
US6190877B1 (en) 1999-12-27 2001-02-20 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection and fluorescence detection techniques
JP4307070B2 (ja) 2000-11-17 2009-08-05 バイオモーダ・インコーポレーテツド ５，１０，１５，２０−テトラキス（カルボキシフェニル）ポルフィンを使用する、細胞および組織サンプルにおける前がん症状を検出するための組成物および方法
EP1925930A1 (de) 2003-02-13 2008-05-28 Hamamatsu Photonics K.K. Fluoreszenzkorrelationsspektroskopie-Analysegerät
US20070172392A1 (en) * 2005-12-13 2007-07-26 Sen Chandan K Apparatus, system and method for tissue oximetry
US8983581B2 (en) 2008-05-27 2015-03-17 Massachusetts Institute Of Technology System and method for large field of view, single cell analysis
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
CN103168234B (zh) 2009-07-17 2015-11-25 保爱菲技术公司 用于分析被5，10，15，20四(4-羧基苯基)卟吩(tcpp)标记的样品的系统和方法

Also Published As

Publication number Publication date
EP1364044A4 (de) 2008-11-26
US20100216169A1 (en) 2010-08-26
CA2725716C (en) 2015-02-10
EP1364044B1 (de) 2012-01-11
AU3926902A (en) 2002-06-03
CN1545557A (zh) 2004-11-10
US20150177245A1 (en) 2015-06-25
US20050079561A1 (en) 2005-04-14
JP2011185947A (ja) 2011-09-22
US20120149057A1 (en) 2012-06-14
WO2002042267A3 (en) 2003-07-10
CA2429526A1 (en) 2002-05-30
ES2380261T3 (es) 2012-05-10
EP1364044A2 (de) 2003-11-26
JP2009020122A (ja) 2009-01-29
AU2002239269B2 (en) 2008-08-21
ES2523378T3 (es) 2014-11-25
US7384764B2 (en) 2008-06-10
US7670799B2 (en) 2010-03-02
JP4307070B2 (ja) 2009-08-05
US20140162287A1 (en) 2014-06-12
DK2372361T3 (da) 2014-11-10
CA2429526C (en) 2011-03-15
US7960138B2 (en) 2011-06-14
EP2372361A1 (de) 2011-10-05
US20050233410A1 (en) 2005-10-20
EP2372361B1 (de) 2014-08-06
JP4768005B2 (ja) 2011-09-07
US9417241B2 (en) 2016-08-16
US20020115121A1 (en) 2002-08-22
US20090004690A1 (en) 2009-01-01
US8486656B2 (en) 2013-07-16
DK1364044T3 (da) 2012-05-07
CA2725716A1 (en) 2002-05-30
WO2002042267A2 (en) 2002-05-30
JP2004536275A (ja) 2004-12-02
MXPA03004406A (es) 2004-10-15
US8975038B2 (en) 2015-03-10
US6838248B2 (en) 2005-01-04

Similar Documents

Publication Publication Date Title
ATE541214T1 (de) Zusammensetzungen und verfahren zum nachweis von präkanzerösen bedingungen in zell- und gewebeproben unter anwendung von 5,10,15,20- tetrakis(carbophenyl)porphin
DE60029369D1 (de) Verfahren und Sondenset zur Erkennung von Krebs
BG104275A (en) Method and device for express analysis of tested parameters in biological samples
ATE490466T1 (de) Als interne funktionskontrolle in tests zum nachweis von seltenen zellen verwendete markierte zellen
SG111139A1 (en) Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays
ATE432470T1 (de) Verfahren zur unterscheidung des reizkolons von der entzündlichen darmerkrankung (inflammatory bowel disease, ibd) und zur überwachung von patienten mit ibd unter verwendung von endogenem gesamt-lactoferrin als marker
NO20003485L (no) Kjemiluminiserende dioksetanderivater samt fremgangsmÕte for deteksjon
SE0000538L (sv) Metoder och kit för analytdetektion mha proximitets-probning
BR9611461A (pt) Aparelho de coleta de amostras, kit para a detecçao de um analisado em uma amostra, uso do aparelho de coleta de amostra e do kit e processo para detectar um analisado em uma amostra.
DE60312091D1 (de) Verfahren, Vorrichtung und Reagenziensatz zum Zählen von Bakterien
EA200500355A1 (ru) Способ обнаружения, характеристики и мониторинга углеводородных месторождений
DE69826816D1 (de) Verfahren zum Nachweis und zur Identifizierung, Zählung und Bestätigung von zirkulierenden Krebszellen und/oder hämatologischen Vorläuferzellen in Vollblut
ZA200800974B (en) Apoptosis sensitivity to Apo2L/TRAIL by testing for 'GalNac-T14 expression in cells/tissues
ATE433572T1 (de) Methode, apparat, reagenzkit und reagenz zur unterscheidung von erythrozyten in biologischen proben
EP1057896A4 (de) Verfahren zur identifizierug oder testung von agonisten für bzw. antagonisten gegen ppar
AU2003260457A1 (en) A method and kit for the quantitative and/or qualitative detection of components in a sample
AU2001248159A1 (en) Method and kit for the screening, the detection and/or the quantification of transcriptional factors
ATE434760T1 (de) Blutzellen-detektor, blutanalysegerät und blutanalyseverfahren unter verwendung des detektors
ATE462001T1 (de) Markerproteine zur diagnose einer lebererkrankung und verfahren zur diagnose einer lebererkrankung damit
ATE74211T1 (de) Verfahren zum nachweis eines analyten sowie hierfuer geeignetes mittel.
WO2002016947A3 (en) Methods and kits for separation and detection of proteins in biological samples
DE69833218D1 (de) Verfahren und kit zum nachweis von cryptosporidium oozysten
WO2004016802A3 (en) Methods and apparatus for preparing and assaying biological samples to determine protein concentration
ATE344457T1 (de) Protein-arrays, verfahren zu ihrer herstellung sowie verfahren zum nachweis intermolekularer wechselwirkungen
FI20011908A0 (fi) Menetelmä vatsasyövän osoittamiseksi