ATE547405T1 - Verfahren zur herstellung einer 1,2- dihydropyridin-2-onverbindung - Google Patents

Verfahren zur herstellung einer 1,2- dihydropyridin-2-onverbindung

Info

Publication number: ATE547405T1
Authority: AT; Austria
Prior art keywords: dihydropyridin; compound; producing; cyanophenyl; pyridyl
Prior art date: 2004-07-06

Application number

AT05758231T

Other languages

English (en)

Inventor

Akio Kayano

Katsutoshi Nishiura

Original Assignee

Eisai R&D Man Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-06

Filing date

2005-07-05

Publication date

2012-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35782900&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE547405(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-07-05 Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE547405T1 publication Critical patent/ATE547405T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
-1 1,2-DIHYDROPYRIDIN-2-ONE COMPOUND Chemical class 0.000 title 1
239000013078 crystal Substances 0.000 abstract 1
PRMWGUBFXWROHD-UHFFFAOYSA-N perampanel Chemical compound O=C1C(C=2C(=CC=CC=2)C#N)=CC(C=2N=CC=CC=2)=CN1C1=CC=CC=C1 PRMWGUBFXWROHD-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)

AT05758231T 2004-07-06 2005-07-05 Verfahren zur herstellung einer 1,2- dihydropyridin-2-onverbindung ATE547405T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2004198709		2004-07-06
PCT/JP2005/012364 WO2006004100A1 (ja)	2004-07-06	2005-07-05	１，２－ジヒドロピリジン－２－オン化合物の製造方法

Publications (1)

Publication Number	Publication Date
ATE547405T1 true ATE547405T1 (de)	2012-03-15

Family

ID=35782900

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05758231T ATE547405T1 (de)	2004-07-06	2005-07-05	Verfahren zur herstellung einer 1,2- dihydropyridin-2-onverbindung

Country Status (28)

Country	Link
US (3)	US8304548B2 (de)
EP (3)	EP2586771A3 (de)
JP (3)	JP5030206B2 (de)
KR (2)	KR101187218B1 (de)
CN (7)	CN104402807A (de)
AT (1)	ATE547405T1 (de)
AU (2)	AU2005258385B2 (de)
BR (1)	BRPI0510254B8 (de)
CA (2)	CA2561829C (de)
CY (1)	CY1114313T1 (de)
DK (1)	DK1764361T3 (de)
ES (1)	ES2404697T3 (de)
HR (1)	HRP20130363T1 (de)
IL (2)	IL180024A (de)
JO (1)	JO2832B1 (de)
ME (1)	ME01520B (de)
MX (1)	MXPA06014458A (de)
MY (1)	MY148809A (de)
NO (1)	NO339101B1 (de)
NZ (1)	NZ550720A (de)
PL (2)	PL1764361T3 (de)
PT (1)	PT1764361E (de)
RS (1)	RS52752B (de)
RU (1)	RU2323930C1 (de)
SI (2)	SI1764361T1 (de)
TW (1)	TW200606144A (de)
WO (2)	WO2006004107A1 (de)
ZA (1)	ZA200609274B (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2545813C (en)	2003-11-14	2011-01-04	Shanghai Genomics, Inc.	The derivatives of pyridone and use thereof
ATE511843T1 (de) *	2005-04-04	2011-06-15	Eisai R&D Man Co Ltd	Dihydropyridin-verbindungen für neurodegenerative erkrankungen und demenz
MX2007014114A (es)	2005-05-10	2008-03-14	Intermune Inc	Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
AU2006328385B2 (en) *	2005-12-21	2011-08-25	Eisai R & D Management Co., Ltd.	Amorphous form of 1,2-dihydropyridine compound
US20090088574A1 (en) *	2005-12-21	2009-04-02	Eisai R&D Management Co., Ltd.	Crystal of 1,2-dihydropyridine compound (type iv)
WO2007126060A1 (ja)	2006-04-28	2007-11-08	Eisai R & D Management Co., Ltd	１，２－ジヒドロピリジン化合物の塩
JP5318757B2 (ja)	2006-06-16	2013-10-16	ハー・ルンドベック・アクチエゼルスカベット	神経因性疼痛の治療のための、組み合わされたセロトニンおよびノルエピネフリン再取り込み阻害を有する４−［２−（４−メチルフェニルスルファニル）−フェニル］ピペリジンの結晶形
US20100099714A1 (en) *	2007-03-05	2010-04-22	Eisai R&D Management Co., Ltd.	AMPA and NMDA Receptor Antagonists for Neurodegenerative Diseases
CN101663256A (zh) *	2007-03-29	2010-03-03	新加坡科技研究局	生产旋光羟腈衍生物的方法
US20100130537A1 (en) *	2007-04-26	2010-05-27	Eisai R&D Management Co., Ltd	Cinnamide compounds for dementia
WO2009011411A1 (en) *	2007-07-13	2009-01-22	Eisai R & D Management Co., Ltd.	Ampa receptor antagonists and zonisamide for neuropathic pain
EP2164488A1 (de) *	2007-07-13	2010-03-24	Eisai R&D Management Co., Ltd.	Ampa-rezeptor-antagonisten und aldose-reduktase-hemmer für neuropathische schmerzen
EP2164489A2 (de) *	2007-07-13	2010-03-24	Eisai R&D Management Co., Ltd.	Kombination aus ampa-rezeptor-antagonisten und acetylcholinesterase-hemmern zur behandlung neuropathischer schmerzen
WO2009054544A1 (en) *	2007-10-26	2009-04-30	Eisai R & D Management Co., Ltd.	Ampa receptor antagonists for parkinson's disease and movement disorders
JP5627574B2 (ja) *	2008-06-03	2014-11-19	インターミューン，インコーポレイテッド	炎症性および線維性疾患を治療するための化合物および方法
CN105924386A (zh)	2009-03-25	2016-09-07	Abbvie 公司	抗病毒化合物和其用途
ITMI20111952A1 (it)	2011-10-27	2013-04-28	Italiana Sint Spa	Procedimento per la prepazione di 2-metossi-5-(piridin-2-il)piridina, un intermedio del perampanel
US9096574B2 (en)	2012-01-03	2015-08-04	Mapi Pharma Ltd.	Polymorphs of perampanel
ITMI20121390A1 (it)	2012-08-06	2014-02-07	F I S Fabbrica Italiana Sint P A	Procedimento per la preparazione di acido 2-cianofenilboronico e suoi esteri, intermedi del perampanel o di e2040
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
WO2015013520A1 (en)	2013-07-25	2015-01-29	IVAX International GmbH	Process for the preparation of perampanel
CN104649962A (zh) *	2013-11-25	2015-05-27	天津市汉康医药生物技术有限公司	吡仑帕奈倍半水合物化合物
CN103664756A (zh) *	2013-11-26	2014-03-26	苏州晶云药物科技有限公司	吡仑帕奈新晶型a及其制备方法
CN104706604A (zh) *	2013-12-12	2015-06-17	北京星昊医药股份有限公司	一种吡仑帕奈冻干口崩片及其制备方法
US10233195B2 (en)	2014-04-02	2019-03-19	Intermune, Inc.	Anti-fibrotic pyridinones
CN105085382B (zh) *	2014-05-14	2019-10-18	江苏豪森药业集团有限公司	吡仑帕奈异构体晶型及其制备方法和用途
CN103980188B (zh) *	2014-05-30	2016-01-27	浙江永宁药业股份有限公司	一种吡仑帕奈的合成方法及其中间体和中间体的合成方法
EP3259262A4 (de)	2015-02-17	2018-08-01	Mapi Pharma Limited	Verfahren und zwischenprodukte zur herstellung von perampanel
WO2016147104A1 (en) *	2015-03-14	2016-09-22	Intas Pharmaceuticals Ltd.	Novel process for the preparation of perampanel and its intermediates thereof
WO2016172333A1 (en) *	2015-04-21	2016-10-27	Teva Pharmaceuticals International Gmbh	A solid state form of perampanel
CN105287411A (zh) *	2015-09-22	2016-02-03	美吉斯制药（厦门）有限公司	一种吡仑帕奈分散片及其制备方法
CN105906557A (zh) *	2016-03-30	2016-08-31	北京万全德众医药生物技术有限公司	2-甲氧基-5-（吡啶-2-基）吡啶的一种合成方法
CN106389367B (zh) *	2016-11-16	2020-12-18	杭州朱养心药业有限公司	吡仑帕奈包衣片剂药物组合物
CN110028442B (zh) *	2018-01-11	2020-07-17	新发药业有限公司	一种吡仑帕奈的简便制备方法
CN111801096B (zh)	2018-03-20	2024-03-05	卫材R&D管理有限公司	癫痫治疗剂
EP3560934A1 (de)	2018-04-26	2019-10-30	F.I.S.- Fabbrica Italiana Sintetici S.p.A.	Verfahren zur herstellung von reiner 2-cyanophenylboronsäure und deren ester, zwischenprodukte von perampanel oder e2040
CN113226286B (zh) *	2018-12-14	2024-08-20	卫材R&D管理有限公司	1,2-二氢吡啶化合物的水基药物制剂
KR102392825B1 (ko)	2020-02-18	2022-04-29	명인제약주식회사	2-(2-옥소-1-페닐-5-피리딘-2-일피리딘-3-일)벤조니트릴과 ｌ-말릭산의 공결정 화합물 및 이의 제조 방법
WO2021240540A1 (en)	2020-05-26	2021-12-02	Celagenex Research (India) Pvt. Ltd.	Novel synergistic nutritional compositions for treating seizures and chronic inflammatory diseases
CN114853666A (zh) *	2021-02-03	2022-08-05	北京万全德众医药生物技术有限公司	一种制备高纯度吡仑帕奈中间体的纯化方法
GR1010285B (el) *	2021-05-31	2022-08-24	Elpen Αε Φαρμακευτικη Βιομηχανια,	Στερεες φαρμακοτεχνικες μορφες περαμπανελης
KR102768044B1 (ko) *	2022-07-12	2025-02-17	이화여자대학교 산학협력단	연속 흐름 공정을 포함하는 페람파넬 유도체의 제조 방법
CN115745876B (zh) *	2022-11-01	2025-03-04	南京海纳医药科技股份有限公司	一种吡仑帕奈的制备方法
CN119060372B (zh) *	2023-06-02	2026-05-01	中国石油化工股份有限公司	交联共聚物、水凝胶及其制备方法和应用以及产品
CN118415997B (zh) *	2024-07-04	2024-10-18	山东则正医药技术有限公司	一种吡仑帕奈细粒剂的制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5283761A (en)	1976-01-01	1977-07-12	Yamanouchi Pharmaceut Co Ltd	Novel pyridone derivative
JPS5531072A (en)	1979-07-30	1980-03-05	Rikagaku Kenkyusho	Preparation of 2-pyridone compound
DE4221583A1 (de) *	1991-11-12	1993-05-13	Bayer Ag	Substituierte biphenylpyridone
IL109397A0 (en)	1993-04-28	1994-07-31	Schering Ag	Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HU219777B (hu)	1993-07-02	2001-07-30	Gyógyszerkutató Intézet Kft.	Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására
DE69524246T2 (de)	1994-09-27	2002-06-27	Yamanouchi Pharmaceutical Co., Ltd.	1,2,3,4-Tetrahydroquinoxalindion Derivate und ihre Verwendung als Glutamat Rezeptor Antagonisten
US5948785A (en)	1995-04-27	1999-09-07	The Green Cross Corporation	Heterocyclic amide compounds and pharmaceutical use of the same
US5935551A (en)	1995-11-15	1999-08-10	California Institute Of Technology	Synthesis of zeolites by hydrothermal reaction of zeolite P1
DE19604920A1 (de)	1996-02-01	1997-08-07	Schering Ag	Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
US5891871A (en)	1996-03-21	1999-04-06	Cocensys, Inc.	Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en)	1996-04-04	1996-05-28	Gyogyszerkutato Intezet	New 2,3-benzodiazepine derivatives
PT901487E (pt)	1996-05-15	2003-08-29	Pfizer	4(3h)-quinazolinonas 2,3,6-trissubstituidas
DE19643037A1 (de)	1996-10-18	1998-04-23	Boehringer Ingelheim Kg	Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
ID22711A (id)	1997-02-28	1999-12-09	Pfizer Prod Inc	Atropisomer dari 3-aril-4(3h)-kinazolinon dan penggunaannya sebagai antagonis reseptor-ampa
GB9708945D0 (en) *	1997-05-01	1997-06-25	Merck Sharp & Dohme	Therapeutic agents
GB9711753D0 (en)	1997-06-06	1997-08-06	Merck Sharp & Dohme	Therapeutic agents
WO1999031062A1 (en)	1997-12-17	1999-06-24	Shionogi & Co., Ltd.	Novel pyridine compounds
CA2330304A1 (en) *	1998-04-27	1999-11-04	Centre National De La Recherche Scientifique	3-(amino- or aminoalkyl)pyridinone derivatives and their use for the treatment of hiv related diseases
WO2000001376A2 (en)	1998-07-02	2000-01-13	Eisai Co., Ltd	Pharmaceutical compositions and their uses for treatment of demyelinating disorders
DE19835918A1 (de)	1998-08-07	2000-02-10	Dresden Arzneimittel	Neue antikonvulsiv wirkende 4-Amino-1-aryl-pyridin-2-one und Verfahren zu deren Herstellung
PT1300396E (pt)	2000-06-12	2009-04-20	Eisai R&D Man Co Ltd	Compostos de 1,2-di-hidropiridina, processos para a sua preparação e sua utilização
GB0129260D0 (en) *	2001-12-06	2002-01-23	Eisai London Res Lab Ltd	Pharmaceutical compositions and their uses
JP4208512B2 (ja)	2002-07-23	2009-01-14	株式会社クラレ	５−（２’−ピリジル）−２−ピリドン誘導体の製造方法

2005
- 2005-06-03 MY MYPI20052537A patent/MY148809A/en unknown
- 2005-07-04 TW TW094122578A patent/TW200606144A/zh unknown
- 2005-07-04 JO JO200597A patent/JO2832B1/en active
- 2005-07-05 BR BRPI0510254A patent/BRPI0510254B8/pt active IP Right Grant
- 2005-07-05 RU RU2007104342/04A patent/RU2323930C1/ru active Protection Beyond IP Right Term
- 2005-07-05 DK DK05758232.2T patent/DK1764361T3/da active
- 2005-07-05 PL PL05758232T patent/PL1764361T3/pl unknown
- 2005-07-05 KR KR1020067027447A patent/KR101187218B1/ko not_active Expired - Lifetime
- 2005-07-05 CN CN201410561671.5A patent/CN104402807A/zh active Pending
- 2005-07-05 AT AT05758231T patent/ATE547405T1/de active
- 2005-07-05 RS RS20130164A patent/RS52752B/sr unknown
- 2005-07-05 EP EP13152837.4A patent/EP2586771A3/de not_active Withdrawn
- 2005-07-05 CN CN201110261753.4A patent/CN102382047B/zh not_active Expired - Lifetime
- 2005-07-05 CN CN201410561673.4A patent/CN104402808A/zh active Pending
- 2005-07-05 JP JP2006528897A patent/JP5030206B2/ja not_active Expired - Lifetime
- 2005-07-05 CN CN2005800115659A patent/CN1942443B/zh not_active Ceased
- 2005-07-05 HR HRP20130363TT patent/HRP20130363T1/hr unknown
- 2005-07-05 JP JP2006528904A patent/JPWO2006004107A1/ja active Pending
- 2005-07-05 NZ NZ550720A patent/NZ550720A/en not_active IP Right Cessation
- 2005-07-05 PT PT57582322T patent/PT1764361E/pt unknown
- 2005-07-05 AU AU2005258385A patent/AU2005258385B2/en active Active
- 2005-07-05 CN CNA2005800230712A patent/CN1984890A/zh active Pending
- 2005-07-05 WO PCT/JP2005/012388 patent/WO2006004107A1/ja not_active Ceased
- 2005-07-05 CN CN2010102462261A patent/CN101914057B/zh not_active Expired - Lifetime
- 2005-07-05 EP EP05758232A patent/EP1764361B1/de not_active Expired - Lifetime
- 2005-07-05 AU AU2005258378A patent/AU2005258378B2/en not_active Expired
- 2005-07-05 ES ES05758232T patent/ES2404697T3/es not_active Expired - Lifetime
- 2005-07-05 SI SI200531716T patent/SI1764361T1/sl unknown
- 2005-07-05 PL PL05758231T patent/PL1772450T3/pl unknown
- 2005-07-05 KR KR1020067020395A patent/KR100939743B1/ko not_active Expired - Lifetime
- 2005-07-05 ME MEP-2013-40A patent/ME01520B/me unknown
- 2005-07-05 WO PCT/JP2005/012364 patent/WO2006004100A1/ja not_active Ceased
- 2005-07-05 EP EP05758231A patent/EP1772450B1/de not_active Expired - Lifetime
- 2005-07-05 CN CN2009101385759A patent/CN101544599B/zh not_active Expired - Lifetime
- 2005-07-05 SI SI200531518T patent/SI1772450T1/sl unknown
- 2005-07-05 MX MXPA06014458A patent/MXPA06014458A/es active IP Right Grant
- 2005-07-05 CA CA002561829A patent/CA2561829C/en not_active Expired - Lifetime
- 2005-07-05 CA CA2570177A patent/CA2570177C/en not_active Expired - Lifetime
2006
- 2006-11-07 ZA ZA200609274A patent/ZA200609274B/en unknown
- 2006-12-12 IL IL180024A patent/IL180024A/en active IP Right Grant
- 2006-12-13 NO NO20065754A patent/NO339101B1/no unknown
- 2006-12-18 IL IL180151A patent/IL180151A/en active IP Right Grant
2007
- 2007-01-04 US US11/649,299 patent/US8304548B2/en active Active
2010
- 2010-08-27 US US12/870,507 patent/US8772497B2/en active Active
2011
- 2011-10-12 JP JP2011224926A patent/JP5419944B2/ja not_active Expired - Lifetime
2013
- 2013-04-29 CY CY20131100350T patent/CY1114313T1/el unknown
2014
- 2014-01-27 US US14/165,365 patent/US9045426B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP5030206B2 (ja)	2012-09-19
CA2570177A1 (en)	2006-01-12
CN101914057A (zh)	2010-12-15
NZ550720A (en)	2009-10-30
US20070142640A1 (en)	2007-06-21
CN101544599B (zh)	2012-06-06
US9045426B2 (en)	2015-06-02
US8772497B2 (en)	2014-07-08
JP5419944B2 (ja)	2014-02-19
IL180151A0 (en)	2007-06-03
EP1772450B1 (de)	2012-02-29
CN104402808A (zh)	2015-03-11
EP1764361A4 (de)	2012-05-30
CN1942443A (zh)	2007-04-04
ZA200609274B (en)	2008-06-25
PT1764361E (pt)	2013-04-23
TW200606144A (en)	2006-02-16
AU2005258385A1 (en)	2006-01-12
CN101544599A (zh)	2009-09-30
EP2586771A3 (de)	2013-07-31
WO2006004100A8 (ja)	2006-02-23
CN102382047B (zh)	2014-04-23
KR20070008617A (ko)	2007-01-17
CA2561829A1 (en)	2006-01-12
TWI346660B (de)	2011-08-11
RU2323930C1 (ru)	2008-05-10
BRPI0510254A (pt)	2007-10-23
WO2006004100A1 (ja)	2006-01-12
AU2005258378B2 (en)	2011-04-28
KR100939743B1 (ko)	2010-02-04
IL180151A (en)	2012-01-31
JPWO2006004100A1 (ja)	2008-04-24
EP1772450A4 (de)	2009-06-10
US20140142315A1 (en)	2014-05-22
CA2570177C (en)	2012-11-20
SI1772450T1 (sl)	2012-06-29
CN101914057B (zh)	2012-07-04
CN1984890A (zh)	2007-06-20
EP1764361A1 (de)	2007-03-21
CN1942443B (zh)	2012-05-09
US20100324297A1 (en)	2010-12-23
US8304548B2 (en)	2012-11-06
KR20070028459A (ko)	2007-03-12
NO339101B1 (no)	2016-11-14
AU2005258385B2 (en)	2009-11-05
BRPI0510254B1 (pt)	2019-10-29
ME01520B (me)	2014-04-20
JP2012021029A (ja)	2012-02-02
EP1772450A1 (de)	2007-04-11
ES2404697T3 (es)	2013-05-28
SI1764361T1 (sl)	2013-07-31
BRPI0510254B8 (pt)	2021-05-25
EP2586771A2 (de)	2013-05-01
CA2561829C (en)	2009-11-24
WO2006004107A1 (ja)	2006-01-12
KR101187218B1 (ko)	2012-10-02
HK1104999A1 (en)	2008-02-01
IL180024A (en)	2011-09-27
DK1764361T3 (da)	2013-05-06
CY1114313T1 (el)	2016-08-31
HRP20130363T1 (en)	2013-05-31
MXPA06014458A (es)	2007-03-01
NO20065754L (no)	2007-04-04
RS52752B (sr)	2013-08-30
CN102382047A (zh)	2012-03-21
HK1102127A1 (en)	2007-11-09
CN104402807A (zh)	2015-03-11
IL180024A0 (en)	2007-05-15
MY148809A (en)	2013-05-31
AU2005258378A1 (en)	2006-01-12
EP1764361B1 (de)	2013-01-30
PL1764361T3 (pl)	2013-06-28
PL1772450T3 (pl)	2012-07-31
JPWO2006004107A1 (ja)	2008-04-24
JO2832B1 (en)	2014-09-15

Publication	Publication Date	Title
IL180151A0 (en)	2007-06-03	Method for producing 1,2-dihydropyridine-2-one compound
ATE507224T1 (de)	2011-05-15	Verfahren und zwischenverbindungen zur herstellung von n4-phenyl-quinazolin-4-amin derivaten
DK1838677T3 (da)	2010-01-11	Krystallinske former af (R)-8-chlor-1.methyl-2,3,4,5-tetrahydro-1H-3-benzazepinhydrochlorid
ATE544754T1 (de)	2012-02-15	Verfahren zur herstellung von ivabradinhydrochlorid
DE60325188D1 (de)	2009-01-22	Verfahren zur herstellung von sterilen, stabilisierten nanodispersionen
ATE442424T1 (de)	2009-09-15	Wässrige tinte, damit aufgezeichnetes bild und verfahren zur erzeugung dieses bildes
ATE340042T1 (de)	2006-10-15	Verfahren zur herstellung einer rasch erstarrten legierung für magnete
DE60206031D1 (de)	2005-10-13	Verfahren zur herstellung von seltenerdlegierungs sinterformteilen
WO2004099197A3 (de)	2005-01-27	Substituierte oxyarene und deren verwendung zur bekämpfung von schädlingen
ATE527012T1 (de)	2011-10-15	Verfahren zur herstellung von medizinprodukten mit einer opferstruktur
DE602004025267D1 (de)	2010-03-11	Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat
ATE430140T1 (de)	2009-05-15	Verfahren zur herstellung von ä1,4,5ü- oxadiazepinderivaten
EP1925697A4 (de)	2009-11-11	Aln-kristall und züchtungsverfahren dafür und aln-kristallsubstrat
DE60105314D1 (de)	2004-10-07	Verfahren zur herstellung von taxanderivaten
ATE424892T1 (de)	2009-03-15	Verfahren zur herstellung von derivaten des 4a,5, 9,10,11,12-hexahydrobenzofuro ä3a,3,2üä 2 ü- benzazepins
ATE556055T1 (de)	2012-05-15	Verfahren zur herstellung von 3-(4-(2,4- difluorbenzyloxy)-3-brom-6-methyl- 2-oxopyridin- 1(2h)-yl)-n,4-dimethylbenzamid
DE602004019983D1 (de)	2009-04-23	Verfahren zur herstellung von kamm-ansteuereinrichtungen unter verwendung von ätzpuffern
DE60235820D1 (de)	2010-05-12	Verfahren zur herstellung von azoverbindungen
ATE369357T1 (de)	2007-08-15	Verfahren zur herstellung von pantoprazol und seinen salzen
DE502004002180D1 (de)	2007-01-11	Verfahren zur steuerung der fertigungsreihenfolge
ATE515502T1 (de)	2011-07-15	Verfahren zur herstellung von tetranorlabdanderivaten
ATE380183T1 (de)	2007-12-15	Verfahren zur herstellung von phenyltetrazolderivaten
ATE405554T1 (de)	2008-09-15	Verfahren zur herstellung von pramipexole
DE602006005275D1 (de)	2009-04-09	Katalysatorzusammensetzung umfassend einen Alkylendiamin-Nickel-Komplex und Verfahren zur Herstellung einer kreuzgekuppelten Verbindung unter Verwendung derselben
ATA14822002A (de)	2005-08-15	Verfahren zur herstellung von substituierten pyridin-n-oxid-verbindungen