ATE548357T1 - Gonadotropin freisetzende hormon rezeptor antagonisten und ihre verwandten verfahren - Google Patents

Gonadotropin freisetzende hormon rezeptor antagonisten und ihre verwandten verfahren

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Publication number
ATE548357T1
ATE548357T1 AT01910362T AT01910362T ATE548357T1 AT E548357 T1 ATE548357 T1 AT E548357T1 AT 01910362 T AT01910362 T AT 01910362T AT 01910362 T AT01910362 T AT 01910362T AT E548357 T1 ATE548357 T1 AT E548357T1
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Austria
Prior art keywords
receptor antagonists
releasing hormone
related methods
hormone receptor
gonadotropin releasing
Prior art date
Application number
AT01910362T
Other languages
English (en)
Inventor
Yun-Fei Zhu
Chen Chen
Fabio Tucci
Zhiqiang Guo
Timothy Gross
Martin Rowbottom
R Struthers
Original Assignee
Neurocrine Biosciences Inc
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Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Application granted granted Critical
Publication of ATE548357T1 publication Critical patent/ATE548357T1/de

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
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AT01910362T 2000-01-25 2001-01-25 Gonadotropin freisetzende hormon rezeptor antagonisten und ihre verwandten verfahren ATE548357T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17793300P 2000-01-25 2000-01-25
US23968300P 2000-10-11 2000-10-11
PCT/US2001/002740 WO2001055119A2 (en) 2000-01-25 2001-01-25 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

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ATE548357T1 true ATE548357T1 (de) 2012-03-15

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