ATE549921T1 - Radioaktiv markierte glycintransporter-hemmer - Google Patents

Radioaktiv markierte glycintransporter-hemmer

Info

Publication number
ATE549921T1
ATE549921T1 AT06815187T AT06815187T ATE549921T1 AT E549921 T1 ATE549921 T1 AT E549921T1 AT 06815187 T AT06815187 T AT 06815187T AT 06815187 T AT06815187 T AT 06815187T AT E549921 T1 ATE549921 T1 AT E549921T1
Authority
AT
Austria
Prior art keywords
transporter inhibitors
glycine transporter
radioactive labeled
labeled glycine
radioactive
Prior art date
Application number
AT06815187T
Other languages
English (en)
Inventor
H Donald Burns
Terence Hamill
Craig Lindsley
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE549921T1 publication Critical patent/ATE549921T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06815187T 2005-09-29 2006-09-25 Radioaktiv markierte glycintransporter-hemmer ATE549921T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72178205P 2005-09-29 2005-09-29
PCT/US2006/036989 WO2007041025A2 (en) 2005-09-29 2006-09-25 Radiolabeled glycine transporter inhibitors

Publications (1)

Publication Number Publication Date
ATE549921T1 true ATE549921T1 (de) 2012-04-15

Family

ID=37906660

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06815187T ATE549921T1 (de) 2005-09-29 2006-09-25 Radioaktiv markierte glycintransporter-hemmer

Country Status (5)

Country Link
US (1) US7834031B2 (de)
EP (1) EP1942733B1 (de)
AT (1) ATE549921T1 (de)
ES (1) ES2382818T3 (de)
WO (1) WO2007041025A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0515954A (pt) 2004-09-30 2008-08-12 Merck & Co Inc composto e sais farmaceuticamente aceitáveis do mesmo e enanciÈmeros e diaestereÈmeros individuais do mesmo, composição farmacêutica, e, métodos para inibição do transportador de glicina glyt1 em um mamìfero, para a fabricação de um medicamento para inibir o transportador de glicina glyt1 em um mamìfero, para tratar um distúbios neurológicos e psiquiátricos associados com disfunçao de neurotransmissão glicinérgica ou glutamatérgica em um paciente mamìfero e para tratar esquizofrenia em um paciente mamìfero
CA2739869C (en) * 2008-11-04 2016-09-27 F. Hoffmann-La Roche Ag Radiolabelled inhibitors of the glycine 1 transporter
US8431700B2 (en) 2009-03-03 2013-04-30 Vanderbilt University Alkylsulfonyl-2,3-dihydrospiro[indene-1,4′-piperidine] analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders
US8897518B2 (en) * 2009-03-19 2014-11-25 Koninklijke Philips N.V. Functional imaging
JP5618047B2 (ja) * 2010-01-29 2014-11-05 国立大学法人千葉大学 ポジトロン断層撮影法およびポジトロン放出化合物
US9045445B2 (en) 2010-06-04 2015-06-02 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
MX2013014007A (es) 2011-06-07 2014-03-12 Hoffmann La Roche [1,3] oxazinas.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931270A (en) * 1988-07-07 1990-06-05 Nelson Research & Development Method for detecting dopaminergic diseases using fluorine-18 radiolabelled D2 dopamine receptor ligands
US6228875B1 (en) 1998-04-14 2001-05-08 The General Hospital Corporation Methods for treating neuropsychiatric disorders
AU1309100A (en) * 1998-09-29 2000-04-17 Merck & Co., Inc. Radiolabeled neurokinin-1 receptor antagonists
US6303637B1 (en) * 1998-10-30 2001-10-16 Merck & Co., Inc. Heterocyclic potassium channel inhibitors
US6458935B1 (en) * 1999-06-23 2002-10-01 Merck & Co., Inc. Radiolabeled farnesyl-protein transferase inhibitors
US6939966B2 (en) * 2001-07-24 2005-09-06 Merck & Co., Inc. Radiolabeled neuropeptide Y Y5 receptor antagonists
ES2354151T3 (es) * 2002-09-24 2011-03-10 MERCK SHARP & DOHME CORP. Antagonistas del receptor de neuroquinina-1 radiomarcados.
US20070105902A1 (en) * 2003-11-12 2007-05-10 Lindsley Craig W 4-Phenyl piperdine sulfonyl glycine transporter inhibitors
US7825135B2 (en) * 2004-03-24 2010-11-02 Merck Sharp & Dohme Limited Heteroaryl piperidine glycine transporter inhibitors

Also Published As

Publication number Publication date
EP1942733A4 (de) 2010-11-10
WO2007041025A2 (en) 2007-04-12
US7834031B2 (en) 2010-11-16
ES2382818T3 (es) 2012-06-13
WO2007041025A3 (en) 2007-08-30
EP1942733A2 (de) 2008-07-16
EP1942733B1 (de) 2012-03-21
US20090269278A1 (en) 2009-10-29

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