ATE552031T1 - Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz - Google Patents

Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz

Info

Publication number: ATE552031T1
Authority: AT; Austria
Prior art keywords: compositions containing; treatment; pharmaceutical compositions; insulin resistance; containing non
Prior art date: 2001-12-18

Application number

AT02787266T

Other languages

English (en)

Inventor

Ezio Ghigo

Der Lely Aart Jan Van

Original Assignee

Alize Pharma Sas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-18

Filing date

2002-12-18

Publication date

2012-04-15

2002-12-18 Application filed by Alize Pharma Sas filed Critical Alize Pharma Sas

2012-04-15 Application granted granted Critical

2012-04-15 Publication of ATE552031T1 publication Critical patent/ATE552031T1/de

Links

GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical class C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title abstract 2
206010022489 Insulin Resistance Diseases 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
208000001072 type 2 diabetes mellitus Diseases 0.000 title 1
230000032683 aging Effects 0.000 abstract 1
230000002950 deficient Effects 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT02787266T 2001-12-18 2002-12-18 Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz ATE552031T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA2365704		2001-12-18
PCT/CA2002/001964 WO2003051389A2 (en)	2001-12-18	2002-12-18	Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof

Publications (1)

Publication Number	Publication Date
ATE552031T1 true ATE552031T1 (de)	2012-04-15

Family

ID=4170909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02787266T ATE552031T1 (de)	2001-12-18	2002-12-18	Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz

Country Status (7)

Country	Link
US (1)	US7485620B2 (de)
EP (1)	EP1455814B1 (de)
JP (1)	JP4562394B2 (de)
AT (1)	ATE552031T1 (de)
AU (1)	AU2002351593A1 (de)
ES (1)	ES2383796T3 (de)
WO (1)	WO2003051389A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7666833B2 (en)	2001-12-18	2010-02-23	Alizé Pharma SAS	Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof
ATE441429T1 (de) *	2002-07-19	2009-09-15	Cytos Biotechnology Ag	Ghrelin-träger-konjugate
US7825090B2 (en)	2003-10-24	2010-11-02	Alizé Pharma SAS	Use of ghrelin and unacylated ghrelin compositions for treating insulin resistance
JP2007532495A (ja) *	2004-04-07	2007-11-15	ガストロテック・ファルマ・アクティーゼルスカブ	グレリン欠乏を治療するための分泌促進薬の使用
CA2587627A1 (en) *	2004-11-15	2006-05-26	Eli Lilly And Company	Desacyl ghrelin antibodies and therapeutic uses thereof
US7803768B2 (en) *	2005-02-23	2010-09-28	Kyoto University	Method for treatment of hyperglycemia in a subject in need thereof
EP1757290A1 (de)	2005-08-16	2007-02-28	Zentaris GmbH	Triazolderivate als Liganden der Wachstumshormonrezeptoren
CA2625447C (en)	2005-09-29	2015-06-09	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Compositions and methods for stimulating gastrointestinal motility
EP1818061A1 (de) *	2005-12-02	2007-08-15	Charite-Universitätsmedizin Berlin	Verwendung von Ghrelin zur Stimulierung des Haarwachstums
WO2007126792A2 (en) *	2006-03-28	2007-11-08	Liat Mintz	Use of ghrelin splice variant for treating high cholesterol levels or high plasma glucose levels and releated diseases
DK2118123T3 (en)	2007-01-31	2016-01-25	Dana Farber Cancer Inst Inc	Stabilized p53 peptides and uses thereof
US8592377B2 (en)	2007-03-28	2013-11-26	President And Fellows Of Harvard College	Stitched polypeptides
US8318664B2 (en)	2007-05-31	2012-11-27	Alize Pharma Sas	Unacylated ghrelin fragments as therapeutic agent in the treatment of obesity
EP2152297B1 (de) *	2007-05-31	2015-04-29	Alizé Pharma SAS	Nicht acyliertes ghrelin als therapeutikum zur behandlung von stoffwechselerkrankungen
EP2067481A1 (de)	2007-12-03	2009-06-10	Charité-Universitätsmedizin Berlin	Therapeutische Verwendung von Desacylghrelin
US8476408B2 (en) *	2008-06-13	2013-07-02	Alize Pharma Sas	Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease
US8399643B2 (en)	2009-02-26	2013-03-19	Transposagen Biopharmaceuticals, Inc.	Nucleic acids encoding hyperactive PiggyBac transposases
ES2711526T3 (es)	2010-08-13	2019-05-06	Aileron Therapeutics Inc	Macrociclos peptidomiméticos
EP2431035A1 (de)	2010-09-16	2012-03-21	Æterna Zentaris GmbH	Neue Triazolderivate mit verbesserter Rezeptoraktivität und Bioverfügbarkeitseigenschaften als Ghrelin-Antagonisten der Wachstumshormon-Sekretagogum-Rezeptoren
TW201806968A (zh)	2011-10-18	2018-03-01	艾利倫治療公司	擬肽巨環化合物
PL2790721T3 (pl)	2011-12-15	2019-05-31	Millendo Therapeutics Sas	Fragmenty nieacylowanej greliny do zastosowania do leczenia zespołu pradera-williego
BR112014020103A2 (pt)	2012-02-15	2018-10-09	Aileron Therapeutics, Inc.	macrociclos peptidomiméticos
EP2819688A4 (de)	2012-02-15	2015-10-28	Aileron Therapeutics Inc	Triazol- und thioethervernetzte peptidomimetische makrozyklen
WO2014071241A1 (en)	2012-11-01	2014-05-08	Aileron Therapeutics, Inc.	Disubstituted amino acids and methods of preparation and use thereof
EP3010529B1 (de)	2013-06-21	2020-05-06	Millendo Therapeutics SAS	Verwendung von nichtacyliertem ghrelin sowie fragmenten und analogen davon als antioxidantien
EP3197478A4 (de)	2014-09-24	2018-05-30	Aileron Therapeutics, Inc.	Peptidomimetische makrozyklen und verwendungen davon
WO2016154058A1 (en)	2015-03-20	2016-09-29	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001056592A1 (en)	2000-02-01	2001-08-09	Novo Nordisk A/S	Use of compounds for the regulation of food intake
EP1286697A2 (de)	2000-05-17	2003-03-05	Eli Lilly And Company	Methode zur selektiven hemmung der aktivität von ghrelin
CA2470235C (en)	2001-12-18	2012-02-07	Theratechnologies Inc.	Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof
EP1506786B1 (de)	2002-05-21	2016-11-23	Daiichi Sankyo Company, Limited	Medizinische, ghrelin enthaltende zusammensetzungen
US7825090B2 (en)	2003-10-24	2010-11-02	Alizé Pharma SAS	Use of ghrelin and unacylated ghrelin compositions for treating insulin resistance

2002
- 2002-12-18 AU AU2002351593A patent/AU2002351593A1/en not_active Abandoned
- 2002-12-18 ES ES02787266T patent/ES2383796T3/es not_active Expired - Lifetime
- 2002-12-18 EP EP02787266A patent/EP1455814B1/de not_active Expired - Lifetime
- 2002-12-18 JP JP2003552322A patent/JP4562394B2/ja not_active Expired - Fee Related
- 2002-12-18 AT AT02787266T patent/ATE552031T1/de active
- 2002-12-18 WO PCT/CA2002/001964 patent/WO2003051389A2/en not_active Ceased
- 2002-12-18 US US10/499,376 patent/US7485620B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP4562394B2 (ja)	2010-10-13
WO2003051389A3 (en)	2003-09-12
ES2383796T3 (es)	2012-06-26
JP2005511771A (ja)	2005-04-28
WO2003051389A2 (en)	2003-06-26
EP1455814A2 (de)	2004-09-15
AU2002351593A1 (en)	2003-06-30
US20050080007A1 (en)	2005-04-14
US7485620B2 (en)	2009-02-03
EP1455814B1 (de)	2012-04-04

Publication	Publication Date	Title
ATE552031T1 (de)	2012-04-15	Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz
MY145590A (en)	2012-02-29	Phenylacetamides and their use as glucokinase modulators
PT1112275E (pt)	2003-12-31	Novos inibidores heteroaromaticos da frutose-1,6-bisfosfatase
AU2002305450A1 (en)	2002-11-18	Proteomimetic compounds and methods
WO2007128817A3 (en)	2008-03-06	Insulin derivative
ATE495739T1 (de)	2011-02-15	Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa
AP1763A (en)	2007-08-02	Pulmonary administration of chemically modified insulin
ATE503490T1 (de)	2011-04-15	Monodisperse mischungen und verfahren zur behandlung von diabetes
DK1196444T3 (da)	2003-09-29	Exendin-4-konjugater og deres medicinske anvendelighed
GB0222495D0 (en)	2002-11-06	Compounds
GEP20125565B (en)	2012-07-10	Lactam compounds and their pharmaceutical use
WO2003099771A3 (en)	2004-04-01	Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
DE60028970D1 (de)	2006-08-03	An her2 bindende peptidverbindungen
DE60331236D1 (de)	2010-03-25	Orale zusammensetzungen zur behandlung von diabetes
TW200612987A (en)	2006-05-01	Combination treatment for non-hematologic malignancies
ATE442142T1 (de)	2009-09-15	Fredericamycin-derivate als arzneimittel zur tumorbehandlung
PL1654253T3 (pl)	2007-05-31	Podstawione pochodne 3-pirolidynoindolu
CY1112184T1 (el)	2015-12-09	Πυριδοξαμινη για χρηση στην αγωγη της διαβητικης nεφροπαθειας στο διαβητη τυπου ii
DE602004017326D1 (de)	2008-12-04	Tetrahydrocarbazolderivate und deren pharmazeutische verwendung
ATE368455T1 (de)	2007-08-15	Verwendung von (+)-tramadol, o-demethyltramadol, o-desmethyl-n-mono-desmethyl-tramadol zur therapie der harninkontinenz
SE0102147D0 (sv)	2001-06-18	New methods
ATE410155T1 (de)	2008-10-15	Verwendung von cyclin-d1-hemmern zur brustkrebsbehandlung
CY1107231T1 (el)	2012-11-21	Υποκατεστημενα παραγωγα 4-αμινοκυκλοεξανολης
EA200800397A1 (ru)	2008-08-29	Композиции тизанидина и способы лечения с применением композиций
DK1605957T3 (da)	2008-08-11	Anvendelse af lupin-konglutin til behandling af type II-diabetes