ATE552031T1 - Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz - Google Patents

Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz

Info

Publication number: ATE552031T1
Authority: AT; Austria
Prior art keywords: compositions containing; treatment; pharmaceutical compositions; insulin resistance; containing non
Prior art date: 2001-12-18

Application number

AT02787266T

Other languages

English (en)

Inventor

Ezio Ghigo

Der Lely Aart Jan Van

Original Assignee

Alize Pharma Sas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-18

Filing date

2002-12-18

Publication date

2012-04-15

2002-12-18 Application filed by Alize Pharma Sas filed Critical Alize Pharma Sas

2012-04-15 Application granted granted Critical

2012-04-15 Publication of ATE552031T1 publication Critical patent/ATE552031T1/de

Links

GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical class C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title abstract 2
206010022489 Insulin Resistance Diseases 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
208000001072 type 2 diabetes mellitus Diseases 0.000 title 1
230000032683 aging Effects 0.000 abstract 1
230000002950 deficient Effects 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT02787266T 2001-12-18 2002-12-18 Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz ATE552031T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA2365704		2001-12-18
PCT/CA2002/001964 WO2003051389A2 (en)	2001-12-18	2002-12-18	Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof

Publications (1)

Publication Number	Publication Date
ATE552031T1 true ATE552031T1 (de)	2012-04-15

Family

ID=4170909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02787266T ATE552031T1 (de)	2001-12-18	2002-12-18	Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz

Country Status (7)

Country	Link
US (1)	US7485620B2 (de)
EP (1)	EP1455814B1 (de)
JP (1)	JP4562394B2 (de)
AT (1)	ATE552031T1 (de)
AU (1)	AU2002351593A1 (de)
ES (1)	ES2383796T3 (de)
WO (1)	WO2003051389A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7666833B2 (en)	2001-12-18	2010-02-23	Alizé Pharma SAS	Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof
US20040076645A1 (en) *	2002-07-19	2004-04-22	Bachmann Martin F.	Ghrelin-carrier conjugates
US7825090B2 (en)	2003-10-24	2010-11-02	Alizé Pharma SAS	Use of ghrelin and unacylated ghrelin compositions for treating insulin resistance
CA2603295A1 (en) *	2004-04-07	2006-10-20	Gastrotech Pharma A/S	Use of ghrelin for the treatment of hyperthyroidism
CA2587627A1 (en) *	2004-11-15	2006-05-26	Eli Lilly And Company	Desacyl ghrelin antibodies and therapeutic uses thereof
KR101295104B1 (ko) *	2005-02-23	2013-08-09	다이이찌 산쿄 가부시키가이샤	췌장 β 세포의 재생 촉진제 및 췌장 β 세포의 인슐린생산 촉진제
EP1757290A1 (de)	2005-08-16	2007-02-28	Zentaris GmbH	Triazolderivate als Liganden der Wachstumshormonrezeptoren
PT1937262T (pt) *	2005-09-29	2019-08-21	Ipsen Pharma Sas	Composição para utilização no tratamento de dismotilidade gastrointestinal
EP1818061A1 (de) *	2005-12-02	2007-08-15	Charite-Universitätsmedizin Berlin	Verwendung von Ghrelin zur Stimulierung des Haarwachstums
WO2007126792A2 (en) *	2006-03-28	2007-11-08	Liat Mintz	Use of ghrelin splice variant for treating high cholesterol levels or high plasma glucose levels and releated diseases
CA2939778C (en)	2007-01-31	2019-01-29	Dana-Farber Cancer Institute, Inc.	Stabilized p53 peptides and uses thereof
CA2682174C (en)	2007-03-28	2021-04-06	President And Fellows Of Harvard College	Stitched polypeptides
US8318664B2 (en)	2007-05-31	2012-11-27	Alize Pharma Sas	Unacylated ghrelin fragments as therapeutic agent in the treatment of obesity
ES2538111T3 (es) *	2007-05-31	2015-06-17	Alizé Pharma SAS	Grelina no acilada como agente terapéutico en el tratamiento de trastornos metabólicos
EP2067481A1 (de)	2007-12-03	2009-06-10	Charité-Universitätsmedizin Berlin	Therapeutische Verwendung von Desacylghrelin
US8476408B2 (en) *	2008-06-13	2013-07-02	Alize Pharma Sas	Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease
EP3184632B1 (de)	2009-02-26	2024-04-03	Poseida Therapeutics, Inc.	Hyperaktive piggybac-transposasen
KR20130099938A (ko)	2010-08-13	2013-09-06	에일러론 테라퓨틱스 인코포레이티드	펩티도미메틱 거대고리
EP2431035A1 (de)	2010-09-16	2012-03-21	Æterna Zentaris GmbH	Neue Triazolderivate mit verbesserter Rezeptoraktivität und Bioverfügbarkeitseigenschaften als Ghrelin-Antagonisten der Wachstumshormon-Sekretagogum-Rezeptoren
CN104039342A (zh)	2011-10-18	2014-09-10	爱勒让治疗公司	拟肽大环化合物
US9550821B2 (en)	2011-12-15	2017-01-24	Alize Pharma Sas	Modulation of ghrelin levels and ghrelin/unacylated ghrelin ratio using unacylated ghrelin
NZ627528A (en)	2012-02-15	2016-05-27	Aileron Therapeutics Inc	Peptidomimetic macrocycles
HK1205454A1 (en)	2012-02-15	2015-12-18	Aileron Therapeutics, Inc.	Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
SG11201503052RA (en)	2012-11-01	2015-05-28	Aileron Therapeutics Inc	Disubstituted amino acids and methods of preparation and use thereof
WO2014203074A2 (en)	2013-06-21	2014-12-24	Alize Pharma Sas	Use of unacylated ghrelin, fragments and analogs thereof as antioxidant
MX2017003797A (es)	2014-09-24	2017-06-15	Aileron Therapeutics Inc	Macrociclos peptidomimeticos y usos de los mismos.
WO2016154058A1 (en)	2015-03-20	2016-09-29	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001228325A1 (en)	2000-02-01	2001-08-14	Novo-Nordisk A/S	Use of compounds for the regulation of food intake
AU2001259056A1 (en)	2000-05-17	2001-11-26	Eli Lilly And Company	Method for selectively inhibiting ghrelin action
CA2470235C (en)	2001-12-18	2012-02-07	Theratechnologies Inc.	Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof
IL162796A0 (en)	2002-05-21	2005-11-20	Kenji Kangawa	Medicinal compositions containing ghrelin
US7825090B2 (en)	2003-10-24	2010-11-02	Alizé Pharma SAS	Use of ghrelin and unacylated ghrelin compositions for treating insulin resistance

2002
- 2002-12-18 AT AT02787266T patent/ATE552031T1/de active
- 2002-12-18 ES ES02787266T patent/ES2383796T3/es not_active Expired - Lifetime
- 2002-12-18 US US10/499,376 patent/US7485620B2/en not_active Expired - Fee Related
- 2002-12-18 JP JP2003552322A patent/JP4562394B2/ja not_active Expired - Fee Related
- 2002-12-18 WO PCT/CA2002/001964 patent/WO2003051389A2/en not_active Ceased
- 2002-12-18 AU AU2002351593A patent/AU2002351593A1/en not_active Abandoned
- 2002-12-18 EP EP02787266A patent/EP1455814B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2003051389A2 (en)	2003-06-26
JP2005511771A (ja)	2005-04-28
WO2003051389A3 (en)	2003-09-12
JP4562394B2 (ja)	2010-10-13
US20050080007A1 (en)	2005-04-14
EP1455814B1 (de)	2012-04-04
US7485620B2 (en)	2009-02-03
ES2383796T3 (es)	2012-06-26
EP1455814A2 (de)	2004-09-15
AU2002351593A1 (en)	2003-06-30

Publication	Publication Date	Title
ATE552031T1 (de)	2012-04-15	Pharmazeutische zusammensetzungen enthaltend nicht-acyliertes ghrelin zur behandlung von insulinresistenz
BRPI0207700B8 (pt)	2021-05-25	mistura de conjugados monodispersa, composição farmacêutica, e, uso de uma mistura substancialmente monodispersa de um conjugado de polipeptídeo de insulina-oligômero
MY145590A (en)	2012-02-29	Phenylacetamides and their use as glucokinase modulators
AU2002305450A1 (en)	2002-11-18	Proteomimetic compounds and methods
WO2007128817A3 (en)	2008-03-06	Insulin derivative
AP1763A (en)	2007-08-02	Pulmonary administration of chemically modified insulin
DK1196444T3 (da)	2003-09-29	Exendin-4-konjugater og deres medicinske anvendelighed
GB0222495D0 (en)	2002-11-06	Compounds
NZ515902A (en)	2004-02-27	Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, and type 2 diabetes
WO2003099771A3 (en)	2004-04-01	Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
DE60028970D1 (de)	2006-08-03	An her2 bindende peptidverbindungen
DE60331236D1 (de)	2010-03-25	Orale zusammensetzungen zur behandlung von diabetes
TW200612987A (en)	2006-05-01	Combination treatment for non-hematologic malignancies
ATE442142T1 (de)	2009-09-15	Fredericamycin-derivate als arzneimittel zur tumorbehandlung
DE602004031134D1 (de)	2011-03-03	Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa
ATE399553T1 (de)	2008-07-15	Pharmazeutische zusammensetzungen mit dextromethorphan und chinidin zur behandlung von neurologischen erkrankungen
PL1654253T3 (pl)	2007-05-31	Podstawione pochodne 3-pirolidynoindolu
CY1112184T1 (el)	2015-12-09	Πυριδοξαμινη για χρηση στην αγωγη της διαβητικης nεφροπαθειας στο διαβητη τυπου ii
SE0102147D0 (sv)	2001-06-18	New methods
DE602004017326D1 (de)	2008-12-04	Tetrahydrocarbazolderivate und deren pharmazeutische verwendung
ATE372776T1 (de)	2007-09-15	Arzneimittel enthaltend deuterium zur behandlung der zuckerkrankheit
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AU2003260436A1 (en)	2004-03-11	Pyrimidine compounds
EA200800397A1 (ru)	2008-08-29	Композиции тизанидина и способы лечения с применением композиций