ATE554754T1 - Verfahren zur herstellung und verwendung von eisenhaltigen pyrophosphat-citrat-chelat- zusammensetzungen - Google Patents

Verfahren zur herstellung und verwendung von eisenhaltigen pyrophosphat-citrat-chelat- zusammensetzungen

Info

Publication number: ATE554754T1
Authority: AT; Austria
Prior art keywords: ferric; citrate; iron; production; chelate
Prior art date: 2007-07-20

Application number

AT08159949T

Other languages

English (en)

Inventor

William S Mccall Jr

Original Assignee

Rockwell Medical Technologies Inc A Corp Of The State Of Michigan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-20

Filing date

2008-07-08

Publication date

2012-05-15

2008-07-08 Application filed by Rockwell Medical Technologies Inc A Corp Of The State Of Michigan filed Critical Rockwell Medical Technologies Inc A Corp Of The State Of Michigan

2012-05-15 Application granted granted Critical

2012-05-15 Publication of ATE554754T1 publication Critical patent/ATE554754T1/de

Links

239000013522 chelant Substances 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 2
CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical class [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 abstract 1
206010022971 Iron Deficiencies Diseases 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
238000007796 conventional method Methods 0.000 abstract 1
239000002552 dosage form Substances 0.000 abstract 1
235000007144 ferric diphosphate Nutrition 0.000 abstract 1
229940036417 ferric pyrophosphate citrate Drugs 0.000 abstract 1
150000004676 glycans Chemical class 0.000 abstract 1
SXAWSYZURCZSDX-UHFFFAOYSA-B hydron;[hydroxy(oxido)phosphoryl] hydrogen phosphate;2-hydroxypropane-1,2,3-tricarboxylate;iron(3+);phosphonato phosphate Chemical compound [H+].[H+].[H+].[H+].[H+].[Fe+3].[Fe+3].[Fe+3].[Fe+3].OP([O-])(=O)OP(O)([O-])=O.OP([O-])(=O)OP(O)([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O SXAWSYZURCZSDX-UHFFFAOYSA-B 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
229920001282 polysaccharide Polymers 0.000 abstract 1
239000005017 polysaccharide Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/287—Dialysates therefor

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Inorganic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Obesity (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Dental Preparations (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT08159949T 2007-07-20 2008-07-08 Verfahren zur herstellung und verwendung von eisenhaltigen pyrophosphat-citrat-chelat- zusammensetzungen ATE554754T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US96132707P	2007-07-20	2007-07-20
US12/138,018 US7816404B2 (en)	2007-07-20	2008-06-12	Methods for the preparation and use of ferric pyrophosphate citrate chelate compositions

Publications (1)

Publication Number	Publication Date
ATE554754T1 true ATE554754T1 (de)	2012-05-15

Family

ID=40019183

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08159949T ATE554754T1 (de)	2007-07-20	2008-07-08	Verfahren zur herstellung und verwendung von eisenhaltigen pyrophosphat-citrat-chelat- zusammensetzungen

Country Status (11)

Country	Link
US (1)	US7816404B2 (de)
EP (1)	EP2016940B1 (de)
JP (1)	JP5489196B2 (de)
AT (1)	ATE554754T1 (de)
CY (1)	CY1113903T1 (de)
DK (1)	DK2016940T3 (de)
ES (1)	ES2383713T3 (de)
HR (1)	HRP20120416T1 (de)
PL (1)	PL2016940T3 (de)
PT (1)	PT2016940E (de)
SI (1)	SI2016940T1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090124572A1 (en) *	2007-11-09	2009-05-14	Deanna Jean Nelson	Iron-containing nutritional supplement
CN102159205A (zh) *	2008-06-25	2011-08-17	Fe3医学有限公司	用于经皮递送治疗有效量的铁的贴片和方法
BRPI0823117B8 (pt) *	2008-09-29	2021-06-22	Vifor Int Ag	receptáculo e método para armazenar e suprir um líquido e uma preparação médica líquida
US8190252B2 (en)	2009-02-12	2012-05-29	Incube Labs, Llc	Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes
US8348922B2 (en) *	2009-02-12	2013-01-08	Incube Labs, Llc	Method and apparatus for oscillatory iontophoretic transdermal delivery of a therapeutic agent
US8961492B2 (en)	2009-02-12	2015-02-24	Incube Labs, Llc	System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation
US8821945B2 (en) *	2009-04-25	2014-09-02	Fe3 Medical, Inc.	Method for transdermal iontophoretic delivery of chelated agents
WO2010151845A2 (en) *	2009-06-26	2010-12-29	Incube Labs, Llc	Corrosion resistant electrodes for iontophoretic transdermal delivery devices and methods of use
US8178709B2 (en) *	2009-07-21	2012-05-15	Biolink Life Sciences, Inc.	Iron preparation suitable for pharmaceutical formulation and process for the preparation thereof
US8903485B2 (en) *	2009-08-06	2014-12-02	Incube Labs, Llc	Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes
US8685038B2 (en)	2009-12-07	2014-04-01	Incube Labs, Llc	Iontophoretic apparatus and method for marking of the skin
WO2011100376A2 (en)	2010-02-10	2011-08-18	Incube Labs, Llc	Methods and architecture for power optimization of iontophoretic transdermal drug delivery
EP2497380A1 (de) *	2011-03-10	2012-09-12	DSM IP Assets B.V.	Verfahren für die Eisenergänzung in Getränken
AU2012230701B2 (en)	2011-03-24	2016-09-29	Incube Labs, Llc	System and method for biphasic transdermal iontophoretic delivery of therapeutic agents
WO2012154704A2 (en)	2011-05-06	2012-11-15	Incube Labs, Llc	System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings
RU2472500C1 (ru) *	2012-05-05	2013-01-20	Илья Николаевич Медведев	Способ нормализации активности антитромбина iii в крови у новорожденных телят с железодефицитной анемией
WO2013167506A1 (en) *	2012-05-08	2013-11-14	Dsm Ip Assets B.V.	Iron supplementation of rice kernels
JP2016507527A (ja) *	2013-02-01	2016-03-10	チャラクエルエルシー	可溶性ピロリン酸第二鉄を用いて鉄欠乏症を治療する方法
EP3038475B1 (de) *	2013-08-28	2018-06-27	DSM IP Assets B.V.	Eisenergänzung eines bouillonkonzentrats
CA2929536A1 (en) *	2013-11-05	2015-05-14	Rockwell Medical, Inc.	Methods of reducing doses of erythropoietin stimulating agents in hyporesponsive patients
EP3157516A4 (de)	2014-06-22	2017-12-13	Dexcel Pharma Technologies Ltd.	Pharmazeutische zusammensetzungen mit eisencitrat und verfahren zur herstellung davon
CN107735358B (zh) *	2015-04-13	2019-12-06	富田制药株式会社	含有焦磷酸铁的粉末及其制造方法
SG10202107245UA (en)	2015-09-04	2021-08-30	Rockwell Medical Inc	Solid soluble ferric pyrophosphate formulations, kits, and methods using the same
US10456418B2 (en) *	2015-10-05	2019-10-29	Navinta, Llc	Preparation of pharmaceutical dosage forms containing iron (III) salts
WO2017120311A1 (en)	2016-01-06	2017-07-13	Rockwell Medical, Inc.	Composition therapy with an iron compound and a citrate compound
CN106977552B (zh) *	2016-01-19	2019-11-05	山东诚创医药技术开发有限公司	枸橼酸焦磷酸铁混配络合物的制备方法
JP6887598B2 (ja) *	2016-07-21	2021-06-16	富田製薬株式会社	鉄含有飲食品
CN106619494A (zh) *	2016-10-10	2017-05-10	泰州海达医药科技有限公司	枸橼酸焦磷酸铁溶液及其制备方法
US11785974B2 (en)	2017-03-31	2023-10-17	Abbott Laboratories	Liquid nutritional compositions containing oxidizable fish oil, rosmarinic acid, and ferric iron
EP3778868B1 (de)	2019-08-16	2022-01-26	UGA Biopharma GmbH	Zellkulturmedium zur kultivierung von zellen, verfahren zum kultivieren von zellen und verfahren zur expression von mindestens einem rekombinanten protein in einer zellkultur
CN112159434A (zh) *	2020-09-23	2021-01-01	北京沣瑞医药科技有限公司	枸橼酸焦磷酸铁配合物的制备方法
WO2022072439A1 (en) *	2020-09-29	2022-04-07	Lg Bionano Co. Ltd	Methods of preparing iron complexes
CN112516163A (zh) *	2020-12-21	2021-03-19	西安医学院	一种难溶性三价铁纳米脂质体复合物及其制备方法
WO2026017897A1 (en)	2024-07-18	2026-01-22	Malian Biologicals Gmbh	Iron supplementation in affective disorders and/or post-traumatic stress disorder (ptsd) and/or serotonin-dependent diseases

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE579299A (de)	1958-06-04
US3275514A (en)	1960-04-12	1966-09-27	Paul D Saltman	Process for introduction of metals into the mammalian system
US3259500A (en)	1961-10-11	1966-07-05	Kentucky Res Foundation	Method for inhibiting anemia in young pigs by feeding the sow an iron agent
US3367834A (en)	1965-05-04	1968-02-06	Dexter Martin	Method and compositions for enhancing the utilization of iron by mammals
AT279048B (de) *	1967-07-04	1970-02-25	Pharmazeutische Fabrik Montavit Gmbh	Verfahren zur Herstellung neuer, löslicher und stabiler organischer Eisen(III)-Komplexverbindungen und Injektionslösungen davon
US3686397A (en)	1970-05-18	1972-08-22	Mueller Arthur	Parenteral iron preparations
SE359447B (de)	1971-10-06	1973-09-03	Astra Laekemedel Ab
US4167564A (en)	1974-09-23	1979-09-11	Albion Laboratories, Inc.	Biological assimilation of metals
US4058621A (en)	1975-02-24	1977-11-15	Peter, Strong & Company, Inc.	Iron complexes and foodstuffs containing them
JPS5626709A (en) *	1979-08-04	1981-03-14	Nichia Kagaku Kogyo Kk	Manufacture of water soluble iron salt
GB2128998B (en)	1982-10-22	1986-07-16	Nat Res Dev	Pharmaceutical compositions of iron complexes of 3 hydroxy-4-pyrone
US5177068A (en)	1984-04-19	1993-01-05	National Research Development Corporation	Pharmaceutical compositions
GB8713169D0 (en)	1987-06-05	1987-07-08	Peters T J	Uptake of iron by body
CO4410161A1 (es)	1994-02-28	1997-01-09	Kellog Co	Producto de cereal listo para comer fortificado con complejo de edta ferrico y metodo para producirlo
AU736053B2 (en) *	1996-12-31	2001-07-26	Ajay Gupta	Method and pharmaceutical composition for iron delivery in hemodialysis and peritoneal dialysis patients
AU6605100A (en)	1999-06-30	2001-01-31	Ajay Gupta	Method and pharmaceutical composition for parenteral administration of iron
US20030190355A1 (en)	2002-04-05	2003-10-09	Hermelin Marc S.	Modified release minerals
TWI335218B (en) *	2003-02-19	2011-01-01	Panion & Bf Biotech Inc	Ferric organic compounds, uses thereof and methods of making same
US20060134227A1 (en)	2004-12-22	2006-06-22	Bortz Jonathan D	Compositions including iron
ES2634142T3 (es) *	2005-12-23	2017-09-26	Ajay Gupta	Composición de nutrición parenteral que contiene hierro

2008
- 2008-06-12 US US12/138,018 patent/US7816404B2/en active Active
- 2008-07-08 DK DK08159949.0T patent/DK2016940T3/da active
- 2008-07-08 EP EP08159949A patent/EP2016940B1/de active Active
- 2008-07-08 PL PL08159949T patent/PL2016940T3/pl unknown
- 2008-07-08 ES ES08159949T patent/ES2383713T3/es active Active
- 2008-07-08 AT AT08159949T patent/ATE554754T1/de active
- 2008-07-08 SI SI200830627T patent/SI2016940T1/sl unknown
- 2008-07-08 PT PT08159949T patent/PT2016940E/pt unknown
- 2008-07-18 JP JP2008186771A patent/JP5489196B2/ja not_active Expired - Fee Related
2012
- 2012-05-15 HR HRP20120416AT patent/HRP20120416T1/hr unknown
- 2012-07-23 CY CY20121100653T patent/CY1113903T1/el unknown

Also Published As

Publication number	Publication date
PT2016940E (pt)	2012-07-12
CY1113903T1 (el)	2016-07-27
HRP20120416T1 (hr)	2012-07-31
JP5489196B2 (ja)	2014-05-14
JP2009108027A (ja)	2009-05-21
PL2016940T3 (pl)	2012-09-28
ES2383713T3 (es)	2012-06-25
EP2016940B1 (de)	2012-04-25
US20090023686A1 (en)	2009-01-22
US7816404B2 (en)	2010-10-19
SI2016940T1 (sl)	2012-07-31
EP2016940A1 (de)	2009-01-21
DK2016940T3 (da)	2012-06-18

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PL2016940T3 (pl)	2012-09-28	Sposoby wytwarzania i zastosowanie kompozycji kompleksów chelatowych pirofosforanu (V) i cytrynianu z jonami żelaza (III)
NZ580226A (en)	2012-11-30	Dimer compounds as inhibitors of iap
BRPI0409198A (pt)	2006-05-02	derivados quinolin-2-ona para o tratamento de doenças de vias aéreas
MX2010009654A (es)	2010-09-28	Derivados de acido carboxilico de conformacion restringida utiles para tratar trastornos metabolicos.
MX2010004074A (es)	2010-07-02	Combinacion 059.
EA201001143A1 (ru)	2011-02-28	Активаторы прокаспаз "исполнителей" 3, 6 и 7
TW200716519A (en)	2007-05-01	Benzoyl-substituted serineamides
GEP20084551B (en)	2008-11-25	4-phenylamino-quinazolin-6-yl-amides
TN2010000305A1 (en)	2011-11-11	Pyrrolopyrimidines and pyrrolopyridines
MX2009005413A (es)	2009-06-01	Formas cristalinas del acido zoledronico.
GB0305152D0 (en)	2003-04-09	Organic compounds
TW200716558A (en)	2007-05-01	Heteroaroyl-substituted serineamides
TW200519106A (en)	2005-06-16	Organic compounds
ECSP088969A (es)	2009-01-30	Amino-imidazolones y su uso como medicamento para tratar deficiencias cognitivas, enfermedad de alzheimer, neurodegeneración y demencia
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TW200603746A (en)	2006-02-01	Iron sulfate based phosphate adsorbent
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