ATE60575T1 - (n-substituierte 2-hydroxy)-benzamide und nsubstituierte 2-hydroxy-alpha-oxo-benzenacetamide und ihre pharmazeutische zusammensetzungen mit wirkung als modulatoren der arachidonicsaeure- kaskaden. - Google Patents

(n-substituierte 2-hydroxy)-benzamide und nsubstituierte 2-hydroxy-alpha-oxo-benzenacetamide und ihre pharmazeutische zusammensetzungen mit wirkung als modulatoren der arachidonicsaeure- kaskaden.

Info

Publication number
ATE60575T1
ATE60575T1 AT86113490T AT86113490T ATE60575T1 AT E60575 T1 ATE60575 T1 AT E60575T1 AT 86113490 T AT86113490 T AT 86113490T AT 86113490 T AT86113490 T AT 86113490T AT E60575 T1 ATE60575 T1 AT E60575T1
Authority
AT
Austria
Prior art keywords
hydroxy
substituted
oxo
benzenacetamides
benzamides
Prior art date
Application number
AT86113490T
Other languages
English (en)
Inventor
David T Connor
Daniel L Flynn
Wiaczeslaw A Cetenko
Jagadish C Sircar
Charles F Schwender
Elizabeth A Johnson
Roderick J Sorenson
Paul C Unangst
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE60575T1 publication Critical patent/ATE60575T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT86113490T 1985-10-01 1986-10-01 (n-substituierte 2-hydroxy)-benzamide und nsubstituierte 2-hydroxy-alpha-oxo-benzenacetamide und ihre pharmazeutische zusammensetzungen mit wirkung als modulatoren der arachidonicsaeure- kaskaden. ATE60575T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/782,763 US4939133A (en) 1985-10-01 1985-10-01 N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade
EP86113490A EP0221346B1 (de) 1985-10-01 1986-10-01 (N-Substituierte 2-Hydroxy)-benzamide und N-substituierte 2-Hydroxy-alpha-oxo-benzenacetamide und ihre pharmazeutische Zusammensetzungen mit Wirkung als Modulatoren der Arachidonicsäure-Kaskaden

Publications (1)

Publication Number Publication Date
ATE60575T1 true ATE60575T1 (de) 1991-02-15

Family

ID=25127108

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86113490T ATE60575T1 (de) 1985-10-01 1986-10-01 (n-substituierte 2-hydroxy)-benzamide und nsubstituierte 2-hydroxy-alpha-oxo-benzenacetamide und ihre pharmazeutische zusammensetzungen mit wirkung als modulatoren der arachidonicsaeure- kaskaden.

Country Status (10)

Country Link
US (1) US4939133A (de)
EP (1) EP0221346B1 (de)
JP (1) JPS6281359A (de)
AT (1) ATE60575T1 (de)
AU (1) AU606848B2 (de)
DE (1) DE3677320D1 (de)
DK (1) DK463986A (de)
ES (1) ES2005073A6 (de)
GR (1) GR3001880T3 (de)
ZA (1) ZA866940B (de)

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DE3643403A1 (de) * 1986-12-19 1988-06-30 Shell Agrar Gmbh & Co Kg Benzophenone und verfahren zu ihrer herstellung
JP2671059B2 (ja) * 1990-11-30 1997-10-29 富士レビオ株式会社 ナフトエ酸誘導体
US5972980A (en) * 1995-10-05 1999-10-26 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
US6001866A (en) * 1995-10-05 1999-12-14 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
US6303645B1 (en) 1998-05-22 2001-10-16 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
BR9910642A (pt) * 1998-05-22 2001-10-09 Avanir Pharmaceuticals Análogos de benzimidazol como reguladores descendentes de ige
US6919366B2 (en) 1998-05-22 2005-07-19 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
US6369091B1 (en) 1998-05-22 2002-04-09 Avanir Pharmaceuticals Benzimidazole analogs as down-regulators of IgE
US6911462B2 (en) 1998-05-22 2005-06-28 Avanir Pharmaceuticals Benzimidazole compounds for regulating IgE
US6653309B1 (en) 1999-04-26 2003-11-25 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme technical field of the invention
US6759425B2 (en) 1999-10-21 2004-07-06 Avanir Pharmaceuticals Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
US20070208087A1 (en) * 2001-11-02 2007-09-06 Sanders Virginia J Compounds, compositions and methods for the treatment of inflammatory diseases
JP4224566B2 (ja) * 2000-12-18 2009-02-18 株式会社医薬分子設計研究所 炎症性サイトカイン産生遊離抑制剤
CZ20032691A3 (en) 2001-03-12 2004-04-14 Avanir Pharmaceuticals Benzimidazole compounds for modulating ige and inhibiting cellular proliferation
DE10222895A1 (de) * 2002-05-23 2003-12-11 Bosch Gmbh Robert Hochdruckspeicher für Kraftstoffeinspritzsysteme mit integriertem Druckregelventil
EP1512396A4 (de) * 2002-06-05 2008-12-31 Inst Med Molecular Design Inc Hemmer gegen aktivierung von ap-1 und nfat
CN101103977A (zh) * 2002-06-05 2008-01-16 株式会社医药分子设计研究所 糖尿病治疗药
CN1658854A (zh) * 2002-06-05 2005-08-24 株式会社医药分子设计研究所 免疫关联蛋白激酶抑制剂
CA2488363C (en) * 2002-06-06 2011-01-04 Institute Of Medicinal Molecular Design, Inc. O-substituted hydroxyaryl derivatives
EA009701B1 (ru) * 2002-06-06 2008-02-28 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. Противоаллергические средства
EA010470B1 (ru) * 2002-06-10 2008-08-29 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. ИНГИБИТОРЫ АКТИВАЦИИ NF-kB
EP1535610A4 (de) * 2002-06-10 2008-12-31 Inst Med Molecular Design Inc Therapeutisches krebsmittel
US20060035944A1 (en) * 2002-06-11 2006-02-16 Susumu Muto Remedies for neurodegenerative diseases
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
WO2004024655A2 (en) 2002-09-12 2004-03-25 Avanir Pharmaceuticals Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation
AU2003244325A1 (en) * 2002-11-12 2004-06-03 Nok Corporation Rubber-like elastic part
EP1853610A1 (de) * 2005-03-03 2007-11-14 Sirtris Pharmaceuticals, Inc. N-phenyl-benzamid-derivate als sirtuin-modulatoren
US7855289B2 (en) * 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
DK1910384T3 (da) * 2005-08-04 2012-12-17 Sirtris Pharmaceuticals Inc Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser
US8088928B2 (en) * 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8093401B2 (en) * 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
CL2008001822A1 (es) * 2007-06-20 2009-03-13 Sirtris Pharmaceuticals Inc Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
TW200918542A (en) * 2007-06-20 2009-05-01 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
WO2009058348A1 (en) * 2007-11-01 2009-05-07 Sirtris Pharmaceuticals, Inc. Amide derivatives as sirtuin modulators
MX2010005186A (es) * 2007-11-08 2010-05-27 Sirtris Pharmaceuticals Inc Tiazolopiridinas solubilizadas.
BRPI0922435A2 (pt) 2008-12-19 2018-09-11 Sirtris Pharmaceuticals Inc "composto de tiazolopiridina moduladores de sirtuina, composição farmacêutica compreendendo o mesmo e seu uso."
WO2011118759A1 (ja) * 2010-03-25 2011-09-29 国立大学法人 岡山大学 ベンズアニリド誘導体
JP6811196B2 (ja) * 2018-01-10 2021-01-13 日本碍子株式会社 焼成用セッター

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CH477163A (de) * 1967-07-26 1969-10-15 Ciba Geigy Verwendung von Salicylsäure-o-hydroxyphenylamiden zum antimikrobiellen Ausrüsten bzw. zum Schützen von textilem Material gegen schädliche Mikroorganismen
DE2600513A1 (de) * 1976-01-08 1977-07-28 Hoechst Ag Acylamino(alkyl)benzolderivate und verfahren zu ihrer herstellung
SU623356A1 (ru) * 1977-03-02 1981-09-07 Пермский ордена Трудового Красного Знамени государственный университет им. А.М.Горького Фениламид @ -бромбензоилпировиноградной кислоты,про вл ющий противоспалительную активность
JPS55113751A (en) * 1979-02-27 1980-09-02 Grelan Pharmaceut Co Ltd 2-oxo-3-(4-aminophenyl)butaneamide and its preparation
IT1198351B (it) * 1981-09-21 1988-12-21 Montedison Spa Processo per la carbonilazione di alogenuri benzilici secondari
US4562201A (en) * 1982-07-26 1985-12-31 American Hospital Supply Corporation Aminomethyl benzanilides
US4742083A (en) * 1983-08-24 1988-05-03 Lever Brothers Company Method of relieving pain and inflammatory conditions employing substituted salicylamides
LU86258A1 (fr) * 1986-01-21 1987-09-03 Rech Dermatologiques C I R D S Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
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Also Published As

Publication number Publication date
DK463986A (da) 1987-04-02
DK463986D0 (da) 1986-09-29
US4939133A (en) 1990-07-03
JPS6281359A (ja) 1987-04-14
DE3677320D1 (de) 1991-03-07
EP0221346B1 (de) 1991-01-30
AU6279186A (en) 1987-04-02
GR3001880T3 (en) 1992-11-23
ZA866940B (en) 1988-04-27
EP0221346A1 (de) 1987-05-13
ES2005073A6 (es) 1989-03-01
AU606848B2 (en) 1991-02-21

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