ATE60996T1 - Verfahren zur reinigung von faktor viii-c. - Google Patents

Verfahren zur reinigung von faktor viii-c.

Info

Publication number
ATE60996T1
ATE60996T1 AT84114693T AT84114693T ATE60996T1 AT E60996 T1 ATE60996 T1 AT E60996T1 AT 84114693 T AT84114693 T AT 84114693T AT 84114693 T AT84114693 T AT 84114693T AT E60996 T1 ATE60996 T1 AT E60996T1
Authority
AT
Austria
Prior art keywords
factor viii
purification procedure
purification
procedure
purified
Prior art date
Application number
AT84114693T
Other languages
English (en)
Inventor
Godfrey A Amphlett
Michael E Hrinda
Original Assignee
Armour Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armour Pharma filed Critical Armour Pharma
Application granted granted Critical
Publication of ATE60996T1 publication Critical patent/ATE60996T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
AT84114693T 1983-12-05 1984-12-03 Verfahren zur reinigung von faktor viii-c. ATE60996T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/557,805 US4508709A (en) 1983-12-05 1983-12-05 Process for purifying factor VIII:C
EP84114693A EP0144957B1 (de) 1983-12-05 1984-12-03 Verfahren zur Reinigung von Faktor VIII-C

Publications (1)

Publication Number Publication Date
ATE60996T1 true ATE60996T1 (de) 1991-03-15

Family

ID=24226953

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84114693T ATE60996T1 (de) 1983-12-05 1984-12-03 Verfahren zur reinigung von faktor viii-c.

Country Status (19)

Country Link
US (1) US4508709A (de)
EP (1) EP0144957B1 (de)
JP (1) JPS60136518A (de)
KR (1) KR850004593A (de)
AT (1) ATE60996T1 (de)
AU (1) AU569129B2 (de)
CA (1) CA1248449A (de)
DE (1) DE3484179D1 (de)
DK (1) DK162896C (de)
ES (1) ES8600690A1 (de)
FI (1) FI844804A7 (de)
IE (1) IE57644B1 (de)
IL (1) IL73734A (de)
IN (1) IN162586B (de)
MX (1) MX7552E (de)
NO (1) NO167627C (de)
NZ (1) NZ210427A (de)
SG (1) SG14992G (de)
ZA (1) ZA849434B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614795A (en) * 1982-08-05 1986-09-30 University Of Rochester Deglycosylated Human Factor VIII:C
DE3481109D1 (de) * 1983-05-09 1990-03-01 Novo Nordisk As Antihaemophilie-faktor-viii-konzentrat und dessen herstellungsverfahren.
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US5043428A (en) * 1984-08-31 1991-08-27 Behringwerke Aktiengesellschaft Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production
DE3432083A1 (de) * 1984-08-31 1986-03-06 Behringwerke Ag, 3550 Marburg Pasteurisierte, isoagglutininfreie faktor viii-praeparation und verfahren zu ihrer herstellung
US4847362A (en) * 1985-02-01 1989-07-11 New York University Method for purifying antihemophilic factor
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
US4952675A (en) * 1985-02-01 1990-08-28 New York University Method for purifying antihemophilic factor
GB2178533B (en) * 1985-07-22 1989-07-19 Asahi Chemical Ind Analytical method of enzyme precursors and device therefor
JPS63108000A (ja) * 1986-05-15 1988-05-12 Green Cross Corp:The 第８因子の精製方法
JPH0789951B2 (ja) * 1986-06-18 1995-10-04 財団法人阪大微生物病研究会 遺伝子発現産物の精製法
US4795806A (en) * 1987-07-16 1989-01-03 Miles Laboratories, Inc. Phospholipid affinity purification of Factor VIII:C
NL8701915A (nl) * 1987-08-14 1989-03-01 Waander Riethorst Adsorbensmateriaal en toepassing daarvan voor het isoleren van stollingsfaktoren.
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
DE3826792C1 (de) * 1988-08-06 1989-07-06 Biotest Pharma Gmbh, 6072 Dreieich, De
EP0367840B1 (de) * 1988-11-05 1993-02-03 Octapharma AG Verfahren zur Herstellung eines hochreinen, nicht infektiösen Antihämophiliefaktors mittels Chromatographie
FR2665449B1 (fr) * 1990-08-02 1995-04-14 Aquitaine Developp Transf Sang Procede de fabrication de facteur von willebrand ayant une tres haute purete, depourvu en majeure partie de facteur antihemophilique (fviiic), et facteur von willebrand ainsi obtenu, ainsi qu'une composition pharmaceutique le contenant.
FR2644064B1 (fr) * 1989-02-17 1994-05-27 Aquitaine Dev Transf Sanguine Procede de fabrication du facteur antihemophilique fviiic ayant une tres haute purete et facteur antihemophilique fviiic ainsi obtenu, ainsi que composition pharmaceutique le contenant
GB8913183D0 (en) * 1989-06-08 1989-07-26 Central Blood Lab Authority Chemical products
DE3939346A1 (de) * 1989-11-29 1991-06-06 Behringwerke Ag Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide
JPH0427865A (ja) * 1989-12-21 1992-01-30 Kurita Water Ind Ltd 血液凝固因子用分離剤およびその製造方法
FR2681867B1 (fr) * 1991-09-26 1993-12-31 Pasteur Merieux Serums Vaccins Procede de purification du facteur viii et preparations obtenues.
US5278289A (en) * 1991-11-12 1994-01-11 Johnson Alan J Antihemophilic factor stabilization
WO1995003332A1 (en) * 1993-07-23 1995-02-02 Baxter International Inc. Activated human factor viii and method of preparation
US5576291A (en) * 1993-09-13 1996-11-19 Baxter International Inc. Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4397841A (en) * 1982-06-28 1983-08-09 Monsanto Company Production of blood coagulation factor VIII:C
DK525384D0 (da) * 1984-11-05 1984-11-05 Nordisk Insulinlab Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat

Also Published As

Publication number Publication date
NO844837L (no) 1985-06-06
EP0144957A3 (en) 1987-09-30
EP0144957A2 (de) 1985-06-19
AU569129B2 (en) 1988-01-21
FI844804A0 (fi) 1984-12-05
IE843105L (en) 1985-06-05
IL73734A (en) 1989-09-28
US4508709A (en) 1985-04-02
JPS60136518A (ja) 1985-07-20
DE3484179D1 (de) 1991-04-04
NO167627B (no) 1991-08-19
EP0144957B1 (de) 1991-02-27
CA1248449A (en) 1989-01-10
MX7552E (es) 1989-09-25
DK575184A (da) 1985-06-06
ES538912A0 (es) 1985-11-01
IL73734A0 (en) 1985-03-31
FI844804L (fi) 1985-06-06
ZA849434B (en) 1985-07-31
FI844804A7 (fi) 1985-06-06
JPH0535159B2 (de) 1993-05-25
NZ210427A (en) 1988-09-29
IE57644B1 (en) 1993-02-10
KR850004593A (ko) 1985-07-25
NO167627C (no) 1991-11-27
SG14992G (en) 1992-04-16
AU3598284A (en) 1985-06-13
DK162896B (da) 1991-12-23
IN162586B (de) 1988-06-11
DK162896C (da) 1992-05-11
ES8600690A1 (es) 1985-11-01
DK575184D0 (da) 1984-12-04

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Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time