ATE67406T1 - Nicorandil enthaltende zubereitung zum einspritzen. - Google Patents
Nicorandil enthaltende zubereitung zum einspritzen.Info
- Publication number
- ATE67406T1 ATE67406T1 AT87100334T AT87100334T ATE67406T1 AT E67406 T1 ATE67406 T1 AT E67406T1 AT 87100334 T AT87100334 T AT 87100334T AT 87100334 T AT87100334 T AT 87100334T AT E67406 T1 ATE67406 T1 AT E67406T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- nicorandil
- freeze
- dissolved
- dried
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- LBHIOVVIQHSOQN-UHFFFAOYSA-N nicorandil Chemical compound [O-][N+](=O)OCCNC(=O)C1=CC=CN=C1 LBHIOVVIQHSOQN-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002497 nicorandil Drugs 0.000 title abstract 3
- 238000002347 injection Methods 0.000 title abstract 2
- 239000007924 injection Substances 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- -1 N-(2-hydroxyethyl)-nicotinamide nitrate ester Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP574286 | 1986-01-14 | ||
| EP87100334A EP0236679B1 (de) | 1986-01-14 | 1987-01-13 | Nicorandil enthaltende Zubereitung zum Einspritzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE67406T1 true ATE67406T1 (de) | 1991-10-15 |
Family
ID=11619552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87100334T ATE67406T1 (de) | 1986-01-14 | 1987-01-13 | Nicorandil enthaltende zubereitung zum einspritzen. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4769381A (de) |
| EP (1) | EP0236679B1 (de) |
| JP (1) | JPH0713018B2 (de) |
| KR (1) | KR950010150B1 (de) |
| AT (1) | ATE67406T1 (de) |
| AU (1) | AU594266B2 (de) |
| CA (1) | CA1285485C (de) |
| DE (1) | DE3773017D1 (de) |
| ES (1) | ES2038605T3 (de) |
| GR (1) | GR3003355T3 (de) |
| HK (1) | HK65193A (de) |
| SG (1) | SG64693G (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6351326A (ja) * | 1986-08-22 | 1988-03-04 | Nisshin Flour Milling Co Ltd | ニコランジル外用剤 |
| CA1336963C (en) * | 1988-07-18 | 1995-09-12 | Gary James Grover | Method for inhibiting myocardial cell necrosis and preserving heart function during myocardial ischemia and/or reperfusion |
| EP0816514B1 (de) * | 1996-06-24 | 2003-04-09 | Tosoh Corporation | Enzymsubstrat |
| SE9803517D0 (sv) | 1998-10-15 | 1998-10-15 | Astra Ab | Pharmaceutical preparation |
| US6417207B1 (en) * | 1999-05-12 | 2002-07-09 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
| WO2003018058A1 (fr) * | 2001-08-22 | 2003-03-06 | Mitsuhiro Yokota | Inhibiteur d'apoptose de cellules myocardiques |
| CN100417381C (zh) * | 2006-02-09 | 2008-09-10 | 西安力邦医药科技有限责任公司 | 尼可地尔冻干粉的制备方法 |
| CN101474161B (zh) * | 2009-01-14 | 2011-11-16 | 北京四环科宝制药有限公司 | 尼可地尔冻干粉针剂及其制备方法 |
| KR20140053907A (ko) * | 2011-06-30 | 2014-05-08 | 모찌다 세이야쿠 가부시끼가이샤 | 니코란딜 함유 의약 조성물 |
| CN110123749B (zh) * | 2019-06-03 | 2022-01-25 | 太阳升(亳州)生物医药科技有限公司 | 尼可地尔脂微球制剂及其制备方法 |
| CN111574441B (zh) * | 2020-05-26 | 2021-12-31 | 中国科学院上海药物研究所 | 一种尼可地尔与水杨酸的共晶及其制备方法和应用 |
| CN111606847B (zh) * | 2020-05-26 | 2021-12-31 | 中国科学院上海药物研究所 | 尼可地尔与1-羟基-2-萘甲酸的共晶及其制备方法和应用 |
| CN115624527A (zh) * | 2022-09-20 | 2023-01-20 | 朗天药业(湖北)有限公司 | 一种尼可地尔冻干粉针剂及其制备方法和用途 |
| CN115487156A (zh) * | 2022-10-17 | 2022-12-20 | 南京正科医药股份有限公司 | 一种注射用尼可地尔粉针剂及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3168438A (en) * | 1962-08-09 | 1965-02-02 | Synergistics Inc | Vasodilation by nitric acid ester derivatives of nicotinic acid |
| US3332848A (en) * | 1963-07-10 | 1967-07-25 | Hoffmann La Roche | Microcrystalline cellulose with starch in niacinamide ascorbic acid tablet granulations |
| US4200640A (en) * | 1976-04-02 | 1980-04-29 | Chugai Seiyaku Kabushiki Kaisha | Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use |
| JPS599539B2 (ja) * | 1979-11-13 | 1984-03-03 | 日本化薬株式会社 | ニトログリセリン水溶液及びその製造法 |
| JPS56139414A (en) * | 1980-04-01 | 1981-10-30 | Dai Ichi Seiyaku Co Ltd | Stabilizing method of aqueous solution |
| JPS5727087A (en) * | 1980-07-25 | 1982-02-13 | Toshiba Corp | Wavelength sweeping laser |
| EP0045238B1 (de) * | 1980-07-29 | 1986-10-01 | Sanofi S.A. | Durch Säure stabilisierte Mischungen von Thienopyridinderivaten und Verfahren zum Verhindern der Zersetzung solcher Verbindungen |
| US4490377A (en) * | 1980-07-29 | 1984-12-25 | Syntex (U.S.A.) Inc. | Acid stabilized compositions of thieno-pyridine derived compounds |
| JPS5762284A (en) * | 1980-10-01 | 1982-04-15 | Sumitomo Chem Co Ltd | Stabilizing method |
| US4382091A (en) * | 1981-04-30 | 1983-05-03 | Syntex (U.S.A.) Inc. | Stabilization of 1-substituted imidazole derivatives in talc |
| JPS5839618A (ja) * | 1981-09-04 | 1983-03-08 | Chugai Pharmaceut Co Ltd | 持続性積層錠剤 |
| DE3244178A1 (de) * | 1982-11-30 | 1984-05-30 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| JPS60185727A (ja) * | 1984-03-05 | 1985-09-21 | Sumitomo Chem Co Ltd | ４−カルバモイルイミダゾリウム−５−オレ−ト製剤の安定化法 |
| JPH0653658B2 (ja) * | 1984-12-17 | 1994-07-20 | 中外製薬株式会社 | 安定な錠剤の製造法 |
-
1986
- 1986-12-31 KR KR1019860011644A patent/KR950010150B1/ko not_active Expired - Lifetime
-
1987
- 1987-01-13 JP JP557387A patent/JPH0713018B2/ja not_active Expired - Lifetime
- 1987-01-13 DE DE8787100334T patent/DE3773017D1/de not_active Expired - Lifetime
- 1987-01-13 ES ES198787100334T patent/ES2038605T3/es not_active Expired - Lifetime
- 1987-01-13 EP EP87100334A patent/EP0236679B1/de not_active Expired - Lifetime
- 1987-01-13 US US07/003,036 patent/US4769381A/en not_active Expired - Lifetime
- 1987-01-13 AT AT87100334T patent/ATE67406T1/de not_active IP Right Cessation
- 1987-01-14 AU AU67562/87A patent/AU594266B2/en not_active Expired
- 1987-01-14 CA CA000527318A patent/CA1285485C/en not_active Expired - Lifetime
-
1991
- 1991-12-16 GR GR91401997T patent/GR3003355T3/el unknown
-
1993
- 1993-05-18 SG SG646/93A patent/SG64693G/en unknown
- 1993-07-08 HK HK651/93A patent/HK65193A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR3003355T3 (en) | 1993-02-17 |
| EP0236679B1 (de) | 1991-09-18 |
| KR950010150B1 (ko) | 1995-09-11 |
| JPH0713018B2 (ja) | 1995-02-15 |
| KR870006892A (ko) | 1987-08-13 |
| US4769381A (en) | 1988-09-06 |
| AU6756287A (en) | 1987-07-16 |
| DE3773017D1 (de) | 1991-10-24 |
| HK65193A (en) | 1993-07-16 |
| SG64693G (en) | 1993-08-06 |
| ES2038605T3 (es) | 1993-08-01 |
| JPS62252722A (ja) | 1987-11-04 |
| CA1285485C (en) | 1991-07-02 |
| EP0236679A1 (de) | 1987-09-16 |
| AU594266B2 (en) | 1990-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |