ATE71526T1 - Stabilisierte anthracyclin-zubereitung. - Google Patents

Stabilisierte anthracyclin-zubereitung.

Info

Publication number: ATE71526T1
Authority: AT; Austria
Prior art keywords: stabilized; anthracycline; preparation; salts; anthracycline preparation
Prior art date: 1987-08-05

Application number

AT88307214T

Other languages

English (en)

Inventor

Yasuhisa Sakamaki

Yukio Ozaki

Tanno Norihiko

Original Assignee

Sumitomo Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-05

Filing date

1988-08-04

Publication date

1992-02-15

1988-08-04 Application filed by Sumitomo Pharma filed Critical Sumitomo Pharma

1992-02-15 Application granted granted Critical

1992-02-15 Publication of ATE71526T1 publication Critical patent/ATE71526T1/de

Links

229940045799 anthracyclines and related substance Drugs 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
235000013878 L-cysteine Nutrition 0.000 abstract 1
239000004201 L-cysteine Substances 0.000 abstract 1
VJZITPJGSQKZMX-XDPRQOKASA-N amrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC=C4C(=O)C=3C(O)=C21)(N)C(=O)C)[C@H]1C[C@H](O)[C@H](O)CO1 VJZITPJGSQKZMX-XDPRQOKASA-N 0.000 abstract 1
238000004108 freeze drying Methods 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT88307214T 1987-08-05 1988-08-04 Stabilisierte anthracyclin-zubereitung. ATE71526T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP62197032A JP2603480B2 (ja)	1987-08-05	1987-08-05	安定化されたアンスラサイクリン系製剤
EP88307214A EP0302729B1 (de)	1987-08-05	1988-08-04	Stabilisierte Anthracyclin-Zubereitung

Publications (1)

Publication Number	Publication Date
ATE71526T1 true ATE71526T1 (de)	1992-02-15

Family

ID=16367605

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88307214T ATE71526T1 (de)	1987-08-05	1988-08-04	Stabilisierte anthracyclin-zubereitung.

Country Status (14)

Country	Link
US (1)	US4952566A (de)
EP (1)	EP0302729B1 (de)
JP (1)	JP2603480B2 (de)
KR (1)	KR970000507B1 (de)
AT (1)	ATE71526T1 (de)
AU (1)	AU609168B2 (de)
CA (1)	CA1324959C (de)
DE (1)	DE3867751D1 (de)
DK (1)	DK173317B1 (de)
ES (1)	ES2038763T3 (de)
FI (1)	FI91483C (de)
GR (1)	GR3004330T3 (de)
NO (1)	NO175134C (de)
NZ (1)	NZ225654A (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU222489B1 (hu) *	1990-07-25	2003-07-28	Novartis Ag.	Stabilizált gyógyszerkészítmények és eljárás az előállításukra
US6300361B1 (en)	1990-07-25	2001-10-09	Novartis Ag	Stabilized pharmaceutical compositions comprising acid donors
FR2665834B1 (fr) *	1991-07-24	2001-02-23	Sandoz Sa	Composition pharmaceutique stabilisee par un donneur d'acide chlorhydrique, et sa preparation.
DE19741715A1 (de) *	1997-09-22	1999-03-25	Hoechst Ag	Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE69833220T2 (de) *	1997-11-28	2006-07-13	Dainippon Sumitomo Pharma Co., Ltd.	Kristallines amrubicin-hydrochlorid
WO2003035660A1 (en) *	2001-10-23	2003-05-01	Sumitomo Chemical Company, Limited	Stabilization of amrubicin hydrochloride
KR101059715B1 (ko) *	2002-11-29	2011-08-29	다이닛본 스미토모 세이야꾸 가부시끼가이샤	안정화된 안트라사이클린계 화합물의 동결 건조 제제
CN100395255C (zh) *	2005-02-02	2008-06-18	江苏豪森药业股份有限公司	马来酸氨柔比星盐及其制备方法和用途
WO2006122309A2 (en) *	2005-05-11	2006-11-16	Sicor, Inc.	Stable lyophilized anthracycline glycosides
JP5389910B2 (ja) *	2009-05-27	2014-01-15	大日本住友製薬株式会社	アンスラサイクリン系化合物の安定な凍結乾燥製剤
IN2015DN04211A (de) *	2012-12-19	2015-10-16	Colgate Palmolive Co
WO2016024369A1 (ja) *	2014-08-13	2016-02-18	テバ製薬株式会社	がん治療用医薬組成物
WO2019094819A2 (en) *	2017-11-09	2019-05-16	Abon Pharmaceuticals, Llc	Intravenous delivery systems for chemotherapy drugs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2522187C2 (de) *	1975-05-17	1977-10-28	Byk Gulden Lomberg Chem Fab	Verwendung von Cystein oder dessen Säureadditionssalz und Natriumdisulfit zur Stabilisierung von injizierbaren, einen pH-Wert zwischen 7 und 9 aufweisenden, Vitamin B tief 12 und nichtsteroidal Entzündungshemmer enthaltenden Arzneimitteln
US4540695A (en) *	1981-08-12	1985-09-10	Sumitomo Chemical Co., Ltd.	Aminonaphthacene derivatives and their use
JPS5976099A (ja) *	1982-10-22	1984-04-28	Sumitomo Chem Co Ltd	アミノナフタセン誘導体とその製造方法
GB8426672D0 (en) *	1984-10-22	1984-11-28	Erba Farmitalia	Pharmaceutical compositions

1987
- 1987-08-05 JP JP62197032A patent/JP2603480B2/ja not_active Expired - Lifetime
1988
- 1988-08-01 FI FI883602A patent/FI91483C/fi not_active IP Right Cessation
- 1988-08-02 NZ NZ225654A patent/NZ225654A/en unknown
- 1988-08-02 US US07/227,135 patent/US4952566A/en not_active Expired - Lifetime
- 1988-08-03 NO NO883447A patent/NO175134C/no not_active IP Right Cessation
- 1988-08-04 KR KR1019880009960A patent/KR970000507B1/ko not_active Expired - Lifetime
- 1988-08-04 DE DE8888307214T patent/DE3867751D1/de not_active Expired - Lifetime
- 1988-08-04 DK DK198804366A patent/DK173317B1/da not_active IP Right Cessation
- 1988-08-04 AT AT88307214T patent/ATE71526T1/de not_active IP Right Cessation
- 1988-08-04 EP EP88307214A patent/EP0302729B1/de not_active Expired - Lifetime
- 1988-08-04 ES ES198888307214T patent/ES2038763T3/es not_active Expired - Lifetime
- 1988-08-04 AU AU20421/88A patent/AU609168B2/en not_active Expired
- 1988-08-05 CA CA000574065A patent/CA1324959C/en not_active Expired - Lifetime
1992
- 1992-04-10 GR GR920400681T patent/GR3004330T3/el unknown

Also Published As

Publication number	Publication date
DK436688D0 (da)	1988-08-04
JPS6440493A (en)	1989-02-10
EP0302729A1 (de)	1989-02-08
FI91483C (fi)	1994-07-11
KR890003791A (ko)	1989-04-18
AU609168B2 (en)	1991-04-26
FI91483B (fi)	1994-03-31
FI883602A0 (fi)	1988-08-01
ES2038763T3 (es)	1993-08-01
GR3004330T3 (de)	1993-03-31
DK173317B1 (da)	2000-07-17
KR970000507B1 (ko)	1997-01-13
FI883602L (fi)	1989-02-06
DK436688A (da)	1989-02-06
EP0302729B1 (de)	1992-01-15
US4952566A (en)	1990-08-28
AU2042188A (en)	1989-02-09
NO175134B (no)	1994-05-30
NO883447D0 (no)	1988-08-03
CA1324959C (en)	1993-12-07
NO883447L (no)	1989-02-06
NZ225654A (en)	1991-03-26
JP2603480B2 (ja)	1997-04-23
NO175134C (no)	1994-09-07
DE3867751D1 (de)	1992-02-27

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Legal Events

Date	Code	Title
1992-09-15	UEP	Publication of translation of european patent specification
2007-12-15	EEIH	Change in the person of patent owner
2008-11-15	EELA	Cancelled due to lapse of time