ATE71617T1 - Chinolinonderivate, ihre herstellung und ihre verwendung als arzneimittel. - Google Patents
Chinolinonderivate, ihre herstellung und ihre verwendung als arzneimittel.Info
- Publication number
- ATE71617T1 ATE71617T1 AT89402700T AT89402700T ATE71617T1 AT E71617 T1 ATE71617 T1 AT E71617T1 AT 89402700 T AT89402700 T AT 89402700T AT 89402700 T AT89402700 T AT 89402700T AT E71617 T1 ATE71617 T1 AT E71617T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- quinolinone derivatives
- medicinal products
- alkyl radical
- hydrogen atom
- Prior art date
Links
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- UCFFGYASXIPWPD-UHFFFAOYSA-N methyl hypochlorite Chemical group COCl UCFFGYASXIPWPD-UHFFFAOYSA-N 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical group O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8813324A FR2637591B1 (fr) | 1988-10-11 | 1988-10-11 | Derives de quinoleinone, leur preparation et leur application en therapeutique |
| EP89402700A EP0364327B1 (de) | 1988-10-11 | 1989-10-02 | Chinolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE71617T1 true ATE71617T1 (de) | 1992-02-15 |
Family
ID=9370884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89402700T ATE71617T1 (de) | 1988-10-11 | 1989-10-02 | Chinolinonderivate, ihre herstellung und ihre verwendung als arzneimittel. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4983607A (de) |
| EP (1) | EP0364327B1 (de) |
| JP (1) | JPH02157267A (de) |
| KR (1) | KR900006317A (de) |
| AT (1) | ATE71617T1 (de) |
| AU (1) | AU619349B2 (de) |
| CS (1) | CS404891A3 (de) |
| DE (1) | DE68900717D1 (de) |
| DK (1) | DK500189A (de) |
| ES (1) | ES2037980T3 (de) |
| FI (1) | FI91748C (de) |
| FR (1) | FR2637591B1 (de) |
| GR (1) | GR3003921T3 (de) |
| HU (1) | HU204813B (de) |
| IE (1) | IE61830B1 (de) |
| IL (1) | IL91930A (de) |
| NO (1) | NO173058C (de) |
| NZ (1) | NZ230959A (de) |
| PT (1) | PT91939B (de) |
| ZA (1) | ZA897672B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2635105B1 (fr) * | 1988-08-03 | 1991-01-25 | Synthelabo | Derives de piperazine et leur procede de preparation |
| US5457099A (en) * | 1992-07-02 | 1995-10-10 | Sawai Pharmaceutical Co., Ltd. | Carbostyril derivatives and antiallergic agent |
| DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
| US5607946A (en) * | 1993-03-05 | 1997-03-04 | Merck Sharp & Dohme Ltd. | Quinolone derivatives as dopamine D4 ligands |
| CA2158457C (en) * | 1993-03-16 | 2001-04-17 | Bertrand Leo Chenard | Naphthalene derivatives |
| FR2737723B1 (fr) * | 1995-08-09 | 1997-09-05 | Synthelabo | Derives de 1-(2-(1h-inden-3-yl)ethyl)-4-(naphtalen-1-yl)- piperazine, leur preparation et leur application en therapeutique |
| FR2738823B1 (fr) * | 1995-09-15 | 1997-10-31 | Synthelabo | Derives de 3-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)-3,4-dihydroquinolein-2(1h)-one,leur preparation et leur application en therapeutique |
| FR2761071B1 (fr) * | 1997-03-20 | 1999-12-03 | Synthelabo | Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique |
| FR2761067B1 (fr) * | 1997-03-20 | 1999-04-23 | Synthelabo | Derives de quinolein-2-(1h)-one, leur preparation et leur application en therapeutique |
| US6562837B1 (en) * | 1998-10-21 | 2003-05-13 | Korea Institute Of Science & Technology | Use of tetrahydroisoquinoline compounds for the treatment of septicemia |
| ES2332770T3 (es) | 2000-11-07 | 2010-02-12 | Novartis Ag | Derivados de indolilmaleimida como inhibidores de la proteina quinasa c. |
| US7053092B2 (en) * | 2001-01-29 | 2006-05-30 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1a receptor subtype agonist |
| US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| AR033485A1 (es) * | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| TW200803855A (en) * | 2006-02-24 | 2008-01-16 | Kalypsys Inc | Quinolones useful as inducible nitric oxide synthase inhibitors |
| JP2011520956A (ja) * | 2008-05-20 | 2011-07-21 | アストラゼネカ・アクチエボラーグ | 不安大うつ病性障害を処置する方法 |
| MA41168A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54128588A (en) * | 1978-03-29 | 1979-10-05 | Dainippon Pharmaceut Co Ltd | Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline |
| JPS54130587A (en) * | 1978-03-30 | 1979-10-09 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
| US4284768A (en) * | 1980-07-02 | 1981-08-18 | American Home Products Corporation | 1,2-Dihydro-4-amino-2-oxo-3-quinoline-carboxylic acid derivatives |
| GB8827189D0 (en) * | 1988-11-21 | 1988-12-29 | Fujisawa Pharmaceutical Co | 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same |
-
1988
- 1988-10-11 FR FR8813324A patent/FR2637591B1/fr not_active Expired - Fee Related
-
1989
- 1989-10-02 DE DE8989402700T patent/DE68900717D1/de not_active Expired - Lifetime
- 1989-10-02 EP EP89402700A patent/EP0364327B1/de not_active Expired - Lifetime
- 1989-10-02 AT AT89402700T patent/ATE71617T1/de not_active IP Right Cessation
- 1989-10-02 ES ES198989402700T patent/ES2037980T3/es not_active Expired - Lifetime
- 1989-10-09 ZA ZA897672A patent/ZA897672B/xx unknown
- 1989-10-10 PT PT91939A patent/PT91939B/pt not_active IP Right Cessation
- 1989-10-10 FI FI894803A patent/FI91748C/fi not_active IP Right Cessation
- 1989-10-10 AU AU42750/89A patent/AU619349B2/en not_active Ceased
- 1989-10-10 IE IE326589A patent/IE61830B1/en not_active IP Right Cessation
- 1989-10-10 DK DK500189A patent/DK500189A/da not_active Application Discontinuation
- 1989-10-10 IL IL91930A patent/IL91930A/xx not_active IP Right Cessation
- 1989-10-10 HU HU895268A patent/HU204813B/hu not_active IP Right Cessation
- 1989-10-10 NZ NZ230959A patent/NZ230959A/en unknown
- 1989-10-10 KR KR1019890014520A patent/KR900006317A/ko not_active Withdrawn
- 1989-10-10 US US07/417,970 patent/US4983607A/en not_active Expired - Lifetime
- 1989-10-10 NO NO894036A patent/NO173058C/no not_active IP Right Cessation
- 1989-10-11 JP JP1266051A patent/JPH02157267A/ja active Pending
-
1991
- 1991-12-23 CS CS914048A patent/CS404891A3/cs unknown
-
1992
- 1992-02-27 GR GR920400344T patent/GR3003921T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT91939B (pt) | 1995-05-31 |
| AU619349B2 (en) | 1992-01-23 |
| ES2037980T3 (es) | 1993-07-01 |
| PT91939A (pt) | 1990-04-30 |
| NO894036D0 (no) | 1989-10-10 |
| DE68900717D1 (de) | 1992-02-27 |
| HU204813B (en) | 1992-02-28 |
| IL91930A (en) | 1993-08-18 |
| NZ230959A (en) | 1990-12-21 |
| FI894803A0 (fi) | 1989-10-10 |
| DK500189A (da) | 1990-04-12 |
| NO173058C (no) | 1993-10-20 |
| NO173058B (no) | 1993-07-12 |
| EP0364327B1 (de) | 1992-01-15 |
| ZA897672B (en) | 1990-07-25 |
| CS404891A3 (en) | 1992-04-15 |
| FR2637591A1 (fr) | 1990-04-13 |
| IE61830B1 (en) | 1994-11-30 |
| IE893265L (en) | 1990-04-11 |
| FI91748C (fi) | 1994-08-10 |
| FI894803L (fi) | 1990-04-12 |
| FR2637591B1 (fr) | 1992-10-23 |
| KR900006317A (ko) | 1990-05-07 |
| GR3003921T3 (de) | 1993-03-16 |
| HUT51612A (en) | 1990-05-28 |
| FI91748B (fi) | 1994-04-29 |
| NO894036L (no) | 1990-04-17 |
| DK500189D0 (da) | 1989-10-10 |
| US4983607A (en) | 1991-01-08 |
| IL91930A0 (en) | 1990-06-10 |
| HU895268D0 (en) | 1990-01-28 |
| JPH02157267A (ja) | 1990-06-18 |
| EP0364327A1 (de) | 1990-04-18 |
| AU4275089A (en) | 1990-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |