ATE71630T1 - 1,2-diaminocyclohexan-platin-komplexe mit antitumor-wirkung. - Google Patents

1,2-diaminocyclohexan-platin-komplexe mit antitumor-wirkung.

Info

Publication number: ATE71630T1
Authority: AT; Austria
Prior art keywords: animals; butyl; platinum complexes; antitumor effects; treatment
Prior art date: 1986-11-17

Application number

AT87908064T

Other languages

English (en)

Inventor

Abdul R Khokhar

Robert A Newman

Irwin H Krakoff

Original Assignee

Univ Texas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-17

Filing date

1987-11-16

Publication date

1992-02-15

1987-11-16 Application filed by Univ Texas filed Critical Univ Texas

1992-02-15 Application granted granted Critical

1992-02-15 Publication of ATE71630T1 publication Critical patent/ATE71630T1/de

Links

230000000259 anti-tumor effect Effects 0.000 title 1
POQBJIOLWPDPJE-UHFFFAOYSA-N cyclohexane-1,2-diamine;platinum Chemical class [Pt].NC1CCCCC1N POQBJIOLWPDPJE-UHFFFAOYSA-N 0.000 title 1
241001465754 Metazoa Species 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
150000001768 cations Chemical class 0.000 abstract 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
150000002892 organic cations Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229910052697 platinum Inorganic materials 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT87908064T 1986-11-17 1987-11-16 1,2-diaminocyclohexan-platin-komplexe mit antitumor-wirkung. ATE71630T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US06/932,176 US5011959A (en)	1986-11-17	1986-11-17	1,2-diaminocyclohexane-platinum complexes with antitumor activity
PCT/US1987/002996 WO1988003925A1 (en)	1986-11-17	1987-11-16	1,2-diaminocyclohexane-platinum complexes with antitumor activity
EP87908064A EP0333756B1 (de)	1986-11-17	1987-11-16	1,2-diaminocyclohexan-platin-komplexe mit antitumor-wirkung

Publications (1)

Publication Number	Publication Date
ATE71630T1 true ATE71630T1 (de)	1992-02-15

Family

ID=25461896

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87908064T ATE71630T1 (de)	1986-11-17	1987-11-16	1,2-diaminocyclohexan-platin-komplexe mit antitumor-wirkung.

Country Status (7)

Country	Link
US (2)	US5011959A (de)
EP (1)	EP0333756B1 (de)
JP (1)	JPH02500745A (de)
AT (1)	ATE71630T1 (de)
AU (1)	AU8335987A (de)
DE (1)	DE3776154D1 (de)
WO (1)	WO1988003925A1 (de)

Families Citing this family (11)

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US5384127A (en) *	1985-10-18	1995-01-24	Board Of Regents, The University Of Texas System	Stable liposomal formulations of lipophilic platinum compounds
US5041581A (en) *	1985-10-18	1991-08-20	The University Of Texas System Board Of Regents	Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US5434256A (en) *	1988-11-22	1995-07-18	Board Of Regents, The University Of Texas System	Diamine platinum complexes as antitumor agents
US5393909A (en) *	1988-11-22	1995-02-28	Board Of Regents, The University Of Texas System	Diamine platinum complexes as antitumor agents
US5041578A (en) *	1988-11-22	1991-08-20	Board Of Regents, The University Of Texas System	Water soluble 1,2-diaminocyclohexane platinum (IV) complexes as antitumor agents
JPH0776229B2 (ja) *	1989-12-12	1995-08-16	東レ株式会社	新規白金（２）錯体および悪性腫瘍治療剤
JP3154399B2 (ja) *	1996-07-04	2001-04-09	デビオファームエス．アー．	白金化合物の製造方法
US5843475A (en) *	1996-12-06	1998-12-01	Board Of Regents, The University Of Texas System	Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes
CA2385528C (en)	1999-10-01	2013-12-10	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2001036431A1 (en) *	1999-11-15	2001-05-25	Parker Hughes Institute	Diamino platinum (ii) antitumor complexes
DE10314780A1 (de) *	2003-03-19	2004-09-30	Ktb Tumorforschungsgesellschaft Mbh	Proteinbindende Derivate von Platinkomplexen mit Cyclobutan-1,1-dicarboxylatliganden

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JPS6041077B2 (ja) *	1976-09-06	1985-09-13	喜徳喜谷	１，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
JPS5829957B2 (ja) *	1977-09-12	1983-06-25	喜徳喜谷	新規な白金錯体
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US4584392A (en) *	1982-11-10	1986-04-22	Inco Alloys International, Inc.	Platinum and palladium complexes
JPS59112995A (ja) *	1982-12-21	1984-06-29	Shionogi & Co Ltd	新規グリコ−ル酸白金錯体
IL67789A (en) *	1983-01-31	1986-09-30	Yissum Res Dev Co	Amino-substituted malonato platinum(ii)complexes and method for their preparation
US4584316A (en) *	1983-03-25	1986-04-22	Research Corporation	Palladium anti-cancer complexes
US4617189A (en) *	1983-04-14	1986-10-14	Stockel Richard F	Use of selenium-containing compounds for negating the toxic effects of platinum compounds used in chemotherapy, and a novel selenium-containing platinum compound and use thereof as an anti-cancer medicine
US4565884A (en) *	1983-05-10	1986-01-21	Andrulis Research Corporation	Bis-platinum complexes as antitumor agents
US4720504A (en) *	1983-05-10	1988-01-19	Andrulis Research Corporation	Use of bis-platinum complexes as antitumor agents
JPS59222498A (ja) *	1983-06-01	1984-12-14	Shionogi & Co Ltd	新規グリコ−ル酸系白金錯体および抗悪性腫瘍剤
DK301684A (da) *	1983-06-20	1984-12-21	Research Corp	Diaminocyklohexanplatinkomplekser
US4661516A (en) *	1983-06-20	1987-04-28	Research Corporation	Diaminocyclohexane platinum complexes
US4710577A (en) *	1983-08-05	1987-12-01	Yoshinori Kidani	Cytostatic platinum organic complexes
US4673754A (en) *	1983-10-14	1987-06-16	Inco Alloys International, Inc.	Platinum and palladium complexes
BE898614A (fr) *	1984-01-05	1984-05-02	Abello Quimicos Farma Prod Sa	Nouveaux composes de coordination contenant du platine
US4707352A (en) *	1984-01-30	1987-11-17	Enzo Biochem, Inc.	Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4599352A (en) *	1984-03-01	1986-07-08	The United States Of America As Represented By The Department Of Health And Human Services	Antineoplastic platinum (IV) complexes and compositions
US4562275A (en) *	1984-03-23	1985-12-31	Bristol-Myers Co.	Antitumor platinum complexes
JPS617283A (ja) *	1984-06-20	1986-01-13	Shionogi & Co Ltd	新規白金錯体および抗悪性腫瘍剤
CS253069B1 (en) *	1984-11-09	1987-10-15	Jaroslav Drobnik	Macromolecular anticarcinogenetic remedy containing platinum and method of its production
US4665210A (en) *	1984-12-17	1987-05-12	American Cyanamid Company	Platinum complexes of aliphatic tricarboxylic acids
DE3575144D1 (de) *	1984-12-17	1990-02-08	American Cyanamid Co	Platinkomplexe von aliphatischen tricarbonsaeuren.
US4739087A (en) *	1985-01-10	1988-04-19	Bristol-Myers Company	Antineoplastic platinum complexes
JPS6296A (ja) *	1985-03-06	1987-01-06	Sumitomo Pharmaceut Co Ltd	脂溶性白金（２）錯体
US4675336A (en) *	1985-06-26	1987-06-23	American Cyanamid Company	Platinum complexes of amines with dibasic acids
US4658047A (en) *	1985-09-27	1987-04-14	The United States Of America As Represented By The Department Of Health And Human Services	Method of preparing 1,2-diaminocyclohexane tetrachloro platinum (IV) isomers
US4680308A (en) *	1985-12-26	1987-07-14	Andrulis Research Corporation	Stable soluble 1,2-diaminocyclohexane platinum complexes
US4670458A (en) *	1986-01-31	1987-06-02	American Cyanamid Company	Hydroxylated 1,2-diaminocyclohexane platinum complexes

1986
- 1986-11-17 US US06/932,176 patent/US5011959A/en not_active Expired - Fee Related
1987
- 1987-11-16 DE DE8787908064T patent/DE3776154D1/de not_active Expired - Lifetime
- 1987-11-16 EP EP87908064A patent/EP0333756B1/de not_active Expired - Lifetime
- 1987-11-16 WO PCT/US1987/002996 patent/WO1988003925A1/en not_active Ceased
- 1987-11-16 AT AT87908064T patent/ATE71630T1/de not_active IP Right Cessation
- 1987-11-16 AU AU83359/87A patent/AU8335987A/en not_active Abandoned
- 1987-11-16 JP JP63500306A patent/JPH02500745A/ja active Pending
1990
- 1990-12-20 US US07/631,013 patent/US5132323A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5011959A (en)	1991-04-30
EP0333756B1 (de)	1992-01-15
WO1988003925A1 (en)	1988-06-02
DE3776154D1 (de)	1992-02-27
AU8335987A (en)	1988-06-16
EP0333756A1 (de)	1989-09-27
US5132323A (en)	1992-07-21
JPH02500745A (ja)	1990-03-15

Legal Events

Date	Code	Title	Description
1992-10-15	UEP	Publication of translation of european patent specification
1994-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
US4863898A (en)	1989-09-05	Amino acid chelated compositions for delivery to specific biological tissue sites
DE3776154D1 (de)	1992-02-27	1,2-diaminocyclohexan-platin-komplexe mit antitumor-wirkung.
ES8205231A1 (es)	1982-06-01	Procedimiento para preparar complejos de platino (iv)-diami-na
HUT49363A (en)	1989-09-28	Process for producing 1,2-bis-(aminomethyl)-cyclobutane-platinum complexes and pharmaceutical compositions comprising same
MY101934A (en)	1992-02-15	Composition useful for producing analgesia
DK0612248T3 (da)	2003-12-08	Præparat, der indeholder cisplatin og topotecan som antitumormiddel
DE3569332D1 (en)	1989-05-18	Porphyrins and cancer treatment
EP0344880A3 (en)	1990-04-18	Pharmaceutical compositions with anti-cancer activity and method for the treatment of cancer
Magnuson et al.	1972	Mixed oxidation states in osmium ammine dinitrogen complexes
AU4484989A (en)	1990-06-12	Water soluble 1,2-diaminocyclohexane platinum (iv) complexes as antitumor agents
ATE19520T1 (de)	1986-05-15	Loesliche platin(ii)-komplexe.
HU895608D0 (en)	1990-01-28	Process for the preparation of chelates containing ortho ligating functional group and complexes thereof
PH24452A (en)	1990-06-25	(2,2-bis(aminomethyl 1,3,propanediol-n,n)platinum complexes
FR2534907B1 (fr)	1988-08-19	Complexes diamine-platine, un procede pour leur preparation, un procede pour la preparation d'une composition medicinale utilisant un tel complexe diamine platine pour le traitement du cancer ainsi que la composition ainsi formee
DE3570981D1 (en)	1989-07-20	Antitumor pharmaceutical compositions and compounds for treating tumors employing (alpha-omega-bis(disubstitutedphosphino)-hydrocarbon) digold(i), digold(iii), disilver(i), and dicopper(i) derivatives
HUT40452A (en)	1986-12-28	Process for preparing tumor inhibiting (1-benzyl-ethylene-diamine)-platinum(ii) complexes
DE3378524D1 (en)	1988-12-29	Anti-cancer drugs comprising platinum complexes
ES8604248A1 (es)	1986-01-16	Un procedimiento para la preparacion de complejos de amino- antracenodionas-platino
ES391016A1 (es)	1974-04-01	Un procedimiento de preparacion de un polinucleotido de fi-lamentos multiples.
GB2019405A (en)	1979-10-31	Pt (II) and (IV) Amino-Acid Complexes
ES2013433A6 (es)	1990-05-01	Procedimiento para la preparacion de un complejo de platino.
HUT44573A (en)	1988-03-28	Process for preparing (geminal-heterocyclo-dimethane-n,n')-platinum complexes and pharmaceuticals comprising the same
EP0127389A3 (en)	1985-08-07	N,n-diethyl-5-methyl-2h-1-benzothiopyrano-(4,3,2-cd)-indazole-2-ethanamine, compositions comprising the same and uses therefor
FR2288516A2 (fr)	1976-05-21	Nouveaux bis-(carboxyalcoylene-thio)-1,10 decanes et leurs derives
CA2103708A1 (en)	1992-08-22	Treatment of ovarian cancer