ATE7702T1 - Verfahren zum entfernen von trityl-schutzgruppen aus 5'-o-trityl-nukleosiden und oligonukleotiden. - Google Patents

Verfahren zum entfernen von trityl-schutzgruppen aus 5'-o-trityl-nukleosiden und oligonukleotiden.

Info

Publication number: ATE7702T1
Authority: AT; Austria
Prior art keywords: nucleoside; polymer; trityl; oligonucleotides; modified
Prior art date: 1980-02-29

Application number

AT81101444T

Other languages

English (en)

Inventor

Marvin H. Caruthers

Mark D. Matteucci

Original Assignee

University Patents, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-02-29

Filing date

1981-02-27

Publication date

1984-06-15

1981-02-27 Application filed by University Patents, Inc. filed Critical University Patents, Inc.

1984-06-15 Application granted granted Critical

1984-06-15 Publication of ATE7702T1 publication Critical patent/ATE7702T1/de

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 2
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000002777 nucleoside Substances 0.000 abstract 7
229920000592 inorganic polymer Polymers 0.000 abstract 6
125000003835 nucleoside group Chemical group 0.000 abstract 5
150000003833 nucleoside derivatives Chemical class 0.000 abstract 4
229920000642 polymer Polymers 0.000 abstract 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical class O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
239000007822 coupling agent Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00286—Reactor vessels with top and bottom openings
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00389—Feeding through valves
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Saccharide Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

AT81101444T 1980-02-29 1981-02-27 Verfahren zum entfernen von trityl-schutzgruppen aus 5'-o-trityl-nukleosiden und oligonukleotiden. ATE7702T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12602580A	1980-02-29	1980-02-29
EP81101444A EP0035255B1 (de)	1980-02-29	1981-02-27	Verfahren zum Entfernen von Trityl-Schutzgruppen aus 5'-O-trityl-Nukleosiden und Oligonukleotiden

Publications (1)

Publication Number	Publication Date
ATE7702T1 true ATE7702T1 (de)	1984-06-15

Family

ID=22422602

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT81101444T ATE7702T1 (de)	1980-02-29	1981-02-27	Verfahren zum entfernen von trityl-schutzgruppen aus 5'-o-trityl-nukleosiden und oligonukleotiden.
AT85200673T ATE56723T1 (de)	1980-02-29	1981-02-27	Verfahren zur herstellung von modifizierten anorganischen polymeren.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT85200673T ATE56723T1 (de)	1980-02-29	1981-02-27	Verfahren zur herstellung von modifizierten anorganischen polymeren.

Country Status (7)

Country	Link
EP (4)	EP0097805A3 (de)
JP (4)	JPS56133299A (de)
AT (2)	ATE7702T1 (de)
AU (2)	AU542967B2 (de)
CA (2)	CA1159052A (de)
DE (2)	DE3177215D1 (de)
MX (1)	MX158743A (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA821534B (en) *	1981-03-10	1984-04-25	Bioresearch Inc	Rapid solid phase synthesis of olignucleotides using phosphorus oxychloride activation
US4415732A (en) *	1981-03-27	1983-11-15	University Patents, Inc.	Phosphoramidite compounds and processes
JPS58148896A (ja) *	1982-02-26	1983-09-05	Shimadzu Corp	Ｄｎａ等微量自動合成装置
DE3208565A1 (de) *	1982-03-10	1983-11-10	Köster, Hubert, Prof. Dr., 2000 Hamburg	Verfahren zur abspaltung von tritylschutzgruppen
EP0090789A1 (de) *	1982-03-26	1983-10-05	Monsanto Company	Chemische DNA-Synthese
US4474948A (en) *	1982-04-08	1984-10-02	Biosearch	Benzazolides and their employment in phosphite ester oligonucleotide synthesis processes
IL69196A0 (en) *	1982-08-20	1983-11-30	Genex Corp	Solid phase synthesis of oligonucleotides
JPS60500535A (ja) *	1982-12-29	1985-04-18	サザン　イリノイ　ユニバ−シテイ　フアウンデイシヨン	ポリヌクレオチドの製造方法
FR2544720B1 (fr) *	1983-04-19	1987-11-27	California Inst Of Techn	Installation perfectionnee et procede pour la synthese de composes chimiques, en particulier d'oligonucleotides
DE3329892A1 (de)	1983-08-18	1985-03-07	Köster, Hubert, Prof. Dr., 2000 Hamburg	Verfahren zur herstellung von oligonucleotiden
US5539097A (en) *	1983-09-02	1996-07-23	Molecular Biosystems, Inc.	Oligonucleotide polymeric support system
JPS61152695A (ja) *	1984-12-26	1986-07-11	Nippon Shinyaku Co Ltd	長鎖ｄｎａの合成法
US4818681A (en) *	1985-02-22	1989-04-04	Molecular Diagnostics, Inc.	Fast and specific immobilization of nucleic acids to solid supports
WO1986007362A1 (en) *	1985-06-14	1986-12-18	University Patents, Inc.	Method for synthesizing deoxyoligonucleotides
FR2596761B1 (fr) *	1986-04-08	1988-05-20	Commissariat Energie Atomique	Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
US5071974A (en) *	1986-10-31	1991-12-10	Amoco Corporation	Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini
DE3801987A1 (de) *	1988-01-23	1989-07-27	Boehringer Mannheim Gmbh	Traeger zur chemischen oder/und enzymatischen umsetzung von nukleinsaeuren oder nukleinsaeurefragmenten an festphasen
SE9003743D0 (sv) *	1990-11-26	1990-11-26	Pharmacia Ab	Method and means for oligonucleotide synthesis
CA2114355A1 (en) *	1993-01-29	1994-07-30	Hidehiko Furukawa	Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
US5503816A (en) *	1993-09-27	1996-04-02	Becton Dickinson And Company	Silicate compounds for DNA purification
FR2714061B1 (fr)	1993-12-16	1996-03-08	Genset Sa	Procédé de préparation de polynucléotides sur support solide et appareil permettant sa mise en Óoeuvre.
US5874554A (en) *	1996-12-13	1999-02-23	Incyte Pharmaceuticals, Inc.	Methods and solvent vehicles for reagent delivery in oligonucleotide synthesis using automated pulse jetting devices
DE69825722T2 (de)	1998-02-04	2005-08-25	Corning Inc.	Substrat zum Drucken einer Matrize
US6399765B1 (en) *	1999-03-17	2002-06-04	Isis Pharmaceuticals, Inc.	Methods for removing dimethoxytrityl groups from oligonucleotides
WO2001034620A2 (de) *	1999-11-10	2001-05-17	Merckle Gmbh	Verfahren und vorrichtung zur herstellung von oligomeren und arrays von oligomeren sowie die verwendung der vorrichtung
ATE289610T1 (de) *	2000-09-07	2005-03-15	Avecia Biotechnology Inc	Synthone zur herstellung von oligonukleotiden
WO2006038324A1 (ja)	2004-09-30	2006-04-13	Waseda University	半導体センシング用電界効果型トランジスタ、半導体センシングデバイス、半導体センサチップ及び半導体センシング装置
US7396676B2 (en)	2005-05-31	2008-07-08	Agilent Technologies, Inc.	Evanescent wave sensor with attached ligand
US20090247595A1 (en) *	2005-06-06	2009-10-01	Nuria Soldevilla Madrid	Process for the preparation of tetrazolyl compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1113937B (de) *	1959-11-13	1961-09-21	Shell Int Research	Verfahren zur Herstellung von heterocyclischen Amiden der Phosphorsaeure
US3557077A (en) *	1967-09-18	1971-01-19	Kay Brunfeldt	Reactions system
US3531258A (en) *	1967-11-16	1970-09-29	Us Health Education & Welfare	Apparatus for the automated synthesis of peptides
IL62834A0 (en) *	1980-05-14	1981-07-31	Ens Bio Logicals Inc	Polynucleotide synthesis
US4415732A (en) *	1981-03-27	1983-11-15	University Patents, Inc.	Phosphoramidite compounds and processes

1981
- 1981-02-27 AT AT81101444T patent/ATE7702T1/de not_active IP Right Cessation
- 1981-02-27 DE DE8585200673T patent/DE3177215D1/de not_active Expired - Lifetime
- 1981-02-27 CA CA000371992A patent/CA1159052A/en not_active Expired
- 1981-02-27 MX MX186167A patent/MX158743A/es unknown
- 1981-02-27 AU AU67942/81A patent/AU542967B2/en not_active Expired
- 1981-02-27 AT AT85200673T patent/ATE56723T1/de not_active IP Right Cessation
- 1981-02-27 EP EP83104852A patent/EP0097805A3/de not_active Withdrawn
- 1981-02-27 EP EP81101444A patent/EP0035255B1/de not_active Expired
- 1981-02-27 EP EP81101445A patent/EP0035719B1/de not_active Expired
- 1981-02-27 EP EP85200673A patent/EP0173356B1/de not_active Expired - Lifetime
- 1981-02-27 DE DE8181101444T patent/DE3163811D1/de not_active Expired
- 1981-02-27 CA CA000371946A patent/CA1168229A/en not_active Expired
- 1981-02-27 AU AU67943/81A patent/AU550148B2/en not_active Expired
- 1981-02-28 JP JP2927281A patent/JPS56133299A/ja active Pending
- 1981-02-28 JP JP2927381A patent/JPS56138199A/ja active Granted
1988
- 1988-01-21 JP JP63009782A patent/JPS63225395A/ja active Granted
1989
- 1989-11-29 JP JP1310496A patent/JPH0327395A/ja active Pending

Also Published As

Publication number	Publication date
DE3163811D1 (en)	1984-07-05
CA1168229A (en)	1984-05-29
DE3177215D1 (de)	1990-10-25
JPS56138199A (en)	1981-10-28
JPS63225395A (ja)	1988-09-20
EP0035255A1 (de)	1981-09-09
JPH0259158B2 (de)	1990-12-11
EP0097805A2 (de)	1984-01-11
MX158743A (es)	1989-03-10
CA1159052A (en)	1983-12-20
EP0035255B1 (de)	1984-05-30
JPS6330316B2 (de)	1988-06-17
EP0035719B1 (de)	1989-09-20
AU6794381A (en)	1981-09-03
EP0097805A3 (de)	1984-02-22
EP0173356A3 (en)	1987-01-14
ATE56723T1 (de)	1990-10-15
EP0035719A2 (de)	1981-09-16
AU6794281A (en)	1981-09-03
AU542967B2 (en)	1985-03-28
EP0173356A2 (de)	1986-03-05
JPH0327395A (ja)	1991-02-05
AU550148B2 (en)	1986-03-06
EP0035719A3 (en)	1981-11-18
JPS56133299A (en)	1981-10-19
EP0173356B1 (de)	1990-09-19

Legal Events

Date	Code	Title	Description
1984-12-15	UEP	Publication of translation of european patent specification
2001-05-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE7702T1 (de)	1984-06-15	Verfahren zum entfernen von trityl-schutzgruppen aus 5'-o-trityl-nukleosiden und oligonukleotiden.
AT379127B (de)	1985-11-25	Verfahren und vorrichtung zum herstellen von glasfasern aus schmelzfluessigem glas
DE69108708D1 (de)	1995-05-11	Verfahren und vorrichtung zum herstellen von migrationsfreien glasfaserbündeln.
ATE210128T1 (de)	2001-12-15	Nicht-nucleosidische cumarin-derivate als reagenzien zum crosslinking von polynucleotiden
DE68924345D1 (de)	1995-10-26	Reagenzien zum Ionenfangen und Verfahren zur Verrichtung von Bindungsmessungen.
DE3765617D1 (de)	1990-11-22	Verfahren zum herstellen eines hohlfaser-stoffaustauschmoduls und nach diesem verfahren hergestelltes modul.
DE69420818D1 (de)	1999-10-28	Verfahren zum Herstellen von Vorformen für optische Fasern
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DE59909971D1 (de)	2004-08-19	Vernetzbare polymere, verfahren zu deren herstellung und formkörper aus vernetzten polymeren
ATE57939T1 (de)	1990-11-15	Bei umgebungsbedingungen vernetzbare silylierte derivate von isobuten und verfahren zu deren herstellung.
ATE208827T1 (de)	2001-11-15	Konjugate von dns und pns und verfahren zu deren herstellung
ATE133986T1 (de)	1996-02-15	Polystyren-formmasse und verfahren zu deren herstellung
DE69407864D1 (de)	1998-02-19	Verfahren zum Herstellen von porösen Vorformen für optische Fasern
DE68901623D1 (de)	1992-07-02	Vorrichtung zum herstellen von vorformen fuer optische fasern.
DE3382556D1 (de)	1992-06-11	Verfahren und vorrichtung fuer multipolymersynthesesysteme.
DE3787349D1 (de)	1993-10-14	Verfahren zum Herstellen von Faltenrohren und Vorrichtung zu dessen Durchführung.
DE69500319D1 (de)	1997-07-03	Verfahren zum Herstellen von monomodalen optischen Fasern aus Fluoridglas
KR910000810A (ko)	1991-01-30	촉매
DE69305277D1 (de)	1996-11-14	Verfahren zur Herstellung von borhaltigen porösen Gelmassen
DE68913887D1 (de)	1994-04-21	Verfahren zum Biegen von Glasscheiben.
DE69108880D1 (de)	1995-05-18	Verfahren und Vorrichtung zum Herstellen von gebogen Glasscheiben.
FR2541598B1 (fr)	1990-03-23	Procede de fabrication d'articles a partir de boue residuelle de peinture
DE69332141D1 (de)	2002-08-29	Verfahren zum Aufbereiten heisser Aluminiumkrätze; Verfahren zum Herstellen eines Desoxydationsmittels
DE68925913D1 (de)	1996-04-18	Verfahren und Vorrichtung zum Herstellen einer wärmegeleiteten Polymerschicht hoher Reinheit
ATE139234T1 (de)	1996-06-15	Verfahren zur herstellung von silizium- und aluminium-n,n-dialkylcarbamaten und deren hydrolyseprodukte