ATE77391T1 - Peptide. - Google Patents

Peptide.

Info

Publication number
ATE77391T1
ATE77391T1 AT86301755T AT86301755T ATE77391T1 AT E77391 T1 ATE77391 T1 AT E77391T1 AT 86301755 T AT86301755 T AT 86301755T AT 86301755 T AT86301755 T AT 86301755T AT E77391 T1 ATE77391 T1 AT E77391T1
Authority
AT
Austria
Prior art keywords
insulin
charge
amino acid
neutral
insulin derivatives
Prior art date
Application number
AT86301755T
Other languages
English (en)
Inventor
Jan Markussen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE77391T1 publication Critical patent/ATE77391T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT86301755T 1985-03-12 1986-03-11 Peptide. ATE77391T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK113585A DK113585D0 (da) 1985-03-12 1985-03-12 Nye peptider
EP86301755A EP0194864B1 (de) 1985-03-12 1986-03-11 Peptide

Publications (1)

Publication Number Publication Date
ATE77391T1 true ATE77391T1 (de) 1992-07-15

Family

ID=8101410

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86301755T ATE77391T1 (de) 1985-03-12 1986-03-11 Peptide.

Country Status (22)

Country Link
EP (1) EP0194864B1 (de)
JP (1) JPS61212598A (de)
KR (1) KR930007433B1 (de)
CN (1) CN86101489A (de)
AT (1) ATE77391T1 (de)
AU (1) AU612964B2 (de)
CS (1) CS259536B2 (de)
DD (1) DD244345A5 (de)
DE (1) DE3685668T2 (de)
DK (2) DK113585D0 (de)
ES (1) ES8800276A1 (de)
FI (1) FI861007L (de)
GR (1) GR860687B (de)
HU (1) HU201097B (de)
IL (1) IL78103A0 (de)
MY (1) MY102102A (de)
NO (1) NO172441C (de)
NZ (1) NZ215445A (de)
PH (1) PH24260A (de)
PT (1) PT82173B (de)
YU (1) YU46001B (de)
ZA (1) ZA861432B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
ATE93238T1 (de) * 1988-07-20 1993-09-15 Novo Nordisk As Menschliche insulinanalage und zubereitungen daraus.
DE3827533A1 (de) * 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
AUPP609198A0 (en) * 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
EP2368579A1 (de) 2004-01-21 2011-09-28 Novo Nordisk Health Care AG Tranglutaminase vermittelte konjugation von peptiden.
US20090074882A1 (en) 2005-12-28 2009-03-19 Novo Nordisk A/S Insulin compositions and method of making a composition
DE102006031962A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
NZ586589A (en) * 2008-01-09 2012-04-27 Sanofi Aventis Deutschland Novel insulin analogues having an extremely delayed time-action profile
PL2229407T3 (pl) 2008-01-09 2017-06-30 Sanofi-Aventis Deutschland Gmbh Nowe pochodne insuliny o ekstremalnie spowolnionym profilu czasu działania
DE102008003566A1 (de) * 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
EP3228320B1 (de) 2008-10-17 2019-12-18 Sanofi-Aventis Deutschland GmbH Kombination von einem insulin und einem glp-1-agonisten
EP3202394A1 (de) 2009-07-06 2017-08-09 Sanofi-Aventis Deutschland GmbH Wässrige insulinzubereitungen enthaltend methionin
US20120241356A1 (en) * 2009-07-06 2012-09-27 Sanofi-Aventis Deutschland Gmbh Heat- and vibration-stable insulin preparations
PE20121316A1 (es) 2009-11-13 2012-10-05 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1 y metionina
PT2554183T (pt) 2009-11-13 2018-07-09 Sanofi Aventis Deutschland Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
EP2569002B1 (de) * 2010-05-10 2016-10-26 Novo Nordisk A/S Verfahren zur herstellung von insulin-zink komlexen
US20140148384A1 (en) 2010-08-30 2014-05-29 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
CN102174495A (zh) * 2011-01-20 2011-09-07 马忠仁 一种提取糜胰蛋白酶的方法
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN108079281A (zh) 2011-08-29 2018-05-29 赛诺菲-安万特德国有限公司 用于2型糖尿病患者中的血糖控制的药物组合
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
TWI758239B (zh) 2014-12-12 2022-03-21 德商賽諾菲阿凡提斯德意志有限公司 甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
CN114096269B (zh) 2019-07-12 2024-06-11 诺和诺德股份有限公司 高浓度胰岛素制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat

Also Published As

Publication number Publication date
AU612964B2 (en) 1991-07-25
ES8800276A1 (es) 1987-11-01
CN86101489A (zh) 1987-01-21
DK107086A (da) 1986-11-07
YU34586A (en) 1988-10-31
AU5449586A (en) 1986-09-18
NO172441C (no) 1993-07-21
DE3685668D1 (en) 1992-07-23
NO860920L (no) 1986-09-15
DE3685668T2 (de) 1993-01-14
YU46001B (sh) 1992-12-21
EP0194864A2 (de) 1986-09-17
CS259536B2 (en) 1988-10-14
KR860007288A (ko) 1986-10-10
PH24260A (en) 1990-05-04
MY102102A (en) 1992-03-31
KR930007433B1 (ko) 1993-08-10
DK113585D0 (da) 1985-03-12
HU201097B (en) 1990-09-28
HUT41052A (en) 1987-03-30
DD244345A5 (de) 1987-04-01
DK158677B (da) 1990-07-02
GR860687B (en) 1986-07-11
NZ215445A (en) 1989-07-27
EP0194864A3 (en) 1989-01-11
NO172441B (no) 1993-04-13
PT82173B (pt) 1988-07-29
JPS61212598A (ja) 1986-09-20
PT82173A (en) 1986-04-01
FI861007A0 (fi) 1986-03-11
DK158677C (da) 1990-12-31
ZA861432B (en) 1986-11-26
FI861007A7 (fi) 1986-09-13
EP0194864B1 (de) 1992-06-17
FI861007L (fi) 1986-09-13
CS166686A2 (en) 1987-12-17
IL78103A0 (en) 1986-07-31
ES552879A0 (es) 1987-11-01
DK107086D0 (da) 1986-03-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee