ATE77753T1 - Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen. - Google Patents

Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen.

Info

Publication number
ATE77753T1
ATE77753T1 AT89401076T AT89401076T ATE77753T1 AT E77753 T1 ATE77753 T1 AT E77753T1 AT 89401076 T AT89401076 T AT 89401076T AT 89401076 T AT89401076 T AT 89401076T AT E77753 T1 ATE77753 T1 AT E77753T1
Authority
AT
Austria
Prior art keywords
haemoglobin
sites
polymer
hand
macromolecular
Prior art date
Application number
AT89401076T
Other languages
English (en)
Inventor
Edith Dellacherie
Michele Leonard
Daniel Sacco
Claude Vigneron
Original Assignee
Pasteur Merieux Serums Vacc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Merieux Serums Vacc filed Critical Pasteur Merieux Serums Vacc
Application granted granted Critical
Publication of ATE77753T1 publication Critical patent/ATE77753T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6445—Haemoglobin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
AT89401076T 1988-04-20 1989-04-18 Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen. ATE77753T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8805240A FR2630329B1 (fr) 1988-04-20 1988-04-20 Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
EP89401076A EP0338916B1 (de) 1988-04-20 1989-04-18 Makromolekulare Hämoglobinkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendungen

Publications (1)

Publication Number Publication Date
ATE77753T1 true ATE77753T1 (de) 1992-07-15

Family

ID=9365495

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89401076T ATE77753T1 (de) 1988-04-20 1989-04-18 Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen.

Country Status (8)

Country Link
US (1) US5110909A (de)
EP (1) EP0338916B1 (de)
JP (1) JPH0242023A (de)
AT (1) ATE77753T1 (de)
DE (1) DE68901944T2 (de)
ES (1) ES2043054T3 (de)
FR (1) FR2630329B1 (de)
GR (1) GR3005220T3 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
FR2680369B1 (fr) * 1991-08-14 1993-11-05 Pasteur Merieux Serums Vaccins Derives d'hemoglobine humaine, leur procede de preparation, produits en derivant et utilisation de ces derives et produits.
EP0767675A4 (de) * 1995-04-10 1998-08-05 Baxter Int Verwendung von vernetztem hämoglobin zur behandlung von subarachnoidalblutungen
US5928916A (en) * 1996-04-25 1999-07-27 Medtronic, Inc. Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces
DE19628705A1 (de) * 1996-07-08 1998-01-15 Fresenius Ag Neue Sauerstoff-Transport-Mittel, diese enthaltende Hämoglobin-Hydroxyethylstärke-Konjugate, Verfahren zu deren Herstellung, sowie deren Verwendung als Blutersatzstoffe
US6018035A (en) * 1997-07-21 2000-01-25 Baxter International Inc. Reagents for isotropic size enhancement of a peptide, protein, nucleotide or other substrate
US5981710A (en) * 1997-07-21 1999-11-09 Baxter International, Inc. Therapeutic hemoglobin composition having isotropically increased size
DE69830326T2 (de) * 1997-10-03 2006-02-02 Galenica Pharmaceuticals, Inc. Iminbildende polysaccharide, deren herstellung und verwendung als zusatzmittel und immunstimulierende mittel
CA2233725A1 (en) * 1998-03-31 1999-09-30 Hemosol Inc. Hemoglobin-hydroxyethyl starch complexes
US6573245B1 (en) 1998-04-28 2003-06-03 Galenica Pharmaceuticals, Inc. Modified polysaccharide adjuvant-protein antigen conjugates, the preparation thereof and the use thereof
JP2003507430A (ja) * 1999-08-25 2003-02-25 ジーエムピー カンパニーズ，インコーポレーテッド 哺乳動物中で酸素運搬を向上する薬剤
CA2319966A1 (en) * 2000-09-19 2002-03-19 Dextro-Sang Corporation Improved dextran-hemoglobin conjugate as potential blood substitute
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
CA2488347A1 (en) * 2002-06-06 2003-12-18 University Of Washington Methods of using artemisinin-like compounds to prevent or delay the appearance of cancer
BR0314227A (pt) 2002-09-11 2005-10-25 Fresenius Kabi De Gmbh Derivados de amido de hidroxialquila
US7538092B2 (en) 2002-10-08 2009-05-26 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
PL1660134T3 (pl) * 2003-08-08 2011-05-31 Fresenius Kabi Deutschland Gmbh Koniugaty hydroksyalkiloskrobi i G-CSF
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
KR100580642B1 (ko) * 2004-01-12 2006-05-16 삼성전자주식회사 표면에 활성화된 카르복실기를 갖는 기판을 이용하여 생물분자를 고체 기판상에 고밀도로 고정화하는 방법 및 그에 의하여 제조되는 마이크로어레이
JP5191729B2 (ja) 2004-03-11 2013-05-08 フレゼニウス・カビ・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 還元的アミノ化によって製造される、ヒドロキシアルキルデンプンとタンパク質とのコンジュゲート
ES2390885T3 (es) * 2004-03-11 2012-11-19 Fresenius Kabi Deutschland Gmbh Conjugados de hidroxialquilalmidón y una proteína
WO2005103080A2 (en) * 2004-04-21 2005-11-03 Albert Einstein College Of Medicine Of Yeshiva University Stable oxidation resistant powdered hemoglobin, methods of preparing same, and uses thereof
CN101137396A (zh) * 2005-03-11 2008-03-05 弗雷泽纽斯卡比德国有限公司 由无活性初始材料制备生物活性糖蛋白
EP1762250A1 (de) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen
EP2070950A1 (de) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
EP2070951A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Verfahren zur Herstellung eines Hydroxyalkylstärkederivats mit zwei Linkern

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1055932A (en) * 1975-10-22 1979-06-05 Hematech Inc. Blood substitute based on hemoglobin
FR2551660B1 (fr) * 1983-09-13 1986-11-14 Centre Nat Rech Scient Hemoglobine modifiee chimiquement, sa preparation, solutions aqueuses en contenant et leur utilisation
GB8328917D0 (en) * 1983-10-28 1983-11-30 Fisons Plc Blood substitute
DE3501349A1 (de) * 1985-01-17 1986-07-17 Battelle-Institut E.V., 6000 Frankfurt Blutersatz
FR2600894B1 (fr) * 1986-07-02 1989-01-13 Centre Nat Rech Scient Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications

Also Published As

Publication number Publication date
FR2630329A1 (fr) 1989-10-27
DE68901944T2 (de) 1992-12-10
EP0338916A1 (de) 1989-10-25
DE68901944D1 (de) 1992-08-06
JPH0242023A (ja) 1990-02-13
US5110909A (en) 1992-05-05
EP0338916B1 (de) 1992-07-01
FR2630329B1 (fr) 1991-07-05
GR3005220T3 (de) 1993-05-24
ES2043054T3 (es) 1993-12-16

Similar Documents

Publication Publication Date Title
ATE77753T1 (de) Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen.
ATE67673T1 (de) Makromolekulare haemoglobinkonjugate, verfahren zu ihrer herstellung und ihre verwendungen.
Righetti et al. Isoelectric points and molecular weights of proteins: A new table
EP0080614A2 (de) Ein Latex, biologisch aktive Latexkonjugate und Verfahren zu ihrer Herstellung
KR850007982A (ko) 폴리삭카라이드-단백질 결합체의 제조방법
ATE106433T1 (de) Wässriges gel von hyaluronsäure und desoxynibonukleinsäure, verwendbar für kosmetik und verfahren zu seiner herstellung.
DE3481844D1 (de) Blutersatz.
ATE318848T1 (de) Superabsorbierende gele aus poly(vinylamin) und verfahren zur herstellung davon
ATE162424T1 (de) Affinitätstrennung mit mikroporösen aktivierten polyamidmembranen
PL322251A1 (en) Polymer-modified asphalt compositions of acidic reactivity and their production
EP0259097A3 (de) Schlagfestigkeits modifiziermittel für thermoplastische Polymere
FI843265A0 (fi) Haerdande sammansaettningar.
ATE277624T1 (de) Kovalent gebundenes n,o-carboxymethylchitosan und seine verwendungen
DE59812365D1 (de) Polymermodifizierte anionische stärke, verfahren zu ihrer herstellung und ihre verwendung
DE59105884D1 (de) Cyclodextrin-polymerisate und verfahren zu deren herstellung.
DK58185A (da) Bughuledialyse og reagenser til brug herfor
ATE68196T1 (de) Wasserverduennbare bindemittel, ein verfahren zu ihrer herstellung und ihre verwendung.
EP0245893A3 (de) Katalysator-Zusammensetzungen
EP0315009A3 (de) Chromanderivate, Verfahren zu ihrer Herstelllung und ihre Verwendung in Arzneimitteln
DE68904617D1 (de) Jodhaltige polymere mit skeletten von dextran, verfahren zu ihrer herstellung und ihre verwendungen als kontrastmittel.
ATE90790T1 (de) Verfahren zur herstellung einer festphasenmatrix.
ATE22899T1 (de) Antithrombin-heparin komplex.
EP0321818A3 (de) Wasserlösliche Polykondensate auf Basis von Fettsäuren, dialkanolamin und Maleinsäureanhydrid, Verfahren zu ihrer Herstellung, sie enthaltende hydraulische Massen und ihre Verwendung
IE41040B1 (en) Biologically active compounds and process for their manufacture
ATE66534T1 (de) Nortriptylinderivate, verfahren zu ihrer herstellung, deren konjugate mit antigenischen proteinen und enzymen, antikoerper davon und verwandte verfahren zur bestimmung.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee