ATE79612T1 - Verfahren zur herstellung von alpha-(alkylphenyl)-4-(hydroxydiphenylmethyl)-1 piperidinbutanol. - Google Patents
Verfahren zur herstellung von alpha-(alkylphenyl)-4-(hydroxydiphenylmethyl)-1 piperidinbutanol.Info
- Publication number
- ATE79612T1 ATE79612T1 AT88107024T AT88107024T ATE79612T1 AT E79612 T1 ATE79612 T1 AT E79612T1 AT 88107024 T AT88107024 T AT 88107024T AT 88107024 T AT88107024 T AT 88107024T AT E79612 T1 ATE79612 T1 AT E79612T1
- Authority
- AT
- Austria
- Prior art keywords
- alkylphenyl
- alpha
- piperidinebutanol
- hydroxydiphenylmethyl
- preparation
- Prior art date
Links
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- -1 phenylmagnesium halide Chemical class 0.000 abstract 1
- SRJOCJYGOFTFLH-UHFFFAOYSA-M piperidine-4-carboxylate Chemical compound [O-]C(=O)C1CCNCC1 SRJOCJYGOFTFLH-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20674/87A IT1205685B (it) | 1987-05-26 | 1987-05-26 | Processo per la preparazione di alfa-(alchilfenil)-4-(idrossi difenilmetil)-1-piperidina butanolo |
| EP88107024A EP0292735B1 (de) | 1987-05-26 | 1988-05-02 | Verfahren zur Herstellung von Alpha-(alkylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinbutanol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE79612T1 true ATE79612T1 (de) | 1992-09-15 |
Family
ID=11170377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88107024T ATE79612T1 (de) | 1987-05-26 | 1988-05-02 | Verfahren zur herstellung von alpha-(alkylphenyl)-4-(hydroxydiphenylmethyl)-1 piperidinbutanol. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5112978A (de) |
| EP (1) | EP0292735B1 (de) |
| JP (1) | JPH0681743B2 (de) |
| AT (1) | ATE79612T1 (de) |
| CA (1) | CA1314893C (de) |
| DE (1) | DE3873824T2 (de) |
| DK (1) | DK241188A (de) |
| ES (1) | ES2051792T3 (de) |
| GR (1) | GR3005621T3 (de) |
| IE (1) | IE62186B1 (de) |
| IT (1) | IT1205685B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0294183B1 (de) * | 1987-06-02 | 1994-03-30 | Ajinomoto Co., Inc. | Verwendung von Äthylamin-Derivaten als antihypertensive Wirkstoffe |
| US6004980A (en) * | 1990-06-01 | 1999-12-21 | Merrell Pharmaceuticals, Inc. | (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
| WO1991018602A1 (en) * | 1990-06-01 | 1991-12-12 | Merrell Dow Pharmaceuticals Inc. | (+)-α-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL |
| WO1996035667A1 (en) * | 1995-05-08 | 1996-11-14 | Hoescht Marion Roussel, Inc. | Alpha-(substituted alkylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidine butanol derivatives, their preparation and their use as anti-histamines, anti-allergy agents and bronchodilators |
| US6028083A (en) * | 1997-07-25 | 2000-02-22 | Hoechst Marion Roussel, Inc. | Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol |
| US7556858B2 (en) | 2004-09-30 | 2009-07-07 | 3M Innovative Properties Company | Substrate with attached dendrimers |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3000896A (en) * | 1961-09-19 | Process for the manufacture of second- | ||
| US2833775A (en) * | 1951-08-17 | 1958-05-06 | Schering Corp | Substituted piperidines |
| US3806526A (en) * | 1972-01-28 | 1974-04-23 | Richardson Merrell Inc | 1-aroylalkyl-4-diphenylmethyl piperidines |
| ZA728544B (en) * | 1972-01-28 | 1974-02-27 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
| DE3433036A1 (de) * | 1984-09-08 | 1986-03-20 | Basf Ag, 6700 Ludwigshafen | Piperidinderivate und diese enthaltende fungizide sowie verfahren zur bekaempfung von pilzen |
-
1987
- 1987-05-26 IT IT20674/87A patent/IT1205685B/it active
-
1988
- 1988-05-02 DE DE8888107024T patent/DE3873824T2/de not_active Expired - Fee Related
- 1988-05-02 ES ES88107024T patent/ES2051792T3/es not_active Expired - Lifetime
- 1988-05-02 EP EP88107024A patent/EP0292735B1/de not_active Expired - Lifetime
- 1988-05-02 AT AT88107024T patent/ATE79612T1/de not_active IP Right Cessation
- 1988-05-03 IE IE133288A patent/IE62186B1/en not_active IP Right Cessation
- 1988-05-04 DK DK241188A patent/DK241188A/da not_active Application Discontinuation
- 1988-05-16 CA CA000566863A patent/CA1314893C/en not_active Expired - Fee Related
- 1988-05-26 JP JP63127249A patent/JPH0681743B2/ja not_active Expired - Lifetime
-
1989
- 1989-09-22 US US07/411,021 patent/US5112978A/en not_active Expired - Fee Related
-
1992
- 1992-09-07 GR GR920401948T patent/GR3005621T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE62186B1 (en) | 1994-12-28 |
| DK241188A (da) | 1988-11-27 |
| DE3873824T2 (de) | 1993-01-14 |
| IE881332L (en) | 1988-11-26 |
| GR3005621T3 (de) | 1993-06-07 |
| CA1314893C (en) | 1993-03-23 |
| ES2051792T3 (es) | 1994-07-01 |
| EP0292735A1 (de) | 1988-11-30 |
| US5112978A (en) | 1992-05-12 |
| IT8720674A0 (it) | 1987-05-26 |
| IT1205685B (it) | 1989-03-31 |
| DE3873824D1 (de) | 1992-09-24 |
| JPH01125366A (ja) | 1989-05-17 |
| EP0292735B1 (de) | 1992-08-19 |
| DK241188D0 (da) | 1988-05-04 |
| JPH0681743B2 (ja) | 1994-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |