ATE81123T1 - 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel. - Google Patents

3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.

Info

Publication number: ATE81123T1
Authority: AT; Austria
Prior art keywords: loweralkyl; substituted; piperazinyl; butyl; production
Prior art date: 1987-11-20

Application number

AT88118614T

Other languages

English (en)

Inventor

Nicholas J Hrib

John Gerard Jurcak

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-20

Filing date

1988-11-09

Publication date

1992-10-15

1988-11-09 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1992-10-15 Application granted granted Critical

1992-10-15 Publication of ATE81123T1 publication Critical patent/ATE81123T1/de

Links

-1 1-SUBSTITUTED-4-PIPERAZINYL Chemical class 0.000 title abstract 4
229940126601 medicinal product Drugs 0.000 title 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 6
DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 abstract 6
RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 abstract 2
XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000003386 piperidinyl group Chemical group 0.000 abstract 2
IBBLKSWSCDAPIF-UHFFFAOYSA-N thiopyran Chemical compound S1C=CC=C=C1 IBBLKSWSCDAPIF-UHFFFAOYSA-N 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
230000001773 anti-convulsant effect Effects 0.000 abstract 1
230000000561 anti-psychotic effect Effects 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
229960003965 antiepileptics Drugs 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT88118614T 1987-11-20 1988-11-09 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel. ATE81123T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12362287A	1987-11-20	1987-11-20
EP88118614A EP0316723B1 (de)	1987-11-20	1988-11-09	3-[4(1-Substituierte-4-Piperazinyl)butyl]-4-Thiazolidinone, Verfahren zu deren Herstellung und ihre Anwendung als Arzneimittel

Publications (1)

Publication Number	Publication Date
ATE81123T1 true ATE81123T1 (de)	1992-10-15

Family

ID=22409774

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88118614T ATE81123T1 (de)	1987-11-20	1988-11-09	3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.

Country Status (20)

Country	Link
US (5)	US4933453A (de)
EP (1)	EP0316723B1 (de)
JP (1)	JP2617546B2 (de)
KR (1)	KR0130976B1 (de)
AT (1)	ATE81123T1 (de)
AU (1)	AU624092B2 (de)
CA (1)	CA1317955C (de)
DE (1)	DE3875073T2 (de)
DK (1)	DK645688A (de)
ES (1)	ES2052675T3 (de)
FI (1)	FI89916C (de)
GR (1)	GR3006698T3 (de)
HU (1)	HU206709B (de)
IE (1)	IE62229B1 (de)
IL (1)	IL88414A (de)
NO (1)	NO176143C (de)
NZ (1)	NZ226999A (de)
PH (1)	PH27330A (de)
PT (1)	PT89020B (de)
ZA (1)	ZA888651B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3875073T2 (de) *	1987-11-20	1993-03-11	Hoechst Roussel Pharma	3-(4(1-substituierte-4-piperazinyl)butyl)-4-thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
US5801186A (en) *	1987-11-20	1998-09-01	Hoechst Marion Roussel, Inc.	3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
WO1991000863A1 (en) *	1989-07-07	1991-01-24	Pfizer Inc.	Heteroaryl piperazine antipsychotic agents
HU205092B (en) *	1989-11-24	1992-03-30	Richter Gedeon Vegyeszet	Process for producing new thiazolidinone derivatives and pharmaceutical compositions comprising same
US5216002A (en) *	1989-12-21	1993-06-01	Eli Lilly And Company	Method of treating inflammatory bowel disease
US5034392A (en) *	1990-04-16	1991-07-23	Hoechst-Roussel Pharmaceuticals Incorporated	4-(3-(4-oxothiazolidinyl)butynylamines
US5041445A (en) *	1990-05-21	1991-08-20	Hoechst-Roussel Pharmaceuticals Incorporated	3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles
US5045546A (en) *	1990-10-26	1991-09-03	Hoechst-Roussel Pharmaceuticals Inc.	8-azabicyclo[3.2.1]octylalkylthiazolidines
US5194436A (en) *	1991-01-10	1993-03-16	Hoechst-Roussel Pharmaceuticals Inc.	1-piperazinyl-2-butenes and -2-butynes
US5130315A (en) *	1991-01-10	1992-07-14	Raymond R. Wittekind	1-piperazinyl-2-butenes and -2-butynes
US5240927A (en) *	1992-05-19	1993-08-31	Hoechst-Roussel Pharmaceuticals Incorporated	Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
AU664084B2 (en) *	1992-06-03	1995-11-02	Ciba-Geigy Ag	Novel thiosemicarbazonic acid esters
US5272148A (en) *	1992-09-09	1993-12-21	Hoechst-Roussel Pharmaceuticals Incorporated	Heteroarenylpiperazines
CZ181493A3 (en) *	1992-09-10	1994-03-16	Lilly Co Eli	The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease
EP0635506A4 (de) *	1993-02-04	1995-04-12	Meiji Seika Co	Verbindung mit antipsychotischerwirkung.
US5391570A (en) *	1993-10-14	1995-02-21	Bristol-Myers Squibb	Aminomethyl-benzodioxane and benzopyran serotonergic agents
CA2157348A1 (en) *	1994-09-01	1996-03-02	Aventis Pharmaceuticals Inc.	3-¬4-(1-substituted-4-piperazinyl)butyl\|-4-thiazolidinone and related compounds
KR960022486A (ko) *	1994-12-29	1996-07-18	김준웅	신규 티아졸리딘-4-온 유도체
DE69618050T2 (de) *	1995-03-17	2002-07-11	Aventis Pharmaceuticals Inc., Cincinnati	Substituierte Benzylthienylpiperazine, ihre Anwendung als Arzneimittel und Verfahren für ihre Herstellung
KR970032857A (ko) *	1995-12-29	1997-07-22	김준웅	약제 조성물
US5880121A (en) *	1996-01-05	1999-03-09	Hoechst Marion Roussel Inc.	4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
ZA9711376B (en) *	1996-12-20	1998-07-21	Lundbeck & Co As H	Indole or dihydroindole derivatives
US6506751B1 (en)	1999-11-12	2003-01-14	Millennium Pharmaceuticals, Inc.	Thiazolidinone compounds useful as chemokine inhibitors
US7122376B2 (en) *	2001-11-01	2006-10-17	Facet Analytical Services And Technology, Llc	Calibration standards, methods, and kits for water determination
US7049146B2 (en) *	2000-11-14	2006-05-23	Facet Analytical Services And Technology, Llc	Calibration standards, methods, and kits for water determination
IL159765A0 (en) *	2001-07-16	2004-06-20	Euro Celtique Sa	Aryl substituted thiazolidinone derivatives and pharmaceutical compositions containing the same
AU2003270727A1 (en) *	2002-09-17	2004-04-08	Luna Innovations, Inc.	Remote temperature sensing of small volume and related apparatus thereof
EP2159226B1 (de) *	2007-03-29	2016-08-31	Joint-stock Company "Obninsk Chemical Pharmaceutical Company"	Antihistamin- und antiallergienmittel sowie verfahren zu seiner herstellung
EP2350002A1 (de) *	2008-10-02	2011-08-03	Abbott Laboratories	Neue verbindungen als kalziumkanalblocker
US8815869B2 (en) *	2010-03-18	2014-08-26	Abbvie Inc.	Lactam acetamides as calcium channel blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2520179A (en) *	1949-02-02	1950-08-29	Sterling Drug Inc	4-thiazolidones and a method for preparation thereof
JPS51125389A (en) *	1975-04-09	1976-11-01	Yoshitomi Pharmaceut Ind Ltd	A process for preparing heterocyclic compovnds
US4456756A (en) *	1981-08-03	1984-06-26	Mead Johnson & Company	Spirothiazolidinyl piperazine derivatives
US4411901A (en) *	1981-12-23	1983-10-25	Mead Johnson & Company	Benzisothiazole and benzisoxazole piperazine derivatives
US4619930A (en) *	1985-01-16	1986-10-28	Bristol-Myers Company	Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
GB8512163D0 (en) *	1985-05-14	1985-06-19	Fujisawa Pharmaceutical Co	Oxothiazolidine compound
DE3875073T2 (de) *	1987-11-20	1993-03-11	Hoechst Roussel Pharma	3-(4(1-substituierte-4-piperazinyl)butyl)-4-thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
US5041445A (en) *	1990-05-21	1991-08-20	Hoechst-Roussel Pharmaceuticals Incorporated	3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles

1988
- 1988-11-09 DE DE8888118614T patent/DE3875073T2/de not_active Expired - Fee Related
- 1988-11-09 ES ES88118614T patent/ES2052675T3/es not_active Expired - Lifetime
- 1988-11-09 EP EP88118614A patent/EP0316723B1/de not_active Expired - Lifetime
- 1988-11-09 AT AT88118614T patent/ATE81123T1/de not_active IP Right Cessation
- 1988-11-17 PT PT89020A patent/PT89020B/pt not_active IP Right Cessation
- 1988-11-17 FI FI885332A patent/FI89916C/fi not_active IP Right Cessation
- 1988-11-18 NZ NZ226999A patent/NZ226999A/en unknown
- 1988-11-18 PH PH37834A patent/PH27330A/en unknown
- 1988-11-18 IL IL88414A patent/IL88414A/xx not_active IP Right Cessation
- 1988-11-18 ZA ZA888651A patent/ZA888651B/xx unknown
- 1988-11-18 AU AU25694/88A patent/AU624092B2/en not_active Ceased
- 1988-11-18 DK DK645688A patent/DK645688A/da not_active Application Discontinuation
- 1988-11-18 CA CA000583546A patent/CA1317955C/en not_active Expired - Fee Related
- 1988-11-18 JP JP63290346A patent/JP2617546B2/ja not_active Expired - Lifetime
- 1988-11-18 KR KR1019880015210A patent/KR0130976B1/ko not_active Expired - Fee Related
- 1988-11-18 HU HU885964A patent/HU206709B/hu not_active IP Right Cessation
- 1988-11-18 IE IE346388A patent/IE62229B1/en not_active IP Right Cessation
- 1988-11-18 NO NO885152A patent/NO176143C/no not_active IP Right Cessation
1989
- 1989-10-31 US US07/430,688 patent/US4933453A/en not_active Expired - Lifetime
1990
- 1990-03-02 US US07/487,328 patent/US5037984A/en not_active Expired - Fee Related
1991
- 1991-06-07 US US07/713,247 patent/US5136037A/en not_active Expired - Fee Related
- 1991-11-21 US US07/795,608 patent/US5229388A/en not_active Expired - Fee Related
1992
- 1992-12-30 GR GR920402519T patent/GR3006698T3/el unknown
1993
- 1993-06-29 US US08/085,273 patent/US5371087A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL88414A0 (en)	1989-06-30
AU624092B2 (en)	1992-06-04
US4933453A (en)	1990-06-12
US5229388A (en)	1993-07-20
NO885152L (no)	1989-05-22
EP0316723B1 (de)	1992-09-30
FI89916B (fi)	1993-08-31
ZA888651B (en)	1989-09-27
NO176143B (no)	1994-10-31
HUT54149A (en)	1991-01-28
KR890008137A (ko)	1989-07-10
NZ226999A (en)	1991-05-28
KR0130976B1 (ko)	1998-04-16
US5037984A (en)	1991-08-06
PT89020B (pt)	1993-02-26
GR3006698T3 (de)	1993-06-30
EP0316723A1 (de)	1989-05-24
CA1317955C (en)	1993-05-18
FI885332A7 (fi)	1989-05-21
DE3875073D1 (de)	1992-11-05
FI885332A0 (fi)	1988-11-17
DK645688A (da)	1989-05-21
HU206709B (en)	1992-12-28
JP2617546B2 (ja)	1997-06-04
IE883463L (en)	1989-05-20
NO176143C (no)	1995-02-08
FI89916C (fi)	1993-12-10
NO885152D0 (no)	1988-11-18
US5136037A (en)	1992-08-04
ES2052675T3 (es)	1994-07-16
IE62229B1 (en)	1995-01-11
PT89020A (pt)	1988-12-01
IL88414A (en)	1993-07-08
DK645688D0 (da)	1988-11-18
AU2569488A (en)	1989-05-25
JPH01160975A (ja)	1989-06-23
PH27330A (en)	1993-06-08
US5371087A (en)	1994-12-06
DE3875073T2 (de)	1993-03-11

Legal Events

Date	Code	Title	Description
1993-04-15	UEP	Publication of translation of european patent specification
2005-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ZA888651B (en)	1989-09-27	3-(4(1-substituted-4-piperazinyl)butyl)-4-thiazolidinones,a process for their preparation and their use as medicaments
ATE163012T1 (de)	1998-02-15	N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel
DE3772905D1 (de)	1991-10-17	Alpha-alkyl-4-amino-3-chinolin-methanole und 1-(4-aralkylamino-3-chinolyl)alkanone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE127807T1 (de)	1995-09-15	N-heteroaryl-purin-6-amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE140006T1 (de)	1996-07-15	1-(pyrido(3,4-b>-1,4-oxazinyl-4-yl)-1h-indole, zwischenprodukte und ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE47856T1 (de)	1989-11-15	11-substituierte 5h,11h-pyrrolo(2,1c>(1,4>benzoxazepine, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE69011013D1 (de)	1994-09-01	1-(Pyridinylamino)-2-pyrrolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
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