ATE85976T1 - Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number: ATE85976T1
Authority: AT; Austria
Prior art keywords: group; substituted; tryptophan; pharmaceutical compositions; compositions containing
Prior art date: 1984-12-12

Application number

AT86900106T

Other languages

English (en)

Inventor

Francesco Makovec

Rolando Chiste

Angelo Luigi Rovati

Original Assignee

Rotta Research Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-12

Filing date

1985-12-05

Publication date

1993-03-15

1985-12-05 Application filed by Rotta Research Lab filed Critical Rotta Research Lab

1993-03-15 Application granted granted Critical

1993-03-15 Publication of ATE85976T1 publication Critical patent/ATE85976T1/de

Links

QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical class C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
230000001575 pathological effect Effects 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT86900106T 1984-12-12 1985-12-05 Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen. ATE85976T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT68241/84A IT1179866B (it)	1984-12-12	1984-12-12	Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono
EP86900106A EP0237522B1 (de)	1984-12-12	1985-12-05	Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen
PCT/EP1985/000672 WO1986003489A1 (en)	1984-12-12	1985-12-05	Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
ATE85976T1 true ATE85976T1 (de)	1993-03-15

Family

ID=11308641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86900106T ATE85976T1 (de)	1984-12-12	1985-12-05	Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (14)

Country	Link
US (1)	US4870097A (de)
EP (1)	EP0237522B1 (de)
JP (1)	JPS62501292A (de)
AT (1)	ATE85976T1 (de)
AU (1)	AU589938B2 (de)
CA (1)	CA1256441A (de)
DE (1)	DE3587122T2 (de)
DK (1)	DK168564B1 (de)
ES (1)	ES8706630A1 (de)
IE (1)	IE58502B1 (de)
IT (1)	IT1179866B (de)
PT (1)	PT81674B (de)
WO (1)	WO1986003489A1 (de)
ZA (1)	ZA859526B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4814463A (en) *	1985-12-31	1989-03-21	Biomeasure, Inc.	CCK antagonists
US4880938A (en) *	1986-06-16	1989-11-14	Merck & Co., Inc.	Amino acid analogs
US5089638A (en) *	1986-06-16	1992-02-18	Merck & Co., Inc.	Amino acid analogs as CCK-antagonists
SE8901149D0 (sv) *	1989-04-03	1989-04-03	Pharmacia Ab	Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat
US5360814A (en) *	1991-02-28	1994-11-01	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
DK0501378T3 (da) *	1991-02-28	1995-03-20	Merrell Dow Pharma	NMDA-antagonister
US5484814A (en) *	1991-02-28	1996-01-16	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
US20030199523A1 (en) *	2002-02-28	2003-10-23	Snutch Terrance P.	Heterocyclic calcium in channel blockers
PT1549333E (pt)	2002-09-20	2012-01-03	Univ Pennsylvania	Análogos de compstatina com actividade melhorada
US8168584B2 (en)	2005-10-08	2012-05-01	Potentia Pharmaceuticals, Inc.	Methods of treating age-related macular degeneration by compstatin and analogs thereof
EP2662089A3 (de)	2005-10-08	2014-02-19	Potentia Pharmaceuticals, Inc.	Compstatin und Analoga davon für Augenerkrankungen
CN102977191B (zh)	2005-11-28	2016-08-10	宾夕法尼亚州大学理事会	有效的c3补体抑制素类似物
HUE026001T2 (en)	2007-02-05	2016-04-28	Apellis Pharmaceuticals Inc	Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system
CA2760839C (en)	2009-05-01	2019-02-12	The Trustees Of The University Of Pennsylvania	Modified compstatin with peptide backbone and c-terminal modifications
CA2813049A1 (en)	2010-09-23	2012-03-29	The Trustees Of The University Of Pennsylvania	Modified compstatin with improved stability and binding properties
JP2014503592A (ja)	2011-01-26	2014-02-13	ニコワールドワイド，インコーポレイテッド	片頭痛の療法
MX356528B (es)	2011-05-11	2018-06-01	Apellis Pharmaceuticals Inc	Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y usos de los mismos.
EP3524258B1 (de)	2011-06-22	2025-10-01	Apellis Pharmaceuticals, Inc.	Verfahren zur behandlung chronischer erkrankungen mit komplementinhibitoren
CA2847862C (en)	2011-09-07	2021-01-12	The Trustees Of The University Of Pennsylvania	Compstatin analogs with improved pharmacokinetic properties
MX366404B (es)	2012-11-15	2019-07-08	Apellis Pharmaceuticals Inc	Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y composiciones y metodos relacionados.
WO2014152391A1 (en)	2013-03-15	2014-09-25	Apellis Pharmaceuticals, Inc.	Cell-penetrating compstatin analogs and uses thereof
US10213476B2 (en)	2014-03-17	2019-02-26	The Trustees Of The University Of Pennsylvania	Compstatin analogs with improved potency and pharmacokinetic properties
US11903994B2 (en)	2015-10-07	2024-02-20	Apellis Pharmaceuticals, Inc.	Dosing regimens
EP3374027B1 (de) *	2015-11-12	2021-06-23	The Trustees of Columbia University in the City of New York	Rationelles arzneimitteldesign zum targeting resistenter gramnegativer bakterieller infektionen gegen polymyxin-klasse-antibiotika
IL269844B2 (en)	2017-04-07	2025-01-01	Apellis Pharmaceuticals Inc	Dosage regimens and related compositions and methods
AU2018260628A1 (en)	2017-04-25	2019-12-12	Temple Otorongo Llc	Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions
WO2019118938A1 (en)	2017-12-15	2019-06-20	Apellis Pharmaceuticals, Inc.	Dosing regimens and related compositions and methods
EP4011905A3 (de)	2018-04-06	2022-06-29	The Trustees Of The University Of Pennsylvania	Compstatinanaloga mit erhöhter löslichkeit und verbesserten pharmakokinetischen eigenschaften

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1055518B (it) *	1971-05-18	1982-01-11	Rotta Research Lab	Derivatives del triptofano
US4482567A (en) *	1982-10-07	1984-11-13	Research Foundation For Mental Hygiene, Inc.	N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics

1984
- 1984-12-12 IT IT68241/84A patent/IT1179866B/it active
1985
- 1985-12-02 IE IE302985A patent/IE58502B1/en not_active IP Right Cessation
- 1985-12-05 DE DE8686900106T patent/DE3587122T2/de not_active Expired - Fee Related
- 1985-12-05 EP EP86900106A patent/EP0237522B1/de not_active Expired - Lifetime
- 1985-12-05 AT AT86900106T patent/ATE85976T1/de active
- 1985-12-05 WO PCT/EP1985/000672 patent/WO1986003489A1/en not_active Ceased
- 1985-12-05 AU AU52099/86A patent/AU589938B2/en not_active Ceased
- 1985-12-05 JP JP61500191A patent/JPS62501292A/ja active Pending
- 1985-12-09 CA CA000497174A patent/CA1256441A/en not_active Expired
- 1985-12-11 ES ES549822A patent/ES8706630A1/es not_active Expired
- 1985-12-12 PT PT81674A patent/PT81674B/pt not_active IP Right Cessation
- 1985-12-12 ZA ZA859526A patent/ZA859526B/xx unknown
1986
- 1986-08-11 DK DK381486A patent/DK168564B1/da not_active IP Right Cessation
1988
- 1988-07-11 US US07/217,116 patent/US4870097A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1986003489A1 (en)	1986-06-19
DE3587122T2 (de)	1993-07-15
DK381486D0 (da)	1986-08-11
EP0237522B1 (de)	1993-02-24
IT8468241A0 (it)	1984-12-12
IT8468241A1 (it)	1986-06-12
ZA859526B (en)	1986-08-27
ES8706630A1 (es)	1987-06-01
JPS62501292A (ja)	1987-05-21
AU5209986A (en)	1986-07-01
US4870097A (en)	1989-09-26
IE58502B1 (en)	1993-10-06
EP0237522A1 (de)	1987-09-23
ES549822A0 (es)	1987-06-01
IE853029L (en)	1986-06-12
CA1256441A (en)	1989-06-27
PT81674B (pt)	1987-10-20
DK168564B1 (da)	1994-04-25
IT1179866B (it)	1987-09-16
DK381486A (da)	1986-08-11
AU589938B2 (en)	1989-10-26
DE3587122D1 (de)	1993-04-01
PT81674A (en)	1986-01-01

Publication	Publication Date	Title
ATE85976T1 (de)	1993-03-15	Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen.
OA09482A (fr)	1992-11-15	"Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent".
NO821494L (no)	1982-11-09	Terapeutisk nyttige 1-alkyl-2-aminotetralinderivater
HUP9701694A2 (hu)	1999-06-28	Betegségek kezelésére alkalmas indolinonszármazékok, alkalmazásuk és a vegyületeket tartalmazó gyógyászati készítmények
HUP9600448A2 (hu)	1998-09-28	Naftilvegyületek, e vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra, intermedierjeik és alkalmazásuk
KR970069985A (ko)	1997-11-07	1,2-디페닐피롤 유도체,그의 제법 및 그의 치료학적 용도
DE69228879D1 (de)	1999-05-12	Amidino-derivate und ihre verwendung als no-synthase inhibitoren
PT1106178E (pt)	2005-02-28	Utilizacao de ibudilast para a preparacao de um medicamento para o tratamento da esclerose multipla
ATE89731T1 (de)	1993-06-15	Zusammensetzungen zur propylaktischen behandlung von osteitis und osteomyelitis.
ATE33831T1 (de)	1988-05-15	Analgesia wirkende 5-hydroxytryptophan-derivate.
RU94045271A (ru)	1996-10-10	Применение 2-фенил-3-ароилбензотиофенов для ингибирования синдрома тернера
PT77666B (fr)	1986-05-12	Procede de preparation de nouveaux derives de la nitrosouree
FR2631827B1 (fr)	1992-03-27	Nouveaux derives d'(hetero)aryl-5 tetrazole, leur procede de preparation et leur application en therapeutique
NO923413D0 (no)	1992-09-01	Terapeutiske benzazepin-forbindelser
LV11323A (lv)	1996-06-20	Izohinolina atvasinajumi ka arstnieciskie lidzekli
ZA87685B (en)	1988-10-26	Phenylacetonitriles which are substituted by basic groups,their preparation and drugs containing these substances
KR920006277A (ko)	1992-04-27	칼슘 흡수 억제제
ATE22555T1 (de)	1986-10-15	Mercaptoessigsaeure und 3-mercaptopropionsaeureamidderivate fuer ihre verwendung bei der therapeutischen behandlung von menschlichen oder tierischen koerpern, einige neue derivate und diese enthaltende pharmazeutische zusammensetzungen.
ES8705405A1 (es)	1987-05-16	Procedimiento de preparar nuevos derivados morfolinicos
ES2119454T3 (es)	1998-10-01	Derivados de pirrolidina para el tratamiento de los desordenes relacionados con la csk y la gastrina.
KR940703656A (ko)	1994-12-12	에이즈 바이러스 감염 저해용 조성물
FR2456111A1 (fr)	1980-12-05	Nouveaux derives de l'indole, leur preparation et les medicaments qui les contiennent
MX11977A (es)	1993-11-01	Derivados de 1-bencil-2-oxo-5-alcoxi-pirrolidina y procedimiento para su preparacion.