DK381486A - N-acylerede derivater af l-tryptophan, deres fremstilling og anvendelse - Google Patents

N-acylerede derivater af l-tryptophan, deres fremstilling og anvendelse Download PDF

Info

Publication number: DK381486A
Authority: DK; Denmark
Prior art keywords: tryptophan; group; monosubstituted; disubstituted; meta
Prior art date: 1984-12-12

Application number

DK381486A

Other languages

English (en)

Other versions

DK168564B1 (da

DK381486D0 (da

Inventor

Francesco Makovec

Chiste Rolando

Angelo Luigi Rovati

Original Assignee

Rotta Research Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-12

Filing date

1986-08-11

Publication date

1986-08-11

1986-08-11 Application filed by Rotta Research Lab filed Critical Rotta Research Lab

1986-08-11 Publication of DK381486A publication Critical patent/DK381486A/da

1986-08-11 Publication of DK381486D0 publication Critical patent/DK381486D0/da

1994-04-25 Application granted granted Critical

1994-04-25 Publication of DK168564B1 publication Critical patent/DK168564B1/da

Links

IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical class [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 title 1
230000001575 pathological effect Effects 0.000 abstract 2
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical class C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
-1 benzhydryloxy group Chemical group 0.000 abstract 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK381486A 1984-12-12 1986-08-11 Anvendelse af N-acylerede derivater af L-tryptophan til fremstilling af et lægemiddel til lindring af human smerte, farmaceutiske præparater indeholdende dem, samt sådanne nye farmaceutisk aktive derivater DK168564B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
IT68241/84A IT1179866B (it)	1984-12-12	1984-12-12	Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono
IT6824184		1984-12-12
PCT/EP1985/000672 WO1986003489A1 (en)	1984-12-12	1985-12-05	Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them
EP8500672		1985-12-05

Publications (3)

Publication Number	Publication Date
DK381486A true DK381486A (da)	1986-08-11
DK381486D0 DK381486D0 (da)	1986-08-11
DK168564B1 DK168564B1 (da)	1994-04-25

Family

ID=11308641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK381486A DK168564B1 (da)	1984-12-12	1986-08-11	Anvendelse af N-acylerede derivater af L-tryptophan til fremstilling af et lægemiddel til lindring af human smerte, farmaceutiske præparater indeholdende dem, samt sådanne nye farmaceutisk aktive derivater

Country Status (14)

Country	Link
US (1)	US4870097A (da)
EP (1)	EP0237522B1 (da)
JP (1)	JPS62501292A (da)
AT (1)	ATE85976T1 (da)
AU (1)	AU589938B2 (da)
CA (1)	CA1256441A (da)
DE (1)	DE3587122T2 (da)
DK (1)	DK168564B1 (da)
ES (1)	ES8706630A1 (da)
IE (1)	IE58502B1 (da)
IT (1)	IT1179866B (da)
PT (1)	PT81674B (da)
WO (1)	WO1986003489A1 (da)
ZA (1)	ZA859526B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4814463A (en) *	1985-12-31	1989-03-21	Biomeasure, Inc.	CCK antagonists
US4880938A (en) *	1986-06-16	1989-11-14	Merck & Co., Inc.	Amino acid analogs
US5089638A (en) *	1986-06-16	1992-02-18	Merck & Co., Inc.	Amino acid analogs as CCK-antagonists
SE8901149D0 (sv) *	1989-04-03	1989-04-03	Pharmacia Ab	Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat
US5484814A (en) *	1991-02-28	1996-01-16	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
US5360814A (en) *	1991-02-28	1994-11-01	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
DK0624569T3 (da) *	1991-02-28	1998-10-26	Merrell Pharma Inc	MMDA-antagonister
US20030199523A1 (en) *	2002-02-28	2003-10-23	Snutch Terrance P.	Heterocyclic calcium in channel blockers
US7989589B2 (en)	2002-09-20	2011-08-02	The Trustees Of The University Of Pennsylvania	Compstatin analogs with improved activity
US8168584B2 (en)	2005-10-08	2012-05-01	Potentia Pharmaceuticals, Inc.	Methods of treating age-related macular degeneration by compstatin and analogs thereof
CN101325963B (zh)	2005-10-08	2016-01-27	博泰迪亚制药公司	用于眼部病症的补体抑制素和其类似物
ES2390828T3 (es)	2005-11-28	2012-11-16	The Trustees Of The University Of Pennsylvania	Análogos potentes de la compstatina
EP2148691B1 (en)	2007-02-05	2015-05-20	Apellis Pharmaceuticals, Inc.	Compstatin analogues for use in the treatment of inflammatory conditions of the respiratory system
CA2760839C (en)	2009-05-01	2019-02-12	The Trustees Of The University Of Pennsylvania	Modified compstatin with peptide backbone and c-terminal modifications
CA2813049A1 (en)	2010-09-23	2012-03-29	The Trustees Of The University Of Pennsylvania	Modified compstatin with improved stability and binding properties
JP2014503592A (ja)	2011-01-26	2014-02-13	ニコワールドワイド，インコーポレイテッド	片頭痛の療法
RU2653439C9 (ru)	2011-05-11	2018-10-16	Апеллис Фармасьютикалс, Инк.	Клеточно-реактивные аналоги компстатина, аналоги компстатина длительного действия или аналоги компстатина нацеленного действия и их применение
CA2840270C (en)	2011-06-22	2023-09-26	Apellis Pharmaceuticals, Inc.	Methods of treating chronic disorders with complement inhibitors
PL2753636T3 (pl)	2011-09-07	2020-05-18	The Trustees Of The University Of Pennsylvania	Analogi kompstatyny o ulepszonych właściwościach farmakokinetycznych
US10035822B2 (en)	2012-11-15	2018-07-31	Apellis Pharmaceuticals, Inc.	Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods
WO2014152391A1 (en)	2013-03-15	2014-09-25	Apellis Pharmaceuticals, Inc.	Cell-penetrating compstatin analogs and uses thereof
US10213476B2 (en)	2014-03-17	2019-02-26	The Trustees Of The University Of Pennsylvania	Compstatin analogs with improved potency and pharmacokinetic properties
KR20180090785A (ko)	2015-10-07	2018-08-13	아펠리스 파마슈티컬스 인코포레이티드	투여 요법
WO2017083859A1 (en) *	2015-11-12	2017-05-18	The Trustees Of Columbia University In The City Of New York	Rational drug design targeting resistant gram-negative bacterial infections to polymyxin-class antibiotics
BR112019020955A2 (pt)	2017-04-07	2020-05-05	Apellis Pharmaceuticals, Inc.	regimes de dosagem e composições e métodos relacionados
WO2018200381A1 (en)	2017-04-25	2018-11-01	Temple Otorongo Llc	Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions
JP2021507884A (ja)	2017-12-15	2021-02-25	アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	投与レジメンならびに関連組成物および方法
HUE057693T2 (hu)	2018-04-06	2022-05-28	Univ Pennsylvania	Fokozott oldhatóságú és javított farmakokinetikai tulajdonságú kompsztatin analógok

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1055518B (it) *	1971-05-18	1982-01-11	Rotta Research Lab	Derivatives del triptofano
US4482567A (en) *	1982-10-07	1984-11-13	Research Foundation For Mental Hygiene, Inc.	N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics

1984
- 1984-12-12 IT IT68241/84A patent/IT1179866B/it active
1985
- 1985-12-02 IE IE302985A patent/IE58502B1/en not_active IP Right Cessation
- 1985-12-05 AT AT86900106T patent/ATE85976T1/de active
- 1985-12-05 JP JP61500191A patent/JPS62501292A/ja active Pending
- 1985-12-05 AU AU52099/86A patent/AU589938B2/en not_active Ceased
- 1985-12-05 WO PCT/EP1985/000672 patent/WO1986003489A1/en not_active Ceased
- 1985-12-05 EP EP86900106A patent/EP0237522B1/en not_active Expired - Lifetime
- 1985-12-05 DE DE8686900106T patent/DE3587122T2/de not_active Expired - Fee Related
- 1985-12-09 CA CA000497174A patent/CA1256441A/en not_active Expired
- 1985-12-11 ES ES549822A patent/ES8706630A1/es not_active Expired
- 1985-12-12 PT PT81674A patent/PT81674B/pt not_active IP Right Cessation
- 1985-12-12 ZA ZA859526A patent/ZA859526B/xx unknown
1986
- 1986-08-11 DK DK381486A patent/DK168564B1/da not_active IP Right Cessation
1988
- 1988-07-11 US US07/217,116 patent/US4870097A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPS62501292A (ja)	1987-05-21
EP0237522A1 (en)	1987-09-23
PT81674A (en)	1986-01-01
IE853029L (en)	1986-06-12
AU5209986A (en)	1986-07-01
US4870097A (en)	1989-09-26
DE3587122T2 (de)	1993-07-15
IT1179866B (it)	1987-09-16
DE3587122D1 (de)	1993-04-01
DK168564B1 (da)	1994-04-25
ATE85976T1 (de)	1993-03-15
ES549822A0 (es)	1987-06-01
IT8468241A0 (it)	1984-12-12
AU589938B2 (en)	1989-10-26
IT8468241A1 (it)	1986-06-12
DK381486D0 (da)	1986-08-11
WO1986003489A1 (en)	1986-06-19
ES8706630A1 (es)	1987-06-01
IE58502B1 (en)	1993-10-06
CA1256441A (en)	1989-06-27
PT81674B (pt)	1987-10-20
ZA859526B (en)	1986-08-27
EP0237522B1 (en)	1993-02-24

Legal Events

Date	Code	Title	Description
1994-04-25	B1	Patent granted (law 1993)
1995-08-28	PBP	Patent lapsed

Publication	Publication Date	Title
DK381486D0 (da)	1986-08-11	N-acylerede derivater af l-tryptophan, deres fremstilling og anvendelse
EA200000723A1 (ru)	2001-04-23	Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
EA200001224A1 (ru)	2001-08-27	Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
EA200001223A1 (ru)	2001-10-22	Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
ES8103744A1 (es)	1981-03-16	Un metodo para la preparacion de derivados de ftalimidina
DK282488A (da)	1988-05-24	Farmaceutiske praeparater, deri indgaaende phenylalkylaminger eller salte deraf og forbindelsernes fremstilling
ES526765A0 (es)	1984-07-01	Procedimiento para preparar derivados de 2-amino-3-acilamino-6-bencilamino-piridina
ES526896A0 (es)	1984-08-01	Procedimiento para la preparacion de b-carbolinas
DK281482A (da)	1982-12-25	Fremgangsmaade til fremstilling af 2-aryl-3,4-diazabicyclo(4.n.o)alken-(2)-on-5-forbindelser
ES530311A0 (es)	1984-11-01	Procedimiento para preparar derivados de prolina disustituidos.
ATE124681T1 (de)	1995-07-15	Arzneimittelzusammensetzungen zur behandlung von psoriasis.
ES2018208B3 (es)	1991-04-01	Derivados de hidroxipirazol, procedimiento para su obtencion y su aplicacion contra microorganismos.
DK483683A (da)	1984-04-23	Cyclohexan-1,3-dion-derivater og deres salte, fremgangsmaade til fremstilling deraf, herbicid og fremgangsmaade til bekaempelse af uoensket plantevaekst
FI863565A0 (fi)	1986-09-04	Foerfarande foer framstaellning av nya pyrrobenzimidazoler, pyrrolbenzoxazoler och pyrrolbenztiazoler.
ATE223721T1 (de)	2002-09-15	Edelfosin zur behandlung von hirntumoren
DK0548103T3 (da)	2002-04-02	Anvendelse af pyridylmethylsulfinyl-1H-benzimidazolderivater til behandling af sygdomme, der er fremkaldt af Helicobacter-bakterier
PT77666B (fr)	1986-05-12	Procede de preparation de nouveaux derives de la nitrosouree
ES503093A0 (es)	1982-04-01	Procedimiento para preparar difenilbutil-1-acilpiperazinas
DK532679A (da)	1980-06-17	Fremgangsmaade til fremstilling af 2-aryl-3,4-diaza-bicyclo (4,1,0)hepten-(2)-on-(5).
ES553826A0 (es)	1987-03-16	Procedimiento para preparar derivados de difluorociclopropano
ES523853A0 (es)	1984-11-01	Procedimiento para la preparacion de derivados de quinazolinona.
PT82407B (pt)	1988-08-17	Processo para a preparacao de novos derivados do triazole
MX10256A (es)	1993-11-01	Procedimiento para preparar nuevas 3-fenil-7h-tiazolo(3, 2-b) (1, 2, 4) triazin-7-onas.
ES8705405A1 (es)	1987-05-16	Procedimiento de preparar nuevos derivados morfolinicos
ES2037166T3 (es)	1993-06-16	Eter de dihidropiridina, procedimiento para su fabricacion y su utilizacion.