ES549822A0 - Procedimiento para la preparacion de derivados n-acilados del-triptofano - Google Patents

Procedimiento para la preparacion de derivados n-acilados del-triptofano

Info

Publication number
ES549822A0
ES549822A0 ES549822A ES549822A ES549822A0 ES 549822 A0 ES549822 A0 ES 549822A0 ES 549822 A ES549822 A ES 549822A ES 549822 A ES549822 A ES 549822A ES 549822 A0 ES549822 A0 ES 549822A0
Authority
ES
Spain
Prior art keywords
group
substituted
derivatives
meta
mono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES549822A
Other languages
English (en)
Other versions
ES8706630A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rottapharm SpA
Original Assignee
Rotta Research Laboratorium SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Laboratorium SpA filed Critical Rotta Research Laboratorium SpA
Publication of ES549822A0 publication Critical patent/ES549822A0/es
Publication of ES8706630A1 publication Critical patent/ES8706630A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES549822A 1984-12-12 1985-12-11 Procedimiento para la preparacion de derivados n-acilados del-triptofano Expired ES8706630A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT68241/84A IT1179866B (it) 1984-12-12 1984-12-12 Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono

Publications (2)

Publication Number Publication Date
ES549822A0 true ES549822A0 (es) 1987-06-01
ES8706630A1 ES8706630A1 (es) 1987-06-01

Family

ID=11308641

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549822A Expired ES8706630A1 (es) 1984-12-12 1985-12-11 Procedimiento para la preparacion de derivados n-acilados del-triptofano

Country Status (14)

Country Link
US (1) US4870097A (es)
EP (1) EP0237522B1 (es)
JP (1) JPS62501292A (es)
AT (1) ATE85976T1 (es)
AU (1) AU589938B2 (es)
CA (1) CA1256441A (es)
DE (1) DE3587122T2 (es)
DK (1) DK168564B1 (es)
ES (1) ES8706630A1 (es)
IE (1) IE58502B1 (es)
IT (1) IT1179866B (es)
PT (1) PT81674B (es)
WO (1) WO1986003489A1 (es)
ZA (1) ZA859526B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
US4880938A (en) * 1986-06-16 1989-11-14 Merck & Co., Inc. Amino acid analogs
US5089638A (en) * 1986-06-16 1992-02-18 Merck & Co., Inc. Amino acid analogs as CCK-antagonists
SE8901149D0 (sv) * 1989-04-03 1989-04-03 Pharmacia Ab Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat
AU643365B2 (en) * 1991-02-28 1993-11-11 Aventisub Ii Inc. NMDA antagonists
US5484814A (en) * 1991-02-28 1996-01-16 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US5360814A (en) * 1991-02-28 1994-11-01 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US20030199523A1 (en) * 2002-02-28 2003-10-23 Snutch Terrance P. Heterocyclic calcium in channel blockers
PT1549333E (pt) 2002-09-20 2012-01-03 Univ Pennsylvania Análogos de compstatina com actividade melhorada
MX351152B (es) 2005-10-08 2017-10-04 Potentia Pharmaceuticals Inc Compstatina y analogos de la misma para tratar trastornos oculares.
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
ES2390828T3 (es) 2005-11-28 2012-11-16 The Trustees Of The University Of Pennsylvania Análogos potentes de la compstatina
PL2148691T3 (pl) 2007-02-05 2015-12-31 Apellis Pharmaceuticals Inc Analogi kompstatyny do stosowania w leczeniu stanów zapalnych układu oddechowego
PL2424557T3 (pl) 2009-05-01 2018-04-30 The Trustees Of The University Of Pennsylvania Zmodyfikowana kompstatyna z modyfikacjami szkieletu peptydowego i c-końca
CA2813049A1 (en) 2010-09-23 2012-03-29 The Trustees Of The University Of Pennsylvania Modified compstatin with improved stability and binding properties
CN103501609A (zh) 2011-01-26 2014-01-08 尼科环球有限公司 用于偏头痛的治疗
CN103687867B (zh) 2011-05-11 2017-02-08 阿佩利斯制药公司 细胞反应性的、长效的或靶向的坎普他汀类似物及其用途
CN103796667A (zh) 2011-06-22 2014-05-14 艾普莱斯制药公司 用补体抑制剂治疗慢性障碍的方法
CN110229216B (zh) 2011-09-07 2023-06-16 宾夕法尼亚州大学理事会 具有改善的药代动力学性质的坎普他汀类肽
ES2879430T3 (es) 2012-11-15 2021-11-22 Apellis Pharmaceuticals Inc Análogos de compstatina de acción prolongada y composiciones y métodos relacionados
WO2014152391A1 (en) 2013-03-15 2014-09-25 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
US10213476B2 (en) 2014-03-17 2019-02-26 The Trustees Of The University Of Pennsylvania Compstatin analogs with improved potency and pharmacokinetic properties
EP3359555B1 (en) 2015-10-07 2023-12-20 Apellis Pharmaceuticals, Inc. Dosing regimens
JP2018534303A (ja) * 2015-11-12 2018-11-22 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク ポリミキシン系抗生物質に対する耐性グラム陰性細菌感染を標的にする合理的薬物設計
JP2020516607A (ja) 2017-04-07 2020-06-11 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 投与レジメンならびに関連組成物および方法
WO2018200381A1 (en) 2017-04-25 2018-11-01 Temple Otorongo Llc Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions
AU2018386304B2 (en) 2017-12-15 2023-12-07 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods
EP3645550B1 (en) 2018-04-06 2021-11-03 The Trustees Of The University Of Pennsylvania Compstatin analogs with increased solubility and improved pharmacokinetic properties

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1055518B (it) * 1971-05-18 1982-01-11 Rotta Research Lab Derivatives del triptofano
US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics

Also Published As

Publication number Publication date
IT8468241A1 (it) 1986-06-12
DE3587122D1 (de) 1993-04-01
IT1179866B (it) 1987-09-16
US4870097A (en) 1989-09-26
DK168564B1 (da) 1994-04-25
CA1256441A (en) 1989-06-27
PT81674B (pt) 1987-10-20
IE58502B1 (en) 1993-10-06
ZA859526B (en) 1986-08-27
DK381486D0 (da) 1986-08-11
EP0237522A1 (en) 1987-09-23
AU589938B2 (en) 1989-10-26
DE3587122T2 (de) 1993-07-15
WO1986003489A1 (en) 1986-06-19
PT81674A (en) 1986-01-01
IE853029L (en) 1986-06-12
DK381486A (da) 1986-08-11
ES8706630A1 (es) 1987-06-01
AU5209986A (en) 1986-07-01
EP0237522B1 (en) 1993-02-24
JPS62501292A (ja) 1987-05-21
ATE85976T1 (de) 1993-03-15
IT8468241A0 (it) 1984-12-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612