ATE90967T1 - Proteinanaloge des gewebs-plasminogenaktivators. - Google Patents

Proteinanaloge des gewebs-plasminogenaktivators.

Info

Publication number
ATE90967T1
ATE90967T1 AT87903044T AT87903044T ATE90967T1 AT E90967 T1 ATE90967 T1 AT E90967T1 AT 87903044 T AT87903044 T AT 87903044T AT 87903044 T AT87903044 T AT 87903044T AT E90967 T1 ATE90967 T1 AT E90967T1
Authority
AT
Austria
Prior art keywords
tpa
analogues
fragment
fibrin binding
natural
Prior art date
Application number
AT87903044T
Other languages
English (en)
Inventor
Roberto Crea
Roy Ho Loi Pang
Hermann Oppermann
Peter C Keck
Gabriel Alvarado-Urbina
Gay-May Wu
Charles M Cohen
Original Assignee
Creative Biomolecules Inc
Menarini Farma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creative Biomolecules Inc, Menarini Farma Ind filed Critical Creative Biomolecules Inc
Application granted granted Critical
Publication of ATE90967T1 publication Critical patent/ATE90967T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT87903044T 1986-03-28 1987-03-26 Proteinanaloge des gewebs-plasminogenaktivators. ATE90967T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84554186A 1986-03-28 1986-03-28
US2933687A 1987-03-23 1987-03-23
EP87903044A EP0263172B1 (de) 1986-03-28 1987-03-26 Proteinanaloge des gewebs-plasminogenaktivators
PCT/US1987/000760 WO1987005934A1 (en) 1986-03-28 1987-03-26 Protein analogues of tissue plasminogen activator

Publications (1)

Publication Number Publication Date
ATE90967T1 true ATE90967T1 (de) 1993-07-15

Family

ID=26704839

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87903044T ATE90967T1 (de) 1986-03-28 1987-03-26 Proteinanaloge des gewebs-plasminogenaktivators.

Country Status (5)

Country Link
EP (1) EP0263172B1 (de)
AT (1) ATE90967T1 (de)
AU (1) AU7282687A (de)
DE (1) DE3786317T2 (de)
WO (1) WO1987005934A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2031826T3 (es) * 1985-12-23 1993-01-01 Chiron Corporation Procedimiento para producir nuevos peptidos activadores del plasminogeno.
CA1339445C (en) * 1986-11-12 1997-09-09 The General Hospital Corporation Recombinant hybrid immunoglobulin molecules and method of use
GB8705377D0 (en) * 1987-03-07 1987-04-08 Beecham Group Plc Compounds
GB8711957D0 (en) * 1987-05-20 1987-06-24 Beecham Group Plc Compounds
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
JPH02438A (ja) * 1987-10-09 1990-01-05 Collaborative Res Inc 修飾した低分子量プラスミノーゲン活性化因子およびその製造方法
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
WO1989012098A1 (en) * 1988-06-03 1989-12-14 Celltech Limited Hybrid proteins
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators
US5811265A (en) * 1988-08-19 1998-09-22 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
US5609869A (en) * 1988-08-19 1997-03-11 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
DE3942580A1 (de) * 1989-12-22 1991-06-27 Basf Ag Verfahren zur herstellung von hirudin
US20030017147A1 (en) * 1996-09-20 2003-01-23 Guy L Reed Composition and method for enhancing fibrinolysis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79202B (de) * 1982-05-05 1984-10-22 Genentech Inc
EP0289508A1 (de) * 1985-12-20 1988-11-09 The Upjohn Company Analoge des gewebespezifischen plasminogenaktivators
EP0234051B1 (de) * 1986-02-17 1991-12-11 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Gewebeplasminogen-Aktivator-Mutant, dafür kodierende rekombinante genetische Information und Verfahren zur Herstellung dieser Mutanten, deren Verwendung und pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
EP0263172A1 (de) 1988-04-13
WO1987005934A1 (en) 1987-10-08
DE3786317T2 (de) 1994-02-03
EP0263172B1 (de) 1993-06-23
DE3786317D1 (de) 1993-07-29
AU7282687A (en) 1987-10-20

Similar Documents

Publication Publication Date Title
ATE90967T1 (de) Proteinanaloge des gewebs-plasminogenaktivators.
Nickel et al. Structure of polyubiquitinated histone H2A
AU605124B2 (en) Novel peptide plasminogen activators
Matsuda et al. A simple, large scale method for preparation of plasminogen-free fibrinogen
KR880700856A (ko) 조직 플라스미노겐 활성화인자(tpa)상사체
DE69633825D1 (de) Modifiziertes enzym mit lipolytischer aktivität
DE69929886D1 (de) Überexpression von phytase in hefesystemen
ES2187527T3 (es) Estructura de orden superior y enlace de acidos nucleicos peptidicos.
DK0618976T3 (da) Syntetisk DNA-sekvens med forbedret insekticid virkning i majs
DK0941318T3 (da) Håndvægtformede konstruerede ekspressionssystemer til genterapi
KR970707153A (ko) 카텝신 02 프로테아제(cathepsin 02 protease)
DE69435020D1 (en) Protein-tyrosin-phosphatase ptp-s31
DE69735207D1 (de) Neuartiges, fibrinogen-bindendes protein, welches von einem koagulase-negativen staphylokokkus abstammt
AU1207301A (en) Stabilized proteins
ATE281528T1 (de) Rekombinante ribonuklease proteine
WO1994003611A3 (en) Ptp-d subfamily of protein tyrosine phosphatases
DK0901526T3 (da) Cortistatin: neuropeptider, sammensætninger og metoder
DE60015988D1 (de) Modifizierung von schaumeigenschaften von proteinen
EP1702071A4 (de) Transaktivierungssystem für säugerzellen
KR900702017A (ko) 혼성 단백질(bybrid proteins)
DE69634757D1 (de) Vektor zur expression von n-terminal verlängerten proteinen in hefezellen
Williams et al. Dye-ligand affinity purification of human complement factor B and β2 glycoprotein I
WO2000060103A3 (en) Dna construct comprising a cyanophage of cyanobacteria promoter and its use
DE69316388D1 (de) CRF Bindungsproteine
Medved' et al. The cleavage of β‐chain in bovine fibrinogen DH fragment (95 kDa) leads to a significant increase in its anticlotting activity

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee