ATE91283T1 - Verbindungen mit aktivitaet gegen gewebemalaria und verfahren zu ihrer herstellung. - Google Patents

Verbindungen mit aktivitaet gegen gewebemalaria und verfahren zu ihrer herstellung.

Info

Publication number: ATE91283T1
Authority: AT; Austria
Prior art keywords: free amine; acid; peptide; amino acid; carboxyl group
Prior art date: 1988-09-23

Application number

AT89402593T

Other languages

English (en)

Inventor

Philippe Pirson

Jean-Bernard Falmagne

Andre Trouet

Original Assignee

Wallone Region

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-23

Filing date

1989-09-21

Publication date

1993-07-15

1989-09-21 Application filed by Wallone Region filed Critical Wallone Region

1993-07-15 Application granted granted Critical

1993-07-15 Publication of ATE91283T1 publication Critical patent/ATE91283T1/de

Links

150000001875 compounds Chemical class 0.000 title 1
201000004792 malaria Diseases 0.000 title 1
229940024606 amino acid Drugs 0.000 abstract 4
235000001014 amino acid Nutrition 0.000 abstract 4
150000001413 amino acids Chemical class 0.000 abstract 4
125000003277 amino group Chemical group 0.000 abstract 3
GJOHLWZHWQUKAU-UHFFFAOYSA-N 5-azaniumylpentan-2-yl-(6-methoxyquinolin-8-yl)azanium;dihydrogen phosphate Chemical class OP(O)(O)=O.OP(O)(O)=O.N1=CC=CC2=CC(OC)=CC(NC(C)CCCN)=C21 GJOHLWZHWQUKAU-UHFFFAOYSA-N 0.000 abstract 2
230000000078 anti-malarial effect Effects 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
150000003248 quinolines Chemical class 0.000 abstract 2
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 1
102000004157 Hydrolases Human genes 0.000 abstract 1
108090000604 Hydrolases Proteins 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical group OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
229940111121 antirheumatic drug quinolines Drugs 0.000 abstract 1
229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 abstract 1
235000003704 aspartic acid Nutrition 0.000 abstract 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000002132 lysosomal effect Effects 0.000 abstract 1
229960005179 primaquine Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Tropical Medicine & Parasitology (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Quinoline Compounds (AREA)

AT89402593T 1988-09-23 1989-09-21 Verbindungen mit aktivitaet gegen gewebemalaria und verfahren zu ihrer herstellung. ATE91283T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8812441A FR2644462B1 (fr)	1988-09-23	1988-09-23	Nouveaux composes actifs sur les formes tissulaires de la malaria et procede de preparation
EP89402593A EP0362031B1 (de)	1988-09-23	1989-09-21	Verbindungen mit Aktivität gegen Gewebemalaria und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number	Publication Date
ATE91283T1 true ATE91283T1 (de)	1993-07-15

Family

ID=9370310

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89402593T ATE91283T1 (de)	1988-09-23	1989-09-21	Verbindungen mit aktivitaet gegen gewebemalaria und verfahren zu ihrer herstellung.

Country Status (7)

Country	Link
US (1)	US5110935A (de)
EP (1)	EP0362031B1 (de)
JP (1)	JPH02129170A (de)
AT (1)	ATE91283T1 (de)
DE (1)	DE68907458T2 (de)
ES (1)	ES2058576T3 (de)
FR (1)	FR2644462B1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5510356A (en) *	1991-10-03	1996-04-23	University Of Nebraska Board Of Regents	Bisquinolines and processes for their production and use to treat malaria
DE69737749T2 (de) *	1996-03-29	2008-01-31	The University Of Mississippi, University	(-)-8-Ä(4-Amino-1-methylbutyl)aminoÜ-5-(3,4-dichlorophenoxy)-6-methoxy-4-methylchinolin-enthaltendes Medikament zur Behandlung parasitärer und opportunistischer Infektionen
ATE248835T1 (de) *	1999-06-25	2003-09-15	Vertex Pharma	Prodrugs von impdh-inhibierenden carbamaten
US6623972B2 (en) *	2000-06-09	2003-09-23	Bayer Corporation	Automated method for detecting, quantifying and monitoring exogenous hemoglobin in whole blood, plasma and serum
AU2003292489A1 (en) *	2003-03-27	2004-10-18	Council Of Scientific And Industrial Research	Ring-substituted 8-aminoqunoline derivates as antimalarial agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3167679D1 (en) *	1980-03-31	1985-01-24	Inst Int Pathologie Cellulaire	Pharmaceutical forms, their preparation and compositions containing the same
FR2546163B1 (fr) *	1983-05-16	1987-10-09	Centre Nat Rech Scient	Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2612778B1 (fr) *	1987-03-24	1991-10-18	Ire Cell Targ Sa	Nouveaux derives d'aminoquinoleine antimalarique, procede de preparation et composition pharmaceutique en contenant
FR2618674B1 (fr) *	1987-07-30	1990-06-15	Ire Celltarg Sa	Microparticules comportant un polymere biodegradable controlant la liberation d'un principe actif antimalarique, compositions pharmaceutiques en comprenant et procede de preparation

1988
- 1988-09-23 FR FR8812441A patent/FR2644462B1/fr not_active Expired - Fee Related
1989
- 1989-09-21 ES ES89402593T patent/ES2058576T3/es not_active Expired - Lifetime
- 1989-09-21 AT AT89402593T patent/ATE91283T1/de active
- 1989-09-21 EP EP89402593A patent/EP0362031B1/de not_active Expired - Lifetime
- 1989-09-21 DE DE89402593T patent/DE68907458T2/de not_active Expired - Fee Related
- 1989-09-22 US US07/410,885 patent/US5110935A/en not_active Expired - Fee Related
- 1989-09-25 JP JP1248986A patent/JPH02129170A/ja active Pending

Also Published As

Publication number	Publication date
ES2058576T3 (es)	1994-11-01
JPH02129170A (ja)	1990-05-17
FR2644462A1 (fr)	1990-09-21
FR2644462B1 (fr)	1993-07-09
US5110935A (en)	1992-05-05
DE68907458T2 (de)	1993-12-16
EP0362031A1 (de)	1990-04-04
EP0362031B1 (de)	1993-07-07
DE68907458D1 (de)	1993-08-12

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