IT1245699B - Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi - Google Patents

Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi

Info

Publication number
IT1245699B
IT1245699B ITRM910363A ITRM910363A IT1245699B IT 1245699 B IT1245699 B IT 1245699B IT RM910363 A ITRM910363 A IT RM910363A IT RM910363 A ITRM910363 A IT RM910363A IT 1245699 B IT1245699 B IT 1245699B
Authority
IT
Italy
Prior art keywords
myopathies
neuronal
degenaration
treatment
therapeutic agents
Prior art date
Application number
ITRM910363A
Other languages
English (en)
Inventor
Claudio Cavazza
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Priority to ITRM910363A priority Critical patent/IT1245699B/it
Publication of ITRM910363A0 publication Critical patent/ITRM910363A0/it
Priority to CA002069520A priority patent/CA2069520A1/en
Priority to EP92830259A priority patent/EP0516594A1/en
Priority to ZA923829A priority patent/ZA923829B/xx
Priority to JP4136886A priority patent/JPH05148200A/ja
Priority to US07/890,009 priority patent/US5227518A/en
Priority to IE169992A priority patent/IE921699A1/en
Publication of ITRM910363A1 publication Critical patent/ITRM910363A1/it
Application granted granted Critical
Publication of IT1245699B publication Critical patent/IT1245699B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Viene descritto l'uso di composti di formula generale (I) (FORMULA I) in cui:Y è idrogeno oppure metile e,R è un radicale alchilico non sostituito oppure sostituito scelto fra metile, etile e isopropile e dei loro sali farmacologicamente accettabili nel trattamento terapeutico di miopatie, della degenerazione neuronale, e di certe patologie epatiche, del muscolo scheletrico e del miocardio.I composti possono essere somministrati per via orale o parenterale.
ITRM910363A 1991-05-29 1991-05-29 Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi IT1245699B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITRM910363A IT1245699B (it) 1991-05-29 1991-05-29 Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi
CA002069520A CA2069520A1 (en) 1991-05-29 1992-05-26 L-carnitine derivatives as therapeutical agents for treating myopathies and neuronal degeneration and for inhibiting proteolysis
EP92830259A EP0516594A1 (en) 1991-05-29 1992-05-26 L-carnitine derivatives as therapeutical agents for treating myopathies and neuronal degeneration and for inhibiting proteolysis
ZA923829A ZA923829B (en) 1991-05-29 1992-05-26 L-carnitine derivatives as therapeutical agents for treating myopathies and neuronal degeneration and for inhibiting proteolysis
JP4136886A JPH05148200A (ja) 1991-05-29 1992-05-28 筋障害および神経退行変性の処置のためのアシル−ｌ−カルニチン誘導体
US07/890,009 US5227518A (en) 1991-05-29 1992-05-29 L-carnitine derivatives as therapeutical agents for treating myopathies and neuronal degeneration and for inhibiting proteolysis
IE169992A IE921699A1 (en) 1991-05-29 1992-07-01 L-carnitine derivatives as therapeutical agents for treating¹myopathies and neuronal degeneration and for inhibiting¹proteolysis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM910363A IT1245699B (it) 1991-05-29 1991-05-29 Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi

Publications (3)

Publication Number Publication Date
ITRM910363A0 ITRM910363A0 (it) 1991-05-29
ITRM910363A1 ITRM910363A1 (it) 1992-11-29
IT1245699B true IT1245699B (it) 1994-10-14

Family

ID=11400163

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM910363A IT1245699B (it) 1991-05-29 1991-05-29 Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi

Country Status (7)

Country Link
US (1) US5227518A (it)
EP (1) EP0516594A1 (it)
JP (1) JPH05148200A (it)
CA (1) CA2069520A1 (it)
IE (1) IE921699A1 (it)
IT (1) IT1245699B (it)
ZA (1) ZA923829B (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254314B (it) * 1992-03-27 1995-09-14 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari.
IT1261230B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
EP0681839A3 (en) * 1994-05-12 1997-11-12 Hirohiko Kuratsune A pharmaceutical preparation comprising an acylcarnitine
US5681739A (en) * 1995-05-25 1997-10-28 Lockheed Idaho Technologies Company Method for in situ or ex situ bioremediation of hexavalent chromium contaminated soils and/or groundwater
IT1276225B1 (it) * 1995-10-17 1997-10-27 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1276253B1 (it) 1995-12-15 1997-10-27 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
IT1290801B1 (it) * 1996-07-05 1998-12-11 Mendes Srl Uso della acetil l-carnitina, della isovaleril l-carnitina, della propionil l-carnitina o dei loro sali farmacologicamente accettabili
IT1291113B1 (it) * 1997-03-20 1998-12-29 Sigma Tau Ind Farmaceuti Composizione nutritiva terapeutica per soggetti affetti da diabete mellito
IT1291127B1 (it) * 1997-04-01 1998-12-29 Sigma Tau Ind Farmaceuti Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica
US5863940A (en) 1997-12-01 1999-01-26 Sigma-Tau Healthscience S.P.A. Medicament and therapeutical method for treating idiopathic asthenozoospermia
US6090848A (en) * 1997-12-01 2000-07-18 Sigma-Tau Healthscience S.P.A. Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
DK0951909T4 (da) 1998-03-19 2011-01-24 Sigma Tau Ind Farmaceuti Kombinationspræparat omfattende en L-carnitin eller en alkanoyl-L-carnitin, en glycosaminoglycan og/eller bestanddel deraf
WO2000063127A1 (en) * 1999-04-14 2000-10-26 Shell Internationale Research Maatschappij B.V. Method of aquifer remediation
IT1317042B1 (it) 2000-06-14 2003-05-26 Biosalts Srl Fumarati doppi di una carnitina e creatina, e integratori alimentari,dietetici e farmaci che li contengono.
IT1317062B1 (it) 2000-07-14 2003-05-26 Sigma Tau Healthscience Spa Integratore alimentare utile per prevenire le disfunzioni epatiche ebiliari comprendente una alcanoil l-carnitina.
US8173618B2 (en) 2003-07-25 2012-05-08 University Of Massachusetts Formulations for reducing neuronal degeneration
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
US8597640B2 (en) 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
US20200129464A1 (en) * 2018-10-29 2020-04-30 Lonza Inc. Method and Composition for Increasing the Bioavailability of Carnitine
CN109395084A (zh) * 2018-11-14 2019-03-01 威海市千谷生物科技有限公司 一种溶脂线和溶脂液及利用其的埋线减肥方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727151A (en) * 1974-06-24 1988-02-23 Interx Research Corporation Labile quaternary ammonium salts as prodrugs
IT1150396B (it) * 1982-12-09 1986-12-10 Sigma Tau Ind Farmaceuti Impiego di alcanoil l-carnitine per il trattamento terapeutico di miopa tie e distrofie muscolari
EP0150688B1 (en) * 1983-12-28 1987-04-22 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
DE3400514A1 (de) * 1984-01-10 1985-07-18 Boehringer Mannheim Gmbh, 6800 Mannheim Neue carbonsaeure-derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
IT1181682B (it) * 1985-06-11 1987-09-30 Sigma Tau Ind Farmaceuti Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto
DE3623215A1 (de) * 1986-07-10 1988-01-21 Henkel Kgaa Neue quartaere ammoniumverbindungen und deren verwendung
IT1196564B (it) * 1986-08-04 1988-11-16 Sigma Tau Ind Farmaceuti Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche
IT1224842B (it) * 1988-12-27 1990-10-24 Sigma Tau Ind Farmaceuti Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso

Also Published As

Publication number Publication date
US5227518A (en) 1993-07-13
EP0516594A1 (en) 1992-12-02
IE921699A1 (en) 1992-12-02
ITRM910363A0 (it) 1991-05-29
ITRM910363A1 (it) 1992-11-29
ZA923829B (en) 1993-01-27
JPH05148200A (ja) 1993-06-15
CA2069520A1 (en) 1992-11-30

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970416