ATE93864T1 - Peptide. - Google Patents

Peptide.

Info

Publication number: ATE93864T1
Authority: AT; Austria
Prior art keywords: residue; methylamino; amino; methyl; group
Prior art date: 1987-07-22

Application number

AT88306696T

Other languages

English (en)

Inventor

Ian James Galpin

Original Assignee

British Tech Group

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-22

Filing date

1988-07-21

Publication date

1993-09-15

1988-07-21 Application filed by British Tech Group filed Critical British Tech Group

1993-09-15 Application granted granted Critical

1993-09-15 Publication of ATE93864T1 publication Critical patent/ATE93864T1/de

Links

102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
125000002015 acyclic group Chemical group 0.000 abstract 5
XJODGRWDFZVTKW-LURJTMIESA-N (2s)-4-methyl-2-(methylamino)pentanoic acid Chemical group CN[C@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-LURJTMIESA-N 0.000 abstract 4
-1 amino, methylamino, mercapto Chemical class 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
125000001931 aliphatic group Chemical group 0.000 abstract 3
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 2
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 2
125000000539 amino acid group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
229930182912 cyclosporin Natural products 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
108010036941 Cyclosporins Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical group CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 abstract 1
AKCRVYNORCOYQT-YFKPBYRVSA-N N-methyl-L-valine Chemical group CN[C@@H](C(C)C)C(O)=O AKCRVYNORCOYQT-YFKPBYRVSA-N 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
IADUEWIQBXOCDZ-UHFFFAOYSA-N azetidine-2-carboxylic acid Chemical compound OC(=O)C1CCN1 IADUEWIQBXOCDZ-UHFFFAOYSA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
229940125721 immunosuppressive agent Drugs 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1
HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 abstract 1
FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical group C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Oncology (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT88306696T 1987-07-22 1988-07-21 Peptide. ATE93864T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878717299A GB8717299D0 (en)	1987-07-22	1987-07-22	Peptides
EP88306696A EP0300784B1 (de)	1987-07-22	1988-07-21	Peptide

Publications (1)

Publication Number	Publication Date
ATE93864T1 true ATE93864T1 (de)	1993-09-15

Family

ID=10621085

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88306696T ATE93864T1 (de)	1987-07-22	1988-07-21	Peptide.

Country Status (6)

Country	Link
US (1)	US4997648A (de)
EP (1)	EP0300784B1 (de)
JP (1)	JPH01151598A (de)
AT (1)	ATE93864T1 (de)
DE (1)	DE3883658T2 (de)
GB (2)	GB8717299D0 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2217319A (en) *	1988-04-19	1989-10-25	Synpharm Ltd	Racemic and optically active fatty amino acids, their homo- abd hetero-oligomers and conjugates, the process of their production, their pharmaceutical composi
GB8916901D0 (en)	1989-07-24	1989-09-06	Sandoz Ltd	Improvements in or relating to organic compounds
US5362629A (en) *	1991-08-05	1994-11-08	President And Fellows Of Harvard College	Detection of immunosuppressants
AU750245B2 (en)	1997-10-08	2002-07-11	Aurinia Phamaceuticals Inc.	Deuterated cyclosporine analogs and their use as immunomodulating agents
US20030220234A1 (en) *	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
JP2003056266A (ja) *	2001-08-15	2003-02-26	Kawajun Co Ltd	固定車輪付き折り畳み脚立
MXPA04003625A (es) *	2001-10-19	2004-12-02	Sotechnika Inc	Sintesis de analogos de ciclosporina.
KR20110111321A (ko)	2009-01-30	2011-10-10	이난타 파마슈티칼스, 인코포레이티드	Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US8481483B2 (en)	2009-02-19	2013-07-09	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8349312B2 (en)	2009-07-09	2013-01-08	Enanta Pharmaceuticals, Inc.	Proline substituted cyclosporin analogues
US8685917B2 (en)	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8367053B2 (en)	2009-07-09	2013-02-05	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8623814B2 (en)	2010-02-23	2014-01-07	Enanta Pharmaceuticals, Inc.	Antiviral agents
WO2012145427A1 (en)	2011-04-18	2012-10-26	The Trustees Of Columbia University In The City Of New York	Methods to treat cancer using cyclosporine and cyclosporine derivatives
ES2657930T3 (es)	2011-09-28	2018-03-07	Nosopharm	Nuevos derivados de péptidos como antibióticos
WO2014085623A1 (en)	2012-11-28	2014-06-05	Enanta Pharmaceuticals, Inc.	Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
JP2016538317A (ja)	2013-08-26	2016-12-08	エナンタファーマシューティカルズインコーポレイテッド	Ｃ型肝炎を防止または治療するための新規シクロスポリン類似体
US9669095B2 (en)	2014-11-03	2017-06-06	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues for preventing or treating hepatitis C infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH614931A5 (de) *	1975-11-04	1979-12-28	Sandoz Ag
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
US4075194A (en) *	1976-12-09	1978-02-21	Yeda Research And Development Co., Ltd.	Novel synthetic undecapeptide and clinical assay
GB8303994D0 (en) *	1983-02-14	1983-03-16	Council Of Governors Of United	Antigenic materials

1987
- 1987-07-22 GB GB878717299A patent/GB8717299D0/en active Pending
1988
- 1988-07-21 US US07/222,530 patent/US4997648A/en not_active Expired - Fee Related
- 1988-07-21 DE DE88306696T patent/DE3883658T2/de not_active Expired - Fee Related
- 1988-07-21 EP EP88306696A patent/EP0300784B1/de not_active Expired - Lifetime
- 1988-07-21 AT AT88306696T patent/ATE93864T1/de not_active IP Right Cessation
- 1988-07-21 GB GB8817433A patent/GB2207433B/en not_active Expired - Lifetime
- 1988-07-22 JP JP63184460A patent/JPH01151598A/ja active Pending

Also Published As

Publication number	Publication date
GB2207433A (en)	1989-02-01
DE3883658D1 (de)	1993-10-07
US4997648A (en)	1991-03-05
JPH01151598A (ja)	1989-06-14
GB8817433D0 (en)	1988-08-24
EP0300784A3 (en)	1990-06-13
EP0300784A2 (de)	1989-01-25
GB2207433B (en)	1990-10-10
DE3883658T2 (de)	1994-01-05
GB8717299D0 (en)	1987-08-26
EP0300784B1 (de)	1993-09-01

Legal Events

Date	Code	Title	Description
1994-03-15	UEP	Publication of translation of european patent specification
1996-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3883658D1 (de)	1993-10-07	Peptide.
DE3885959D1 (de)	1994-01-13	Cyclosporine.
HUP9802603A2 (hu)	1999-04-28	Lipofil peptid hormonszármazékok
CA2097192A1 (en)	1992-05-30	Bombesin antagonists
DE69832984D1 (de)	2006-02-02	DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN
HUP9802372A2 (hu)	1999-02-01	Szomatosztatin gyűrűs peptid analógjai
DE69429176D1 (en)	2002-01-03	Protegrine
DE60144561D1 (de)	2011-06-16	N- und/oder c-terminal mit kurzen geladenen peptidsequenzen modifizierte peptide
ATE127476T1 (de)	1995-09-15	Lhrh-analoge.
AU551892B2 (en)	1986-05-15	Gnrh antagonists
EP0297456A3 (de)	1990-09-26	Immunsuppressive Peptide
ATE47880T1 (de)	1989-11-15	Vorlaeufer eines an dem c-ende amidierten peptids und dessen herstellung.
GB1489326A (en)	1977-10-19	Pharmaceutically active polypeptides
CA2086243A1 (en)	1992-01-25	Anticoagulant peptides
GB992957A (en)	1965-05-26	New decapeptides and their manufacture
AU2002212623A1 (en)	2002-06-11	Compound for chelating a metal, radiopharmaceutical, manufacturing process therefor, and diagnostic kit
KR870007206A (ko)	1987-08-17	폴리펩타이드 화합물
ES416516A1 (es)	1976-03-01	Un procedimiento para la preparacion de nonapeptidos.
RU96118282A (ru)	1998-12-27	Пептиды для ингибирования высвобождения пепсина
NO931745L (no)	1993-05-13	Stabiliserte, sterkt virkende grf-analoger
HUP9904615A2 (hu)	2000-06-28	Polipeptid-átmenetifém-sók és eljárás polipeptid HIV-gátló hatásosságának fokozására
ATE17585T1 (de)	1986-02-15	Peptide.
GB1524319A (en)	1978-09-13	Polypeptide
ES447686A1 (es)	1977-06-16	Procedimiento para la preparacion de tripeptidos derivados de la l-prolina.