ATE95179T1 - Carbaminsaeureester von substituierten 7-hydroxy2,3,4,5-tetrahydro-1h-3-benzazepinen. - Google Patents
Carbaminsaeureester von substituierten 7-hydroxy2,3,4,5-tetrahydro-1h-3-benzazepinen.Info
- Publication number
- ATE95179T1 ATE95179T1 AT89103531T AT89103531T ATE95179T1 AT E95179 T1 ATE95179 T1 AT E95179T1 AT 89103531 T AT89103531 T AT 89103531T AT 89103531 T AT89103531 T AT 89103531T AT E95179 T1 ATE95179 T1 AT E95179T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- halogen
- formula
- ring
- chem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK107688A DK107688D0 (da) | 1988-03-01 | 1988-03-01 | Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner |
| EP89103531A EP0331130B1 (de) | 1988-03-01 | 1989-02-28 | Carbaminsäureester von substituierten 7-Hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE95179T1 true ATE95179T1 (de) | 1993-10-15 |
Family
ID=8100728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89103531T ATE95179T1 (de) | 1988-03-01 | 1989-02-28 | Carbaminsaeureester von substituierten 7-hydroxy2,3,4,5-tetrahydro-1h-3-benzazepinen. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5017571A (de) |
| EP (1) | EP0331130B1 (de) |
| JP (1) | JPH01254679A (de) |
| KR (1) | KR0126473B1 (de) |
| AT (1) | ATE95179T1 (de) |
| AU (1) | AU613716B2 (de) |
| CA (1) | CA1312863C (de) |
| DE (1) | DE68909448T2 (de) |
| DK (1) | DK107688D0 (de) |
| ES (1) | ES2059592T3 (de) |
| FI (1) | FI94955C (de) |
| IE (1) | IE64247B1 (de) |
| IL (1) | IL89207A0 (de) |
| NO (1) | NO173825C (de) |
| NZ (1) | NZ228151A (de) |
| PH (1) | PH26368A (de) |
| PT (1) | PT89887B (de) |
| ZA (1) | ZA891537B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK67489D0 (da) * | 1989-02-14 | 1989-02-14 | Novo Industri As | Nye benzazepinderivater |
| AU666318B2 (en) * | 1991-06-28 | 1996-02-08 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| US5470850A (en) * | 1992-02-24 | 1995-11-28 | Novo Nordisk A/S | 2,3,4,5-tetrahydro-1H-3-benzazepines |
| MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
| US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
| US20030125317A1 (en) * | 1996-10-02 | 2003-07-03 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| US7704993B2 (en) | 2003-06-17 | 2010-04-27 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
| US20080009478A1 (en) * | 2003-10-22 | 2008-01-10 | Arena Pharmaceuticals, Inc. | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases |
| BRPI0515862A2 (pt) | 2004-12-23 | 2011-10-11 | Arena Pharm Inc | uso de fentermina e agonista seletivo do receptor de 5ht-2c na preparação de composições, composições moduladoras do receptor de 5ht-2c e forma de dosagem unitária compreendendo as mesmas |
| US8822727B2 (en) | 2008-03-04 | 2014-09-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
| KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법 |
| KR20130138770A (ko) | 2010-09-01 | 2013-12-19 | 아레나 파마슈티칼스, 인크. | 광학적으로 활성 산을 갖는 로르카세린의 염 |
| SG188361A1 (en) | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Non-hygroscopic salts of 5-ht2c agonists |
| US8999970B2 (en) | 2010-09-01 | 2015-04-07 | Arena Pharmaceuticals, Inc. | Administration of an anti-obesity compound to individuals with renal impairment |
| EP3485878A1 (de) | 2010-09-01 | 2019-05-22 | Arena Pharmaceuticals, Inc. | Darreichungsformen von 5-ht2c-agonisten, die nützlich für gewichtskontrolle sind |
| CA2886875A1 (en) | 2012-10-09 | 2014-04-17 | Arena Pharmaceuticals, Inc. | Method of weight management |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3393192A (en) * | 1965-04-26 | 1968-07-16 | Schering Corp | Novel benzazepines |
| US3609138A (en) * | 1967-12-22 | 1971-09-28 | Ciba Geigy Corp | 1-aryl-3-benzazepines |
| US4011319A (en) * | 1975-07-02 | 1977-03-08 | Smithkline Corporation | Pharmaceutical compositions and methods involving benzazepine derivatives |
| ZA792044B (en) * | 1978-05-08 | 1980-05-28 | Scherico Ltd | Substituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof,and pharmaceutical compositions containing them |
| US4284555A (en) * | 1979-04-27 | 1981-08-18 | Schering Corporation | 7-Chloro-8(substituted amino carbonyloxy)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| DK180485D0 (da) * | 1985-04-22 | 1985-04-23 | Novo Industri As | Nitrogenholdige forbindelser |
| ZA882080B (en) * | 1987-03-27 | 1989-04-26 | Schering Corp | Substituted benzazepines,their preparation and pharmaceutical compositions containing them |
-
1988
- 1988-03-01 DK DK107688A patent/DK107688D0/da not_active Application Discontinuation
-
1989
- 1989-02-07 IL IL89207A patent/IL89207A0/xx not_active IP Right Cessation
- 1989-02-10 IE IE42089A patent/IE64247B1/en not_active IP Right Cessation
- 1989-02-14 CA CA000590992A patent/CA1312863C/en not_active Expired - Fee Related
- 1989-02-20 PH PH38219A patent/PH26368A/en unknown
- 1989-02-22 FI FI890841A patent/FI94955C/fi not_active IP Right Cessation
- 1989-02-25 KR KR1019890002236A patent/KR0126473B1/ko not_active Expired - Fee Related
- 1989-02-27 NZ NZ228151A patent/NZ228151A/xx unknown
- 1989-02-28 DE DE89103531T patent/DE68909448T2/de not_active Expired - Fee Related
- 1989-02-28 NO NO890857A patent/NO173825C/no unknown
- 1989-02-28 ZA ZA891537A patent/ZA891537B/xx unknown
- 1989-02-28 US US07/317,016 patent/US5017571A/en not_active Expired - Fee Related
- 1989-02-28 ES ES89103531T patent/ES2059592T3/es not_active Expired - Lifetime
- 1989-02-28 EP EP89103531A patent/EP0331130B1/de not_active Expired - Lifetime
- 1989-02-28 AT AT89103531T patent/ATE95179T1/de not_active IP Right Cessation
- 1989-03-01 PT PT89887A patent/PT89887B/pt not_active IP Right Cessation
- 1989-03-01 JP JP1046695A patent/JPH01254679A/ja active Pending
- 1989-03-01 AU AU30907/89A patent/AU613716B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA1312863C (en) | 1993-01-19 |
| NZ228151A (en) | 1991-08-27 |
| NO173825B (no) | 1993-11-01 |
| NO890857D0 (no) | 1989-02-28 |
| ZA891537B (en) | 1989-11-29 |
| KR0126473B1 (ko) | 1997-12-24 |
| NO890857L (no) | 1989-09-04 |
| ES2059592T3 (es) | 1994-11-16 |
| JPH01254679A (ja) | 1989-10-11 |
| NO173825C (no) | 1994-02-09 |
| IE890420L (en) | 1989-09-01 |
| US5017571A (en) | 1991-05-21 |
| DE68909448T2 (de) | 1994-02-10 |
| EP0331130B1 (de) | 1993-09-29 |
| AU613716B2 (en) | 1991-08-08 |
| KR890014494A (ko) | 1989-10-24 |
| DE68909448D1 (de) | 1993-11-04 |
| AU3090789A (en) | 1989-09-07 |
| PH26368A (en) | 1992-06-01 |
| FI94955B (fi) | 1995-08-15 |
| FI94955C (fi) | 1995-11-27 |
| EP0331130A1 (de) | 1989-09-06 |
| DK107688D0 (da) | 1988-03-01 |
| FI890841A7 (fi) | 1989-09-02 |
| FI890841A0 (fi) | 1989-02-22 |
| IL89207A0 (en) | 1989-09-10 |
| IE64247B1 (en) | 1995-07-26 |
| PT89887A (pt) | 1989-11-10 |
| PT89887B (pt) | 1994-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |