ATE96437T1 - (1-hydroxy-2-piperidinylalkyl)-2-indolon, 2quinolinon, 2-benzo(b>azepinon, 2-benzimidazolon und 2-quinazolinon-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. - Google Patents

(1-hydroxy-2-piperidinylalkyl)-2-indolon, 2quinolinon, 2-benzo(b>azepinon, 2-benzimidazolon und 2-quinazolinon-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Info

Publication number
ATE96437T1
ATE96437T1 AT89401898T AT89401898T ATE96437T1 AT E96437 T1 ATE96437 T1 AT E96437T1 AT 89401898 T AT89401898 T AT 89401898T AT 89401898 T AT89401898 T AT 89401898T AT E96437 T1 ATE96437 T1 AT E96437T1
Authority
AT
Austria
Prior art keywords
group
denotes
optionally substituted
piperidinylalkyl
azepinone
Prior art date
Application number
AT89401898T
Other languages
English (en)
Inventor
Jonathan Frost
Patrick Lardenois
Jean Bertin
Alfred Saarmets
Corinne Rousselle
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8809449A external-priority patent/FR2634206B1/fr
Application filed by Synthelabo filed Critical Synthelabo
Application granted granted Critical
Publication of ATE96437T1 publication Critical patent/ATE96437T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
AT89401898T 1988-07-12 1989-07-03 (1-hydroxy-2-piperidinylalkyl)-2-indolon, 2quinolinon, 2-benzo(b>azepinon, 2-benzimidazolon und 2-quinazolinon-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. ATE96437T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8809449A FR2634206B1 (fr) 1988-07-12 1988-07-12 Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2 et quinoleinones-2, leur preparation et leur application en therapeutique
FR888816373A FR2640266B2 (fr) 1988-07-12 1988-12-13 Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
EP89401898A EP0351282B1 (de) 1988-07-12 1989-07-03 (1-Hydroxy-2-piperidinylalkyl)-2-indolon, 2-quinolinon, 2-benzo[b]azepinon, 2-benzimidazolon und 2-quinazolinon-Derivate, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung

Publications (1)

Publication Number Publication Date
ATE96437T1 true ATE96437T1 (de) 1993-11-15

Family

ID=26226791

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89401898T ATE96437T1 (de) 1988-07-12 1989-07-03 (1-hydroxy-2-piperidinylalkyl)-2-indolon, 2quinolinon, 2-benzo(b>azepinon, 2-benzimidazolon und 2-quinazolinon-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Country Status (18)

Country Link
US (1) US5034401A (de)
EP (1) EP0351282B1 (de)
JP (1) JPH0272173A (de)
KR (1) KR900001684A (de)
AT (1) ATE96437T1 (de)
AU (1) AU618378B2 (de)
CA (1) CA1317292C (de)
DE (1) DE68910210T2 (de)
DK (1) DK341989A (de)
ES (1) ES2062064T3 (de)
FI (1) FI93012C (de)
FR (1) FR2640266B2 (de)
HU (1) HU201544B (de)
IE (1) IE62216B1 (de)
IL (1) IL90908A0 (de)
NO (1) NO174100C (de)
NZ (1) NZ229903A (de)
PT (1) PT91126B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182278A (en) * 1989-02-28 1993-01-26 Adir Et Compagnie Analgesic benzoxazolinones having at the 6-position a 1-hydroxy-3-morpholinopropyl side chain
CA2023492A1 (en) * 1989-08-31 1991-03-01 Barry Clifford Lange Herbicidal glutarimides
CA2080475C (en) * 1990-05-10 2001-04-17 Bertrand Leo Chenard Neuroprotective indolone and related derivatives
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
FR2668149B1 (fr) * 1990-10-18 1994-09-23 Synthelabo Le 1-(3,4-dihydro-2-oxo-1h-quinolein-6-yl)-2-[4-(2-phenyl-ethyl)piperidin-1-yl]ethanol, sa preparation et son application en therapeutique.
TW197435B (de) * 1990-11-22 1993-01-01 Takeda Pharm Industry Co Ltd
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
EP0524846A1 (de) * 1991-06-27 1993-01-27 Synthelabo 2-(Piperidin-1-yl)ethanolderivate, ihre Herstellung und ihre Anwendung in der Therapie
FR2678270B1 (fr) * 1991-06-27 1995-01-13 Synthelabo Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique.
HUT70528A (en) * 1991-07-17 1995-10-30 Pfizer 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents and process for production thereof
TW263504B (de) * 1991-10-03 1995-11-21 Pfizer
FR2684379B1 (fr) * 1991-12-02 1995-04-28 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique.
TW218875B (de) * 1992-03-09 1994-01-11 Takeda Pharm Industry Co Ltd
US5462934A (en) * 1992-03-09 1995-10-31 Takeda Chemical Industries Condensed heterocyclic ketone derivatives and their use
FR2688504B1 (fr) * 1992-03-13 1995-05-05 Synthelabo Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique.
US6255322B1 (en) 1992-06-19 2001-07-03 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
DE69309297T2 (de) * 1992-10-30 1997-07-03 Pfizer Neuroprotektive 3,4-dihydro-2(1h)-chinolone
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
WO1995020587A1 (en) * 1994-01-31 1995-08-03 Pfizer Inc. Neuroprotective chroman compounds
EP0709384B1 (de) * 1994-10-31 1998-12-23 MERCK PATENT GmbH Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren
CA2231326A1 (en) * 1995-09-08 1997-03-13 Synthelabo Derivatives of 4- (cycloalkyl) piperidines and of 4- (cycloalkylalkyl) piperidines, their preparation and their therapeutic application
FR2738568B1 (fr) * 1995-09-08 1997-10-17 Synthelabo Derives de 4-(cycloalkyl)piperidines et 4-(cycloalkylalkyl) piperidines, leur preparation et leur application en therapeutique
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
JP2001522846A (ja) * 1997-11-05 2001-11-20 ニューロサーチ、アクティーゼルスカブ アザ環−エーテル誘導体及びこれをニコチン性ａｃｈレセプターモジュレーターとして使用する方法
GB9725541D0 (en) * 1997-12-02 1998-02-04 Pharmacia & Upjohn Spa Amino-benzothiazole derivatives
AR033485A1 (es) * 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
CA2802733C (en) * 2010-06-24 2017-11-21 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
MA41169A (fr) * 2014-12-17 2017-10-24 Acraf Composés antibactériens à large spectre d'activité

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3217011A (en) * 1965-05-07 1965-11-09 Sterling Drug Inc 1-(indolyglyoxalyl)-piperidines
JPS51125291A (en) * 1974-12-07 1976-11-01 Otsuka Pharmaceut Co Ltd A process for preparing novel carbostyryl derivatives
JPS51118772A (en) * 1975-04-09 1976-10-18 Otsuka Pharmaceut Co Ltd Method for preparing carbostyryl derivatives
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2528043A1 (fr) * 1982-06-03 1983-12-09 Roussel Uclaf Nouveaux derives de la 1,3-dihydro 4-/1-hydroxy-2-amino-ethyl/2h-indol-2-one, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2581993B1 (fr) * 1985-05-14 1988-03-18 Synthelabo Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
US4788201A (en) * 1987-01-22 1988-11-29 Hoechst-Roussel Pharmaceuticals Inc. 3-methylenespiro (benzofuranpiperidines)

Also Published As

Publication number Publication date
IE892237L (en) 1990-01-12
IE62216B1 (en) 1995-01-11
PT91126B (pt) 1994-12-30
NO892870L (no) 1990-01-15
FI893365A7 (fi) 1990-01-13
AU618378B2 (en) 1991-12-19
DK341989D0 (da) 1989-07-11
DK341989A (da) 1990-04-25
NZ229903A (en) 1991-04-26
US5034401A (en) 1991-07-23
PT91126A (pt) 1990-02-08
HU201544B (en) 1990-11-28
FR2640266B2 (fr) 1992-07-10
NO174100C (no) 1994-03-16
FI93012C (fi) 1995-02-10
AU3802989A (en) 1990-01-18
FI93012B (fi) 1994-10-31
DE68910210T2 (de) 1994-05-11
JPH0272173A (ja) 1990-03-12
DE68910210D1 (de) 1993-12-02
KR900001684A (ko) 1990-02-27
EP0351282B1 (de) 1993-10-27
EP0351282A1 (de) 1990-01-17
FI893365A0 (fi) 1989-07-11
ES2062064T3 (es) 1994-12-16
FR2640266A2 (fr) 1990-06-15
IL90908A0 (en) 1990-02-09
CA1317292C (en) 1993-05-04
HUT50328A (en) 1990-01-29
NO174100B (no) 1993-12-06
NO892870D0 (no) 1989-07-11

Similar Documents

Publication Publication Date Title
ATE96437T1 (de) (1-hydroxy-2-piperidinylalkyl)-2-indolon, 2quinolinon, 2-benzo(b>azepinon, 2-benzimidazolon und 2-quinazolinon-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
NL180206C (nl) Verbinding en geneesmiddel met analgetische werking.
DE59401924D1 (de) Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
TW336939B (en) Lipopeptide derivatives, a process for their preparation and their use
ATE147071T1 (de) 1,4-disubstituierte piperidinderivate, ihre herstellung und therapeutische verwendung
YU32196A (sh) Upotreba jedinjenja za pripremanje leka korisnog za inhibiranje migracije vaskularnih ćelija glatkog mišića
DK0652004T3 (da) Fremgangsmåder til behandling af resistente neoplasmer
DE3788701D1 (de) Oxadiazolylalkylpurin-Derivate, ihre Herstellung und ihre Verwendung in pharmazeutischen Mitteln.
ATE113943T1 (de) Bestimmte 3-substituierte 2-alkyl-benzofuran- derivate.
ATE82969T1 (de) 6-phenyl-3-piperazinylalkyl-1h,3h-pyrimidindion 2,4-derivate, deren herstellung und verwendung als heilmittel.
ATE173252T1 (de) Arylmorpholine, herstellung und verwendung
NO164351C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 5-alkyl-l-fenyl-2-piperazinoalkylpyrazolin-3-on-forbindelser.
ATE21101T1 (de) N-iminopyridinium-betain-derivate, ihre herstellung und ihre verwendung als arzneimittel.
ATE139441T1 (de) Verwendung von 2-iminothiazolidin-4-onderivaten als neuartige arzneimittelwirkstoffe
KR900701770A (ko) 벤조 티아디아제핀 유도체
FI843155A0 (fi) Framstaellning av indolinderivat och deras terapeutiska tillaempning.
DK0379414T3 (da) Derivater af 1,8-benzonaphthyridin og fremstilling deraf
FR2683221B1 (fr) Nouveaux derives de cinnolinones-4, leur preparation et leur application en therapeutique.
SE8302452D0 (sv) Method for treatment of senile dementia
DK0461012T3 (da) Derivater af ((1-arylpyrrolidin-2-yl)methyl)piperazin, fremstillingen heraf og deres terapeutiske anvendelse
ATE200623T1 (de) Verwendung von 2-phenyl-3-aroylbenzothiophen derivaten zur herstellung eines medikaments zur hemmung der primären endometriumhyperplasie
DE3860117D1 (de) 2,3-dihydro-3-phenyl-benzofuran-2-on-acetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee