ATE96805T1 - Verfahren zur rueckgewinnung rekombinanter proteine. - Google Patents

Verfahren zur rueckgewinnung rekombinanter proteine.

Info

Publication number
ATE96805T1
ATE96805T1 AT90907861T AT90907861T ATE96805T1 AT E96805 T1 ATE96805 T1 AT E96805T1 AT 90907861 T AT90907861 T AT 90907861T AT 90907861 T AT90907861 T AT 90907861T AT E96805 T1 ATE96805 T1 AT E96805T1
Authority
AT
Austria
Prior art keywords
protein
molecular weight
high molecular
solution
methods
Prior art date
Application number
AT90907861T
Other languages
English (en)
Inventor
Vikram P Mehrotra
Ray E Barker
Original Assignee
Pitman Moore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pitman Moore Inc filed Critical Pitman Moore Inc
Application granted granted Critical
Publication of ATE96805T1 publication Critical patent/ATE96805T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/303—Extraction; Separation; Purification by precipitation by salting out

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT90907861T 1989-06-12 1990-05-10 Verfahren zur rueckgewinnung rekombinanter proteine. ATE96805T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/364,846 US5101018A (en) 1989-06-12 1989-06-12 Method for recovering recombinant proteins
PCT/US1990/002652 WO1990015876A1 (en) 1989-06-12 1990-05-10 Method for recovering recombinant proteins

Publications (1)

Publication Number Publication Date
ATE96805T1 true ATE96805T1 (de) 1993-11-15

Family

ID=23436347

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90907861T ATE96805T1 (de) 1989-06-12 1990-05-10 Verfahren zur rueckgewinnung rekombinanter proteine.

Country Status (14)

Country Link
US (1) US5101018A (de)
EP (1) EP0477198B1 (de)
JP (1) JP2957695B2 (de)
KR (1) KR0178274B1 (de)
AT (1) ATE96805T1 (de)
AU (1) AU634547B2 (de)
BR (1) BR9007433A (de)
CA (1) CA2060505C (de)
DE (1) DE69004429T2 (de)
DK (1) DK0477198T3 (de)
ES (1) ES2046782T3 (de)
HU (2) HUT61053A (de)
RU (1) RU2075509C1 (de)
WO (1) WO1990015876A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047511A (en) * 1989-08-28 1991-09-10 Pitman-Moore, Inc. Method for recovering recombinant proteins
US5605691A (en) * 1992-09-17 1997-02-25 Ophidian Pharmaceuticals, Inc. Immunologically active proteins from inclusion bodies
US5869604A (en) * 1995-11-09 1999-02-09 Georgia Institute Of Technology Crystallization and purification of polypeptides
DE10044360A1 (de) * 2000-09-08 2002-03-21 Merck Patent Gmbh Verfahren zur Aufreinigung von rekombinanten als unlösliche Aggregate exprimierte Proteinen
CA2498319A1 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
RU2233879C1 (ru) * 2002-12-17 2004-08-10 Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова РАН Рекомбинантная плазмидная днк pes1-6, кодирующая полипептид соматотропин, и штамм escherichia coli bl 21(de3)/pes1-6-продуцент рекомбинантного соматотропина
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
CA2747825A1 (en) * 2009-01-22 2010-07-29 Novo Nordisk Health Care Ag Stable growth hormone compounds
RU2012134974A (ru) 2010-01-22 2014-02-27 Ново Нордиск Хелс Кеа Аг Стабилизированное соединение гормона роста
RU2605627C2 (ru) 2010-01-22 2016-12-27 Ново Нордиск Хелс Кеа Аг Гормоны роста с пролонгированной эффективностью in vivo
EP2981282B1 (de) 2013-04-05 2020-11-04 Novo Nordisk Health Care AG Wachstumshormonverbindungsformulierung

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2175090A (en) * 1938-06-22 1939-10-03 Lederie Lab Inc Purification of antibody compositions
US3657071A (en) * 1968-11-12 1972-04-18 Hans Ulrich Bergmeyer Fractionation of proteins
US3749668A (en) * 1971-05-03 1973-07-31 Rohm & Haas Water purification with amine oxide resins
DE2718325C2 (de) * 1977-04-25 1986-09-25 Behringwerke Ag, 3550 Marburg Leucinreiches 3,1-S-α↓2↓-Glykoprotein sowie dessen Verwendung
US4204989A (en) * 1978-12-13 1980-05-27 Merck & Co., Inc. Isolation of hepatitis B e antigen
DE2946458A1 (de) * 1979-11-17 1981-06-11 Behringwerke Ag, 3550 Marburg Neues protein pp(pfeil abwaerts)11(pfeil abwaerts)
US4778813A (en) * 1981-07-07 1988-10-18 Buckman Laboratories International, Inc. Polymeric quaternary ammonium compounds, their preparation and use
JPH0738880B2 (ja) * 1983-06-24 1995-05-01 東レ株式会社 エンドトキシン血症治療剤
US4634673A (en) * 1984-03-28 1987-01-06 Nabisco Brands, Inc. Enzyme purification process
DE3484713D1 (de) * 1984-09-10 1991-07-18 Toray Industries Ionenaustausch- oder adsorptionsverfahren.
SE462100B (sv) * 1985-08-08 1990-05-07 Perstorp Ab Komposition och dess anvaendning i ett tvaa- eller flerfassystem
US4677196A (en) * 1985-09-06 1987-06-30 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
DE3608091A1 (de) * 1986-03-12 1987-09-17 Basf Ag Verfahren zum isolieren und reinigen von haemin
US4771128A (en) * 1986-10-10 1988-09-13 Cetus Corporation Method of purifying toxin conjugates using hydrophobic interaction chromatography
AU612133B2 (en) * 1987-02-20 1991-07-04 Natinco Nv Production of proteins in active forms
EP0295859B1 (de) * 1987-06-15 1994-11-17 Southern Cross Biotech Pty.Ltd. Herstellung von Proteinen in aktiver Form

Also Published As

Publication number Publication date
HU904388D0 (en) 1992-04-28
CA2060505C (en) 2001-06-12
AU634547B2 (en) 1993-02-25
HU209651B (en) 1994-09-28
EP0477198A1 (de) 1992-04-01
HUT61053A (en) 1992-11-30
JPH04505706A (ja) 1992-10-08
ES2046782T3 (es) 1994-02-01
AU5644290A (en) 1991-01-08
DE69004429T2 (de) 1994-03-31
BR9007433A (pt) 1992-06-16
DE69004429D1 (de) 1993-12-09
CA2060505A1 (en) 1990-12-13
DK0477198T3 (da) 1993-11-29
EP0477198B1 (de) 1993-11-03
KR0178274B1 (ko) 1999-04-01
US5101018A (en) 1992-03-31
RU2075509C1 (ru) 1997-03-20
WO1990015876A1 (en) 1990-12-27
JP2957695B2 (ja) 1999-10-06

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee