ATE99543T1 - Pulverfoermige zubereitungen zur intranasalen verabreichung von polypeptiden. - Google Patents

Pulverfoermige zubereitungen zur intranasalen verabreichung von polypeptiden.

Info

Publication number
ATE99543T1
ATE99543T1 AT88117029T AT88117029T ATE99543T1 AT E99543 T1 ATE99543 T1 AT E99543T1 AT 88117029 T AT88117029 T AT 88117029T AT 88117029 T AT88117029 T AT 88117029T AT E99543 T1 ATE99543 T1 AT E99543T1
Authority
AT
Austria
Prior art keywords
polypeptides
intranasal administration
powdered preparations
biologically active
powdered
Prior art date
Application number
AT88117029T
Other languages
English (en)
Inventor
Brian H Vickery
Cherng-Chyi Fu
Eric J Benjamin
Lynda M Sanders
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of ATE99543T1 publication Critical patent/ATE99543T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT88117029T 1987-10-15 1988-10-13 Pulverfoermige zubereitungen zur intranasalen verabreichung von polypeptiden. ATE99543T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10967887A 1987-10-15 1987-10-15
EP88117029A EP0312052B1 (de) 1987-10-15 1988-10-13 Pulverförmige Zubereitungen zur intranasalen Verabreichung von Polypeptiden

Publications (1)

Publication Number Publication Date
ATE99543T1 true ATE99543T1 (de) 1994-01-15

Family

ID=22328950

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88117029T ATE99543T1 (de) 1987-10-15 1988-10-13 Pulverfoermige zubereitungen zur intranasalen verabreichung von polypeptiden.

Country Status (11)

Country Link
US (3) US6521597B1 (de)
EP (1) EP0312052B1 (de)
JP (1) JP2851627B2 (de)
KR (1) KR890006252A (de)
AT (1) ATE99543T1 (de)
AU (1) AU623609B2 (de)
CA (1) CA1336401C (de)
DE (1) DE3886880T2 (de)
ES (1) ES2061591T3 (de)
NZ (1) NZ226557A (de)
ZA (1) ZA887658B (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8723846D0 (en) * 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
DE3886880T2 (de) * 1987-10-15 1994-07-14 Syntex Inc Pulverförmige Zubereitungen zur intranasalen Verabreichung von Polypeptiden.
US5554388A (en) * 1989-02-25 1996-09-10 Danbiosyst Uk Limited Systemic drug delivery compositions comprising a polycationi substance
GB9020544D0 (en) * 1990-09-20 1990-10-31 Sandoz Ltd Improvements in or relating to organic compounds
EP0565722A1 (de) * 1990-12-25 1993-10-20 Kyowa Hakko Kogyo Co., Ltd. Pharmazeutische zubereitung zur pernasalen verabreichung
WO1993006862A1 (en) * 1991-10-11 1993-04-15 Toray Industries, Inc. Antibody composition
WO1993019771A1 (fr) * 1992-03-27 1993-10-14 Kirin Brewery Company, Limited Preparation administrable par voie nasale contenant un facteur de stimulation de colonies granulocytaires
US5354934A (en) * 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
US6794357B1 (en) 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
US5830853A (en) 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
PT806945E (pt) 1994-12-22 2003-09-30 Astrazeneca Ab Preparacao terapeutica para inalacao que contem a hormona paratiroide, hpt
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
WO1996019198A1 (en) 1994-12-22 1996-06-27 Astra Aktiebolag Aerosol drug formulations
JP3098401B2 (ja) * 1995-07-12 2000-10-16 株式会社エルティーティー研究所 経鼻投与用製剤
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
CZ433898A3 (cs) * 1996-07-03 1999-04-14 Alza Corporation Nevodné protické peptidové formulace
US5981489A (en) * 1996-07-18 1999-11-09 Alza Corporation Non-aqueous protic peptide formulations
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6284282B1 (en) 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
US7303768B2 (en) 1998-07-24 2007-12-04 Seo Hong Yoo Preparation of aqueous clear solution dosage forms with bile acids
RU2224523C2 (ru) 1998-07-24 2004-02-27 Сео Хонг Ю Водный раствор, содержащий желчную кислоту, и способ его получения
US7772220B2 (en) 2004-10-15 2010-08-10 Seo Hong Yoo Methods and compositions for reducing toxicity of a pharmaceutical compound
WO2004028444A2 (en) * 1999-06-02 2004-04-08 Scantibodies Laboratory, Inc. Parathyroid hormone antagonists and uses thereof
US20080108086A1 (en) * 1999-06-02 2008-05-08 Cantor Thomas L Parathyroid hormone antagonists and uses thereof
CN100558407C (zh) 2000-02-04 2009-11-11 柳署弘 制备含有胆汁酸的澄清水溶液剂型
US7494669B2 (en) * 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
US20040152639A1 (en) * 2001-08-28 2004-08-05 Siler-Khodr Theresa M. Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
CA2466982A1 (en) * 2001-11-19 2003-05-30 Becton, Dickinson And Company Pharmaceutical compositions in particulate form
IL161446A0 (en) * 2001-11-26 2004-09-27 Daiichi Suntory Pharma Co Ltd Medicinal compositions for nasal absorption
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
WO2004087243A1 (ja) 2003-03-27 2004-10-14 Bioactis Limited 鼻腔用粉末薬剤施薬装置
US7145125B2 (en) 2003-06-23 2006-12-05 Advanced Optical Technologies, Llc Integrating chamber cone light using LED sources
CN103755800B (zh) * 2004-02-02 2016-02-24 Ambrx公司 经修饰的人类生长激素多肽与其用途
WO2006016530A1 (ja) 2004-08-10 2006-02-16 Translational Research, Ltd. 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
KR101414810B1 (ko) 2004-08-30 2014-07-18 주식회사 유스팜인터내셔널 국소 허혈 모델에서의 가용화 ｕｄｃａ의 신경보호 효과
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
US7115561B2 (en) * 2004-09-22 2006-10-03 Patterson James A Medicament composition and method of administration
ATE506955T1 (de) 2004-10-15 2011-05-15 Seo Hong Yoo Zusammensetzungen zur verringerung der toxizität von cisplatin, carboplatin und oxaliplatin
KR100834735B1 (ko) * 2004-11-15 2008-06-09 김두만 부신피질 기능 부전증 치료용 부신피질 자극 호르몬의비강 분무 제형
US20080260858A1 (en) * 2005-02-16 2008-10-23 The Board Of Trustees Of The University Of Illnois Universal Procoagulant
WO2006096345A2 (en) * 2005-03-04 2006-09-14 The Board Of Trustees Of The University Of Illinois Coagulation and fibrinolytic cascades modulator
US20080184618A1 (en) * 2005-08-03 2008-08-07 Amcol International Virus-Interacting Layered Phyllosilicates and Methods of Use
US20070031512A1 (en) * 2005-08-03 2007-02-08 Amcol International Corporation Virus-interacting layered phyllosilicates and methods of inactivating viruses
US20100272769A1 (en) * 2005-08-03 2010-10-28 Amcol International Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use
WO2007025286A2 (en) * 2005-08-26 2007-03-01 The Board Of Trustees Of The Leland Stanford Junior University Therapy procedure for drug delivery for trigeminal pain
WO2008005577A2 (en) * 2006-07-07 2008-01-10 University Of South Florida Compositions of polyphenols and methods of use
ES2652415T3 (es) 2006-12-26 2018-02-02 Shin Nippon Biomedical Laboratories, Ltd. Preparación para aplicación transnasal
PL2167069T3 (pl) 2007-05-23 2012-04-30 Amcol International Corp Krzemiany warstwowe oddziałujące z cholesterolem oraz sposoby zmniejszania hipercholesterolemii u ssaka
WO2009023125A1 (en) * 2007-08-14 2009-02-19 The Board Of Trustees Of The Leland Stanford Junior University Neuronostatin and its uses
JP2010539057A (ja) * 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 治療剤としてのヒト膵臓ポリペプチドの使用
WO2009046194A2 (en) * 2007-10-05 2009-04-09 The Board Of Trustees Of The University Of Illinois Fibrin sealant
US20100297257A1 (en) 2007-11-09 2010-11-25 National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) Anticoagulant antagonist and hemophillia procoagulant
EP2257173B1 (de) 2008-02-27 2014-07-30 Amcol International Corporation Protoniertes wasserstoffionen-austausch schichtschichtsilikat zur behandlung von atherosklerose
EP2429495A4 (de) * 2009-05-15 2014-01-22 Shin Nippon Biomedical Lab Ltd Intranasale pharmazeutische zusammensetzung mit verbesserter pharmakokinetik
GB2472327B (en) * 2009-07-31 2013-03-13 Shin Nippon Biomedical Lab Ltd Intranasal granisetron and nasal applicator
AU2015338717B2 (en) 2014-10-31 2018-12-20 Glaxosmithkline Intellectual Property Development Limited Powder formulation
US11389473B2 (en) 2015-01-07 2022-07-19 Tonix Pharmaceuticals Holding Corp. Magnesium-containing oxytocin formulations and methods of use
US20160361253A1 (en) * 2015-06-13 2016-12-15 Noveome Biotherapeutics, Inc. Novel Methods for Delivering Therapeutic Agents to the Eye via Nasal Passages
MX2018012351A (es) 2016-04-12 2019-02-07 Trigemina Inc Formulaciones de oxitocina que contienen magnesio y metodos de uso.
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
CN110279656B (zh) * 2019-07-11 2021-11-09 温州医科大学 一种用于缓解鼻腔干燥的组合物及其制备方法和使用方法
US20230233635A1 (en) 2020-05-26 2023-07-27 Rhodes Technologies Cannabinoid compositions and dosage forms for intranasal or inhalational delivery

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2465486A1 (fr) * 1979-09-21 1981-03-27 Roussel Uclaf Nouvelle application utilisant la lh-rh ou des agonistes
US4320118A (en) * 1980-12-22 1982-03-16 Syntex (U.S.A.) Inc. Deca-, undeca-, dodeca- and tridecapeptides with thymic activity
JPS58189118A (ja) * 1982-04-30 1983-11-04 Takeda Chem Ind Ltd 経鼻投与製剤
DE3372705D1 (en) * 1982-04-30 1987-09-03 Takeda Chemical Industries Ltd Pharmaceutical composition and its use
US4481190A (en) * 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4581169A (en) * 1982-12-21 1986-04-08 Syntex (U.S.A.) Inc. Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists
US4476116A (en) * 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
JPS59163313A (ja) * 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
US4746508A (en) * 1983-06-06 1988-05-24 Beth Israel Hospital Assn. Drug administration
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
US4659693A (en) * 1984-04-30 1987-04-21 Syntex (U.S.A.) Inc. N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides
JPS60258125A (ja) * 1984-06-06 1985-12-20 Hayashibara Biochem Lab Inc 蛋白性生理活性物質を含有する水溶性乾燥物
JPS6197229A (ja) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
US4690916A (en) * 1984-11-13 1987-09-01 Syntex (U.S.A.) Inc. Nona and decapeptide analogs of LHRH useful as LHRH antagonists
JPS61144949A (ja) * 1984-12-18 1986-07-02 Nec Corp 着信側加入者端末の状態監視方式
JPS61194034A (ja) * 1985-02-25 1986-08-28 Teijin Ltd 経鼻投与用粉末状組成物
JPS632932A (ja) * 1986-06-23 1988-01-07 Teijin Ltd 経鼻投与用粉末状組成物
US4758584A (en) * 1987-02-05 1988-07-19 Ciba-Geigy Corporation Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US5059587A (en) * 1987-08-03 1991-10-22 Toyo Jozo Company, Ltd. Physiologically active peptide composition for nasal administration
DE3886880T2 (de) * 1987-10-15 1994-07-14 Syntex Inc Pulverförmige Zubereitungen zur intranasalen Verabreichung von Polypeptiden.

Also Published As

Publication number Publication date
DE3886880T2 (de) 1994-07-14
ES2061591T3 (es) 1994-12-16
JPH01132532A (ja) 1989-05-25
EP0312052A1 (de) 1989-04-19
US20030181387A1 (en) 2003-09-25
US20050089480A1 (en) 2005-04-28
EP0312052B1 (de) 1994-01-05
ZA887658B (en) 1990-06-27
US6815424B2 (en) 2004-11-09
NZ226557A (en) 1990-07-26
AU623609B2 (en) 1992-05-21
KR890006252A (ko) 1989-06-12
AU2375188A (en) 1989-06-01
DE3886880D1 (de) 1994-02-17
CA1336401C (en) 1995-07-25
US6521597B1 (en) 2003-02-18
JP2851627B2 (ja) 1999-01-27

Similar Documents

Publication Publication Date Title
DE3886880D1 (de) Pulverförmige Zubereitungen zur intranasalen Verabreichung von Polypeptiden.
LV10196A (lv) Olbaltumviela biologiski aktivais hormons olbaltumvielas iegusanas panemiens farmaceitisks preparats
FI943563L (fi) Uusia biologisesti aktiivisia polypeptidejä, niiden valmistus ja niitä sisältävä farmaseuttinen koostumus
ATE261742T1 (de) Pulmonale verabreichung von medikamenten in aerosolform
DE69637961D1 (de) Verabreichung von biologisch aktiven polypeptiden
UA26855C2 (uk) Фармацевтичhа композиція, яка регулює гематопоез
IL74804A0 (en) Human physiologically active polypeptide,its production and pharmaceutical compositions containing it
YU59092A (sh) Formulacije aerosola koji ne sadrže hlorofluorougljenična jedinjenja
IL85136A0 (en) Peptide derivatives,their preparation and pharmaceutical compositions containing them
SE9703133L (sv) Farmaceutiska beredningar för intranasal administration
IL79235A0 (en) Pharmaceutical compositions containing solubilized proteins and their preparation
SE8501050D0 (sv) Biologically active fragments of human antihemophilic factor and method for preparation thereof
AU2724088A (en) Pharmaceutical compositions of recombinant interleukin-2 and formulation processes
FR2577557B1 (fr) Peptides et derives peptidiques, leur preparation, leur utilisation en therapeutique et compositions pharmaceutiques les contenant
EP0340333A3 (en) Novel physiologically active polypeptide and pharmaceutical composition
PT76314A (en) Process for the preparation of biologically active polysaccharide concentrates and of pharmaceutical and cosmetic compositions containing them
FR2768341B1 (fr) Composition pharmaceutique placebo lyophilisable destinee a imiter un medicament, notamment a base de proteines ou de polypeptides
EP0129582A4 (de) Biologisch aktive peptide und proteine für orale verabreichung.
FI864164A7 (fi) Ihmis- -interferonin biologisesti aktiivisia johdoksia, niiden valmistus ja tällaisia johdoksia sisältävlääkkeitä.
DE69528531D1 (de) D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
EP0230264A3 (en) Pharmaceutical composition for nasal application, process for its preparation and its use
NO912271L (no) Somatostatinpreparater, deres fremstilling og anvendelse.
SE8601457D0 (sv) Compositions of liposomes and b?712-receptor active substances for inhalation
NO863027L (no) Peptidpreparater med kontinuerlig avgivelse.
ES8703742A1 (es) Procedimiento para preparar un agente acuoso esteril de ac- cion retardada y prolongada,de un peptido o de una proteina

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time