ATE261742T1 - Pulmonale verabreichung von medikamenten in aerosolform - Google Patents
Pulmonale verabreichung von medikamenten in aerosolformInfo
- Publication number
- ATE261742T1 ATE261742T1 AT96911738T AT96911738T ATE261742T1 AT E261742 T1 ATE261742 T1 AT E261742T1 AT 96911738 T AT96911738 T AT 96911738T AT 96911738 T AT96911738 T AT 96911738T AT E261742 T1 ATE261742 T1 AT E261742T1
- Authority
- AT
- Austria
- Prior art keywords
- medications
- pulmonary administration
- aerosol form
- macromolecule
- carrier
- Prior art date
Links
- 230000002685 pulmonary effect Effects 0.000 title abstract 2
- 239000000443 aerosol Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 229920002521 macromolecule Polymers 0.000 abstract 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0233—Conductive materials, e.g. antistatic coatings for spark prevention
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/073—Syringe, piston type
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Nanotechnology (AREA)
- Biotechnology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- General Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/423,515 US6582728B1 (en) | 1992-07-08 | 1995-04-14 | Spray drying of macromolecules to produce inhaleable dry powders |
| PCT/US1996/005070 WO1996032149A1 (en) | 1995-04-14 | 1996-04-12 | Pulmonary delivery of aerosolized medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE261742T1 true ATE261742T1 (de) | 2004-04-15 |
Family
ID=23679173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96911738T ATE261742T1 (de) | 1995-04-14 | 1996-04-12 | Pulmonale verabreichung von medikamenten in aerosolform |
Country Status (11)
| Country | Link |
|---|---|
| US (10) | US6582728B1 (de) |
| EP (2) | EP1428524A1 (de) |
| JP (2) | JPH11503731A (de) |
| KR (1) | KR100466486B1 (de) |
| AT (1) | ATE261742T1 (de) |
| AU (1) | AU702150B2 (de) |
| CA (1) | CA2218116C (de) |
| DE (1) | DE69631881T2 (de) |
| ES (1) | ES2215191T3 (de) |
| MX (1) | MX9707855A (de) |
| WO (1) | WO1996032149A1 (de) |
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-
1995
- 1995-04-14 US US08/423,515 patent/US6582728B1/en not_active Expired - Lifetime
-
1996
- 1996-04-12 KR KR1019970707278A patent/KR100466486B1/ko not_active Expired - Fee Related
- 1996-04-12 WO PCT/US1996/005070 patent/WO1996032149A1/en not_active Ceased
- 1996-04-12 CA CA002218116A patent/CA2218116C/en not_active Expired - Fee Related
- 1996-04-12 EP EP04075809A patent/EP1428524A1/de not_active Ceased
- 1996-04-12 JP JP8531213A patent/JPH11503731A/ja not_active Withdrawn
- 1996-04-12 DE DE69631881T patent/DE69631881T2/de not_active Revoked
- 1996-04-12 AU AU54827/96A patent/AU702150B2/en not_active Ceased
- 1996-04-12 ES ES96911738T patent/ES2215191T3/es not_active Expired - Lifetime
- 1996-04-12 AT AT96911738T patent/ATE261742T1/de not_active IP Right Cessation
- 1996-04-12 MX MX9707855A patent/MX9707855A/es not_active IP Right Cessation
- 1996-04-12 EP EP96911738A patent/EP0825885B1/de not_active Revoked
-
1999
- 1999-11-22 US US09/447,753 patent/US6372258B1/en not_active Expired - Fee Related
-
2002
- 2002-02-01 US US10/066,106 patent/US20020127188A1/en not_active Abandoned
- 2002-02-08 US US10/072,430 patent/US6797258B2/en not_active Expired - Fee Related
- 2002-09-13 US US10/242,714 patent/US7097827B2/en not_active Expired - Lifetime
- 2002-12-06 US US10/313,961 patent/US20030198601A1/en not_active Abandoned
-
2003
- 2003-01-31 US US10/355,578 patent/US6921527B2/en not_active Expired - Fee Related
- 2003-03-14 US US10/388,814 patent/US20030185765A1/en not_active Abandoned
-
2006
- 2006-06-27 US US11/426,927 patent/US20070042048A1/en not_active Abandoned
-
2007
- 2007-01-26 US US11/627,884 patent/US20070122418A1/en not_active Abandoned
-
2008
- 2008-01-28 JP JP2008016775A patent/JP2008163033A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20020117170A1 (en) | 2002-08-29 |
| JPH11503731A (ja) | 1999-03-30 |
| US6921527B2 (en) | 2005-07-26 |
| US20030129141A1 (en) | 2003-07-10 |
| US6797258B2 (en) | 2004-09-28 |
| US20030198601A1 (en) | 2003-10-23 |
| DE69631881T2 (de) | 2004-08-19 |
| WO1996032149A1 (en) | 1996-10-17 |
| AU702150B2 (en) | 1999-02-18 |
| US20070042048A1 (en) | 2007-02-22 |
| DE69631881D1 (de) | 2004-04-22 |
| US6582728B1 (en) | 2003-06-24 |
| EP0825885A1 (de) | 1998-03-04 |
| EP0825885A4 (de) | 1998-08-26 |
| KR100466486B1 (ko) | 2005-06-16 |
| AU5482796A (en) | 1996-10-30 |
| US20030068279A1 (en) | 2003-04-10 |
| US6372258B1 (en) | 2002-04-16 |
| US7097827B2 (en) | 2006-08-29 |
| CA2218116A1 (en) | 1996-10-17 |
| ES2215191T3 (es) | 2004-10-01 |
| US20020127188A1 (en) | 2002-09-12 |
| EP0825885B1 (de) | 2004-03-17 |
| MX9707855A (es) | 1998-02-28 |
| US20030185765A1 (en) | 2003-10-02 |
| KR19980703878A (ko) | 1998-12-05 |
| EP1428524A1 (de) | 2004-06-16 |
| CA2218116C (en) | 2009-12-08 |
| US20070122418A1 (en) | 2007-05-31 |
| JP2008163033A (ja) | 2008-07-17 |
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| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |