AU740928C - New disubstituted trans-3,4,4a,5,6,10b-hexahydro-2H-naphth (1,2-b)-1,4-oxazines, a process for their preparation and pharmaceutical compositions containing them - Google Patents

New disubstituted trans-3,4,4a,5,6,10b-hexahydro-2H-naphth (1,2-b)-1,4-oxazines, a process for their preparation and pharmaceutical compositions containing them

Info

Publication number: AU740928C
Authority: AU; Australia
Prior art keywords: oxazines; hexahydro; naphth; preparation; pharmaceutical compositions
Prior art date: 1997-09-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU83024/98A

Other languages

English (en)

Other versions

AU740928B2 (en

AU8302498A (en

Inventor

Jean-Christophe Harmange

Francoise Lejeune

Mark Millan

Jean-Louis Peglion

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Les Laboratoires Servier SAS

Original Assignee

Les Laboratoires Servier SAS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-01

Filing date

1998-09-01

Publication date

2002-05-16

1998-09-01 Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS

1999-03-11 Publication of AU8302498A publication Critical patent/AU8302498A/en

2001-11-15 Publication of AU740928B2 publication Critical patent/AU740928B2/en

2001-11-29 Assigned to LES LABORATOIRES SERVIER reassignment LES LABORATOIRES SERVIER Alteration of Name(s) of Applicant(s) under S113 Assignors: ADIR ET COMPAGNIE

2002-05-16 Application granted granted Critical

2002-05-16 Publication of AU740928C publication Critical patent/AU740928C/en

2018-09-01 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AU83024/98A 1997-09-01 1998-09-01 New disubstituted trans-3,4,4a,5,6,10b-hexahydro-2H-naphth (1,2-b)-1,4-oxazines, a process for their preparation and pharmaceutical compositions containing them Ceased AU740928C (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9710852A FR2767825A1 (fr)	1997-09-01	1997-09-01	Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR97/10852		1997-09-01

Publications (3)

Publication Number	Publication Date
AU8302498A AU8302498A (en)	1999-03-11
AU740928B2 AU740928B2 (en)	2001-11-15
AU740928C true AU740928C (en)	2002-05-16

Family

ID=9510643

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU83024/98A Ceased AU740928C (en)	1997-09-01	1998-09-01	New disubstituted trans-3,4,4a,5,6,10b-hexahydro-2H-naphth (1,2-b)-1,4-oxazines, a process for their preparation and pharmaceutical compositions containing them

Country Status (18)

Country	Link
US (1)	US6025356A (2)
EP (1)	EP0899267B1 (2)
JP (1)	JP4417451B2 (2)
CN (1)	CN1088064C (2)
AT (1)	ATE229513T1 (2)
AU (1)	AU740928C (2)
BR (1)	BR9803933A (2)
CA (1)	CA2246482C (2)
DE (1)	DE69810034T2 (2)
DK (1)	DK0899267T3 (2)
ES (1)	ES2189108T3 (2)
FR (1)	FR2767825A1 (2)
HU (1)	HU226059B1 (2)
NO (1)	NO311218B1 (2)
NZ (1)	NZ331637A (2)
PL (1)	PL194533B1 (2)
PT (1)	PT899267E (2)
ZA (1)	ZA987963B (2)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0130219D0 (en) *	2001-12-18	2002-02-06	Pfizer Ltd	Compounds for the treatment of sexual dysfunction
AU2003268292A1 (en) *	2002-08-30	2004-03-19	Biostratum, Inc.	Inhibitors of post-amadori advanced glycation end products
BRPI0409492A (pt) *	2003-04-18	2006-05-02	Pharmacia & Up John Company Ll	terapias de combinação
FR2906249B1 (fr) *	2006-09-26	2008-12-19	Servier Lab	Composes tetracycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2098511A1 (en)	2008-03-07	2009-09-09	Solvias AG	Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring
JP2011525893A (ja) *	2008-06-27	2011-09-29	ハー・ルンドベック・アクチエゼルスカベット	新規のフェノールアミン類およびカテコールアミン類ならびにそのプロドラッグ

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0080115A2 (en) *	1981-11-20	1983-06-01	Merck & Co. Inc.	Hexahydronaphth(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4420480A (en) *	1981-11-20	1983-12-13	Merck & Co., Inc.	Hexahydronaphth[1,2-b]-1,4-oxazines
US4540691A (en) *	1984-04-13	1985-09-10	Nelson Research & Development Co.	Dopamine agonists and use thereof
US5486611A (en) *	1989-07-13	1996-01-23	The Upjohn Company	Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives
CA2083146A1 (en) *	1990-06-15	1991-12-16	Gevork Minaskanian	Substituted naphthoxazines useful as dopaminergics

1997
- 1997-09-01 FR FR9710852A patent/FR2767825A1/fr active Pending
1998
- 1998-08-31 US US09/144,025 patent/US6025356A/en not_active Expired - Lifetime
- 1998-08-31 HU HU9801951A patent/HU226059B1/hu not_active IP Right Cessation
- 1998-08-31 PL PL328285A patent/PL194533B1/pl not_active IP Right Cessation
- 1998-08-31 CA CA002246482A patent/CA2246482C/fr not_active Expired - Fee Related
- 1998-08-31 CN CN98119987A patent/CN1088064C/zh not_active Expired - Fee Related
- 1998-08-31 NO NO19984007A patent/NO311218B1/no not_active IP Right Cessation
- 1998-08-31 BR BR9803933-4A patent/BR9803933A/pt not_active Application Discontinuation
- 1998-08-31 NZ NZ331637A patent/NZ331637A/xx not_active IP Right Cessation
- 1998-09-01 DE DE69810034T patent/DE69810034T2/de not_active Expired - Lifetime
- 1998-09-01 ES ES98402155T patent/ES2189108T3/es not_active Expired - Lifetime
- 1998-09-01 PT PT98402155T patent/PT899267E/pt unknown
- 1998-09-01 ZA ZA987963A patent/ZA987963B/xx unknown
- 1998-09-01 JP JP24691098A patent/JP4417451B2/ja not_active Expired - Fee Related
- 1998-09-01 AU AU83024/98A patent/AU740928C/en not_active Ceased
- 1998-09-01 AT AT98402155T patent/ATE229513T1/de active
- 1998-09-01 EP EP98402155A patent/EP0899267B1/fr not_active Expired - Lifetime
- 1998-09-01 DK DK98402155T patent/DK0899267T3/da active

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0080115A2 (en) *	1981-11-20	1983-06-01	Merck & Co. Inc.	Hexahydronaphth(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them

Also Published As

Publication number	Publication date
ATE229513T1 (de)	2002-12-15
PT899267E (pt)	2003-04-30
JP4417451B2 (ja)	2010-02-17
EP0899267B1 (fr)	2002-12-11
NO984007D0 (no)	1998-08-31
CN1088064C (zh)	2002-07-24
EP0899267A1 (fr)	1999-03-03
ES2189108T3 (es)	2003-07-01
US6025356A (en)	2000-02-15
AU740928B2 (en)	2001-11-15
DE69810034D1 (de)	2003-01-23
HK1020340A1 (en)	2000-04-14
NO984007L (no)	1999-03-02
AU8302498A (en)	1999-03-11
CA2246482C (fr)	2002-11-26
HU9801951D0 (en)	1998-11-30
CN1222516A (zh)	1999-07-14
FR2767825A1 (fr)	1999-02-26
NZ331637A (en)	1999-07-29
CA2246482A1 (fr)	1999-03-01
HU226059B1 (en)	2008-04-28
BR9803933A (pt)	2001-04-24
PL328285A1 (en)	1999-03-15
DK0899267T3 (da)	2003-03-10
ZA987963B (en)	1999-03-04
JPH11130759A (ja)	1999-05-18
HUP9801951A2 (hu)	2000-02-28
PL194533B1 (pl)	2007-06-29
HUP9801951A3 (en)	2000-04-28
NO311218B1 (no)	2001-10-29
DE69810034T2 (de)	2003-08-14

Legal Events

Date	Code	Title	Description
2001-11-15	DA2	Applications for amendment section 104	Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20011005
2001-11-29	PC1	Assignment before grant (sect. 113)	Owner name: LES LABORATOIRES SERVIER Free format text: THE FORMER OWNER WAS: ADIR ET COMPAGNIE
2001-12-20	DA3	Amendments made section 104	Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ MARK MILLAN
2002-03-14	FGA	Letters patent sealed or granted (standard patent)
2002-05-16	DA3	Amendments made section 104	Free format text: THE NATURE OF THE AMENDMENT IS AS WAS NOTIFIED IN THE OFFICIAL JOURNAL DATED 20011115

Publication	Publication Date	Title
AU2464997A (en)	1997-12-11	New 3-(piperid-4-YL)-1,2-benzisoxazole and 3-piperazin-4-YL)-1,2-benzisoxazole compounds, processes for their preparation and pharmaceutical compositions containing them
AU8952291A (en)	1992-06-25	2-arylthiazole derivative and pharmaceutical composition containing the same
HUP0000610A2 (hu)	2000-09-28	Fájdalomcsillapító hatású piperidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
DE68908040D1 (de)	1993-09-09	3-(4-piperidin)-5-(2-sulphonylaminoethyl)-indol-derivate.
NO20025035D0 (no)	2002-10-18	Oksadiazolderivater som har anticancer-effekter
ZA987963B (en)	1999-03-04	Disubstituted trans-3,4,4a,5,6,10b-haxahydro-2H-naphth(1,2-b)-1,4-oxazines a process for their preparation and pharmaceutical compositions containing them
AU5473596A (en)	1996-12-19	New indole, indazole benzisoxazole compounds, their process of preparation and the pharmaceutical compositions which contain them
HU0000308D0 (en)	2000-03-28	New cyano-indole serotonin-reuptake inhibitor compounds, a process for their preparation and pharmaceutical compositions containing them
ATE149165T1 (de)	1997-03-15	Stickstoff enthaltende bizyklische derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
AU7170496A (en)	1997-05-15	New tetracyclic 1,4-oxazine compounds, a process for their preparation and pharmaceutical compositions containing them
IL116386A (en)	1999-06-20	Preparation of pharmaceutical compositions containing 1,2-bridged 1,4-dihydropyridines for the control of cns disorders and sickle cell anemia certain such novel compounds and their preparation
IL95322A0 (en)	1991-06-30	2-oxo-1-oxa-8-azaspiro(4,5)decane derivatives,their preparation and pharmaceutical compositions containing them
AU4012393A (en)	1993-12-16	New diacylglycerol nicotinates, process for their preparation and pharmaceutical compositions which contain them
AU2052395A (en)	1995-12-14	New tetracyclic piperidine and 1,4-oxazine compounds, a process for their preparation and pharmaceutical compositions containing them
AU1494295A (en)	1995-09-28	Novel aminoalkyl benzothiazolinones, process for their preparation and the pharmaceutical compositions which contain them
AU657423B2 (en)	1995-03-09	Novel piperidine derivatives and process for preparation thereof
IL94748A0 (en)	1991-04-15	Thioformamide derivatives,process for their preparation and pharmaceutical compositions containing them
AT389309B (de)	1989-11-27	Malonsaeurederivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzung, enthaltend diese verbindungen