ZA987963B - Disubstituted trans-3,4,4a,5,6,10b-haxahydro-2H-naphth(1,2-b)-1,4-oxazines a process for their preparation and pharmaceutical compositions containing them - Google Patents

Disubstituted trans-3,4,4a,5,6,10b-haxahydro-2H-naphth(1,2-b)-1,4-oxazines a process for their preparation and pharmaceutical compositions containing them

Info

Publication number: ZA987963B
Authority: ZA; South Africa
Prior art keywords: oxazines; haxahydro; naphth; preparation; pharmaceutical compositions
Prior art date: 1997-09-01

Application number

ZA987963A

Other languages

English (en)

Inventor

Jean-Louis Peglion

Jean-Christophe Harmange

Mark Millan

Francoise Lejeune

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-01

Filing date

1998-09-01

Publication date

1999-03-04

1998-09-01 Application filed by Adir filed Critical Adir

1999-03-04 Publication of ZA987963B publication Critical patent/ZA987963B/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA987963A 1997-09-01 1998-09-01 Disubstituted trans-3,4,4a,5,6,10b-haxahydro-2H-naphth(1,2-b)-1,4-oxazines a process for their preparation and pharmaceutical compositions containing them ZA987963B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9710852A FR2767825A1 (fr)	1997-09-01	1997-09-01	Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ZA987963B true ZA987963B (en)	1999-03-04

Family

ID=9510643

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA987963A ZA987963B (en)	1997-09-01	1998-09-01	Disubstituted trans-3,4,4a,5,6,10b-haxahydro-2H-naphth(1,2-b)-1,4-oxazines a process for their preparation and pharmaceutical compositions containing them

Country Status (18)

Country	Link
US (1)	US6025356A (2)
EP (1)	EP0899267B1 (2)
JP (1)	JP4417451B2 (2)
CN (1)	CN1088064C (2)
AT (1)	ATE229513T1 (2)
AU (1)	AU740928C (2)
BR (1)	BR9803933A (2)
CA (1)	CA2246482C (2)
DE (1)	DE69810034T2 (2)
DK (1)	DK0899267T3 (2)
ES (1)	ES2189108T3 (2)
FR (1)	FR2767825A1 (2)
HU (1)	HU226059B1 (2)
NO (1)	NO311218B1 (2)
NZ (1)	NZ331637A (2)
PL (1)	PL194533B1 (2)
PT (1)	PT899267E (2)
ZA (1)	ZA987963B (2)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0130219D0 (en) *	2001-12-18	2002-02-06	Pfizer Ltd	Compounds for the treatment of sexual dysfunction
AU2003268292A1 (en) *	2002-08-30	2004-03-19	Biostratum, Inc.	Inhibitors of post-amadori advanced glycation end products
BRPI0409492A (pt) *	2003-04-18	2006-05-02	Pharmacia & Up John Company Ll	terapias de combinação
FR2906249B1 (fr) *	2006-09-26	2008-12-19	Servier Lab	Composes tetracycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2098511A1 (en)	2008-03-07	2009-09-09	Solvias AG	Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring
JP2011525893A (ja) *	2008-06-27	2011-09-29	ハー・ルンドベック・アクチエゼルスカベット	新規のフェノールアミン類およびカテコールアミン類ならびにそのプロドラッグ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1204745A (en) *	1981-11-20	1986-05-20	Merck Co.	Hexahydronaphth (1,2-b) -1,4 -oxazines
US4420480A (en) *	1981-11-20	1983-12-13	Merck & Co., Inc.	Hexahydronaphth[1,2-b]-1,4-oxazines
US4540691A (en) *	1984-04-13	1985-09-10	Nelson Research & Development Co.	Dopamine agonists and use thereof
US5486611A (en) *	1989-07-13	1996-01-23	The Upjohn Company	Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives
CA2083146A1 (en) *	1990-06-15	1991-12-16	Gevork Minaskanian	Substituted naphthoxazines useful as dopaminergics

1997
- 1997-09-01 FR FR9710852A patent/FR2767825A1/fr active Pending
1998
- 1998-08-31 US US09/144,025 patent/US6025356A/en not_active Expired - Lifetime
- 1998-08-31 HU HU9801951A patent/HU226059B1/hu not_active IP Right Cessation
- 1998-08-31 PL PL328285A patent/PL194533B1/pl not_active IP Right Cessation
- 1998-08-31 CA CA002246482A patent/CA2246482C/fr not_active Expired - Fee Related
- 1998-08-31 CN CN98119987A patent/CN1088064C/zh not_active Expired - Fee Related
- 1998-08-31 NO NO19984007A patent/NO311218B1/no not_active IP Right Cessation
- 1998-08-31 BR BR9803933-4A patent/BR9803933A/pt not_active Application Discontinuation
- 1998-08-31 NZ NZ331637A patent/NZ331637A/xx not_active IP Right Cessation
- 1998-09-01 DE DE69810034T patent/DE69810034T2/de not_active Expired - Lifetime
- 1998-09-01 ES ES98402155T patent/ES2189108T3/es not_active Expired - Lifetime
- 1998-09-01 PT PT98402155T patent/PT899267E/pt unknown
- 1998-09-01 ZA ZA987963A patent/ZA987963B/xx unknown
- 1998-09-01 JP JP24691098A patent/JP4417451B2/ja not_active Expired - Fee Related
- 1998-09-01 AU AU83024/98A patent/AU740928C/en not_active Ceased
- 1998-09-01 AT AT98402155T patent/ATE229513T1/de active
- 1998-09-01 EP EP98402155A patent/EP0899267B1/fr not_active Expired - Lifetime
- 1998-09-01 DK DK98402155T patent/DK0899267T3/da active

Also Published As

Publication number	Publication date
ATE229513T1 (de)	2002-12-15
PT899267E (pt)	2003-04-30
JP4417451B2 (ja)	2010-02-17
EP0899267B1 (fr)	2002-12-11
NO984007D0 (no)	1998-08-31
CN1088064C (zh)	2002-07-24
EP0899267A1 (fr)	1999-03-03
ES2189108T3 (es)	2003-07-01
US6025356A (en)	2000-02-15
AU740928B2 (en)	2001-11-15
DE69810034D1 (de)	2003-01-23
HK1020340A1 (en)	2000-04-14
NO984007L (no)	1999-03-02
AU8302498A (en)	1999-03-11
CA2246482C (fr)	2002-11-26
HU9801951D0 (en)	1998-11-30
CN1222516A (zh)	1999-07-14
FR2767825A1 (fr)	1999-02-26
NZ331637A (en)	1999-07-29
AU740928C (en)	2002-05-16
CA2246482A1 (fr)	1999-03-01
HU226059B1 (en)	2008-04-28
BR9803933A (pt)	2001-04-24
PL328285A1 (en)	1999-03-15
DK0899267T3 (da)	2003-03-10
JPH11130759A (ja)	1999-05-18
HUP9801951A2 (hu)	2000-02-28
PL194533B1 (pl)	2007-06-29
HUP9801951A3 (en)	2000-04-28
NO311218B1 (no)	2001-10-29
DE69810034T2 (de)	2003-08-14

Publication	Publication Date	Title
HU9700992D0 (en)	1997-07-28	New 3-(piperid-4-yl)1,2-benzisoxazole and 3-(piperazin-4-yl)-1,2-benzisoxazole compounds, process for their preparation and pharmaceutical compositions containing them
EP0513379A4 (en)	1993-09-01	2-arylthiazole derivative and pharmaceutical composition containing the same
HUP0000610A2 (hu)	2000-09-28	Fájdalomcsillapító hatású piperidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
DE68908040D1 (de)	1993-09-09	3-(4-piperidin)-5-(2-sulphonylaminoethyl)-indol-derivate.
NO20025035D0 (no)	2002-10-18	Oksadiazolderivater som har anticancer-effekter
AU740928C (en)	2002-05-16	New disubstituted trans-3,4,4a,5,6,10b-hexahydro-2H-naphth (1,2-b)-1,4-oxazines, a process for their preparation and pharmaceutical compositions containing them
ZA964842B (en)	1997-01-07	Indole indazole and benzisoxazole compounds their process of preparation and the pharmaceutical compositions which contain them
ZA200000336B (en)	2000-08-15	Cyano-indole serotonin-reuptake inhibitor compounds, a process for their preparation and pharmaceutical compositions containing them.
GR3035432T3 (en)	2001-05-31	Tetracyclic 1,4-oxazine compounds, process for their preparation and pharmaceutical compositions containing them
IL116386A (en)	1999-06-20	Preparation of pharmaceutical compositions containing 1,2-bridged 1,4-dihydropyridines for the control of cns disorders and sickle cell anemia certain such novel compounds and their preparation
ATE349462T1 (de)	2007-01-15	Thiazolidin-derivate
NO972943L (no)	1997-12-29	4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, fremgangsmåter for deres fremstilling, legemidler inneholdende dem og deres anvendelse
IL95322A0 (en)	1991-06-30	2-oxo-1-oxa-8-azaspiro(4,5)decane derivatives,their preparation and pharmaceutical compositions containing them
AU2052395A (en)	1995-12-14	New tetracyclic piperidine and 1,4-oxazine compounds, a process for their preparation and pharmaceutical compositions containing them
AU1494295A (en)	1995-09-28	Novel aminoalkyl benzothiazolinones, process for their preparation and the pharmaceutical compositions which contain them
AT389309B (de)	1989-11-27	Malonsaeurederivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzung, enthaltend diese verbindungen