AU752095B2 - Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha1-blocking action - Google Patents

Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha1-blocking action Download PDF

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Publication number
AU752095B2
AU752095B2 AU16906/99A AU1690699A AU752095B2 AU 752095 B2 AU752095 B2 AU 752095B2 AU 16906/99 A AU16906/99 A AU 16906/99A AU 1690699 A AU1690699 A AU 1690699A AU 752095 B2 AU752095 B2 AU 752095B2
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AU
Australia
Prior art keywords
compound
mmol
group
pct
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU16906/99A
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English (en)
Other versions
AU1690699A (en
Inventor
Harukazu Fukami
Norio Inomata
Tomoe Kamei
Akira Mizuno
Makoto Shibata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asubio Pharma Co Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Publication of AU1690699A publication Critical patent/AU1690699A/en
Application granted granted Critical
Publication of AU752095B2 publication Critical patent/AU752095B2/en
Assigned to DAIICHI SUNTORY PHARMA CO., LTD reassignment DAIICHI SUNTORY PHARMA CO., LTD Alteration of Name(s) in Register under S187 Assignors: SUNTORY LIMITED
Assigned to DAIICHI ASUBIO PHARMA CO., LTD. reassignment DAIICHI ASUBIO PHARMA CO., LTD. Request to Amend Deed and Register Assignors: DAIICHI SUNTORY PHARMA CO., LTD
Assigned to ASUBIO PHARMA CO., LTD. reassignment ASUBIO PHARMA CO., LTD. Request to Amend Deed and Register Assignors: DAIICHI ASUBIO PHARMA CO., LTD.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU16906/99A 1997-12-26 1998-12-25 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha1-blocking action Ceased AU752095B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9-366756 1997-12-26
JP9366756A JPH11193289A (ja) 1997-12-26 1997-12-26 ピロールスルホンアミド誘導体
PCT/JP1998/005954 WO1999033840A2 (en) 1997-12-26 1998-12-25 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha1-blocking action

Publications (2)

Publication Number Publication Date
AU1690699A AU1690699A (en) 1999-07-19
AU752095B2 true AU752095B2 (en) 2002-09-05

Family

ID=18487593

Family Applications (1)

Application Number Title Priority Date Filing Date
AU16906/99A Ceased AU752095B2 (en) 1997-12-26 1998-12-25 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha1-blocking action

Country Status (9)

Country Link
US (3) US6271223B1 (2)
EP (1) EP0970088A2 (2)
JP (1) JPH11193289A (2)
KR (1) KR20000075641A (2)
CN (2) CN1148372C (2)
AU (1) AU752095B2 (2)
CA (1) CA2282458A1 (2)
HU (1) HUP0002291A3 (2)
WO (1) WO1999033840A2 (2)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2212092A1 (en) 1995-12-01 1997-06-12 Makoto Shibata Pyrroloazepine derivatives
JPH11193290A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド系化合物
JPH11193289A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
ATE317846T1 (de) * 2000-03-31 2006-03-15 Purdue Research Foundation Phosphoramidat-prodrugs
WO2018236745A1 (en) 2017-06-20 2018-12-27 Carnot, Llc COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CARDIAC METABOLISM
EP4497474A3 (en) 2018-10-17 2025-04-23 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
EP3976101A4 (en) 2019-05-31 2023-06-21 Imbria Pharmaceuticals, Inc. FIBROSIS TREATMENT METHODS USING COMPOUNDS THAT PROMOTE GLUCOSE OXIDATION
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US208631A (en) 1878-10-01 Improvement in trimmers for wax-thread sewing-machines
US236765A (en) 1881-01-18 Attoenet
US240178A (en) 1881-04-12 Feeding device for button-hole sewing-machines
JP3198117B2 (ja) 1990-02-07 2001-08-13 サントリー株式会社 ピロロアゼピン誘導体
US5075440A (en) 1990-05-03 1991-12-24 Ortho Pharmaceutical Corporation Novel pyrido[2,3-f](1,4)thiazepines and pyrido[3,2-b](1,5)benzothiazepines
FR2675802B1 (fr) * 1991-04-26 1993-12-24 Rhone Poulenc Rorer Sa Antiserotonines, leur preparation et les medicaments les contenant.
EP0557526B8 (en) 1991-08-07 2003-08-13 Daiichi Suntory Pharma Co., Ltd. Pyrroloazepine compound
CA2093631C (en) 1991-08-07 2003-09-23 Akira Mizuno Pyrroloazepine derivative
IL108634A0 (en) * 1993-02-15 1994-05-30 Wellcome Found Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them
CA2156849A1 (en) * 1993-12-24 1995-07-06 Akira Mizuno Benzothiazine derivative
DE69630184T2 (de) 1995-11-02 2004-08-12 Daiichi Suntory Pharma Co., Ltd. Verfahren zur Herstellung von 1-substituierten Pyrrol-3-carbonsäure-Derivaten
CA2212092A1 (en) 1995-12-01 1997-06-12 Makoto Shibata Pyrroloazepine derivatives
JPH10251258A (ja) 1997-03-14 1998-09-22 Suntory Ltd ピロロアゼピン系化合物
JPH11193289A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
JPH11193290A (ja) * 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド系化合物

Also Published As

Publication number Publication date
US7057036B2 (en) 2006-06-06
HUP0002291A3 (en) 2002-12-28
US20020040017A1 (en) 2002-04-04
KR20000075641A (ko) 2000-12-26
US6271223B1 (en) 2001-08-07
AU1690699A (en) 1999-07-19
CN1148372C (zh) 2004-05-05
CN1282643C (zh) 2006-11-01
WO1999033840A3 (en) 1999-09-10
CA2282458A1 (en) 1999-07-08
EP0970088A2 (en) 2000-01-12
US20050038242A2 (en) 2005-02-17
CN1528746A (zh) 2004-09-15
WO1999033840A2 (en) 1999-07-08
US6624314B2 (en) 2003-09-23
CN1260798A (zh) 2000-07-19
US20040127705A1 (en) 2004-07-01
WO1999033840B1 (en) 1999-10-14
HUP0002291A2 (hu) 2001-04-28
JPH11193289A (ja) 1999-07-21

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PC Assignment registered

Owner name: DAIICHI SUNTORY PHARMA CO., LTD

Free format text: FORMER OWNER WAS: SUNTORY LIMITED