AU762039B2 - Gardos channel antagonists - Google Patents

Gardos channel antagonists Download PDF

Info

Publication number: AU762039B2
Authority: AU; Australia
Prior art keywords: substituent; compound; ring; acetamide; para
Prior art date: 1999-02-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU28807/00A

Other languages

English (en)

Other versions

AU2880700A (en

Inventor

Grant Andrew Mcnaughton-Smith

Gregory Cooksey Rigdon

Jonathan Walter Stocker

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Icagen Inc

Original Assignee

Icagen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-23

Filing date

2000-02-10

Publication date

2003-06-19

2000-02-10 Application filed by Icagen Inc filed Critical Icagen Inc

2000-09-14 Publication of AU2880700A publication Critical patent/AU2880700A/en

2003-06-19 Application granted granted Critical

2003-06-19 Publication of AU762039B2 publication Critical patent/AU762039B2/en

2020-02-10 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

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231100000956 nontoxicity Toxicity 0.000 description 1
239000002773 nucleotide Substances 0.000 description 1
125000003729 nucleotide group Chemical group 0.000 description 1
230000008816 organ damage Effects 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
239000012044 organic layer Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000003791 organic solvent mixture Substances 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
238000006213 oxygenation reaction Methods 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000037361 pathway Effects 0.000 description 1
229960001476 pentoxifylline Drugs 0.000 description 1
230000002688 persistence Effects 0.000 description 1
239000012071 phase Substances 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
239000008389 polyethoxylated castor oil Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
150000003109 potassium Chemical class 0.000 description 1
229910001414 potassium ion Inorganic materials 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
239000011369 resultant mixture Substances 0.000 description 1
230000000979 retarding effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
229940100486 rice starch Drugs 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
SCTZUZTYRMOMKT-UHFFFAOYSA-N senicapoc Chemical compound C=1C=C(F)C=CC=1C(C=1C=CC(F)=CC=1)(C(=O)N)C1=CC=CC=C1 SCTZUZTYRMOMKT-UHFFFAOYSA-N 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
238000004904 shortening Methods 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000012439 solid excipient Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000008685 targeting Effects 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000011285 therapeutic regimen Methods 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
231100000440 toxicity profile Toxicity 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
150000003852 triazoles Chemical class 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
OHSJPLSEQNCRLW-UHFFFAOYSA-N triphenylmethyl radical Chemical compound C1=CC=CC=C1[C](C=1C=CC=CC=1)C1=CC=CC=C1 OHSJPLSEQNCRLW-UHFFFAOYSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
239000004474 valine Substances 0.000 description 1
125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
208000021331 vascular occlusion disease Diseases 0.000 description 1
210000005166 vasculature Anatomy 0.000 description 1
208000003663 ventricular fibrillation Diseases 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AU28807/00A 1999-02-23 2000-02-10 Gardos channel antagonists Ceased AU762039B2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US13551199P	1999-02-23	1999-02-23
US60/135511		1999-02-23
US09/386601		1999-08-31
US09/386,601 US6288122B1 (en)	1999-02-23	1999-08-31	Gardos channel antagonists
PCT/US2000/003663 WO2000050026A1 (en)	1999-02-23	2000-02-10	Gardos channel antagonists

Publications (2)

Publication Number	Publication Date
AU2880700A AU2880700A (en)	2000-09-14
AU762039B2 true AU762039B2 (en)	2003-06-19

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ID=26833406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU28807/00A Ceased AU762039B2 (en)	1999-02-23	2000-02-10	Gardos channel antagonists

Country Status (16)

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US (1)	US6288122B1 (2)
EP (1)	EP1158971B1 (2)
JP (2)	JP4038337B2 (2)
KR (1)	KR100705726B1 (2)
CN (1)	CN1193748C (2)
AP (1)	AP1465A (2)
AT (1)	ATE370728T1 (2)
AU (1)	AU762039B2 (2)
BR (1)	BR0008416A (2)
CA (1)	CA2371857C (2)
DE (1)	DE60036093T2 (2)
ES (1)	ES2291191T3 (2)
HK (1)	HK1045262B (2)
IL (2)	IL145012A0 (2)
OA (1)	OA11838A (2)
WO (1)	WO2000050026A1 (2)

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WO2003004010A1 (en) *	2001-07-06	2003-01-16	Poseidon Pharmaceuticals A/S	Carbonylamino derivatives useful for obtaining immune regulation
EP1465863B1 (en)	2002-01-04	2008-07-09	NeuroSearch A/S	Potassium channel modulators
AU2003217810C9 (en) *	2002-02-28	2008-06-12	Icagen, Inc.	Methods for treating diseases related to intraocular pressure
WO2005003143A1 (en) *	2003-07-03	2005-01-13	Poseidon Pharmaceuticals A/S	Novel potassium channel modulators
WO2005003094A1 (en) *	2003-07-03	2005-01-13	Poseidon Pharmaceuticals A/S	Diarylmethyl derivatives as potassium channel modulators
WO2006084031A1 (en) *	2005-02-01	2006-08-10	Icagen, Inc.	Imines as ion channel modulators
US20100056637A1 (en) *	2005-12-20	2010-03-04	Icagen, Inc.	Treatment methods using triaryl methane compounds
EP1968563A4 (en) *	2005-12-20	2010-05-19	Icagen Inc	TREATMENT METHODS USING TRIARYLMETHANE COMPOUNDS
PT2192896E (pt)	2007-08-24	2011-04-04	Neurosearch As	Derivados de carbonilamino úteis para o tratamento de doença inflamatória intestinal
US20090076157A1 (en) *	2007-09-15	2009-03-19	Protia, Llc	Deuterium-enriched senicapoc
EA023596B1 (ru)	2008-04-09	2016-06-30	Сирус Корпорейшн	Способы обработки композиции эритроцитов для инактивации патогена
EP2358750B1 (en)	2008-11-10	2017-01-11	Boehringer Ingelheim International GmbH	Compositions and methods for modulating cell-cell fusion via intermediate-conductance calcium-activated potassium channels
WO2016134353A1 (en) *	2015-02-20	2016-08-25	Children's Medical Center Corporation	Methods for treating malaria using potassium channel inhibitors
EP3106155A1 (en)	2015-06-15	2016-12-21	Universite d'Aix Marseille	Treatment and diagnosis of hereditary xerocytosis
AU2017350760B2 (en) *	2016-10-25	2022-03-31	Paracelsus Neuroscience I, LIc	Use of senicapoc for treatment of neuropathic pain
WO2018162426A1 (en)	2017-03-06	2018-09-13	INSERM (Institut National de la Santé et de la Recherche Médicale)	Treatment and diagnosis of hereditary xerocytosis
WO2020198939A1 (zh) *	2019-03-29	2020-10-08	深圳仁泰医药科技有限公司	2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用
US12186286B2 (en) *	2019-07-29	2025-01-07	Paracelsus Neuroscience Llc	Use of senicapoc for treatment of stroke
CN115943138A (zh) *	2020-07-14	2023-04-07	阿迪玛生物有限责任公司	包含gardos通道拮抗剂的组合物及其用途
CA3201648A1 (en) *	2020-12-11	2022-06-16	Robin VAN BRUGGEN	Treatment and prevention of anaemia of inflammation

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1999
- 1999-08-31 US US09/386,601 patent/US6288122B1/en not_active Expired - Lifetime
2000
- 2000-02-10 DE DE60036093T patent/DE60036093T2/de not_active Expired - Lifetime
- 2000-02-10 ES ES00907283T patent/ES2291191T3/es not_active Expired - Lifetime
- 2000-02-10 BR BR0008416-6A patent/BR0008416A/pt not_active IP Right Cessation
- 2000-02-10 KR KR1020017010707A patent/KR100705726B1/ko not_active Expired - Fee Related
- 2000-02-10 CN CNB008054525A patent/CN1193748C/zh not_active Expired - Fee Related
- 2000-02-10 AP APAP/P/2001/002268A patent/AP1465A/en active
- 2000-02-10 AU AU28807/00A patent/AU762039B2/en not_active Ceased
- 2000-02-10 CA CA002371857A patent/CA2371857C/en not_active Expired - Fee Related
- 2000-02-10 OA OA1200100220A patent/OA11838A/en unknown
- 2000-02-10 HK HK02106773.8A patent/HK1045262B/zh not_active IP Right Cessation
- 2000-02-10 WO PCT/US2000/003663 patent/WO2000050026A1/en not_active Ceased
- 2000-02-10 IL IL14501200A patent/IL145012A0/xx active IP Right Grant
- 2000-02-10 AT AT00907283T patent/ATE370728T1/de active
- 2000-02-10 JP JP2000600638A patent/JP4038337B2/ja not_active Expired - Fee Related
- 2000-02-10 EP EP00907283A patent/EP1158971B1/en not_active Expired - Lifetime
2001
- 2001-08-21 IL IL145012A patent/IL145012A/en not_active IP Right Cessation
2007
- 2007-05-02 JP JP2007121967A patent/JP2007262075A/ja active Pending

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Also Published As

Publication number	Publication date
JP4038337B2 (ja)	2008-01-23
DE60036093T2 (de)	2008-05-15
IL145012A0 (en)	2002-06-30
KR100705726B1 (ko)	2007-04-11
AP1465A (en)	2005-09-22
AU2880700A (en)	2000-09-14
JP2007262075A (ja)	2007-10-11
EP1158971A4 (en)	2003-04-16
IL145012A (en)	2006-12-10
AP2001002268A0 (en)	2001-09-30
US6288122B1 (en)	2001-09-11
BR0008416A (pt)	2002-01-29
CA2371857A1 (en)	2000-08-31
OA11838A (en)	2005-08-22
WO2000050026A1 (en)	2000-08-31
EP1158971A1 (en)	2001-12-05
CN1344158A (zh)	2002-04-10
CN1193748C (zh)	2005-03-23
ATE370728T1 (de)	2007-09-15
HK1045262A1 (en)	2002-11-22
DE60036093D1 (de)	2007-10-04
ES2291191T3 (es)	2008-03-01
HK1045262B (zh)	2005-07-29
EP1158971B1 (en)	2007-08-22
KR20020002393A (ko)	2002-01-09
CA2371857C (en)	2008-07-29
JP2002537331A (ja)	2002-11-05

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2003-10-16	FGA	Letters patent sealed or granted (standard patent)

Publication	Publication Date	Title
AU762039B2 (en)	2003-06-19	Gardos channel antagonists
US20100056637A1 (en)	2010-03-04	Treatment methods using triaryl methane compounds
JP2001521485A (ja)	2001-11-06	鎌状赤血球症のためのトリアリールメタン化合物
US5783597A (en)	1998-07-21	2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and inducible cyclooxygenase (COX-2) enzymes, composition and use
KR20110137321A (ko)	2011-12-22	록소프로펜 유도체 및 그것을 함유하는 의약
US20090036538A1 (en)	2009-02-05	Treatment methods using triaryl methane compounds
US7005539B2 (en)	2006-02-28	Ferulic acid dimers and their pharmaceutically acceptable salts, their preparation and use thereof for treating dementia
ZA200106847B (en)	2002-08-20	Gardos channel antagonists.
US3890445A (en)	1975-06-17	Lactamimide derivatives useful as hypoglycemic agents
FI77840B (fi)	1989-01-31	Foerfarande foer framstaellning av terapeutiskt anvaendbara resorcinderivat.
US3193458A (en)	1965-07-06	Method of lowering blood cholesterol level
US20050014751A1 (en)	2005-01-20	Use of n-acyl homoserine lactones for the treatment of insulitis
US3457354A (en)	1969-07-22	Treatment of hypertension with 2-hydroxy (or amino) - 4,5 - dihydroxyphenethylamine derivatives
NZ206256A (en)	1985-09-13	1-aroyl-4-oxo-2-pyrrolidinepropionic acid derivatives and pharmaceutical compositions
US12194029B1 (en)	2025-01-14	Ethyl-1-(substitutedbenzoyl)-5-methylpyrrolo[1,2-a]quinoline-3-carboxylates as anticancer agents
EP4549425A1 (en)	2025-05-07	Quinone-derived compounds and use thereof against leishmania spp
AU610558B2 (en)	1991-05-23	Saturated fatty acid amides as inhibitors of acyl-coa: cholesterol acyltransferase
RU2002738C1 (ru)	1993-11-15	Способ получени производных N-гидроксимочевин в виде R- или S-энантиомерных форм или их смеси, или их фармацевтически приемлемых солей с щелочным металлом
JPH0374673B2 (2)	1991-11-27
JPS625417B2 (2)	1987-02-04
IT8222696A1 (it)	1984-02-02	Sali dell'ascido 5-(4clorobenzoil)-1,4 dimetil-2-pirrolacetico
JPS6045614B2 (ja)	1985-10-11	ジイン系ポリプレニルアルコ−ルおよびそれを含有する血圧降下剤
JPH0376302B2 (2)	1991-12-05
HK1194302A1 (zh)	2014-10-17	紫檀茋在制造用於治疗、缓解或预防焦虑的药物组合物中的应用
JPH0224265B2 (2)	1990-05-29