OA11838A - Gardos channel antagonists. - Google Patents

Gardos channel antagonists. Download PDF

Info

Publication number: OA11838A
Authority: OA; OAPI
Prior art keywords: substituent; acetamide; ring; compound; para
Prior art date: 1999-02-23

Application number

OA1200100220A

Other languages

English (en)

Inventor

Grant Andrew Mcnaughton-Smith

Gregory Cooksey Rigdon

Jonathan Walter Stocker

Original Assignee

Icagen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-23

Filing date

2000-02-10

Publication date

2005-08-22

2000-02-10 Application filed by Icagen Inc filed Critical Icagen Inc

2005-08-22 Publication of OA11838A publication Critical patent/OA11838A/en

Links

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PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
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239000002511 suppository base Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
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239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
230000008685 targeting Effects 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000011285 therapeutic regimen Methods 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

OA1200100220A 1999-02-23 2000-02-10 Gardos channel antagonists. OA11838A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13551199P	1999-02-23	1999-02-23
US09/386,601 US6288122B1 (en)	1999-02-23	1999-08-31	Gardos channel antagonists

Publications (1)

Publication Number	Publication Date
OA11838A true OA11838A (en)	2005-08-22

Family

ID=26833406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200100220A OA11838A (en)	1999-02-23	2000-02-10	Gardos channel antagonists.

Country Status (16)

Country	Link
US (1)	US6288122B1 (2)
EP (1)	EP1158971B1 (2)
JP (2)	JP4038337B2 (2)
KR (1)	KR100705726B1 (2)
CN (1)	CN1193748C (2)
AP (1)	AP1465A (2)
AT (1)	ATE370728T1 (2)
AU (1)	AU762039B2 (2)
BR (1)	BR0008416A (2)
CA (1)	CA2371857C (2)
DE (1)	DE60036093T2 (2)
ES (1)	ES2291191T3 (2)
HK (1)	HK1045262B (2)
IL (2)	IL145012A0 (2)
OA (1)	OA11838A (2)
WO (1)	WO2000050026A1 (2)

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WO2003004010A1 (en) *	2001-07-06	2003-01-16	Poseidon Pharmaceuticals A/S	Carbonylamino derivatives useful for obtaining immune regulation
EP1465863B1 (en)	2002-01-04	2008-07-09	NeuroSearch A/S	Potassium channel modulators
AU2003217810C9 (en) *	2002-02-28	2008-06-12	Icagen, Inc.	Methods for treating diseases related to intraocular pressure
WO2005003143A1 (en) *	2003-07-03	2005-01-13	Poseidon Pharmaceuticals A/S	Novel potassium channel modulators
WO2005003094A1 (en) *	2003-07-03	2005-01-13	Poseidon Pharmaceuticals A/S	Diarylmethyl derivatives as potassium channel modulators
WO2006084031A1 (en) *	2005-02-01	2006-08-10	Icagen, Inc.	Imines as ion channel modulators
US20100056637A1 (en) *	2005-12-20	2010-03-04	Icagen, Inc.	Treatment methods using triaryl methane compounds
EP1968563A4 (en) *	2005-12-20	2010-05-19	Icagen Inc	TREATMENT METHODS USING TRIARYLMETHANE COMPOUNDS
PT2192896E (pt)	2007-08-24	2011-04-04	Neurosearch As	Derivados de carbonilamino úteis para o tratamento de doença inflamatória intestinal
US20090076157A1 (en) *	2007-09-15	2009-03-19	Protia, Llc	Deuterium-enriched senicapoc
EA023596B1 (ru)	2008-04-09	2016-06-30	Сирус Корпорейшн	Способы обработки композиции эритроцитов для инактивации патогена
EP2358750B1 (en)	2008-11-10	2017-01-11	Boehringer Ingelheim International GmbH	Compositions and methods for modulating cell-cell fusion via intermediate-conductance calcium-activated potassium channels
WO2016134353A1 (en) *	2015-02-20	2016-08-25	Children's Medical Center Corporation	Methods for treating malaria using potassium channel inhibitors
EP3106155A1 (en)	2015-06-15	2016-12-21	Universite d'Aix Marseille	Treatment and diagnosis of hereditary xerocytosis
AU2017350760B2 (en) *	2016-10-25	2022-03-31	Paracelsus Neuroscience I, LIc	Use of senicapoc for treatment of neuropathic pain
WO2018162426A1 (en)	2017-03-06	2018-09-13	INSERM (Institut National de la Santé et de la Recherche Médicale)	Treatment and diagnosis of hereditary xerocytosis
WO2020198939A1 (zh) *	2019-03-29	2020-10-08	深圳仁泰医药科技有限公司	2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用
US12186286B2 (en) *	2019-07-29	2025-01-07	Paracelsus Neuroscience Llc	Use of senicapoc for treatment of stroke
CN115943138A (zh) *	2020-07-14	2023-04-07	阿迪玛生物有限责任公司	包含gardos通道拮抗剂的组合物及其用途
CA3201648A1 (en) *	2020-12-11	2022-06-16	Robin VAN BRUGGEN	Treatment and prevention of anaemia of inflammation

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US5273992A (en)	1992-11-02	1993-12-28	Beth Israel Hospital Assoc. Inc.	Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ
WO1997034589A1 (en)	1996-03-20	1997-09-25	President And Fellows Of Harvard College	Triaryl methane compounds for sickle cell disease

1999
- 1999-08-31 US US09/386,601 patent/US6288122B1/en not_active Expired - Lifetime
2000
- 2000-02-10 DE DE60036093T patent/DE60036093T2/de not_active Expired - Lifetime
- 2000-02-10 ES ES00907283T patent/ES2291191T3/es not_active Expired - Lifetime
- 2000-02-10 BR BR0008416-6A patent/BR0008416A/pt not_active IP Right Cessation
- 2000-02-10 KR KR1020017010707A patent/KR100705726B1/ko not_active Expired - Fee Related
- 2000-02-10 CN CNB008054525A patent/CN1193748C/zh not_active Expired - Fee Related
- 2000-02-10 AP APAP/P/2001/002268A patent/AP1465A/en active
- 2000-02-10 AU AU28807/00A patent/AU762039B2/en not_active Ceased
- 2000-02-10 CA CA002371857A patent/CA2371857C/en not_active Expired - Fee Related
- 2000-02-10 OA OA1200100220A patent/OA11838A/en unknown
- 2000-02-10 HK HK02106773.8A patent/HK1045262B/zh not_active IP Right Cessation
- 2000-02-10 WO PCT/US2000/003663 patent/WO2000050026A1/en not_active Ceased
- 2000-02-10 IL IL14501200A patent/IL145012A0/xx active IP Right Grant
- 2000-02-10 AT AT00907283T patent/ATE370728T1/de active
- 2000-02-10 JP JP2000600638A patent/JP4038337B2/ja not_active Expired - Fee Related
- 2000-02-10 EP EP00907283A patent/EP1158971B1/en not_active Expired - Lifetime
2001
- 2001-08-21 IL IL145012A patent/IL145012A/en not_active IP Right Cessation
2007
- 2007-05-02 JP JP2007121967A patent/JP2007262075A/ja active Pending

Also Published As

Publication number	Publication date
JP4038337B2 (ja)	2008-01-23
DE60036093T2 (de)	2008-05-15
IL145012A0 (en)	2002-06-30
KR100705726B1 (ko)	2007-04-11
AP1465A (en)	2005-09-22
AU2880700A (en)	2000-09-14
JP2007262075A (ja)	2007-10-11
AU762039B2 (en)	2003-06-19
EP1158971A4 (en)	2003-04-16
IL145012A (en)	2006-12-10
AP2001002268A0 (en)	2001-09-30
US6288122B1 (en)	2001-09-11
BR0008416A (pt)	2002-01-29
CA2371857A1 (en)	2000-08-31
WO2000050026A1 (en)	2000-08-31
EP1158971A1 (en)	2001-12-05
CN1344158A (zh)	2002-04-10
CN1193748C (zh)	2005-03-23
ATE370728T1 (de)	2007-09-15
HK1045262A1 (en)	2002-11-22
DE60036093D1 (de)	2007-10-04
ES2291191T3 (es)	2008-03-01
HK1045262B (zh)	2005-07-29
EP1158971B1 (en)	2007-08-22
KR20020002393A (ko)	2002-01-09
CA2371857C (en)	2008-07-29
JP2002537331A (ja)	2002-11-05

Publication	Publication Date	Title
OA11838A (en)	2005-08-22	Gardos channel antagonists.
US20210094900A1 (en)	2021-04-01	Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds
BR9908084B1 (pt)	2009-12-01	composto 2-fenil-1-(3,4-diidróxi-5-nitrofenil)-1-etanona, composição farmacêutica, e, uso de um composto.
US20100056637A1 (en)	2010-03-04	Treatment methods using triaryl methane compounds
US4094908A (en)	1978-06-13	Alpha-substituted benzhydrol derivatives
CN107095864A (zh)	2017-08-29	组蛋白乙酰转移酶激活剂的用途
JPS61218570A (ja)	1986-09-29	新規複素環アミド化合物、およびそれらを含有する医薬組成物
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CS267551B1 (en)	1990-02-12	Pharmaceutical agents for asthma treatment and method of effective substance production
US4835313A (en)	1989-05-30	(5,6-dichloro-3-oxo-9α-propyl-2,3,9,9α-tetrahydrofluoren-7-yl) alkanimidamides
US20240350448A1 (en)	2024-10-24	Dichloroacetic acid conjugating diphenyl ethane compound, and preparation method and application thereof
US4562206A (en)	1985-12-31	Orally effective inotropic compounds
ZA200106847B (en)	2002-08-20	Gardos channel antagonists.
US4418074A (en)	1983-11-29	2,6 Di(t-butyl)-4-(2'-pyrrol)-phenol and anti-inflammatory use thereof
JPS6330283B2 (2)	1988-06-17
US3457354A (en)	1969-07-22	Treatment of hypertension with 2-hydroxy (or amino) - 4,5 - dihydroxyphenethylamine derivatives
US4567192A (en)	1986-01-28	Acylaminophenol derivatives
US12194029B1 (en)	2025-01-14	Ethyl-1-(substitutedbenzoyl)-5-methylpyrrolo[1,2-a]quinoline-3-carboxylates as anticancer agents
US20260001833A1 (en)	2026-01-01	Compounds, compositions, and methods for reducing production of trimethylamine
AU2006320567A1 (en)	2007-06-07	Inhibitors of kynurenine aminotransferase and uses therefor
US20060100289A1 (en)	2006-05-11	Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain
US4146728A (en)	1979-03-27	Esters of 2-[4-(4-chlorobenzoyl)-phenoxy-2-methyl-propionic acid with bis-(hydroxyalkylthio)-alkanes
US4124706A (en)	1978-11-07	Esters of bis-(hydroxyalkylthio)-alkanes
US3740395A (en)	1973-06-19	Ethyl 10 - (beta-morpholylpropionyl)-phenthiazine-2-carbamate hydrochloride
US3673197A (en)	1972-06-27	Exo-dibicycloalkane carboxamides