BE1000734A3 - Clavulanate de potassium. - Google Patents

Clavulanate de potassium. Download PDF

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Publication number
BE1000734A3
BE1000734A3 BE8800098A BE8800098A BE1000734A3 BE 1000734 A3 BE1000734 A3 BE 1000734A3 BE 8800098 A BE8800098 A BE 8800098A BE 8800098 A BE8800098 A BE 8800098A BE 1000734 A3 BE1000734 A3 BE 1000734A3
Authority
BE
Belgium
Prior art keywords
clavulanate
potassium clavulanate
crystalline
new
lactams
Prior art date
Application number
BE8800098A
Other languages
English (en)
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Application granted granted Critical
Publication of BE1000734A3 publication Critical patent/BE1000734A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Clavulanate de potassium sous un nouvel habitus cristallin, à savoir en rosettes cristallines comprenant chacune de nombreux cristaux en aiguilles rayonnant à partir d'un point de nucléation commun. La nouvelle forme, qui présente des propriétés de manipulation améliorées, peut s'obtenir par cristallisation ou bien par précipitation inverse, de préférence à 8-15 degrés C. Ce clavulanate est prévu pour l'association avec des beta-lactames.
BE8800098A 1987-01-29 1988-01-28 Clavulanate de potassium. BE1000734A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US878187A 1987-01-29 1987-01-29
US7494487A 1987-07-17 1987-07-17

Publications (1)

Publication Number Publication Date
BE1000734A3 true BE1000734A3 (fr) 1989-03-21

Family

ID=26678616

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8800098A BE1000734A3 (fr) 1987-01-29 1988-01-28 Clavulanate de potassium.

Country Status (19)

Country Link
EP (1) EP0277008B1 (fr)
JP (2) JP2648321B2 (fr)
KR (1) KR960004535B1 (fr)
AT (1) AT399154B (fr)
AU (1) AU620538B2 (fr)
BE (1) BE1000734A3 (fr)
CA (1) CA1326486C (fr)
CH (1) CH677671A5 (fr)
DE (1) DE3853962T2 (fr)
DK (1) DK175709B1 (fr)
ES (2) ES2074048T3 (fr)
FR (1) FR2610196B1 (fr)
GB (1) GB2200355B (fr)
GR (1) GR1000035B (fr)
IE (1) IE880217L (fr)
IT (1) IT1227072B (fr)
LU (1) LU87123A1 (fr)
NZ (1) NZ223316A (fr)
PT (1) PT86631B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2435859A (en) * 1945-06-06 1948-02-10 John E Whitman Garment hanger
US2494711A (en) * 1946-06-28 1950-01-17 Kusher Hyman Garment hanger
US3474943A (en) * 1967-02-21 1969-10-28 Frank Mcbain Skirt hanger
SE7805391L (sv) * 1978-05-11 1979-11-12 Karner & Co Ab Kledhengare
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SE9401169L (sv) * 1994-04-08 1995-10-09 Corimed Gmbh Förfarande för framställning av ett antibekteriellt aktivt ämne samt användning därav
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
CA2364342C (fr) 1999-04-01 2011-02-01 Dsm N.V. Agglomerats obtenus par cristallisation
ES2225524T5 (es) 2000-05-13 2009-03-01 Smithkline Beecham Plc Procedimiento para la purificacion de una sal de acido clavulanico.
EP1683560A4 (fr) * 2003-06-10 2008-10-01 Taisho Pharmaceutical Co Ltd Produit de cristallisation spherique radial, procede pour produire cette cristallisation et preparation de poudre seche contenant ce produit de cristallisation
CN100384853C (zh) * 2004-05-10 2008-04-30 河北张药股份有限公司 替卡西林钠的合成方法
KR102459377B1 (ko) * 2022-03-18 2022-10-28 주식회사 에이치투뉴트리션 무알콜 단백질 맥주의 제조방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2003863A (en) * 1977-09-01 1979-03-21 Beecham Group Ltd Potassium clavulanate production
EP0026044A1 (fr) * 1979-08-24 1981-04-01 Beecham Group Plc Sel amine de l'acide clavulanique, sa préparation et son utilisation
EP0080862A1 (fr) * 1981-12-02 1983-06-08 Beecham Group Plc Préparation pharmaceutique contenant des antibiotiques béta-lactame
FR2586561A1 (fr) * 1985-09-05 1987-03-06 Rhone Poulenc Sante Procede de preparation d'agglomerats spheriques de paracetamol et produits obtenus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1504425A (en) * 1975-08-20 1978-03-22 Beecham Group Ltd Salts of clavulanic acid
US4454069A (en) * 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2003863A (en) * 1977-09-01 1979-03-21 Beecham Group Ltd Potassium clavulanate production
EP0026044A1 (fr) * 1979-08-24 1981-04-01 Beecham Group Plc Sel amine de l'acide clavulanique, sa préparation et son utilisation
EP0080862A1 (fr) * 1981-12-02 1983-06-08 Beecham Group Plc Préparation pharmaceutique contenant des antibiotiques béta-lactame
FR2586561A1 (fr) * 1985-09-05 1987-03-06 Rhone Poulenc Sante Procede de preparation d'agglomerats spheriques de paracetamol et produits obtenus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 104, no. 11, 17 mars 1986, page 19, résumé no. 81561z, Columbus, Ohio, US; R. SUTHERLAND et al.: "Antibacterial activity of ticarcillin in the presence of clavulanate potassium", & AM. J. MED. 1985, 79(5B), 13-24 *

Also Published As

Publication number Publication date
DK175709B1 (da) 2005-01-31
FR2610196A1 (fr) 1988-08-05
DE3853962D1 (de) 1995-07-20
NZ223316A (en) 1989-10-27
CA1326486C (fr) 1994-01-25
PT86631A (pt) 1988-02-01
IT8847572A0 (it) 1988-06-27
JP2716966B2 (ja) 1998-02-18
AU620538B2 (en) 1992-02-20
DK40488A (da) 1988-07-30
GB2200355B (en) 1990-08-01
ES2008418A6 (es) 1989-07-16
EP0277008B1 (fr) 1995-06-14
KR890002166A (ko) 1989-04-08
LU87123A1 (fr) 1988-05-03
AU1092788A (en) 1988-08-04
IE880217L (en) 1988-07-29
JPH09169771A (ja) 1997-06-30
IT1227072B (it) 1991-03-14
GB8801765D0 (en) 1988-02-24
GB2200355A (en) 1988-08-03
DE3853962T2 (de) 1996-02-08
ES2074048T3 (es) 1995-09-01
GR880100031A (en) 1988-12-16
DK40488D0 (da) 1988-01-27
ATA16388A (de) 1994-08-15
JP2648321B2 (ja) 1997-08-27
CH677671A5 (fr) 1991-06-14
EP0277008A1 (fr) 1988-08-03
FR2610196B1 (fr) 1991-06-28
KR960004535B1 (ko) 1996-04-06
JPS63270687A (ja) 1988-11-08
AT399154B (de) 1995-03-27
PT86631B (pt) 1992-01-31
GR1000035B (el) 1990-03-12

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *BEECHAM GROUP P.L.C.

Effective date: 20080128