|
AU2005230818B2
(en)
|
2004-04-02 |
2010-11-25 |
Osi Pharmaceuticals, Inc. |
6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
|
|
JP2008543941A
(ja)
*
|
2005-06-21 |
2008-12-04 |
インフィニティ・ディスカバリー・インコーポレイテッド |
アンサマイシン製剤およびその使用方法
|
|
MX2008014450A
(es)
*
|
2006-05-18 |
2009-03-09 |
Mannkind Corp |
Inhibidores de cinasa intracelular.
|
|
ATE503484T1
(de)
*
|
2006-08-16 |
2011-04-15 |
Novartis Ag |
Verfahren zur herstellung fester dispersionen von midostaurin
|
|
PT2530083T
(pt)
|
2006-09-22 |
2016-08-01 |
Pharmacyclics Llc |
Inibidores de tirosina cinase de bruton
|
|
ES2403546T3
(es)
|
2006-11-03 |
2013-05-20 |
Pharmacyclics, Inc. |
Sonda de actividad de la tirosina-cinasa de Bruton y procedimiento de utilización
|
|
CA2874756C
(en)
|
2007-03-28 |
2018-05-29 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
US20120101113A1
(en)
*
|
2007-03-28 |
2012-04-26 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
CA2684211A1
(en)
*
|
2007-04-12 |
2008-10-23 |
Infinity Discovery, Inc. |
Hydroquinone ansamycin formulations
|
|
CN101902911B
(zh)
|
2007-10-19 |
2015-12-16 |
阿维拉制药公司 |
杂芳基化合物和其用途
|
|
US7989465B2
(en)
|
2007-10-19 |
2011-08-02 |
Avila Therapeutics, Inc. |
4,6-disubstituted pyrimidines useful as kinase inhibitors
|
|
JP2011510018A
(ja)
*
|
2008-01-18 |
2011-03-31 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
癌治療のためのイミダゾピラジノール誘導体
|
|
ES2396613T3
(es)
*
|
2008-05-19 |
2013-02-22 |
OSI Pharmaceuticals, LLC |
Imidazopirazinas e imidazotriazinas sustituidas
|
|
US20090301928A1
(en)
*
|
2008-06-05 |
2009-12-10 |
United Comb & Novelty Corporation |
Packaging For Lipped Containers
|
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
US8338439B2
(en)
*
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
AU2009262068C1
(en)
|
2008-06-27 |
2015-07-02 |
Celgene Car Llc |
Heteroaryl compounds and uses thereof
|
|
CA2726460C
(en)
|
2008-07-15 |
2017-02-21 |
F. Hoffmann-La Roche Ag |
Novel phenyl-imidazopyridines and pyridazines
|
|
US20110224235A1
(en)
*
|
2008-07-16 |
2011-09-15 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
|
|
AU2013245503B2
(en)
*
|
2008-07-16 |
2015-09-24 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
|
|
MX2011002484A
(es)
*
|
2008-09-05 |
2011-09-26 |
Avila Therapeutics Inc |
Algoritmo para diseñar inhibidores irreversibles.
|
|
WO2010043633A1
(en)
*
|
2008-10-15 |
2010-04-22 |
Palau Pharma, S. A. |
2h-pyrazolo [4,3-d]pyrimidin-5-amine derivatives as h4 histamine receptor antagonists for the treatment of allergic, immunological and inflammatory diseases
|
|
US8778921B2
(en)
|
2008-10-15 |
2014-07-15 |
Infinity Pharmaceuticals, Inc. |
Ansamycin hydroquinone compositions
|
|
US9095592B2
(en)
*
|
2008-11-07 |
2015-08-04 |
The Research Foundation For The State University Of New York |
Bruton's tyrosine kinase as anti-cancer drug target
|
|
US8426428B2
(en)
*
|
2008-12-05 |
2013-04-23 |
Principia Biopharma, Inc. |
EGFR kinase knockdown via electrophilically enhanced inhibitors
|
|
US8513415B2
(en)
|
2009-04-20 |
2013-08-20 |
OSI Pharmaceuticals, LLC |
Preparation of C-pyrazine-methylamines
|
|
EP2424368B1
(en)
|
2009-04-29 |
2014-12-31 |
Locus Pharmaceuticals, Inc. |
Pyrrolotriazine compounds
|
|
CA2760794C
(en)
|
2009-05-05 |
2017-07-25 |
Dana Farber Cancer Institute |
Egfr inhibitors and methods of treating disorders
|
|
JP2012526138A
(ja)
*
|
2009-05-07 |
2012-10-25 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
副腎皮質癌を治療するためのosi−906の使用
|
|
EP3461824B1
(en)
|
2009-09-04 |
2021-08-25 |
Biogen MA Inc. |
Bruton's tyrosine kinase inhibitors
|
|
IN2012DN03112A
(ja)
*
|
2009-09-11 |
2015-09-18 |
Cylene Pharamaceuticals Inc |
|
|
CA2773985A1
(en)
*
|
2009-09-16 |
2011-03-24 |
Avila Therapeutics, Inc. |
Protein kinase conjugates and inhibitors
|
|
US7965498B2
(en)
|
2009-09-30 |
2011-06-21 |
Apple Inc. |
Cover glass to housing interface system
|
|
US7741330B1
(en)
*
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
|
EP2519517B1
(en)
|
2009-12-29 |
2015-03-25 |
Dana-Farber Cancer Institute, Inc. |
Type ii raf kinase inhibitors
|
|
BR112012015721A2
(pt)
|
2009-12-30 |
2017-09-26 |
Avila Therapeutics Inc |
modificação covalente de proteínas dirigida por ligante
|
|
US20130149346A1
(en)
*
|
2010-03-08 |
2013-06-13 |
ratiopharm GmbH Graf-Arco-Strasse 3 |
Dabigatran etexilate-containing pharmaceutical composition
|
|
US9371567B2
(en)
*
|
2010-04-19 |
2016-06-21 |
The Translational Genomics Research Institute |
Methods and kits to predict therapeutic outcome of BTK inhibitors
|
|
MY169745A
(en)
|
2010-05-31 |
2019-05-14 |
Ono Pharmaceutical Co |
Purinone derivative
|
|
MX342405B
(es)
|
2010-06-03 |
2016-09-28 |
Pharmacyclics Inc |
El uso de inhibidores de la tirosina quinasa de bruton (btk).
|
|
US20120053189A1
(en)
*
|
2010-06-28 |
2012-03-01 |
Pharmacyclics, Inc. |
Btk inhibitors for the treatment of immune mediated conditions
|
|
AU2011276955B2
(en)
*
|
2010-07-09 |
2014-11-06 |
The Walter And Eliza Hall Institute Of Medical Research |
Protein kinase inhibitors and methods of treatment
|
|
PT2603081T
(pt)
|
2010-08-10 |
2017-01-13 |
Celgene Avilomics Res Inc |
Sal de besilato de um inibidor de btk
|
|
CN103119045B
(zh)
*
|
2010-08-20 |
2016-02-17 |
和记黄埔医药(上海)有限公司 |
吡咯并嘧啶化合物及其用途
|
|
BR112013010564B1
(pt)
|
2010-11-01 |
2021-09-21 |
Celgene Car Llc |
Compostos heterocíclicos e composições compreendendo os mesmos
|
|
ES2635713T3
(es)
|
2010-11-01 |
2017-10-04 |
Celgene Car Llc |
Compuestos de heteroarilo y usos de los mismos
|
|
EP2637502B1
(en)
|
2010-11-10 |
2018-01-10 |
Celgene CAR LLC |
Mutant-selective egfr inhibitors and uses thereof
|
|
UA106692C2
(uk)
|
2011-02-23 |
2014-09-25 |
Пфайзер Інк. |
ІМІДАЗО[5,1-f][1,2,4]ТРИАЗИНИ ДЛЯ ЛІКУВАННЯ НЕВРОЛОГІЧНИХ РОЗЛАДІВ
|
|
WO2012158810A1
(en)
*
|
2011-05-17 |
2012-11-22 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
|
PL2710007T3
(pl)
*
|
2011-05-17 |
2020-06-01 |
The Regents Of The University Of California |
Inhibitory kinazy
|
|
US9376438B2
(en)
|
2011-05-17 |
2016-06-28 |
Principia Biopharma, Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
|
US8962831B2
(en)
*
|
2011-05-17 |
2015-02-24 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
|
BR112013033534A2
(pt)
*
|
2011-06-28 |
2017-02-07 |
Pharmacyclics Inc |
métodos e composições para inibição de reabsorção de osso
|
|
CA2840687C
(en)
|
2011-07-01 |
2020-04-28 |
Dana-Farber Cancer Institute, Inc. |
Discovery of a somatic mutation in myd88 gene in lymphoplasmacytic lymphoma
|
|
CN103732596B
(zh)
|
2011-07-08 |
2016-06-01 |
诺华股份有限公司 |
吡咯并嘧啶衍生物
|
|
CA2841080A1
(en)
*
|
2011-07-13 |
2013-01-17 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
EP2548877A1
(en)
*
|
2011-07-19 |
2013-01-23 |
MSD Oss B.V. |
4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
|
|
CA2841886C
(en)
|
2011-07-19 |
2016-08-16 |
Merck Sharp & Dohme B.V. |
4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk-inhibitors
|
|
ES2671748T3
(es)
|
2011-07-21 |
2018-06-08 |
Tolero Pharmaceuticals, Inc. |
Inhibidores heterocíclicos de proteína quinasas
|
|
MX391121B
(es)
*
|
2011-10-19 |
2025-03-19 |
Pharmacyclics Llc |
Uso de inhibidores de la tirosina cinasa de bruton (btk).
|
|
TW201325593A
(zh)
|
2011-10-28 |
2013-07-01 |
Celgene Avilomics Res Inc |
治療布魯頓(bruton’s)酪胺酸激酶疾病或病症之方法
|
|
GB2496135B
(en)
|
2011-11-01 |
2015-03-18 |
Valirx Plc |
Inhibitors of the interaction between a Src family kinase and an androgen receptor or estradiol receptor for treatment of endometriosis
|
|
UA111756C2
(uk)
*
|
2011-11-03 |
2016-06-10 |
Ф. Хоффманн-Ля Рош Аг |
Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
|
|
CN104105697B
(zh)
*
|
2011-11-03 |
2016-11-09 |
霍夫曼-拉罗奇有限公司 |
二环哌嗪化合物
|
|
US9212381B2
(en)
*
|
2011-11-10 |
2015-12-15 |
President And Fellows Of Harvard College |
Methods and compositions for labeling polypeptides
|
|
US9382239B2
(en)
|
2011-11-17 |
2016-07-05 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-Jun-N-terminal kinase (JNK)
|
|
CN103958513B
(zh)
*
|
2011-11-29 |
2015-12-23 |
小野药品工业株式会社 |
6-羟基嘌呤衍生物盐酸盐
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
WO2013106414A1
(en)
|
2012-01-09 |
2013-07-18 |
X-Rx, Inc. |
Tryptoline derivatives having kinase inhibitory activity and uses thereof
|
|
JP5985658B2
(ja)
*
|
2012-01-31 |
2016-09-06 |
ナンジン アルゲン ファルマ カンパニー リミテッドNanjing Allgen Pharma Co. Ltd. |
ブルトンチロシンキナーゼ阻害薬としての環状分子
|
|
US8501724B1
(en)
*
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
TW201336847A
(zh)
*
|
2012-02-07 |
2013-09-16 |
Taiho Pharmaceutical Co Ltd |
喹啉基吡咯并嘧啶化合物或其鹽
|
|
ES2580530T3
(es)
*
|
2012-02-23 |
2016-08-24 |
Taiho Pharmaceutical Co., Ltd. |
Compuesto con anillo fusionado de quinolilpirrolopirimidilo o sal del mismo
|
|
CN103312670A
(zh)
|
2012-03-12 |
2013-09-18 |
西安西电捷通无线网络通信股份有限公司 |
一种认证方法及系统
|
|
CN104302178B
(zh)
|
2012-03-15 |
2018-07-13 |
西建卡尔有限责任公司 |
表皮生长因子受体激酶抑制剂的固体形式
|
|
EP2825042B1
(en)
|
2012-03-15 |
2018-08-01 |
Celgene CAR LLC |
Salts of an epidermal growth factor receptor kinase inhibitor
|
|
US9365566B2
(en)
|
2012-03-27 |
2016-06-14 |
Takeda Pharmaceutical Company Limited |
Cinnoline derivatives
|
|
EP2833886B1
(en)
|
2012-04-04 |
2020-08-12 |
HangzhouDeRenYuCheng Biotechnology Ltd. |
Substituted quinolines as bruton's tyrosine kinase inhibitors
|
|
WO2013154778A1
(en)
|
2012-04-11 |
2013-10-17 |
Dana-Farber Cancer Institute, Inc. |
Host targeted inhibitors of dengue virus and other viruses
|
|
HK1206624A1
(en)
|
2012-04-11 |
2016-01-15 |
Acerta Pharma B.V. |
Bruton's tyrosine kinase inhibitors for hematopoietic mobilization
|
|
CN103374001B
(zh)
*
|
2012-04-19 |
2015-10-28 |
山东轩竹医药科技有限公司 |
咪唑并三嗪类mTOR抑制剂
|
|
IN2014MN02338A
(ja)
*
|
2012-05-31 |
2015-08-14 |
Pharmascience Inc |
|
|
CA2875986C
(en)
*
|
2012-06-04 |
2020-06-09 |
Pharmacyclics, Inc. |
Crystalline forms of a bruton's tyrosine kinase inhibitor
|
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
|
US20160045503A1
(en)
*
|
2012-06-18 |
2016-02-18 |
Principia Biopharma Inc. |
Formulations containing reversible covalent compounds
|
|
WO2014004707A1
(en)
|
2012-06-29 |
2014-01-03 |
Principia Biopharma Inc. |
Formulations comprising ibrutinib
|
|
EP2877598A1
(en)
|
2012-07-24 |
2015-06-03 |
Pharmacyclics, Inc. |
Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
|
|
EA201590296A1
(ru)
*
|
2012-07-30 |
2015-07-30 |
Консерт Фармасьютикалс Инк. |
Дейтерированный ибрутиниб
|
|
US9572811B2
(en)
|
2012-08-03 |
2017-02-21 |
Principia Biopharma Inc. |
Treatment of dry eye
|
|
EA029210B1
(ru)
*
|
2012-08-10 |
2018-02-28 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Гетероароматические соединения в качестве ингибиторов btk
|
|
CN103121999A
(zh)
*
|
2012-08-29 |
2013-05-29 |
苏州迪飞医药科技有限公司 |
一种酪氨酸激酶抑制剂pci-32765的合成方法
|
|
EP2890691B1
(en)
|
2012-08-31 |
2018-04-25 |
Principia Biopharma Inc. |
Benzimidazole derivatives as itk inhibitors
|
|
JP6203848B2
(ja)
*
|
2012-09-10 |
2017-09-27 |
プリンシピア バイオファーマ インコーポレイテッド |
キナーゼ阻害剤としてのピラゾロピリミジン化合物
|
|
CH706997A1
(en)
|
2012-09-20 |
2014-03-31 |
Ferag Ag |
Access control on operating modules of a control unit.
|
|
WO2014063068A1
(en)
|
2012-10-18 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
USRE48175E1
(en)
*
|
2012-10-19 |
2020-08-25 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
WO2014063054A1
(en)
|
2012-10-19 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
|
|
GEP201606597B
(en)
*
|
2012-11-02 |
2017-01-10 |
Pfizer |
Bruton's tyrosine kinase inhibitors
|
|
TW201427664A
(zh)
|
2012-11-02 |
2014-07-16 |
Pharmacyclics Inc |
Tec家族激酶抑制劑佐劑療法
|
|
EP2920180A4
(en)
*
|
2012-11-15 |
2016-04-13 |
Pharmacyclics Inc |
PYRROLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS
|
|
JP6322204B2
(ja)
|
2012-11-16 |
2018-05-09 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
ジヒドロピラゾールのgpr40モジュレーター
|
|
CN103848810A
(zh)
*
|
2012-11-30 |
2014-06-11 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
|
JP2016503803A
(ja)
*
|
2012-12-21 |
2016-02-08 |
テバ ファーマシューティカル インダストリーズ リミティド |
酢酸グラチラマーの経粘膜送達
|
|
WO2014100748A1
(en)
|
2012-12-21 |
2014-06-26 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
WO2014113932A1
(en)
*
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
WO2014114185A1
(en)
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
WO2014113942A1
(en)
*
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
CA2900012A1
(en)
|
2013-02-08 |
2014-08-14 |
Celgene Avilomics Research, Inc. |
Erk inhibitors and uses thereof
|
|
US20140357636A1
(en)
*
|
2013-02-21 |
2014-12-04 |
Wayne Rothbaum |
Treatment of Skeletal-Related Disorders
|
|
US9845329B2
(en)
|
2013-02-22 |
2017-12-19 |
Taiho Pharmaceutical Co., Ltd. |
Method for producing a substituted 6,7,8,9-tetrahydropyrimido[5,4-b]indolizine, substituted 7,8,9,10-tetrahydro-6H-pyrimido[5′,4′:4,5]pyrrolo[1,2-a]azepine and substituted 6,7,8,9,10,11-hexahydropyrimido[5′,4′:4,5]pyrrolo[1,2-a]azocine
|
|
JO3377B1
(ar)
|
2013-03-11 |
2019-03-13 |
Takeda Pharmaceuticals Co |
مشتقات بيريدينيل وبيريدينيل مندمج
|
|
WO2014165253A1
(en)
*
|
2013-03-12 |
2014-10-09 |
Nbip, Llc |
Compositions and methods for preventing infection of a wound and for advancing the healing process
|
|
CN103142601A
(zh)
*
|
2013-03-13 |
2013-06-12 |
杭州雷索药业有限公司 |
Pci-32765在制备抗血管生成类药物中的应用
|
|
AU2014244518A1
(en)
*
|
2013-03-14 |
2015-09-17 |
Pharmacyclics Llc |
Combinations of Bruton's tyrosine kinase inhibitors and CYP3A4 inhibitors
|
|
DK2970205T3
(da)
|
2013-03-14 |
2019-07-29 |
Tolero Pharmaceuticals Inc |
JAK2- og ALK2-inhibitorer og fremgangsmåder til anvendelse deraf
|
|
US8895750B2
(en)
|
2013-03-14 |
2014-11-25 |
Boehringer Ingelheim International Gmbh |
Heteroaromatic compounds as BTK inhibitors
|
|
KR20150133172A
(ko)
|
2013-03-15 |
2015-11-27 |
셀진 아빌로믹스 리서치, 인코포레이티드 |
Mk2 억제제 및 이의 용도
|
|
EP2970291B1
(en)
*
|
2013-03-15 |
2022-05-11 |
Janssen Pharmaceutica, N.V. |
Processes and intermediates for preparing a medicament
|
|
US8940893B2
(en)
|
2013-03-15 |
2015-01-27 |
Boehringer Ingelheim International Gmbh |
Heteroaromatic compounds as BTK inhibitors
|
|
US9156847B2
(en)
*
|
2013-03-15 |
2015-10-13 |
Janssen Pharmaceutica Nv |
Processes and intermediates for preparing a medicament
|
|
UY35468A
(es)
|
2013-03-16 |
2014-10-31 |
Novartis Ag |
Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
|
|
KR20160061911A
(ko)
|
2013-04-08 |
2016-06-01 |
데니스 엠. 브라운 |
최적하 투여된 화학 화합물의 치료 효과
|
|
WO2014168975A1
(en)
*
|
2013-04-08 |
2014-10-16 |
Pharmacyclics, Inc. |
Ibrutinib combination therapy
|
|
US8957080B2
(en)
|
2013-04-09 |
2015-02-17 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
|
RS55770B1
(sr)
|
2013-04-25 |
2017-07-31 |
Beigene Ltd |
Fuzionisana heterociklična jedinjenja kao inhibitori protein kinaze
|
|
GB2513615A
(en)
|
2013-05-01 |
2014-11-05 |
Cancer Rec Tech Ltd |
Medical use
|
|
GB201309085D0
(en)
|
2013-05-20 |
2013-07-03 |
Redx Pharma Ltd |
Compounds
|
|
WO2014187319A1
(en)
|
2013-05-21 |
2014-11-27 |
Jiangsu Medolution Ltd |
Substituted pyrazolopyrimidines as kinases inhibitors
|
|
CA2917167A1
(en)
*
|
2013-07-02 |
2015-01-08 |
Pharmacyclics Llc |
Purinone compounds as kinase inhibitors
|
|
CN105358545A
(zh)
|
2013-07-03 |
2016-02-24 |
豪夫迈·罗氏有限公司 |
杂芳基吡啶酮和氮杂-吡啶酮酰胺化合物
|
|
WO2015013581A1
(en)
|
2013-07-26 |
2015-01-29 |
Update Pharma Inc. |
Combinatorial methods to improve the therapeutic benefit of bisantrene
|
|
WO2015017812A1
(en)
|
2013-08-02 |
2015-02-05 |
Pharmacyclics, Inc. |
Methods for the treatment of solid tumors
|
|
EP2832358A1
(en)
|
2013-08-02 |
2015-02-04 |
Bionsil S.r.l. |
Pharmaceutical kit for use in the treatment of colon and colorectal cancer
|
|
JP6429292B2
(ja)
|
2013-08-12 |
2018-11-28 |
ファーマサイクリックス エルエルシー |
Her2増幅性癌の処置のための方法
|
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
|
DK3044234T3
(da)
|
2013-09-13 |
2020-05-18 |
Beigene Switzerland Gmbh |
Anti-PD1-antistoffer og anvendelse deraf som terapeutika og diagnostika
|
|
SG11201602070TA
(en)
*
|
2013-09-30 |
2016-04-28 |
Beijing Synercare Pharma Tech Co Ltd |
Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
|
|
CR20160203A
(es)
|
2013-09-30 |
2016-08-31 |
Pharmacyclics Llc |
Inhibidores de tirosina cinasa de bruton
|
|
JP2016536354A
(ja)
*
|
2013-10-10 |
2016-11-24 |
アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. |
非ホジキンリンパ腫を治療するための、hdac阻害剤単独またはbtk阻害剤との組み合わせ
|
|
WO2015057992A1
(en)
|
2013-10-16 |
2015-04-23 |
Izumi Raquel |
Btk inhibitors for hematopoietic mobilization
|
|
CN105849099B
(zh)
|
2013-10-18 |
2020-01-17 |
达纳-法伯癌症研究所股份有限公司 |
周期蛋白依赖性激酶7(cdk7)的多环抑制剂
|
|
CA2927917C
(en)
|
2013-10-18 |
2022-08-09 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of proliferative diseases
|
|
US20210317140A1
(en)
|
2013-10-18 |
2021-10-14 |
Medivation Technologies, Inc. |
Heterocyclic Compounds and Methods of Use
|
|
WO2015069441A1
(en)
*
|
2013-10-18 |
2015-05-14 |
Medivation Technologies, Inc. |
Pyrazolo-, imidazolo- and pyrrolo-pyridine or -pyrimidine derivatives as inhibitors o brutons kinase (btk)
|
|
MX2016005283A
(es)
*
|
2013-10-25 |
2017-02-20 |
Pharmacyclics Llc |
Tratamiento que utiliza inhibidores de tirosina quinasa de bruton e inmunoterapia.
|
|
KR102452866B1
(ko)
*
|
2013-10-25 |
2022-10-07 |
파마싸이클릭스 엘엘씨 |
이식편 대 숙주 질환의 치료 및 예방 방법
|
|
US9636340B2
(en)
|
2013-11-12 |
2017-05-02 |
Ayyappan K. Rajasekaran |
Kinase inhibitors
|
|
WO2015071432A1
(en)
|
2013-11-14 |
2015-05-21 |
Sandoz Ag |
Pharmaceutical compositions of ibrutinib
|
|
US20150141438A1
(en)
*
|
2013-11-15 |
2015-05-21 |
Pharmacyclics, Inc. |
Methods for delaying or preventing the onset of type 1 diabetes
|
|
CN103626774B
(zh)
|
2013-11-20 |
2015-11-04 |
苏州明锐医药科技有限公司 |
伊鲁替尼的制备方法
|
|
CA2833867A1
(en)
|
2013-11-21 |
2015-05-21 |
Pharmascience Inc. |
Protein kinase inhibitors
|
|
CN103694241A
(zh)
*
|
2013-11-27 |
2014-04-02 |
苏州晶云药物科技有限公司 |
Pci-32765的新晶型a及其制备方法
|
|
US9512084B2
(en)
|
2013-11-29 |
2016-12-06 |
Novartis Ag |
Amino pyrimidine derivatives
|
|
TW202402295A
(zh)
*
|
2013-12-02 |
2024-01-16 |
美商製藥公司 |
治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法
|
|
MX2016007171A
(es)
|
2013-12-05 |
2016-09-08 |
Hoffmann La Roche |
Compuestos de heteroaril piridona y azapiridona con funcionalidad electrofila.
|
|
ES2871524T3
(es)
|
2013-12-05 |
2021-10-29 |
Pfizer |
Pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinil acrilamidas
|
|
US10328080B2
(en)
|
2013-12-05 |
2019-06-25 |
Acerta Pharma, B.V. |
Therapeutic combination of PI3K inhibitor and a BTK inhibitor
|
|
AU2014361800B2
(en)
*
|
2013-12-13 |
2020-05-07 |
Dana-Farber Cancer Institute, Inc. |
Methods to treat lymphoplasmacytic lymphoma
|
|
AU2014361798B2
(en)
|
2013-12-13 |
2020-06-11 |
Dana-Farber Cancer Institute, Inc. |
Methods to treat lymphoplasmacytic lymphoma
|
|
US9415049B2
(en)
|
2013-12-20 |
2016-08-16 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
WO2015095099A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
WO2015095102A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
US10272083B2
(en)
|
2014-01-21 |
2019-04-30 |
Acerta Pharma B.V. |
Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor
|
|
EP3099674B1
(en)
|
2014-01-29 |
2018-10-24 |
Boehringer Ingelheim International Gmbh |
Pyrazole compounds as btk inhibitors
|
|
CN103923084B
(zh)
*
|
2014-01-29 |
2016-08-17 |
苏州晶云药物科技有限公司 |
几种晶型及其制备方法
|
|
NZ721617A
(en)
*
|
2014-02-03 |
2018-01-26 |
Cadila Healthcare Ltd |
Heterocyclic compounds
|
|
KR20160117614A
(ko)
|
2014-02-21 |
2016-10-10 |
프린시피아 바이오파마, 인코퍼레이티드 |
Btk 억제제의 염 및 고체 형태
|
|
JP6526065B2
(ja)
|
2014-02-28 |
2019-06-05 |
ニンバス ラクシュミ, インコーポレイテッド |
Tyk2阻害剤およびその使用
|
|
CA2942528A1
(en)
|
2014-03-20 |
2015-09-24 |
Pharmacyclics Inc. |
Phospholipase c gamma 2 and resistance associated mutations
|
|
GB201404987D0
(en)
*
|
2014-03-20 |
2014-05-07 |
Redx Pharma Ltd |
Compounds
|
|
WO2015146159A1
(en)
|
2014-03-25 |
2015-10-01 |
Ono Pharmaceutical Co., Ltd. |
Prophylactic agent and/or therapeutic agent for diffuse large b-cell lymphoma
|
|
EP3122753A4
(en)
*
|
2014-03-27 |
2017-11-29 |
Perrigo Api Ltd. |
Ibrutinib solid forms and production process therefor
|
|
WO2015151006A1
(en)
*
|
2014-03-29 |
2015-10-08 |
Lupin Limited |
Substituted purine compounds as btk inhibitors
|
|
WO2015181633A2
(en)
|
2014-04-11 |
2015-12-03 |
Acerta Pharma B.V. |
Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bruton's tyrosine kinase
|
|
WO2015185998A2
(en)
|
2014-04-11 |
2015-12-10 |
Acerta Pharma B.V. |
Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bone marrow x kinase
|
|
CN105017256A
(zh)
*
|
2014-04-29 |
2015-11-04 |
浙江导明医药科技有限公司 |
多氟化合物作为布鲁顿酪氨酸激酶抑制剂
|
|
CN105085474B
(zh)
*
|
2014-05-07 |
2018-05-18 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
|
CN105085529A
(zh)
*
|
2014-05-15 |
2015-11-25 |
广东东阳光药业有限公司 |
依鲁替尼新晶型及其制备方法
|
|
CN104086551B
(zh)
*
|
2014-06-06 |
2016-09-21 |
人福医药集团股份公司 |
化合物及其制备方法和用途
|
|
GB201410430D0
(en)
*
|
2014-06-11 |
2014-07-23 |
Redx Pharma Ltd |
Compounds
|
|
WO2015193740A2
(en)
|
2014-06-17 |
2015-12-23 |
Acerta Pharma B.V. |
Therapeutic combinations of a btk inhibitor, a pi3k inhibitor and/or a jak-2 inhibitor
|
|
CN104945404B
(zh)
*
|
2014-06-25 |
2018-09-14 |
广东东阳光药业有限公司 |
一种n-丙烯羰基哌啶衍生物的制备方法
|
|
WO2016004305A2
(en)
*
|
2014-07-02 |
2016-01-07 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
KR102130600B1
(ko)
|
2014-07-03 |
2020-07-08 |
베이진 엘티디 |
Pd-l1 항체와 이를 이용한 치료 및 진단
|
|
CN105294571B
(zh)
*
|
2014-07-03 |
2019-04-23 |
浙江九洲药业股份有限公司 |
一种依鲁替尼中间体及其制备方法和用途
|
|
EP3166608B1
(en)
*
|
2014-07-07 |
2018-12-12 |
Jiangsu Hengrui Medicine Co., Ltd. |
Aminopyridazinone compounds as protein kinase inhibitors
|
|
WO2016008411A1
(en)
*
|
2014-07-18 |
2016-01-21 |
Beigene, Ltd. |
5-amino-4-carbamoyl-pyrazole compounds as selective and irreversible t790m over wt-egfr kinase inhibitors and use thereof
|
|
WO2016019237A2
(en)
*
|
2014-07-31 |
2016-02-04 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
CA2959602A1
(en)
*
|
2014-08-01 |
2016-02-04 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
WO2016020901A1
(en)
|
2014-08-07 |
2016-02-11 |
Acerta Pharma B.V. |
Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy and btk resynthesis rate
|
|
CN106573002A
(zh)
|
2014-08-07 |
2017-04-19 |
药品循环有限责任公司 |
布鲁顿氏酪氨酸激酶抑制剂的新型制剂
|
|
CN106714909A
(zh)
|
2014-08-08 |
2017-05-24 |
药品循环有限责任公司 |
布鲁顿氏酪氨酸激酶抑制剂组合及其用途
|
|
CN105461720B
(zh)
*
|
2014-08-08 |
2019-08-06 |
南京圣和药业股份有限公司 |
吗啉类酪氨酸激酶抑制剂
|
|
SMT202200285T1
(it)
|
2014-08-11 |
2022-09-14 |
Acerta Pharma Bv |
Combinazioni terapeutiche di un inibitore di btk, un inibitore di pd-1 e/o un inibitore di pd-l1
|
|
US20170231995A1
(en)
|
2014-08-11 |
2017-08-17 |
Acerta Pharma B.V. |
BTK Inhibitors to Treat Solid Tumors Through Modulation of the Tumor Microenvironment
|
|
AR101504A1
(es)
|
2014-08-11 |
2016-12-21 |
Acerta Pharma Bv |
Combinaciones terapéuticas de un inhibidor de la btk, un inhibidor de la pi3k, un inhibidor de la jak-2, y/o un inhibidor de la cdk4/6
|
|
ES2900184T3
(es)
|
2014-08-11 |
2022-03-16 |
Acerta Pharma Bv |
Combinaciones terapéuticas de un inhibidor de BTK y un inhibidor de BCL-2
|
|
AU2015303835B2
(en)
|
2014-08-12 |
2020-04-09 |
Monash University |
Lymph directing prodrugs
|
|
TW201613892A
(en)
|
2014-08-13 |
2016-04-16 |
Celgene Avilomics Res Inc |
Forms and compositions of an ERK inhibitor
|
|
EP3180343A1
(en)
|
2014-08-14 |
2017-06-21 |
Assia Chemical Industries Ltd. |
Solid state forms of ibrutinib
|
|
WO2016050921A1
(en)
|
2014-10-02 |
2016-04-07 |
F. Hoffmann-La Roche Ag |
Pyrazole carboxamide compounds for use in the treament of disorders mediated by bruton's tyrosine kinase (btk)
|
|
CA2965178C
(en)
|
2014-10-22 |
2023-09-26 |
Dana-Farber Cancer Institute, Inc. |
Thiazolyl-containing compounds for treating proliferative diseases
|
|
DK3209656T3
(da)
|
2014-10-24 |
2020-07-13 |
Bristol Myers Squibb Co |
Indolcarboxamidforbindelser, der er anvendelige som kinasehæmmere
|
|
EP3212645B1
(en)
|
2014-10-27 |
2018-11-28 |
F.Hoffmann-La Roche Ag |
Process for making tricyclic lactam compounds
|
|
SG11201702845QA
(en)
|
2014-10-29 |
2017-05-30 |
Bicycle Therapeutics Ltd |
Bicyclic peptide ligands specific for mt1-mmp
|
|
US20170327504A1
(en)
*
|
2014-10-30 |
2017-11-16 |
Sandoz Ag |
Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines
|
|
US10196397B2
(en)
|
2014-11-19 |
2019-02-05 |
Sun Pharmaceutical Industries Limited |
Process for the preparation of ibrutinib
|
|
WO2016079216A1
(en)
|
2014-11-20 |
2016-05-26 |
Sandoz Ag |
Physical forms of ibrutinib, a bruton's kinase inhibitor
|
|
CN104447761A
(zh)
*
|
2014-11-27 |
2015-03-25 |
广东东阳光药业有限公司 |
一种吡唑衍生物的制备方法
|
|
WO2016088074A1
(en)
*
|
2014-12-03 |
2016-06-09 |
Dr. Reddy’S Laboratories Limited |
Process for the preparation of amorphous ibrutinib
|
|
AR102871A1
(es)
*
|
2014-12-03 |
2017-03-29 |
Pharmacyclics Llc |
Métodos de tratamiento de fibrosis
|
|
WO2016087994A1
(en)
|
2014-12-05 |
2016-06-09 |
Acerta Pharma B.V. |
Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment
|
|
CN104478884A
(zh)
*
|
2014-12-05 |
2015-04-01 |
广东东阳光药业有限公司 |
一种中间体的制备方法
|
|
TW201702218A
(zh)
|
2014-12-12 |
2017-01-16 |
美國杰克森實驗室 |
關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
|
|
AU2015364335B2
(en)
|
2014-12-18 |
2020-11-26 |
Principia Biopharma Inc. |
Treatment of pemphigus
|
|
PT3233852T
(pt)
|
2014-12-18 |
2020-09-10 |
Hoffmann La Roche |
Tetrahidro-pirido[3,4-b]indóis como moduladores do recetor de estrogénio e suas utilizações
|
|
AU2015371251B2
(en)
|
2014-12-23 |
2020-06-11 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
WO2016106624A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Tertiary alcohol imidazopyrazine btk inhibitors
|
|
WO2016106628A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
WO2016106629A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
WO2016106652A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Biarylether imidazopyrazine btk inhibitors
|
|
CN105820168B
(zh)
*
|
2015-01-09 |
2018-12-04 |
上海医药工业研究院 |
一种依鲁替尼中间体的制备方法
|
|
MA41350A
(fr)
*
|
2015-01-14 |
2017-11-21 |
Janssen Pharmaceutica Nv |
Synthèse d'un inhibiteur de la tyrosine kinase de bruton
|
|
US10266535B2
(en)
|
2015-01-21 |
2019-04-23 |
Hefei Institutes Of Physical Science, Chinese Academy Of Sciences |
Inhibitor of FLT3 kinase and use thereof
|
|
WO2016123504A1
(en)
*
|
2015-01-30 |
2016-08-04 |
Pharmacyclics Llc |
Btk inhibitor combinations and multidrug-resistance
|
|
CZ201584A3
(cs)
|
2015-02-09 |
2016-08-17 |
Zentiva, K.S. |
Sůl Ibrutinib sulfátu
|
|
CN111018862B
(zh)
*
|
2015-02-12 |
2021-12-24 |
正大天晴药业集团股份有限公司 |
伊布替尼的制备方法
|
|
WO2016132383A1
(en)
|
2015-02-18 |
2016-08-25 |
Mylan Laboratories Limited |
Process for the preparation of ibrutinib
|
|
TWI744225B
(zh)
|
2015-02-27 |
2021-11-01 |
美商林伯士拉克許米公司 |
酪胺酸蛋白質激酶2(tyk2)抑制劑及其用途
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
WO2016141044A1
(en)
|
2015-03-04 |
2016-09-09 |
Arizona Board Of Regents On Behalf Of Arizona State University |
Erbb4 inhibitors and methods of use thereof
|
|
CN106146508A
(zh)
*
|
2015-03-19 |
2016-11-23 |
浙江导明医药科技有限公司 |
优化的联合用药及其治疗癌症和自身免疫疾病的用途
|
|
US9717745B2
(en)
|
2015-03-19 |
2017-08-01 |
Zhejiang DTRM Biopharma Co. Ltd. |
Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
|
|
MA41828A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton
|
|
MA41827A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton
|
|
EP3273966B1
(en)
|
2015-03-27 |
2023-05-03 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
WO2016156127A1
(en)
|
2015-04-02 |
2016-10-06 |
Ratiopharm Gmbh |
Co-crystals of ibrutinib with carboxylic acids
|
|
WO2016161248A1
(en)
*
|
2015-04-02 |
2016-10-06 |
Tolero Pharmaceuticals, Inc. |
Targeting pim kinases in combination with btk inhibition
|
|
CN106146511A
(zh)
*
|
2015-04-03 |
2016-11-23 |
安润医药科技(苏州)有限公司 |
吡唑并嘧啶衍生物、制备方法、药物组合物及用途
|
|
CN105906621A
(zh)
*
|
2015-04-06 |
2016-08-31 |
四川百利药业有限责任公司 |
用作fgfr抑制剂的乙醇类化合物
|
|
EP3892302B8
(en)
|
2015-04-06 |
2023-10-18 |
Janssen Pharmaceutica NV |
Compositions containing ibrutinib
|
|
IL254817B2
(en)
|
2015-04-08 |
2023-12-01 |
Novartis Ag |
Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell
|
|
WO2016163531A1
(ja)
|
2015-04-09 |
2016-10-13 |
小野薬品工業株式会社 |
プリノン誘導体の製造方法
|
|
CN106146512B
(zh)
*
|
2015-04-09 |
2018-07-17 |
北京睿创康泰医药研究院有限公司 |
依鲁替尼的制备方法
|
|
KR20170134462A
(ko)
*
|
2015-04-13 |
2017-12-06 |
다이이찌 산쿄 가부시키가이샤 |
Mdm2 저해제와 btk 저해제의 병용 치료법
|
|
CN106146482B
(zh)
*
|
2015-04-14 |
2020-06-23 |
宁波文达医药科技有限公司 |
布鲁顿酪氨酸激酶抑制剂
|
|
WO2016170545A1
(en)
*
|
2015-04-22 |
2016-10-27 |
Msn Laboratories Private Limited |
Process for the preparation of 1-[(3r)-3-[4-amino-3-(4-phenoxyphenvl)-1h- pvrazolo[3,4-d]pyriniidin-1-y1]-1-piperidinvl]-2-propen-1-one and its polymorphs thereof
|
|
US20180289685A1
(en)
|
2015-04-30 |
2018-10-11 |
Bayer Pharma Aktiengesellschaft |
Combinations of inhibitors of irak4 with inhibitors of btk
|
|
EP3195865A1
(de)
|
2016-01-25 |
2017-07-26 |
Bayer Pharma Aktiengesellschaft |
Kombinationen von irak4 inhibitoren und btk inhibitoren
|
|
EP3302550B1
(en)
|
2015-05-26 |
2019-08-28 |
MorphoSys AG |
Combination of an anti-cd19 antibody and a bruton's tyrosine kinase inhibitor and uses thereof
|
|
LT3303334T
(lt)
|
2015-06-03 |
2021-07-12 |
Principia Biopharma Inc. |
Tirozinkinazės inhibitoriai
|
|
US10702527B2
(en)
|
2015-06-12 |
2020-07-07 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
|
US9394312B1
(en)
*
|
2015-06-14 |
2016-07-19 |
Mark Quang Nguyen |
Ibrutinib prodrugs, pharmaceutical compositions thereof, and methods of use
|
|
WO2016208595A1
(ja)
|
2015-06-22 |
2016-12-29 |
小野薬品工業株式会社 |
Brk阻害化合物
|
|
EP3313839A1
(en)
|
2015-06-24 |
2018-05-02 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
|
CZ2015442A3
(cs)
*
|
2015-06-26 |
2017-01-04 |
Zentiva, K.S. |
Ibrutinib hemisulfát
|
|
WO2016207172A1
(en)
*
|
2015-06-26 |
2016-12-29 |
Sandoz Gmbh |
Preparation of pure amorphous ibrutinib
|
|
WO2017004134A1
(en)
|
2015-06-29 |
2017-01-05 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
|
PL3317284T3
(pl)
|
2015-07-02 |
2020-04-30 |
F. Hoffmann-La Roche Ag |
Związki oksazolidynonu benzoksazepiny i sposoby stosowania
|
|
CN111848643A
(zh)
|
2015-07-02 |
2020-10-30 |
豪夫迈·罗氏有限公司 |
苯并氧氮杂*噁唑烷酮化合物及其使用方法
|
|
KR20240115937A
(ko)
|
2015-07-02 |
2024-07-26 |
아세르타 파마. 비.브이. |
(S)-4-(8-아미노-3-(1-(부트-2-이노일)피롤리딘-2-일)이미다조[1,5-a]피라진-1-일)-N-(피리딘-2-일)벤즈아마이드의고체 형태 및 제제
|
|
ITUB20152576A1
(it)
*
|
2015-07-29 |
2017-01-29 |
Laboratorio Chimico Int S P A |
Procedimento per la preparazione di ibrutinib e nuovo intermedio di sintesi.
|
|
EP3337485B1
(en)
*
|
2015-08-19 |
2021-03-17 |
Sun Pharmaceutical Industries Ltd |
Crystalline forms of ibrutinib
|
|
WO2017033113A1
(en)
|
2015-08-21 |
2017-03-02 |
Acerta Pharma B.V. |
Therapeutic combinations of a mek inhibitor and a btk inhibitor
|
|
JP2018525411A
(ja)
|
2015-08-31 |
2018-09-06 |
ファーマサイクリックス エルエルシー |
多発性骨髄腫を治療するためのbtk阻害剤の組み合わせ
|
|
US10023571B2
(en)
|
2015-09-02 |
2018-07-17 |
Nimbus Lakshimi, Inc. |
TYK2 inhibitors and uses thereof
|
|
US11738087B2
(en)
|
2015-09-08 |
2023-08-29 |
Monash University |
Lymph directing prodrugs
|
|
EP3347018B1
(en)
|
2015-09-09 |
2021-09-01 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
CN105753863B
(zh)
*
|
2015-09-11 |
2018-07-31 |
东莞市真兴贝特医药技术有限公司 |
氧代二氢咪唑并吡啶类化合物及其应用
|
|
US10683308B2
(en)
|
2015-09-11 |
2020-06-16 |
Navitor Pharmaceuticals, Inc. |
Rapamycin analogs and uses thereof
|
|
CA2904270A1
(en)
*
|
2015-09-11 |
2017-03-11 |
Pharmascience Inc. |
Protein kinase inhibitors
|
|
FI3747472T3
(fi)
|
2015-09-15 |
2024-06-03 |
Acerta Pharma Bv |
Cd19-inhibiittorin ja btk-inhibiittorin terapeuttiset yhdistelmät
|
|
WO2017046746A1
(en)
|
2015-09-15 |
2017-03-23 |
Acerta Pharma B.V. |
Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist
|
|
EP3350184B1
(en)
|
2015-09-16 |
2022-10-19 |
Loxo Oncology, Inc. |
Pyrazolopyrimidine derivatives as btk inhibitors for the treatment of cancer
|
|
EP3355875B1
(en)
|
2015-10-01 |
2021-09-29 |
Gilead Sciences, Inc. |
Combination of a btk inhibitor and a checkpoint inhibitor for treating cancers
|
|
CN106608877B
(zh)
*
|
2015-10-21 |
2018-11-13 |
新发药业有限公司 |
一种依鲁替尼中间体4-氨基-3-(4-苯氧基)苯基-1H-吡唑并[3,4-d]嘧啶的制备方法
|
|
CN108289866B
(zh)
|
2015-10-23 |
2025-10-28 |
纳维托制药有限公司 |
Sestrin-gator2相互作用的调节剂和其用途
|
|
US9834561B2
(en)
|
2015-10-28 |
2017-12-05 |
Scinopharm Taiwan, Ltd. |
Process for preparing ibrutinib and its intermediates
|
|
PL3377484T3
(pl)
*
|
2015-11-17 |
2024-04-08 |
Merck Patent Gmbh |
Metody dla terapii stwardnienia rozsianego z użyciem związków pirymidynowych i pirydynowych z aktywnością inhibitorową dla btk
|
|
CN105294696A
(zh)
*
|
2015-11-19 |
2016-02-03 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
|
EP3384294B1
(en)
|
2015-12-04 |
2021-10-13 |
Juno Therapeutics, Inc. |
Methods and compositions related to toxicity associated with cell therapy
|
|
EP3383396B1
(en)
|
2015-12-04 |
2023-07-12 |
Alexion Pharmaceuticals, Inc. |
Cerdulatinib and venetoclax for treating non-hodgkin's lymphoma
|
|
JO3793B1
(ar)
|
2015-12-10 |
2021-01-31 |
Janssen Pharmaceutica Nv |
مثبطات تيروزين كاينيز بروتون وأساليب استخدامها
|
|
JO3794B1
(ar)
|
2015-12-10 |
2021-01-31 |
Janssen Pharmaceutica Nv |
المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون
|
|
WO2017106352A1
(en)
|
2015-12-14 |
2017-06-22 |
Raze Therapeutics, Inc. |
Caffeine inhibitors of mthfd2 and uses thereof
|
|
HUE056877T2
(hu)
|
2015-12-16 |
2022-03-28 |
Boehringer Ingelheim Int |
Autoimmun betegségek kezelésére alkalmas bipirazolil-származékok
|
|
PT3390395T
(pt)
|
2015-12-16 |
2020-11-03 |
Loxo Oncology Inc |
Compostos úteis como inibidores de quinase
|
|
US10570118B2
(en)
|
2016-01-13 |
2020-02-25 |
Boehringer Ingelheim International Gmbh |
Isoquinolones as BTK inhibitors
|
|
WO2017122175A1
(en)
|
2016-01-13 |
2017-07-20 |
Acerta Pharma B.V. |
Therapeutic combinations of an antifolate and a btk inhibitor
|
|
HK1259434A1
(zh)
|
2016-01-19 |
2019-11-29 |
Janssen Pharmaceutica Nv |
包含btk抑制剂的配制品/组合物
|
|
US20190290650A1
(en)
|
2016-01-19 |
2019-09-26 |
Janssen Pharmaceutic Nv |
Formulations/compositions comprising a btk inhibitor
|
|
WO2017127371A1
(en)
|
2016-01-21 |
2017-07-27 |
Sunnylife Pharma Inc. |
Bruton's tyrosine kinase inhibitors
|
|
US10793566B2
(en)
|
2016-01-21 |
2020-10-06 |
Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. |
Bruton's tyrosine kinase inhibitors
|
|
CN106995446B
(zh)
*
|
2016-01-22 |
2021-07-02 |
山东新时代药业有限公司 |
布鲁顿酪氨酸激酶抑制剂制备方法
|
|
CN105732638B
(zh)
*
|
2016-01-22 |
2018-01-30 |
成都倍特药业有限公司 |
一种具有螺环或桥环结构的布鲁顿酪氨酸激酶抑制剂及其制备方法
|
|
WO2017134684A2
(en)
|
2016-02-01 |
2017-08-10 |
Natco Pharma Limited |
An improved process for the preparation of ibrutinib
|
|
WO2017134685A2
(en)
*
|
2016-02-02 |
2017-08-10 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazino compounds as btk inhibitors
|
|
US10435409B2
(en)
|
2016-02-04 |
2019-10-08 |
Shilpa Medicare Limited |
Process for the preparation of ibrutinib
|
|
WO2017133630A1
(zh)
*
|
2016-02-05 |
2017-08-10 |
北京盛诺基医药科技有限公司 |
一种布鲁顿酪氨酸激酶抑制剂
|
|
GB2558514A
(en)
*
|
2016-02-09 |
2018-07-18 |
Azad Pharmaceutical Ingredients Ag |
Process for the synthesis of stable amorphous ibrutinib
|
|
CA3015172A1
(en)
|
2016-02-18 |
2017-08-24 |
Privo Technologies, Inc. |
Two-stage microparticle-based therapeutic delivery system and method
|
|
CN105646499A
(zh)
*
|
2016-03-01 |
2016-06-08 |
孙霖 |
依鲁替尼晶型g及制备方法
|
|
CN105646498A
(zh)
*
|
2016-03-01 |
2016-06-08 |
孙霖 |
依鲁替尼晶型f及制备方法
|
|
EP3426243B1
(en)
|
2016-03-09 |
2021-05-19 |
Raze Therapeutics, Inc. |
3-phosphoglycerate dehydrogenase inhibitors and uses thereof
|
|
US11014882B2
(en)
*
|
2016-03-09 |
2021-05-25 |
Raze Therapeutics, Inc. |
3-phosphoglycerate dehydrogenase inhibitors and uses thereof
|
|
WO2017156495A1
(en)
|
2016-03-11 |
2017-09-14 |
Corvus Pharmaceuticals, Inc. |
Compounds and methods for modulating bruton's tyrosine kinase
|
|
WO2017163257A1
(en)
*
|
2016-03-21 |
2017-09-28 |
Ind-Swift Laboratories Limited |
Process for preparing pure lh-pyrazolo[3,4-d] pyrimidine derivative
|
|
PL3436447T3
(pl)
|
2016-03-31 |
2021-12-27 |
Takeda Pharmaceutical Company Limited |
Kompleksy triazolonu izochinolinylowego
|
|
CZ2016196A3
(cs)
|
2016-04-06 |
2017-10-18 |
Zentiva, K.S. |
Pevné formy Ibrutinibu
|
|
CA3019394A1
(en)
|
2016-04-08 |
2017-10-12 |
X4 Pharmaceuticals, Inc. |
Methods for treating cancer
|
|
SG10201911665UA
(en)
|
2016-04-15 |
2020-01-30 |
Cancer Research Tech Ltd |
Heterocyclic compounds as ret kinase inhibitors
|
|
PT3442535T
(pt)
|
2016-04-15 |
2022-09-05 |
Cancer Research Tech Ltd |
Compostos heterocíclicos como inibidores da ret quinase
|
|
EP3445364A4
(en)
|
2016-04-19 |
2019-11-27 |
Acetylon Pharmaceuticals, Inc. |
HDAC INHIBITORS, ONLY OR IN COMBINATION WITH BTK INHIBITORS, FOR THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA
|
|
AU2017258510A1
(en)
*
|
2016-04-29 |
2018-10-11 |
Dana-Farber Cancer Institute, Inc. |
HCK as a therapeutic target in MYD88 mutated diseases
|
|
CZ2016276A3
(cs)
|
2016-05-11 |
2017-11-22 |
Zentiva, K.S. |
Pevné formy volné báze ibrutinibu
|
|
KR102369735B1
(ko)
|
2016-05-20 |
2022-03-02 |
바이오하벤 파마슈티컬 홀딩 컴퍼니 엘티디. |
암을 치료하기 위한 면역요법과의 글루타메이트 조정제의 용도
|
|
CN105859728B
(zh)
*
|
2016-05-26 |
2018-06-08 |
江苏中邦制药有限公司 |
一种依鲁替尼的制备方法
|
|
US10966977B2
(en)
|
2016-05-27 |
2021-04-06 |
Tg Therapeutics, Inc. |
Combination of anti-CD20 antibody, P13 kinase-delta selective inhibitor, and BTK inhibitor to treat b-cell proliferative disorders
|
|
EP3472162B1
(en)
|
2016-06-16 |
2021-11-17 |
F. Hoffmann-La Roche AG |
Heteroaryl estrogen receptor modulators and uses thereof
|
|
CN109843882A
(zh)
|
2016-06-16 |
2019-06-04 |
豪夫迈·罗氏有限公司 |
四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途
|
|
MX388824B
(es)
*
|
2016-06-20 |
2025-03-20 |
Novartis Ag |
Formas cristalinas de compuesto de triazolopirimidina.
|
|
CA3027498A1
(en)
|
2016-06-21 |
2017-12-28 |
X4 Pharmaceuticals, Inc. |
Cxcr4 inhibitors and uses thereof
|
|
CN109640988A
(zh)
|
2016-06-21 |
2019-04-16 |
X4 制药有限公司 |
Cxcr4抑制剂及其用途
|
|
JP6994767B2
(ja)
|
2016-06-21 |
2022-01-14 |
エックス4 ファーマシューティカルズ, インコーポレイテッド |
Cxcr4阻害剤およびその使用
|
|
WO2018000250A1
(zh)
*
|
2016-06-29 |
2018-01-04 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
|
KR102391693B1
(ko)
|
2016-06-29 |
2022-04-29 |
프린시피아 바이오파마, 인코퍼레이티드 |
2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의 변형 방출 제제
|
|
CN106117214A
(zh)
*
|
2016-06-29 |
2016-11-16 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
|
MX388591B
(es)
|
2016-06-30 |
2025-03-20 |
Daewoong Pharmaceutical Co Ltd |
Derivados de pirazolopirimidina como inhibidor de cinasa.
|
|
WO2018002958A1
(en)
|
2016-06-30 |
2018-01-04 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazide containing compounds as btk inhibitors
|
|
WO2018007885A1
(en)
|
2016-07-05 |
2018-01-11 |
Beigene, Ltd. |
COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER
|
|
ES2965081T3
(es)
*
|
2016-07-07 |
2024-04-11 |
Daewoong Pharmaceutical Co Ltd |
Derivados 4-aminopirazolo[3,4-d]pirimidinil-azabiciclo y composición farmacéutica que comprende dichos derivados
|
|
CN107641123A
(zh)
*
|
2016-07-20 |
2018-01-30 |
南京亿华药业有限公司 |
一种依鲁替尼及其关键中间体的制备新方法
|
|
AU2017298035B2
(en)
|
2016-07-21 |
2021-10-28 |
Biogen Ma Inc. |
Succinate forms and compositions of Bruton's tyrosine kinase inhibitors
|
|
TWI884890B
(zh)
|
2016-08-16 |
2025-05-21 |
瑞士商百濟神州瑞士有限責任公司 |
(s)-7-(1-丙烯醯基六氫吡啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氫吡唑並[1,5-a]嘧啶-3-甲醯胺的晶型、其製備和用途
|
|
US11186578B2
(en)
|
2016-08-17 |
2021-11-30 |
Shenzhen Targetrx, Inc. |
Substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines as tyrosine kinase inhibitors
|
|
WO2018033135A1
(en)
|
2016-08-19 |
2018-02-22 |
Beigene, Ltd. |
Use of a combination comprising a btk inhibitor for treating cancers
|
|
US20190201409A1
(en)
|
2016-09-19 |
2019-07-04 |
Mei Pharma, Inc. |
Combination therapy
|
|
JP7590810B2
(ja)
*
|
2016-10-06 |
2024-11-27 |
ヤンセン ファーマシューティカ エヌ.ベー. |
Btk阻害剤を調製するための方法および中間体
|
|
JP7082130B2
(ja)
|
2016-10-14 |
2022-06-07 |
ニンバス ラクシュミ, インコーポレイテッド |
Tyk2阻害剤およびその使用
|
|
WO2018074387A1
(ja)
|
2016-10-17 |
2018-04-26 |
第一三共株式会社 |
Mdm2阻害剤とdnaメチルトランスフェラーゼ阻害剤との併用治療法
|
|
WO2018075937A1
(en)
|
2016-10-21 |
2018-04-26 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
|
HUE054496T2
(hu)
|
2016-10-28 |
2021-09-28 |
Morphosys Ag |
CD19 elleni ellenanyag kombinálása BCL-2-gátlóval és alkalmazásuk
|
|
US20190298772A1
(en)
|
2016-11-03 |
2019-10-03 |
Juno Therapeutics, Inc. |
Combination therapy of a t cell-based therapy and a btk inhibitor
|
|
WO2018089499A1
(en)
|
2016-11-08 |
2018-05-17 |
Navitor Pharmaceuticals, Inc. |
PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF
|
|
WO2018090792A1
(zh)
*
|
2016-11-15 |
2018-05-24 |
杭州和正医药有限公司 |
一种选择性布鲁顿酪氨酸激酶抑制剂及其应用
|
|
CN108101905A
(zh)
*
|
2016-11-24 |
2018-06-01 |
中国科学院上海药物研究所 |
嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
|
|
EP3548005A4
(en)
|
2016-11-29 |
2020-06-17 |
Puretech Health LLC |
Exosomes for delivery of therapeutic agents
|
|
US10183024B2
(en)
|
2016-12-02 |
2019-01-22 |
Apotex Inc. |
Crystalline forms of ibrutinib
|
|
CA3045339A1
(en)
|
2016-12-03 |
2018-06-07 |
Juno Therapeutics, Inc. |
Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors
|
|
US11091451B2
(en)
|
2016-12-05 |
2021-08-17 |
Raze Therapeutics, Inc. |
SHMT inhibitors and uses thereof
|
|
MY203083A
(en)
*
|
2016-12-21 |
2024-06-07 |
Acerta Pharma Bv |
Imidazopyrazine inhibitors of bruton's tyrosine kinase
|
|
EP3559018A1
(en)
|
2016-12-23 |
2019-10-30 |
Bicyclerd Limited |
Peptide derivatives having novel linkage structures
|
|
EP3565638B8
(en)
|
2017-01-06 |
2024-04-10 |
BicycleRD Limited |
Bicycle conjugate for treating cancer
|
|
EP3573989A4
(en)
|
2017-01-25 |
2020-11-18 |
Beigene, Ltd. |
CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) PIPERIDIN-4-YL) -2- (4-PHENOXYPHENYL) -4, 5, 6, 7-TETRAHY DROPYRAZOLO [1, 5-A ] PYRIMIDINE-3-CARBOXAMIDE, PREPARATION AND ASSOCIATED USES
|
|
US20180235899A1
(en)
|
2017-02-17 |
2018-08-23 |
Privo Technologies, Inc. |
Particle-based multi-layer therapeutic delivery device and method
|
|
JP7014811B2
(ja)
|
2017-02-24 |
2022-02-01 |
ギリアド サイエンシズ, インコーポレイテッド |
ブルトン型チロシンキナーゼの阻害剤
|
|
WO2018156901A1
(en)
|
2017-02-24 |
2018-08-30 |
Gilead Sciences, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
CA3055209A1
(en)
|
2017-03-08 |
2018-09-13 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors, uses, and methods for production thereof
|
|
CN108570036A
(zh)
*
|
2017-03-09 |
2018-09-25 |
北京赛林泰医药技术有限公司 |
一种btk抑制剂的多晶型物及其制备方法
|
|
GB201703876D0
(en)
|
2017-03-10 |
2017-04-26 |
Berlin-Chemie Ag |
Pharmaceutical combinations
|
|
EP3375778A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aryl-piperidine derivatives
|
|
EP3595777A4
(en)
*
|
2017-03-14 |
2021-01-20 |
Dana-Farber Cancer Institute, Inc. |
LOW MOLECULAR SENSITIVITY OF BAX ACTIVATION FOR INDUCING CELL DEATH
|
|
EP3375784A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aza-dihydro-acridone derivatives
|
|
US11554118B2
(en)
*
|
2017-03-22 |
2023-01-17 |
Xibin Liao |
Bruton's tyrosine kinase inhibitors
|
|
WO2018191146A1
(en)
|
2017-04-10 |
2018-10-18 |
Navitor Pharmaceuticals, Inc. |
Heteroaryl rheb inhibitors and uses thereof
|
|
GB201705971D0
(en)
|
2017-04-13 |
2017-05-31 |
Cancer Res Tech Ltd |
Inhibitor compounds
|
|
US10800787B2
(en)
|
2017-04-20 |
2020-10-13 |
Apotex Inc. |
Process for the preparation of acalabrutinib
|
|
CN107043366B
(zh)
*
|
2017-04-25 |
2020-05-26 |
中国药科大学 |
4-氨基嘧啶类化合物、其制备方法及医药用途
|
|
TWI776886B
(zh)
|
2017-04-26 |
2022-09-11 |
美商奈維特製藥公司 |
Sestrin-gator2交互作用之調節劑及其用途
|
|
US10857196B2
(en)
|
2017-04-27 |
2020-12-08 |
Bicycletx Limited |
Bicyclic peptide ligands and uses thereof
|
|
US10478403B1
(en)
|
2017-05-03 |
2019-11-19 |
Privo Technologies, Inc. |
Intraoperative topically-applied non-implantable rapid release patch
|
|
JP2020522489A
(ja)
|
2017-06-02 |
2020-07-30 |
ジュノー セラピューティクス インコーポレイテッド |
養子細胞療法を用いる処置のための製造物品および方法
|
|
WO2018223098A1
(en)
|
2017-06-02 |
2018-12-06 |
Juno Therapeutics, Inc. |
Articles of manufacture and methods related to toxicity associated with cell therapy
|
|
CN109111446B
(zh)
*
|
2017-06-22 |
2021-11-30 |
上海度德医药科技有限公司 |
一种具有药物活性的杂芳基化合物
|
|
US10899798B2
(en)
|
2017-06-26 |
2021-01-26 |
Bicyclerd Limited |
Bicyclic peptide ligands with detectable moieties and uses thereof
|
|
WO2019001417A1
(en)
|
2017-06-26 |
2019-01-03 |
Beigene, Ltd. |
IMMUNOTHERAPY FOR HEPATOCELLULAR CARCINOMA
|
|
MX2019015155A
(es)
|
2017-06-29 |
2020-08-03 |
Juno Therapeutics Inc |
Modelo de raton para valorar toxicidades asociadas con inmunoterapias.
|
|
KR102384924B1
(ko)
*
|
2017-07-12 |
2022-04-08 |
주식회사 대웅제약 |
신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
|
|
WO2019013562A1
(ko)
|
2017-07-12 |
2019-01-17 |
주식회사 대웅제약 |
신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
|
|
US11046698B2
(en)
|
2017-07-28 |
2021-06-29 |
Nimbus Lakshmi, Inc. |
TYK2 inhibitors and uses thereof
|
|
JP7670481B2
(ja)
|
2017-08-04 |
2025-04-30 |
バイスクルテクス・リミテッド |
Cd137に対して特異的な二環式ペプチドリガンド
|
|
CN110997677A
(zh)
|
2017-08-12 |
2020-04-10 |
百济神州有限公司 |
具有改进的双重选择性的Btk抑制剂
|
|
US20200291096A1
(en)
|
2017-08-14 |
2020-09-17 |
Bicyclerd Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
|
US20200283482A1
(en)
|
2017-08-14 |
2020-09-10 |
Bicyclerd Limited |
Bicyclic peptide ligand prr-a conjugates and uses thereof
|
|
US11883497B2
(en)
|
2017-08-29 |
2024-01-30 |
Puretech Lyt, Inc. |
Lymphatic system-directing lipid prodrugs
|
|
EP4306524A3
(en)
|
2017-08-29 |
2024-09-11 |
PureTech LYT, Inc. |
Lymphatic system-directing lipid prodrugs
|
|
US20210071258A1
(en)
|
2017-09-01 |
2021-03-11 |
Juno Therapeutics, Inc. |
Gene expression and assessment of risk of developing toxicity following cell therapy
|
|
IL273432B
(en)
|
2017-09-22 |
2022-09-01 |
Kymera Therapeutics Inc |
Protein compounds and their uses
|
|
EP3684366A4
(en)
|
2017-09-22 |
2021-09-08 |
Kymera Therapeutics, Inc. |
Crbn ligands and uses thereof
|
|
EA037031B1
(ru)
*
|
2017-10-06 |
2021-01-28 |
Асерта Фарма Б.В. |
Имидазопиразиновые ингибиторы тирозинкиназы брутона
|
|
KR102613433B1
(ko)
*
|
2017-10-11 |
2023-12-13 |
주식회사 대웅제약 |
신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물
|
|
TW201922256A
(zh)
|
2017-10-27 |
2019-06-16 |
中國大陸商浙江導明醫藥科技有限公司 |
治療淋巴樣惡性疾病之方法
|
|
US11564946B2
(en)
|
2017-11-01 |
2023-01-31 |
Juno Therapeutics, Inc. |
Methods associated with tumor burden for assessing response to a cell therapy
|
|
CN111801334B
(zh)
|
2017-11-29 |
2023-06-09 |
百济神州瑞士有限责任公司 |
使用包含btk抑制剂的组合治疗惰性或侵袭性b-细胞淋巴瘤
|
|
CZ2017787A3
(cs)
|
2017-12-08 |
2019-06-19 |
Zentiva, K.S. |
Farmaceutické kompozice obsahující ibrutinib
|
|
GB201721265D0
(en)
|
2017-12-19 |
2018-01-31 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for EphA2
|
|
TWI825046B
(zh)
|
2017-12-19 |
2023-12-11 |
英商拜西可泰克斯有限公司 |
Epha2特用之雙環胜肽配位基
|
|
EP3727362A4
(en)
|
2017-12-19 |
2021-10-06 |
PureTech LYT, Inc. |
MYCOPHENOLIC ACID LIPID PRODRUGS AND THEIR USES
|
|
US11304954B2
(en)
|
2017-12-19 |
2022-04-19 |
Puretech Lyt, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
|
US11608345B1
(en)
|
2017-12-19 |
2023-03-21 |
Puretech Lyt, Inc. |
Lipid prodrugs of rapamycin and its analogs and uses thereof
|
|
IL315310A
(en)
|
2017-12-26 |
2024-10-01 |
Kymera Therapeutics Inc |
Irak degraders and uses thereof
|
|
WO2019127008A1
(zh)
*
|
2017-12-26 |
2019-07-04 |
清华大学 |
一种靶向降解btk的化合物及其应用
|
|
CN108220261B
(zh)
*
|
2017-12-29 |
2021-05-14 |
安徽联创生物医药股份有限公司 |
酮还原酶、核酸、重组表达载体、重组表达菌株及应用
|
|
EP3737675A4
(en)
|
2018-01-12 |
2022-01-05 |
Kymera Therapeutics, Inc. |
Crbn ligands and uses thereof
|
|
EP3737666A4
(en)
|
2018-01-12 |
2022-01-05 |
Kymera Therapeutics, Inc. |
PROTEIN DEGRADATION AGENTS AND ASSOCIATED USES
|
|
CA3089537A1
(en)
|
2018-01-20 |
2019-07-25 |
Natco Pharma Limited |
Pharmaceutical compositions comprising ibrutinib
|
|
KR20200116481A
(ko)
|
2018-01-29 |
2020-10-12 |
메르크 파텐트 게엠베하 |
Gcn2 억제제 및 이의 용도
|
|
JP7377207B2
(ja)
|
2018-01-29 |
2023-11-09 |
メルク パテント ゲーエムベーハー |
Gcn2阻害剤およびその使用
|
|
US10875894B2
(en)
|
2018-02-23 |
2020-12-29 |
Bicycletx Limited |
Multimeric bicyclic peptide ligands
|
|
CN112189009B
(zh)
|
2018-02-27 |
2023-09-29 |
阿塔克斯生物制药有限公司 |
作为tcr-nck相互作用的抑制剂的色烯衍生物
|
|
SG11202009443RA
(en)
|
2018-04-05 |
2020-10-29 |
Sumitomo Dainippon Pharma Oncology Inc |
Axl kinase inhibitors and use of the same
|
|
US20210113562A1
(en)
|
2018-04-13 |
2021-04-22 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer
|
|
AR114828A1
(es)
|
2018-04-24 |
2020-10-21 |
Vertex Pharma |
Compuestos de pteridinona y sus usos
|
|
DK3784666T3
(da)
|
2018-04-24 |
2022-06-20 |
Merck Patent Gmbh |
Antiproliferationsforbindelser og anvendelser deraf
|
|
KR102106821B1
(ko)
|
2018-04-27 |
2020-05-06 |
재단법인대구경북과학기술원 |
이브루티닙을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물
|
|
EP3789040A4
(en)
|
2018-04-27 |
2022-03-09 |
ONO Pharmaceutical Co., Ltd. |
PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASES WITH A COMPOUND WITH BTK INHIBITING ACTIVITY AS AN INGREDIENT
|
|
MX2020011527A
(es)
|
2018-05-03 |
2021-02-26 |
Juno Therapeutics Inc |
Terapia de combinación de una terapia de células t-receptor de antígeno quimérico (car) y un inhibidor de cinasa.
|
|
EP3788035B1
(en)
|
2018-05-04 |
2024-08-07 |
Alexion Pharmaceuticals, Inc. |
Solid forms of cerdulatinib
|
|
EP3575300A1
(en)
|
2018-05-31 |
2019-12-04 |
Apotex Inc. |
Novel crystalline forms of ibrutinib
|
|
IL259810A
(en)
|
2018-06-04 |
2018-07-31 |
Yeda Res & Dev |
Mitogen-activated protein kinase kinase 7 inhibitors
|
|
RU2711106C2
(ru)
*
|
2018-06-06 |
2020-01-15 |
Общество с ограниченной ответственностью "АКСЕЛЬФАРМ" |
Кристаллическая μ-модификация 1-[(3R)-3-[4-амино-3-(4-фенокси-фенил)-1Н-пиразоло[3,4-d]пиримидин-1-ил]-1-пиперидил]-2-пропенил-1-она, способ её получения и фармацевтическая композиция на её основе
|
|
EA202190045A1
(ru)
|
2018-06-15 |
2021-03-17 |
Янссен Фармацевтика Нв |
Составы/композиции, содержащие ибрутиниб
|
|
FI3813946T3
(fi)
|
2018-06-15 |
2024-06-25 |
Janssen Pharmaceutica Nv |
Rapamysiinianalogeja ja niiden käyttötapoja
|
|
GB201810316D0
(en)
|
2018-06-22 |
2018-08-08 |
Bicyclerd Ltd |
Peptide ligands for binding to EphA2
|
|
IL279489B2
(en)
|
2018-06-22 |
2025-10-01 |
Bicycletx Ltd |
Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
|
|
WO2020005807A1
(en)
|
2018-06-25 |
2020-01-02 |
Dana-Farber Cancer Institute, Inc. |
Taire family kinase inhibitors and uses thereof
|
|
WO2020010227A1
(en)
|
2018-07-06 |
2020-01-09 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
|
WO2020010177A1
(en)
|
2018-07-06 |
2020-01-09 |
Kymera Therapeutics, Inc. |
Tricyclic crbn ligands and uses thereof
|
|
WO2020023910A1
(en)
|
2018-07-26 |
2020-01-30 |
Tolero Pharmaceuticals, Inc. |
Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
|
|
KR102653681B1
(ko)
|
2018-07-31 |
2024-04-03 |
록쏘 온콜로지, 인코포레이티드 |
(s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제
|
|
KR102328682B1
(ko)
|
2018-08-27 |
2021-11-18 |
주식회사 대웅제약 |
신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물
|
|
WO2020045941A1
(ko)
|
2018-08-27 |
2020-03-05 |
주식회사 대웅제약 |
신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물
|
|
CN112218877B
(zh)
|
2018-08-27 |
2025-07-25 |
瑞泽恩制药公司 |
拉曼光谱在下游纯化中的应用
|
|
US10548889B1
(en)
|
2018-08-31 |
2020-02-04 |
X4 Pharmaceuticals, Inc. |
Compositions of CXCR4 inhibitors and methods of preparation and use
|
|
WO2020043321A1
(en)
*
|
2018-08-31 |
2020-03-05 |
Stichting Katholieke Universiteit |
Synergistic combinations of amino acid depletion agent sensitizers (aadas) and amino acid depletion agents (aada), and therapeutic methods of use thereof
|
|
US12030875B2
(en)
|
2018-09-07 |
2024-07-09 |
PIC Therapeutics, Inc. |
EIF4E inhibitors and uses thereof
|
|
CN110964016B
(zh)
*
|
2018-09-29 |
2021-05-28 |
南京药捷安康生物科技有限公司 |
氨基降茨烷衍生物及其制备方法与应用
|
|
IL324623A
(en)
|
2018-10-15 |
2026-01-01 |
Takeda Pharmaceuticals Co |
Tyk2 inhibitors and their uses
|
|
CN112955459A
(zh)
|
2018-10-23 |
2021-06-11 |
拜斯科技术开发有限公司 |
双环肽配体和其用途
|
|
CA3117336A1
(en)
|
2018-10-24 |
2020-04-30 |
Navitor Pharmaceuticals, Inc. |
Polymorphs of (s)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid for use in modulating mtorc1
|
|
CN111170986A
(zh)
|
2018-11-13 |
2020-05-19 |
北京睿熙生物科技有限公司 |
布鲁顿酪氨酸激酶的抑制剂
|
|
CN109293630A
(zh)
*
|
2018-11-15 |
2019-02-01 |
山东大学 |
含取代吡唑类化合物及其制备方法与应用
|
|
CN109369654A
(zh)
*
|
2018-11-20 |
2019-02-22 |
山东大学 |
1,3-二取代-4-氨基吡唑并嘧啶类化合物及其制备方法和应用
|
|
US11352350B2
(en)
|
2018-11-30 |
2022-06-07 |
Kymera Therapeutics, Inc. |
IRAK degraders and uses thereof
|
|
BR112021010120A2
(pt)
|
2018-11-30 |
2021-08-31 |
Juno Therapeutics, Inc. |
Métodos para dosagem e tratamento de malignidades celulares em terapia celular adotiva
|
|
CA3120866A1
(en)
|
2018-11-30 |
2020-06-04 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
|
FI3886875T3
(fi)
|
2018-11-30 |
2024-07-23 |
Juno Therapeutics Inc |
Adoptiivista soluterapiaa käyttäviä hoitomenetelmiä
|
|
GB201820288D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicycle Tx Ltd |
Bicycle peptide ligaands specific for MT1-MMP
|
|
GB201820325D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for psma
|
|
GB201820295D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for MT1-MMP
|
|
EP3670659A1
(en)
|
2018-12-20 |
2020-06-24 |
Abivax |
Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
|
|
WO2020132561A1
(en)
|
2018-12-20 |
2020-06-25 |
C4 Therapeutics, Inc. |
Targeted protein degradation
|
|
JPWO2020130125A1
(ja)
|
2018-12-21 |
2021-11-04 |
第一三共株式会社 |
抗体−薬物コンジュゲートとキナーゼ阻害剤の組み合わせ
|
|
CN113260420A
(zh)
|
2018-12-21 |
2021-08-13 |
拜斯科阿迪有限公司 |
Pd-l1特异性的双环肽配体
|
|
CN113474045A
(zh)
|
2018-12-21 |
2021-10-01 |
拜斯科技术开发有限公司 |
Pd-l1特异性的双环肽配体
|
|
US10688050B1
(en)
|
2018-12-21 |
2020-06-23 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
|
EP3669867A1
(en)
|
2018-12-21 |
2020-06-24 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
|
JP7660063B2
(ja)
|
2018-12-28 |
2025-04-10 |
ダナ-ファーバー キャンサー インスティテュート, インコーポレイテッド |
サイクリン依存性キナーゼ7のインヒビターおよびそれらの使用
|
|
EP3908268A1
(en)
|
2019-01-09 |
2021-11-17 |
Yeda Research and Development Co. Ltd |
Modulators of pin1 activity and uses thereof
|
|
CN111454268B
(zh)
|
2019-01-18 |
2023-09-08 |
明慧医药(上海)有限公司 |
作为布鲁顿酪氨酸激酶抑制剂的环状分子
|
|
US11174264B2
(en)
|
2019-01-23 |
2021-11-16 |
Nimbus Lakshmi, Inc. |
TYK2 inhibitors and uses thereof
|
|
JP7662528B2
(ja)
|
2019-02-12 |
2025-04-15 |
スミトモ ファーマ アメリカ, インコーポレイテッド |
複素環式タンパク質キナーゼ阻害剤を含む製剤
|
|
WO2020165600A1
(en)
|
2019-02-14 |
2020-08-20 |
Bicycletx Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
|
WO2020170270A1
(en)
*
|
2019-02-19 |
2020-08-27 |
Msn Laboratories Private Limited, R&D Center |
Novel crystalline polymorphs of 1-[(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one and process for preparation thereof
|
|
MX2021009863A
(es)
|
2019-03-21 |
2021-11-12 |
Onxeo |
Una molecula dbait en combinacion con inhibidor de quinasa para el tratamiento del cancer.
|
|
SG11202110828UA
(en)
|
2019-04-02 |
2021-10-28 |
Bicycletx Ltd |
Bicycle toxin conjugates and uses thereof
|
|
JP2022527114A
(ja)
|
2019-04-05 |
2022-05-30 |
カイメラ セラピューティクス, インコーポレイテッド |
分解剤およびそれらの使用
|
|
WO2020234379A1
(en)
|
2019-05-21 |
2020-11-26 |
Janssen Pharmaceutica Nv |
Processes and intermediates for preparing a btk inhibitor
|
|
EP3972977A1
(en)
*
|
2019-05-21 |
2022-03-30 |
Janssen Pharmaceutica NV |
Processes and intermediates for preparing a btk inhibitor
|
|
WO2020243193A1
(en)
|
2019-05-28 |
2020-12-03 |
PAIGE.AI, Inc. |
Systems and methods for processing images to prepare slides for processed images for digital pathology
|
|
CN114502540A
(zh)
|
2019-05-31 |
2022-05-13 |
医肯纳肿瘤学公司 |
Tead抑制剂和其用途
|
|
WO2020251972A1
(en)
|
2019-06-10 |
2020-12-17 |
Kymera Therapeutics, Inc. |
Smarca degraders and uses thereof
|
|
CN113939289A
(zh)
|
2019-06-10 |
2022-01-14 |
百济神州瑞士有限责任公司 |
一种含有布鲁顿氏酪氨酸激酶抑制剂的口服固体片剂及其制备方法
|
|
BR112021026517A2
(pt)
|
2019-06-28 |
2022-05-10 |
Kymera Therapeutics Inc |
Degradadores de irak e usos dos mesmos
|
|
WO2021011868A1
(en)
|
2019-07-17 |
2021-01-21 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
TWI862640B
(zh)
|
2019-07-30 |
2024-11-21 |
英商拜西可泰克斯有限公司 |
異質雙環肽複合物
|
|
WO2021038540A1
(en)
|
2019-08-31 |
2021-03-04 |
Sun Pharma Advanced Research Company Limited |
Cycloalkylidene carboxylic acids and derivatives as btk inhibitors
|
|
AU2020345962A1
(en)
|
2019-09-11 |
2022-03-31 |
Vincere Biosciences, Inc. |
USP30 inhibitors and uses thereof
|
|
US12215105B2
(en)
|
2019-09-13 |
2025-02-04 |
Nimbus Saturn, Inc. |
HPK1 antagonists and uses thereof
|
|
CA3157331A1
(en)
|
2019-10-08 |
2021-04-15 |
Dana-Farber Cancer Institute, Inc. |
A pyrazolopyrimidine derivative as a hck inhibitor for use in therapy, in particular myd88 mutated diseases
|
|
TWI877239B
(zh)
|
2019-10-14 |
2025-03-21 |
美商普林斯匹亞生物製藥公司 |
藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法
|
|
JP2022554276A
(ja)
|
2019-11-01 |
2022-12-28 |
ナビター ファーマシューティカルズ, インコーポレイテッド |
Mtorc1モジュレーターを使用する処置方法
|
|
EP4054579A1
(en)
|
2019-11-08 |
2022-09-14 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
|
|
WO2021113665A1
(en)
|
2019-12-05 |
2021-06-10 |
Navitor Pharmaceuticals, Inc. |
Rapamycin analogs and uses thereof
|
|
EP4070097A1
(en)
|
2019-12-06 |
2022-10-12 |
Juno Therapeutics, Inc. |
Methods related to toxicity and response associated with cell therapy for treating b cell malignancies
|
|
CN115175677A
(zh)
|
2019-12-06 |
2022-10-11 |
罗索肿瘤学公司 |
布鲁顿氏酪氨酸激酶抑制剂的给药
|
|
WO2021119159A1
(en)
|
2019-12-10 |
2021-06-17 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
KR20220145325A
(ko)
|
2019-12-17 |
2022-10-28 |
카이메라 쎄라퓨틱스 인코포레이티드 |
Irak 분해제 및 이의 용도
|
|
WO2021127283A2
(en)
|
2019-12-17 |
2021-06-24 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
EP4081308A4
(en)
|
2019-12-23 |
2024-01-24 |
Kymera Therapeutics, Inc. |
SMARCA DEGRADERS AND USES THEREOF
|
|
WO2021133917A1
(en)
|
2019-12-23 |
2021-07-01 |
Kymera Therapeutics, Inc. |
Smarca inhibitors and uses thereof
|
|
CA3168146A1
(en)
|
2020-01-20 |
2021-07-29 |
Genzyme Corporation |
Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
MX2022009009A
(es)
|
2020-01-22 |
2022-08-15 |
Principia Biopharma Inc |
Formas cristalinas de 2-[3-[4-amino-3-(2-fluoro-4-fenoxi-fenil)-1h -pirazolo[3,4-d]pirimidin-1-il]piperidin-1-carbonil]-4-metil-4-[4 -(oxetan-3-il)piperazin-1-il]pent-2-enonitrilo.
|
|
IL295362A
(en)
|
2020-02-05 |
2022-10-01 |
Puretech Lyt Inc |
Lipid drug inhibitors of neurosteroids
|
|
WO2021164697A1
(zh)
*
|
2020-02-18 |
2021-08-26 |
深圳市塔吉瑞生物医药有限公司 |
取代的酰胺衍生物及其组合物及用途
|
|
MX2022010391A
(es)
|
2020-02-26 |
2022-09-05 |
Daewoong Pharmaceutical Co Ltd |
Metodo de preparacion de derivados de amina heterociclica.
|
|
CA3170411A1
(en)
|
2020-03-03 |
2021-09-10 |
Christopher L. Vandeusen |
Eif4e inhibitors and uses thereof
|
|
MX2022011602A
(es)
|
2020-03-19 |
2023-01-04 |
Kymera Therapeutics Inc |
Degradadores de la proteína de homólogo de ratón de minuto 2 (mdm2) y usos de los mismos.
|
|
TW202210483A
(zh)
|
2020-06-03 |
2022-03-16 |
美商凱麥拉醫療公司 |
Irak降解劑之結晶型
|
|
EP4161521A4
(en)
|
2020-06-03 |
2024-07-10 |
Kymera Therapeutics, Inc. |
DEUTERED IRAQ DEGRADERS AND USES THEREOF
|
|
CN114057724B
(zh)
*
|
2020-07-29 |
2025-01-03 |
鲁南制药集团股份有限公司 |
一种btk抑制剂
|
|
CN116348476A
(zh)
|
2020-08-03 |
2023-06-27 |
拜斯科技术开发有限公司 |
基于肽的接头
|
|
US20240240255A1
(en)
|
2020-08-17 |
2024-07-18 |
Bicycletx Limited |
Bicycle conjugates specific for nectin-4 and uses thereof
|
|
US20230320990A1
(en)
|
2020-08-28 |
2023-10-12 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
|
WO2022047289A1
(en)
*
|
2020-08-28 |
2022-03-03 |
Emory University |
Methods of managing cocaine or other drug addictions
|
|
CN114105991A
(zh)
*
|
2020-08-31 |
2022-03-01 |
北京四环制药有限公司 |
一种伊布替尼中间体的制备方法
|
|
CN114105990A
(zh)
*
|
2020-08-31 |
2022-03-01 |
北京四环制药有限公司 |
一种伊布替尼的合成方法
|
|
CN114478548B
(zh)
*
|
2020-10-23 |
2026-01-02 |
上海润石医药科技有限公司 |
一种布鲁顿酪氨酸激酶抑制剂的用途
|
|
EP4232425A4
(en)
|
2020-10-23 |
2024-07-24 |
Nimbus Clotho, Inc. |
Ctps1 inhibitors and uses thereof
|
|
AU2021392040A1
(en)
|
2020-12-02 |
2023-06-29 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
WO2022120353A1
(en)
|
2020-12-02 |
2022-06-09 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
CN118434732A
(zh)
|
2020-12-10 |
2024-08-02 |
建新公司 |
Tolebrutinib的晶型及其制备方法和用途
|
|
CN112574216B
(zh)
*
|
2020-12-16 |
2022-03-08 |
天津济坤医药科技有限公司 |
一种化合物及其制备方法以及其在制备治疗抗癌药物中的应用
|
|
TW202241891A
(zh)
|
2020-12-30 |
2022-11-01 |
美商凱麥拉醫療公司 |
Irak降解劑及其用途
|
|
EP4281454B1
(en)
|
2021-01-21 |
2025-03-05 |
Synthon B.V. |
Process for making ibrutinib
|
|
MX2023009060A
(es)
|
2021-02-02 |
2023-09-29 |
Liminal Biosciences Ltd |
Antagonistas de gpr84 y usos de estos.
|
|
AU2022215844A1
(en)
|
2021-02-02 |
2023-09-14 |
Liminal Biosciences Limited |
Gpr84 antagonists and uses thereof
|
|
JP2024506909A
(ja)
|
2021-02-12 |
2024-02-15 |
ニンバス サターン, インコーポレイテッド |
Hpk1アンタゴニスト及びその使用
|
|
AU2022220869A1
(en)
|
2021-02-15 |
2023-08-24 |
Kymera Therapeutics, Inc. |
Irak4 degraders and uses thereof
|
|
US12171768B2
(en)
|
2021-02-15 |
2024-12-24 |
Kymera Therapeutics, Inc. |
IRAK4 degraders and uses thereof
|
|
CN117295737A
(zh)
|
2021-03-05 |
2023-12-26 |
林伯士萨顿公司 |
Hpk1拮抗剂和其用途
|
|
WO2022213062A1
(en)
|
2021-03-29 |
2022-10-06 |
Nimbus Saturn, Inc. |
Hpk1 antagonists and uses thereof
|
|
CN115160319B
(zh)
*
|
2021-04-01 |
2023-12-26 |
西安新通药物研究股份有限公司 |
含1,3-苯并二氧戊环结构的化合物及其制备方法与用途
|
|
US12325697B2
(en)
|
2021-04-09 |
2025-06-10 |
Nimbus Clio, Inc. |
CBL-B modulators and uses thereof
|
|
CA3215081A1
(en)
|
2021-04-16 |
2022-10-20 |
Alfredo C. Castro |
Mek inhibitors and uses thereof
|
|
IL308314A
(en)
|
2021-05-07 |
2024-01-01 |
Kymera Therapeutics Inc |
CDK2 compounds and their uses
|
|
CA3220269A1
(en)
*
|
2021-06-01 |
2022-12-08 |
Manijeh N. Goldberg |
Enhanced two-stage microparticle-based localized therapeutic delivery system
|
|
US11433072B1
(en)
|
2021-06-10 |
2022-09-06 |
Hikma Pharmaceuticals USA, Inc. |
Oral dosage forms of ibrutinib
|
|
TN2023000295A1
(en)
|
2021-06-10 |
2025-07-02 |
Hikma Pharmaceuticals Usa Inc |
Oral dosage forms of ibrutinib
|
|
CN113583001A
(zh)
*
|
2021-07-13 |
2021-11-02 |
江苏君若药业有限公司 |
依鲁替尼的制备
|
|
WO2023014817A1
(en)
|
2021-08-03 |
2023-02-09 |
Syros Pharmaceuticals, Inc. |
Compositions and methods for treating lymphomas with a cdk7 inhibitor in combination with a btk inhibitor
|
|
CN115702898B
(zh)
*
|
2021-08-04 |
2024-02-09 |
成都倍特药业股份有限公司 |
一种btk抑制剂固体制剂及其制备方法
|
|
AU2022334296A1
(en)
|
2021-08-25 |
2024-03-07 |
PIC Therapeutics, Inc. |
Eif4e inhibitors and uses thereof
|
|
EP4392421A1
(en)
|
2021-08-25 |
2024-07-03 |
PIC Therapeutics, Inc. |
Eif4e inhibitors and uses thereof
|
|
CN113845521B
(zh)
*
|
2021-08-31 |
2024-06-18 |
中原工学院 |
水相中光催化一锅法合成咪唑并含氮杂环肼类衍生物的方法
|
|
CN114940678B
(zh)
*
|
2021-09-26 |
2023-02-07 |
上海贵之言医药科技有限公司 |
一种吡唑并嘧啶酯类化合物
|
|
WO2023071973A1
(en)
*
|
2021-10-26 |
2023-05-04 |
Shenzhen Targetrx, Inc. |
Fused bicyclic compound for inhibiting activity of tyrosine kinase
|
|
JP2024540080A
(ja)
|
2021-10-29 |
2024-10-31 |
カイメラ セラピューティクス, インコーポレイテッド |
Irak4分解剤およびその合成
|
|
US20250144100A1
(en)
|
2021-12-10 |
2025-05-08 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
|
WO2023114984A1
(en)
|
2021-12-17 |
2023-06-22 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
JP2025504059A
(ja)
|
2022-01-31 |
2025-02-06 |
カイメラ セラピューティクス, インコーポレイテッド |
Irakデグレーダー及びその使用
|
|
WO2023173057A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
|
WO2023173053A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
|
CN114605418B
(zh)
*
|
2022-03-15 |
2023-09-05 |
广东医科大学附属医院 |
一类具有抗肿瘤活性的依鲁替尼丙烯酰胺类衍生物及其合成方法与应用
|
|
WO2023211889A1
(en)
|
2022-04-25 |
2023-11-02 |
Ikena Oncology, Inc. |
Polymorphic compounds and uses thereof
|
|
US20250302954A1
(en)
|
2022-05-11 |
2025-10-02 |
Celgene Corporation |
Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
|
|
JP2025519119A
(ja)
|
2022-05-25 |
2025-06-24 |
イケナ オンコロジー, インコーポレイテッド |
Mek阻害剤及びその使用
|
|
US11965032B1
(en)
|
2022-06-01 |
2024-04-23 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
|
US11807689B1
(en)
|
2022-06-01 |
2023-11-07 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
|
US11884740B1
(en)
|
2022-06-01 |
2024-01-30 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
|
US11814439B1
(en)
|
2022-06-01 |
2023-11-14 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
|
US11786531B1
(en)
|
2022-06-08 |
2023-10-17 |
Beigene Switzerland Gmbh |
Methods of treating B-cell proliferative disorder
|
|
WO2023242384A1
(en)
|
2022-06-17 |
2023-12-21 |
Krka, D.D., Novo Mesto |
Crystalline form of ibrutinib
|
|
TW202413364A
(zh)
*
|
2022-06-22 |
2024-04-01 |
美商健臻公司 |
製備經修飾的btk抑制劑的方法
|
|
KR20250056924A
(ko)
|
2022-08-02 |
2025-04-28 |
리미널 바이오사이언시스 리미티드 |
치환된 피리돈 gpr84 길항제 및 이의 용도
|
|
IL318575A
(en)
|
2022-08-02 |
2025-03-01 |
Liminal Biosciences Ltd |
HETEROARYL CARBOXAMIDE AND GPR84-RELATED ANTAGONISTS AND USES THEREOF
|
|
WO2024028364A1
(en)
|
2022-08-02 |
2024-02-08 |
Liminal Biosciences Limited |
Aryl-triazolyl and related gpr84 antagonists and uses thereof
|
|
CN115417827B
(zh)
*
|
2022-09-30 |
2023-05-26 |
中国药科大学 |
6-氨基-1,3,5-三嗪类化合物及其合成方法和应用
|
|
AU2023372386A1
(en)
|
2022-10-31 |
2025-05-08 |
Sumitomo Pharma America, Inc. |
Pim1 inhibitor for treating myeloproliferative neoplasms
|
|
AR131141A1
(es)
|
2022-11-22 |
2025-02-19 |
Pic Therapeutics Inc |
Inhibidores de eif4e y usos de los mismos
|
|
TWI908054B
(zh)
|
2023-05-04 |
2025-12-11 |
南韓商大熊製藥股份有限公司 |
新穎雜環胺衍生物以及包含其之醫藥組成物
|
|
WO2024235166A1
(zh)
*
|
2023-05-12 |
2024-11-21 |
武汉人福创新药物研发中心有限公司 |
含有btk抑制剂的组合物及其用途
|
|
WO2024240025A1
(zh)
*
|
2023-05-22 |
2024-11-28 |
无锡瓴方生物医药科技有限公司 |
一种联合用药物组合物及其应用
|
|
WO2024264017A2
(en)
|
2023-06-23 |
2024-12-26 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
TW202529769A
(zh)
|
2023-09-21 |
2025-08-01 |
日商武田藥品工業股份有限公司 |
Tyk2抑制劑及其用途
|
|
WO2025264860A2
(en)
|
2024-06-18 |
2025-12-26 |
Yale University |
Methods of treating post-covid airway disease
|