BE2019C008I2 - - Google Patents

Download PDF

Info

Publication number: BE2019C008I2
Authority: BE; Belgium
Prior art keywords: compound; acetylaminoisoindoline; methylsulfonylethyl; dione; solvate
Prior art date: 2002-03-20

Application number

BE2019C008C

Other languages

English (en)

Dutch (nl)

Original Assignee

Amgen Europe Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-20

Filing date

2019-06-18

Publication date

2022-08-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28457137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2019C008(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2019-06-18 Application filed by Amgen Europe Gmbh filed Critical Amgen Europe Gmbh

2022-08-09 Publication of BE2019C008I2 publication Critical patent/BE2019C008I2/nl

Links

150000001875 compounds Chemical class 0.000 abstract 2
239000002552 dosage form Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
IMOZEMNVLZVGJZ-UHFFFAOYSA-N n-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide Chemical compound C1=C(OC)C(OCC)=CC(C(CS(C)(=O)=O)N2C(C3=C(NC(C)=O)C=CC=C3C2=O)=O)=C1 IMOZEMNVLZVGJZ-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Virology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Tropical Medicine & Parasitology (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Psychiatry (AREA)
AIDS & HIV (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Otolaryngology (AREA)

BE2019C008C 2002-03-20 2019-06-18 BE2019C008I2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US36651502P	2002-03-20	2002-03-20
US43845003P	2003-01-07	2003-01-07
PCT/US2003/008738 WO2003080049A1 (en)	2002-03-20	2003-03-20	(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
EP03721414A EP1485087B1 (de)	2002-03-20	2003-03-20	(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindolin-1,3-dion zur verwendung in der behandlung von psoriasis durch orale verabreichung
EP09003138.6A EP2074995B1 (de)	2002-03-20	2003-03-20	(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindolin-1,3-dion: Zugehörige Verwendungsverfahren und Zusammensetzungen

Publications (1)

Publication Number	Publication Date
BE2019C008I2 true BE2019C008I2 (de)	2022-08-09

Family

ID=28457137

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE2019C008C BE2019C008I2 (de)	2002-03-20	2019-06-18

Country Status (23)

Country	Link
US (14)	US6962940B2 (de)
EP (9)	EP2420490B1 (de)
JP (4)	JP2005525386A (de)
KR (6)	KR20110022736A (de)
CN (2)	CN101683334A (de)
AT (1)	ATE440599T1 (de)
AU (1)	AU2003224729C1 (de)
BE (1)	BE2019C008I2 (de)
CA (2)	CA2756798A1 (de)
CY (6)	CY1109380T1 (de)
DE (1)	DE60328974D1 (de)
DK (6)	DK2295055T3 (de)
ES (8)	ES2608495T3 (de)
FR (1)	FR19C1046I2 (de)
HU (5)	HUE043539T2 (de)
IL (3)	IL164147A0 (de)
LU (1)	LUC00125I2 (de)
MX (2)	MXPA04009075A (de)
NL (1)	NL300994I2 (de)
NZ (1)	NZ535798A (de)
PT (6)	PT2295055T (de)
SI (5)	SI1485087T1 (de)
WO (1)	WO2003080049A1 (de)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ334148A (en) *	1996-08-12	2001-12-21	Celgene Corp	3-Substituted phenyl-ethyl or ethenyl derivatives terminated with a nitrile, alkane, carboxyl or carbamoyl group useful to reduce cytokine levels
US8030343B2 (en) *	2000-06-08	2011-10-04	Celgene Corporation	Pharmaceutically active isoindoline derivatives
US7893101B2 (en)	2002-03-20	2011-02-22	Celgene Corporation	Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en) *	2002-03-20	2005-11-08	Celgene Corporation	(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7276529B2 (en) *	2002-03-20	2007-10-02	Celgene Corporation	Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
CA2379887C (en) *	2002-04-09	2004-01-20	Bernard Charles Sherman	Stable tablets comprising simvastatin
US20100129363A1 (en) *	2002-05-17	2010-05-27	Zeldis Jerome B	Methods and compositions using pde4 inhibitors for the treatment and management of cancers
EP2258363A1 (de) *	2002-05-17	2010-12-08	Celgene Corporation	Zusammensetzungen zur Behandlung von Krebs
CN1713905A (zh) *	2002-10-15	2005-12-28	细胞基因公司	用于治疗骨髓增生异常综合征的选择性细胞因子抑制药
US20040087558A1 (en) *	2002-10-24	2004-05-06	Zeldis Jerome B.	Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
US20050203142A1 (en) *	2002-10-24	2005-09-15	Zeldis Jerome B.	Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
US7776907B2 (en)	2002-10-31	2010-08-17	Celgene Corporation	Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
TW200501945A (en)	2002-11-06	2005-01-16	Celgene Corp	Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases
MXPA05004777A (es) *	2002-11-06	2005-07-22	Celgene Corp	Metodos de uso y composiciones que comprenden farmacos inhibidores selectivos de citocina para el tratamiento y el manejo de padecimientos mieloproliferativos.
EP1581205A1 (de) *	2002-11-18	2005-10-05	Celgene Corporation	Verfahren zur verwendung undzusammensetzungen umfassend(+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamid
NZ540546A (en) *	2002-11-18	2008-03-28	Celgene Corp	Methods of using and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
US20040175382A1 (en) *	2003-03-06	2004-09-09	Schafer Peter H.	Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
WO2004080393A2 (en) *	2003-03-06	2004-09-23	Celgene Corporation	Selective cytokine inhibitory drugs for treating disorders of the central nervous system
WO2004087148A1 (ja) *	2003-03-31	2004-10-14	Kyowa Hakko Kogyo Co. Ltd.	肺疾患の治療および／または予防剤
CA2543132A1 (en) *	2003-10-23	2005-05-19	Celgene Corporation	Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
KR20060124610A (ko) *	2003-11-06	2006-12-05	셀진 코포레이션	석면-관련된 질환 또는 장애를 치료 및 관리하기 위하여ｊｎｋ 억제제를 사용하는 방법 및 이 물질을 포함하는조성물
US20050142104A1 (en) *	2003-11-06	2005-06-30	Zeldis Jerome B.	Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
WO2005056009A1 (ja) *	2003-12-12	2005-06-23	Kyowa Hakko Kogyo Co., Ltd.	肺疾患治療剤
MXPA06011219A (es)	2004-03-29	2007-05-08	Univ South Florida	Tratamiento efectivo de tumores y cancer con triciribina y compuestos relacionados.
US20100009929A1 (en)	2004-03-29	2010-01-14	Cheng Jin Q	Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
US20110008327A1 (en)	2004-03-29	2011-01-13	Cheng Jin Q	Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100173864A1 (en)	2004-03-29	2010-07-08	Cheng Jin Q	Compositions including triciribine and one or more platinum compounds and methods of use thereof
US20100009928A1 (en) *	2004-03-29	2010-01-14	Cheng Jin Q	Compositions including triciribine and taxanes and methods of use thereof
US20100028339A1 (en)	2004-03-29	2010-02-04	Cheng Jin Q	Compositions including triciribine and trastuzumab and methods of use thereof
US20080213213A1 (en) *	2004-04-14	2008-09-04	Zeldis Jerome B	Method For the Treatment of Myelodysplastic Syndromes Using (+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione
MXPA06012279A (es) *	2004-04-23	2007-01-31	Celgene Corp	Metodos de uso y composiciones que comprenden moduladores de pde4 para el tratamiento y manejo de la hipertension pulmonar.
JP2007536221A (ja) *	2004-05-05	2007-12-13	セルジーン・コーポレーション	骨髄増殖性疾患を治療及び管理するための選択的サイトカイン阻害薬の使用方法及びそれを含む組成物
GB0410103D0 (en) *	2004-05-06	2004-06-09	Biolipox Ab	New method
WO2005108353A2 (en) *	2004-05-06	2005-11-17	Ceptor Corporation	Compounds for treating neurologic diseases, otologic diseases, or ophthalmologic diseases and methods of use thereof
US20070190070A1 (en) *	2004-09-03	2007-08-16	Zeldis Jerome B	Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
KR20070092276A (ko) *	2004-12-13	2007-09-12	셀진 코포레이션	Ｐｄｅ４ 조절인자를 포함하는 조성물 및 이의 기도염의치료 또는 예방을 위한 용도
MX2007016290A (es) *	2005-06-30	2008-03-10	Celgene Corp	Procesos para la preparacion de compuestos de 4-amino-2(2,6-dioxopiperidin-3-il)isoindolin-1,3-diona.
US20080138295A1 (en) *	2005-09-12	2008-06-12	Celgene Coporation	Bechet's disease using cyclopropyl-N-carboxamide
JP2009514969A (ja)	2005-11-09	2009-04-09	コンビナトアールエックスインコーポレーティッド	医学的状態を治療するための方法、組成物、およびキット
CN1870631B (zh) *	2005-11-11	2010-04-14	华为技术有限公司	媒体网关的门控方法
US20070155791A1 (en) *	2005-12-29	2007-07-05	Zeldis Jerome B	Methods for treating cutaneous lupus using aminoisoindoline compounds
US20080103086A1 (en) *	2006-10-25	2008-05-01	Jeon-Soo Shin	Methods for the treatment of diseases associated with the secretion of hmgb1
AU2008276451A1 (en) *	2007-07-17	2009-01-22	Zalicus Inc.	Treatments of B-cell proliferative disorders
TW200914048A (en) *	2007-07-17	2009-04-01	Combinatorx Inc	Combinations for the treatment of B-cell proliferative disorders
US20090081173A1 (en) *	2007-08-10	2009-03-26	The Board Of Regents Of The University Of Texas System	Methods and compositions involving bacteriophage isolates
JP2011515469A (ja) *	2008-03-24	2011-05-19	セルジーンコーポレイション	シクロプロピル−ｎ−｛２−［（１ｓ）−１−（３−エトキシ−４−メトキシフェニル）−２−（メチルスルホニル）エチル］−３−オキソイソインドリン−４−イル｝カルボキサミドを使用した乾癬又は乾癬性関節炎の治療
CN102702070A (zh) *	2008-03-27	2012-10-03	细胞基因公司	包含(+)-2-[1-(3-乙氧基-4-甲氧基苯基)-2-甲基磺酰基乙基]-4-乙酰基氨基异吲哚啉-1,3-二酮的固体形式、其组合物及其用途
EP2687213B1 (de)	2008-03-27	2019-01-23	Celgene Corporation	(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindolin-1,3-dion umfassende feste Formen, Zusammensetzungen daraus und ihre Verwendungszwecke
EP2276483B1 (de) *	2008-03-27	2014-05-07	Celgene Corporation	(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindolin-1,3-dion umfassende feste formen, zusammensetzungen daraus und ihre verwendungszwecke
CN102898349A (zh) *	2008-03-27	2013-01-30	细胞基因公司	包含一种化合物的固体形式、其组合物及其用途
US8053364B2 (en) *	2008-05-01	2011-11-08	Intermolecular, Inc.	Closed-loop sputtering controlled to enhance electrical characteristics in deposited layer
US20100009934A1 (en) *	2008-06-09	2010-01-14	Combinatorx, Incorporated	Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders
US20100052847A1 (en) *	2008-09-01	2010-03-04	Peter Mortensen	Systems and methods to enhance television viewing
US20100186234A1 (en) *	2009-01-28	2010-07-29	Yehuda Binder	Electric shaver with imaging capability
EP2395995A1 (de) *	2009-02-10	2011-12-21	Celgene Corporation	Anwendungsverfahren und zusammensetzungen mit pde4-modulatoren zur behandlung, prävention und management von tuberkulose
CN108059635B (zh)	2009-05-14	2021-10-01	天津合美医药科技有限公司	噻吩衍生物
WO2011011500A1 (en) *	2009-07-21	2011-01-27	Abt Holding Company	Use of stem cells to reduce leukocyte extravasation
CN102053448A (zh) *	2009-10-28	2011-05-11	中国科学院福建物质结构研究所	一种硝基苯胺类手性非线性光学材料
CN102053449A (zh) *	2009-10-28	2011-05-11	中国科学院福建物质结构研究所	一种谷氨酸衍生的手性金属-有机非线性光学材料
EP2498753B1 (de) *	2009-11-10	2019-03-06	Celgene Corporation	Nanosuspension eines schlechtlöslichen arzneistoffs hergestellt über einen mikrofluidisierungsprozess
MX341050B (es)	2010-04-07	2016-08-05	Celgene Corp *	Metodos para tratar infeccion viral respiratoria.
EP2583098B1 (de) *	2010-06-15	2018-08-08	Celgene Corporation	Biomarker zur behandlung von schuppenflechte
JP6143675B2 (ja)	2010-12-16	2017-06-07	セルジーンコーポレイション	難溶性薬物の制御放出経口剤形及びその使用
US9532977B2 (en)	2010-12-16	2017-01-03	Celgene Corporation	Controlled release oral dosage forms of poorly soluble drugs and uses thereof
WO2012083153A1 (en) *	2010-12-16	2012-06-21	Nektar Therapeutics	Oligomer-containing apremilast moiety compounds
JP2014505054A (ja)	2011-01-10	2014-02-27	セルジーンコーポレイション	シクロプロパンカルボン酸｛２−［（１ｓ）−１−（３−エトキシ−４−メトキシ−フェニル）−２−メタンスルホニル−エチル］−３−オキソ−２，３−ジヒドロ−１ｈ−イソインドール−４−イル｝−アミドの経口剤形
EP2663549B1 (de) *	2011-01-10	2018-03-14	Celgene Corporation	Phenethylsulfonisoindolinderivate als pde-4- und/oder zytokin-hemmer
WO2012097116A2 (en)	2011-01-14	2012-07-19	Celgene Corporation	Isotopologues of isoindole derivatives
ES2711100T3 (es)	2011-03-07	2019-04-30	Celgene Corp	Métodos para tratar enfermedades usando compuestos isoindolina
JP6022548B2 (ja) *	2011-04-28	2016-11-09	セルジーンコーポレイション	Ｐｄｅ４阻害剤を自己免疫疾患及び炎症性疾患の治療及び管理に使用する方法及び組成物
RS60415B1 (sr)	2011-12-27	2020-07-31	Amgen (Europe) GmbH	Formulacije (+)-2-[1-(3-etoksi-4-metoksi-fenil)-2-metansulfonil-etil]-4-acetil aminoizoindolin-1,3-diona
WO2013119607A2 (en)	2012-02-08	2013-08-15	Celgene Corporation	Modified release formulations of (+)-2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-4-acetyl aminoisoindoline-1,3-dione
AR090100A1 (es)	2012-02-21	2014-10-22	Celgene Corp	Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
US8981117B2 (en)	2012-09-14	2015-03-17	Celgene Corporation	Processes for the preparation of isoindole compounds and isotopologues thereof
JP2015536991A (ja) *	2012-11-09	2015-12-24	セルジーンコーポレイション	骨量の減少の治療方法
WO2014151180A1 (en)	2013-03-14	2014-09-25	Celgene Corporation	Treatment of psoriatic arthritis using apremilast
EP3539539B1 (de) *	2013-06-17	2025-11-05	Amgen (Europe) GmbH	Tablettenformulierungen aus (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindolin-1,3-dion
KR101561828B1 (ko)	2013-08-23	2015-10-20	주식회사 아미노로직스	α-아미노산의 라세미화 방법
WO2015112568A1 (en)	2014-01-24	2015-07-30	Celgene Corporation	Methods for the treatment of obesity using apremilast
JP2014114308A (ja) *	2014-01-31	2014-06-26	Celgene Corp	（＋）−２−［１−（３−エトキシ−４−メトキシフェニル）−２−メチルスルホニルエチル］−４−アセチルアミノイソインドリン−１，３−ジオンを含む固形物形態、その組成物およびその使用
CN103864670B (zh) *	2014-03-17	2015-08-26	苏州明锐医药科技有限公司	阿普司特的制备方法
IN2014MU01283A (de)	2014-04-04	2015-10-09	Cadila Healthcare Ltd
WO2015173792A1 (en)	2014-05-11	2015-11-19	Mapi Pharma Ltd.	Amorphous form of apremilast
WO2015175251A1 (en)	2014-05-12	2015-11-19	Summit Mining International Inc.	Brine leaching process for recovering valuable metals from oxide materials
ES2751773T3 (es)	2014-05-15	2020-04-01	Amgen Europe Gmbh	Uso de inhibidores pde4 y combinaciones de los mismos para el tratamiento de la fibrosis quística
WO2015175956A1 (en)	2014-05-16	2015-11-19	Celgene Corporation	Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators
EP2949645A1 (de)	2014-05-28	2015-12-02	LEK Pharmaceuticals d.d.	Verfahren zur Herstellung von ß-Aminosulfonverbindungen
MX2016014384A (es)	2014-06-23	2017-01-20	Celgene Corp	Apremilast para el tratamiento de una enfermedad del higado o una anormalidad en la funcion del higado.
CN105294534B (zh) *	2014-07-15	2020-04-10	上海优拓医药科技有限公司	制备阿普司特及其中间体的产业化方法
WO2016016824A1 (en)	2014-07-29	2016-02-04	Fundacio Hospital Universitari Vall D' Hebron-Institut De Recerca	Differential diagnosis and therapy selection for rheumatoid arthritis and psoriatic arthritis
US10092541B2 (en)	2014-08-15	2018-10-09	Celgene Corporation	Methods for the treatment of diseases ameliorated by PDE4 inhibition using dosage titration of apremilast
CN105622380B (zh) *	2014-10-29	2020-06-30	南京安源生物医药科技有限公司	一种阿普斯特的制备方法及其中间体
CN105588886B (zh) *	2014-11-18	2020-01-31	重庆医药工业研究院有限责任公司	一种采用液相色谱法测定阿普斯特及其制剂中杂质的方法
EP3034496A1 (de) *	2014-12-18	2016-06-22	LEK Pharmaceuticals d.d.	Neuartige solvate von n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1h-isoindol-4-yl]acetamid
CN104529869B (zh) *	2014-12-19	2017-06-13	苏州亚宝药物研发有限公司	一种 (s)‑2‑[1‑(3‑乙氧基‑4‑甲氧基苯基)‑2‑甲磺酰基乙基]‑4‑乙酰基氨基异吲哚啉‑1,3‑二酮异构体的制备方法
WO2016135755A1 (en)	2015-02-27	2016-09-01	Mylan Laboratories Limited	Amorphous apremilast, premixes thereof, and novel crystalline forms of apremilast
CN104803906A (zh) *	2015-03-17	2015-07-29	南京新伟方医药科技有限公司	化合物及其制备方法和用途
BR112017019850A2 (pt)	2015-03-19	2018-06-05	Cipla Ltd	?processo melhorado para a preparação de apremilast?
WO2016161996A1 (en)	2015-04-09	2016-10-13	Zentiva, K.S.	A method of chiral resolution of the key intermediate of the synthesis of apremilast and its use for the preparation of pure apremilast
CN106146384B (zh) *	2015-04-23	2020-09-22	石药集团中奇制药技术（石家庄）有限公司	一种高光学纯度的阿普司特的制备方法、所得产品及其应用
WO2016169533A1 (en)	2015-04-24	2016-10-27	Zentiva, K.S.	A solid form of apremilast and a process for preparing the same
WO2016174685A1 (en)	2015-04-27	2016-11-03	Mylan Laboratories Limited	Process for the enantiomeric resolution of apremilast intermediates
CN104945306B (zh) *	2015-05-25	2017-07-21	山东铭康医药技术有限公司	制备光学纯阿普斯特的方法
JP2018516912A (ja) *	2015-05-26	2018-06-28	ルピン・リミテッド	アプレミラストおよびその新規な多形の改善された製造方法
CZ2015383A3 (cs)	2015-06-05	2016-12-14	Zentiva, K.S.	Způsob přípravy klíčového intermediátu apremilastu, využívající enzymatické štěpení racemických aminů
EP3106457A1 (de)	2015-06-15	2016-12-21	LEK Pharmaceuticals d.d.	Neuartiger synthetischer pfad zu apremilast
CN105111127B (zh) *	2015-08-20	2019-02-19	济南纽华医药科技有限公司	阿普斯特无定形及其制备方法
US10494342B2 (en)	2015-08-26	2019-12-03	Glenmark Life Sciences Limited	Process for the preparation of apremilast
US10544097B2 (en)	2015-08-27	2020-01-28	Msn Laboratories Private Limited	Solid state forms of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide and process for preparation thereof
US9765026B2 (en)	2015-08-28	2017-09-19	Scinopharm Taiwan, Ltd.	Forms of apremilast and the process of making the same
EP3144393A1 (de)	2015-09-18	2017-03-22	LEK Pharmaceuticals d.d.	Synthetischer pfad zu apremilast
EP3356327A1 (de) *	2015-09-29	2018-08-08	Pliva Hrvatska D.O.O.	Verfahren zur herstellung von apremilast und zwischenprodukten davon
CN105218428A (zh) *	2015-10-20	2016-01-06	南京美嘉宁逸医药研究开发有限公司	一种高手性纯度的阿普斯特的制备方法
WO2017070291A1 (en)	2015-10-21	2017-04-27	Celgene Corporation	Pde4 modulators for treating and preventing immune reconstitution inflammatory syndrome (iris)
EP3373916A1 (de)	2015-11-11	2018-09-19	Celgene Corporation	Orale retard-darreichungsformen von schwer löslichen arzneimitteln und verwendungen davon
US10399942B2 (en)	2015-11-19	2019-09-03	Alembic Pharmaceuticals Limited	Process and novel polymorphic form of Apremilast
CN105348172B (zh) *	2015-12-04	2017-11-14	新发药业有限公司	(s)‑1‑(4‑甲氧基‑3‑乙氧基)苯基‑2‑甲磺酰基乙胺的制备及阿普斯特的制备方法
EP3181549A1 (de)	2015-12-17	2017-06-21	Zaklady Farmaceutyczne Polpharma SA	Verfahren zur herstellung von apremilast
CN105486785A (zh) *	2015-12-23	2016-04-13	成都百裕金阁莱药业有限公司	阿普斯特中对映异构体杂质的检测方法
CZ20165A3 (cs)	2016-01-06	2017-07-19	Zentiva, K.S.	Způsoby přípravy amorfního apremilastu
US10774041B2 (en)	2016-04-15	2020-09-15	Davuluri Ramamohan Rao	Process for the preparation of apremilast
EP3455209A1 (de)	2016-05-12	2019-03-20	Zaklady Farmaceutyczne Polpharma SA	Kristalline formen von apremilast
WO2017216738A1 (en)	2016-06-15	2017-12-21	Torrent Pharmaceuticals Limited	Topical compositions of apremilast
US10196355B2 (en)	2016-06-20	2019-02-05	Johnson Matthey Public Limited Company	Forms of apremilast
CN106187857B (zh)	2016-06-30	2021-04-06	浙江华海药业股份有限公司	一种制备阿普斯特的方法
IT201600083132A1 (it) *	2016-08-05	2018-02-05	Dipharma Francis Srl	Procedimento per la preparazione di un inibitore della fosfodiesterasi 4
CN110049968A (zh) *	2016-11-09	2019-07-23	广东东阳光药业有限公司	阿普斯特共晶及其制备方法
EP3339292A1 (de)	2016-12-23	2018-06-27	Zaklady Farmaceutyczne Polpharma SA	Cokristalle von apremilast
CN110352052A (zh) *	2017-01-27	2019-10-18	萨鲁德巴瓦制剂私人有限公司	阿普斯特的局部治疗组合物
CN107445875A (zh) *	2017-03-22	2017-12-08	陕西科技大学	一种用于制备阿普斯特的高纯度中间体的手性拆分方法
SI3606908T1 (sl)	2017-04-04	2020-10-30	Quimica Sintetica, S.A.	Delitev racemičnih beta-aminosulfonskih spojin
EP3619195B1 (de)	2017-05-04	2025-07-23	Unichem Laboratories Ltd	Neues verfahren zur herstellung von n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1h-isoindol-4-yl]acetamid
JP2020533383A (ja)	2017-09-14	2020-11-19	グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＤｅｖｅｌｏｐｍｅｎｔＬｉｍｉｔｅｄ	癌の組合せ治療
CN107721902A (zh) *	2017-11-08	2018-02-23	中国科学院上海药物研究所	阿普斯特与烟酰胺的共结晶及其制备方法和应用
CN111821299A (zh) *	2019-04-16	2020-10-27	天津合美医药科技有限公司	噻吩衍生物用于治疗免疫球蛋白E（IgE）介导的疾病的应用
CN111821297A (zh) *	2019-04-16	2020-10-27	天津合美医药科技有限公司	异吲哚啉衍生物用于治疗免疫球蛋白E（IgE）介导的疾病的应用
US11357775B2 (en) *	2019-04-30	2022-06-14	Celgene Corporation	Combination therapies comprising apremilast and Tyk2 inhibitors
SG11202112043PA (en)	2019-04-30	2021-11-29	Celgene Corp	Combination therapies comprising apremilast and tyk2 inhibitors
KR102502616B1 (ko) *	2019-08-08	2023-02-23	구글 엘엘씨	유사(Quasi)-개인화를 위한 저 엔트로피 브라우징 히스토리
US11194866B2 (en) *	2019-08-08	2021-12-07	Google Llc	Low entropy browsing history for content quasi-personalization
TWI733294B (zh) *	2019-12-30	2021-07-11	國立臺灣師範大學	製備阿普斯特片之方法
JP2023531113A (ja) *	2020-02-24	2023-07-21	スーヂョウロングボタイファーマシューティカルズカンパニーリミテッド	Ｐｄｅ４阻害剤化合物及びその医薬用途
EP3929179A1 (de)	2020-06-22	2021-12-29	Biohorm, S.L.	Entzündungshemmende verbindungen und verfahren zu deren herstellung
CN112220785B (zh) *	2020-09-22	2021-12-31	北京鑫开元医药科技有限公司	一种pde4抑制剂药物组合物及其制备方法与用途
KR20220047105A (ko)	2020-10-08	2022-04-15	주식회사 엔비피헬스케어	아프레밀라스트를 함유하는 약학 조성물
CN117203196A (zh) *	2020-12-14	2023-12-08	拜欧斯瑞克斯公司	Pde4降解剂、药物组合物和治疗应用
CN115068467A (zh) *	2021-03-15	2022-09-20	中国医学科学院药物研究所	穿心莲内酯作为ltb4受体抑制剂的医药用途
CN114790164B (zh)	2021-08-13	2022-12-27	苏州璞正医药有限公司	一种取代的异吲哚啉-1,3-二酮类pde4抑制剂及其药物用途
EP4183389A1 (de)	2021-11-18	2023-05-24	KRKA, d.d., Novo mesto	Apremilast enthaltende pharmazeutische zusammensetzung
WO2023105286A1 (en)	2021-12-06	2023-06-15	My Personal Therapeutics Ltd	A combination treatment for cancer
AU2021479711A1 (en) *	2021-12-23	2024-06-13	Amgen Inc.	Oral suspension of apremilast
GB202306663D0 (en)	2023-05-05	2023-06-21	Union Therapeutics As	Combination therapy

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US366515A (en)		1887-07-12		Stove-pipe
US3031450A (en) *	1959-04-30	1962-04-24	Thomae Gmbh Dr K	Substituted pyrimido-[5, 4-d]-pyrimidines
US3322755A (en) *	1964-03-10	1967-05-30	Boehringer Sohn Ingelheim	Basic-substituted 1, 2, 3, 4-tetrahydropyrimido [5, 4-d]-pyrimidines
US3536809A (en)	1969-02-17	1970-10-27	Alza Corp	Medication method
US3598123A (en)	1969-04-01	1971-08-10	Alza Corp	Bandage for administering drugs
US3845770A (en)	1972-06-05	1974-11-05	Alza Corp	Osmatic dispensing device for releasing beneficial agent
JPS4966691A (de)	1972-10-30	1974-06-27
US3916899A (en)	1973-04-25	1975-11-04	Alza Corp	Osmotic dispensing device with maximum and minimum sizes for the passageway
US3820636A (en) *	1973-08-16	1974-06-28	Deere & Co	Self-adjusting control linkage for an external band brake
US4162316A (en) *	1975-03-12	1979-07-24	Dainippon Pharmaceutical Co., Ltd.	1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and compositions containing the same
US4008719A (en)	1976-02-02	1977-02-22	Alza Corporation	Osmotic system having laminar arrangement for programming delivery of active agent
US4060615A (en) *	1976-02-18	1977-11-29	Mead Johnson & Company	2-Piperazinyl-6,7-dimethoxyquinazolines
US4001237A (en) *	1976-02-18	1977-01-04	Bristol-Myers Company	Oxazole, isoxazole, thiazole and isothiazole amides
US4001238A (en) *	1976-02-18	1977-01-04	Bristol-Myers Company	1,3,4-oxadiazole amides
US4047404A (en) *	1976-11-17	1977-09-13	Tanno Senshoku Kogyo Co., Ltd.	Printed fabric washing apparatus
US4101548A (en) *	1977-02-22	1978-07-18	Bristol-Myers Company	1,2,3-Thiadiazole amides
US4209623A (en) *	1978-06-07	1980-06-24	Bristol-Myers Company	Pyrimidine-5-N-(1H-tetrazol-5-yl)-carboxamides
GB2063249A (en)	1979-10-09	1981-06-03	Mitsubishi Yuka Pharma	4-Phenylphthalazine derivatives
IE58110B1 (en)	1984-10-30	1993-07-14	Elan Corp Plc	Controlled release powder and process for its preparation
US4912205A (en)	1986-03-20	1990-03-27	Daicel Chemical Industries, Ltd.	Alkyl-substituted phenylcarbamate derivative of polysaccharide
DE3770095D1 (de) *	1986-08-21	1991-06-20	Pfizer	Chinazolindione und pyridopyrimidindione.
CA1303037C (en) *	1987-02-02	1992-06-09	Smith Kline & French Laboratories Limited	Purinone derivatives as bronchodilators vasodilators and anti-allergic agents
GB8814352D0 (en)	1988-06-16	1988-07-20	Smith Kline French Lab	Chemical compounds
ES2058527T3 (es)	1988-06-16	1994-11-01	Smith Kline French Lab	Derivados de pirimidina condensados procedimiento y compuestos intermedios para su preparacion y composiciones farmaceuticas que los contienen.
US5075310A (en)	1988-07-01	1991-12-24	Smith Kline & French Laboratories, Ltd.	Pyrimidone derivatives as bronchodilators
US5073543A (en)	1988-07-21	1991-12-17	G. D. Searle & Co.	Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
GB8817651D0 (en)	1988-07-25	1988-09-01	Smith Kline French Lab	Chemical compounds
GB8827988D0 (en) *	1988-11-30	1989-01-05	Smith Kline French Lab	Chemical compounds
IT1229203B (it)	1989-03-22	1991-07-25	Bioresearch Spa	Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
GB8909560D0 (en)	1989-04-26	1989-06-14	Smith Kline French Lab	Chemical compounds
GB8923131D0 (en)	1989-10-13	1989-11-29	Smith Kline French Lab	Chemical compounds
US5120548A (en)	1989-11-07	1992-06-09	Merck & Co., Inc.	Swelling modulated polymeric drug delivery device
US5733566A (en)	1990-05-15	1998-03-31	Alkermes Controlled Therapeutics Inc. Ii	Controlled release of antiparasitic agents in animals
GB9013750D0 (en)	1990-06-20	1990-08-08	Pfizer Ltd	Therapeutic agents
US5401774A (en) *	1991-03-08	1995-03-28	University Of Arizona	Method for treating patients with precancerous lesions by administering substituted sulfonyl idenyl acetic and propionic acids and esters to patients with lesions sensitive to such compounds
GB9114760D0 (en)	1991-07-09	1991-08-28	Pfizer Ltd	Therapeutic agents
PT100905A (pt)	1991-09-30	1994-02-28	Eisai Co Ltd	Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
GB9121028D0 (en)	1991-10-03	1991-11-13	Pfizer Ltd	Therapeutic agents
GB9126260D0 (en)	1991-12-11	1992-02-12	Pfizer Ltd	Therapeutic agents
US5580578A (en)	1992-01-27	1996-12-03	Euro-Celtique, S.A.	Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5354571A (en) *	1992-04-27	1994-10-11	Rheon Automatic Machinery Co., Ltd.	Method for aligning and bending individual round elongated dough pieces
US5243826A (en)	1992-07-01	1993-09-14	Apd Cryogenics Inc.	Method and apparatus for collecting liquid cryogen
JP2657760B2 (ja) *	1992-07-15	1997-09-24	小野薬品工業株式会社	４−アミノキナゾリン誘導体およびそれを含有する医薬品
GB9218322D0 (en)	1992-08-28	1992-10-14	Pfizer Ltd	Therapeutic agents
US5591767A (en)	1993-01-25	1997-01-07	Pharmetrix Corporation	Liquid reservoir transdermal patch for the administration of ketorolac
GB9312210D0 (en)	1993-06-14	1993-07-28	Smithkline Beecham Plc	Chemical compounds
US5698579A (en) *	1993-07-02	1997-12-16	Celgene Corporation	Cyclic amides
US5614627A (en) *	1993-09-10	1997-03-25	Eisai Co., Ltd.	Quinazoline compounds
GB9401090D0 (en)	1994-01-21	1994-03-16	Glaxo Lab Sa	Chemical compounds
GB9514465D0 (en)	1995-07-14	1995-09-13	Glaxo Lab Sa	Chemical compounds
IT1270594B (it)	1994-07-07	1997-05-07	Recordati Chem Pharm	Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5608914A (en) *	1994-11-21	1997-03-11	Keesler; Daren	Headcover
GB9423910D0 (en) *	1994-11-26	1995-01-11	Pfizer Ltd	Therapeutic agents
US5801195A (en) *	1994-12-30	1998-09-01	Celgene Corporation	Immunotherapeutic aryl amides
US5703098A (en) *	1994-12-30	1997-12-30	Celgene Corporation	Immunotherapeutic imides/amides
DE19501482A1 (de)	1995-01-19	1996-07-25	Bayer Ag	2,9-disubstituierte Purin-6-one
DE19501481A1 (de)	1995-01-19	1996-07-25	Bayer Ag	2,8-Disubstituierte Chinazolinone
DE19501480A1 (de)	1995-01-19	1996-07-25	Bayer Ag	9-substituierte 2-(2-n-Alkoxyphenyl)-purin-6-one
US5614530A (en) *	1995-03-10	1997-03-25	Sterling Winthrop Inc.	Substituted N-arylmethyl and heterocyclmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines and compositions and methods of use thereof
US5488055A (en) *	1995-03-10	1996-01-30	Sanofi Winthrop Inc.	Substituted N-cycloalkylmethyl-1H-pyrazolo(3,4-b)quinolin-4 amines and compositions and methods of use thereof
CA2217707A1 (en) *	1995-04-10	1996-10-17	Fujisawa Pharmaceutial Co., Ltd.	Indole derivatives as cgmp-pde inhibitors
TW381092B (en)	1995-07-07	2000-02-01	Otsuka Pharma Co Ltd	Novel benzimidazole derivatives for use in treating arteriosclerotic diseases
GB9514464D0 (en)	1995-07-14	1995-09-13	Glaxo Lab Sa	Medicaments
GB9514473D0 (en) *	1995-07-14	1995-09-13	Glaxo Lab Sa	Chemical compounds
US5728844A (en) *	1995-08-29	1998-03-17	Celgene Corporation	Immunotherapeutic agents
US5728845A (en) *	1995-08-29	1998-03-17	Celgene Corporation	Immunotherapeutic nitriles
US5736537A (en)	1995-09-12	1998-04-07	Estee Lauder, Inc.	Dehydroep:androsterone sailcylate useful against skin atrophy
US5658940A (en) *	1995-10-06	1997-08-19	Celgene Corporation	Succinimide and maleimide cytokine inhibitors
US6166041A (en) *	1995-10-11	2000-12-26	Euro-Celtique, S.A.	2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
DE19540475A1 (de)	1995-10-20	1997-04-24	Schering Ag	Chirale Methylphenyloxazolidinone
US5710170A (en) *	1995-12-15	1998-01-20	Merck Frosst Canada, Inc.	Tri-aryl ethane derivatives as PDE IV inhibitors
GB9526246D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526243D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526245D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
WO1997024334A1 (en)	1995-12-28	1997-07-10	Fujisawa Pharmaceutical Co., Ltd.	Benzimidazole derivatives
GB9604926D0 (en)	1996-03-08	1996-05-08	Sandoz Ltd	Organic compounds
DE19617864A1 (de) *	1996-04-23	1997-10-30	Schering Ag	Neue chirale Phenyldihydrofuranone
DE19632423A1 (de)	1996-08-12	1998-02-19	Merck Patent Gmbh	Thienopyrimidine
EP0863144A4 (de)	1996-08-30	2001-04-11	Kyowa Hakko Kogyo Kk	Imidazochinazoline
ATE229527T1 (de)	1996-10-04	2002-12-15	Kyorin Seiyaku Kk	Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung
DE19642451A1 (de)	1996-10-15	1998-04-16	Merck Patent Gmbh	Aminothiophencarbonsäureamide
DE19644228A1 (de)	1996-10-24	1998-04-30	Merck Patent Gmbh	Thienopyrimidine
KR100239800B1 (ko)	1996-11-28	2000-03-02	손경식	4,5-디아미노 피리미딘 유도체 및 이의 제조방법
WO1998038168A1 (en)	1997-02-27	1998-09-03	Tanabe Seiyaku Co., Ltd.	Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors
ES2302350T3 (es) *	1997-02-28	2008-07-01	Nycomed Gmbh	Combinacion sinergica de inhibidores de pde y agonistas de adenilatociclasa o agonistas de guanililciclasa.
US6035089A (en) *	1997-06-11	2000-03-07	Lockheed Martin Energy Research Corporation	Integrated narrowband optical filter based on embedded subwavelength resonant grating structures
HUP0003761A3 (en)	1997-07-31	2001-04-28	Celgene Corp Warren	Substituted alkanohydroxamic acids and pharmaceutical compositions containing them
US6020339A (en) *	1997-10-03	2000-02-01	Merck & Co., Inc.	Aryl furan derivatives as PDE IV inhibitors
US6034089A (en) *	1997-10-03	2000-03-07	Merck & Co., Inc.	Aryl thiophene derivatives as PDE IV inhibitors
DE69813895T2 (de) *	1997-11-25	2003-11-06	Warner-Lambert Co. Llc, Morris Plains	Phenolsulfonamide als pde-iv inhibitoren und ihre therapeutische verwendung
US6020358A (en)	1998-10-30	2000-02-01	Celgene Corporation	Substituted phenethylsulfones and method of reducing TNFα levels
US6025394A (en) *	1999-01-29	2000-02-15	Cell Pathways, Inc.	Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
EP1157007A1 (de) *	1999-02-25	2001-11-28	Merck Frosst Canada Inc.	Pde-iv hemmende verbindungen, zusammensetzungen und verfahren zur herstellung
US6316472B1 (en) *	1999-05-13	2001-11-13	Merck Frosst Canada & Co.	Heterosubstituted pyridine derivatives as PDE 4 inhibitors
US6667316B1 (en) *	1999-11-12	2003-12-23	Celgene Corporation	Pharmaceutically active isoindoline derivatives
SE9904415D0 (sv)	1999-12-03	1999-12-03	Astra Ab	New process
PT1244649E (pt) *	1999-12-23	2005-06-30	Icos Corp	Inibidores de fosfodiesterase especificos de mfa ciclica
CZ20022410A3 (cs)	2000-01-31	2003-08-13	Pfizer Products Inc.	Benzoanelované heterocyklylové deriváty nikotinamidu užitečné jako selektivní inhibitory isozymů PDE4
US7208516B2 (en) *	2002-03-20	2007-04-24	Celgene Corporation	Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7893101B2 (en)	2002-03-20	2011-02-22	Celgene Corporation	Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en)	2002-03-20	2005-11-08	Celgene Corporation	(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7276529B2 (en) *	2002-03-20	2007-10-02	Celgene Corporation	Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7123975B2 (en) *	2004-07-22	2006-10-17	Taiwan Semiconductor Manufacturing Co., Ltd.	Manufacturing management system and method
WO2008063213A2 (en)	2006-04-10	2008-05-29	Abbott Biotechnology Ltd.	Uses and compositions for treatment of psoriatic arthritis
KR100988184B1 (ko)	2007-07-19	2010-10-18	세키스이가가쿠 고교가부시키가이샤	전자 부품용 접착제
CA2712017C (en)	2008-01-18	2016-08-09	Oxagen Limited	Compounds having crth2 antagonist activity
EP2276483B1 (de)	2008-03-27	2014-05-07	Celgene Corporation	(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindolin-1,3-dion umfassende feste formen, zusammensetzungen daraus und ihre verwendungszwecke
US20140004182A1 (en)	2009-11-19	2014-01-02	Jerome B. Zeldis	Methods for the treatment of sarcoidosis
WO2011151372A1 (en)	2010-06-02	2011-12-08	Ab Science	Treatment of rheumatoid arthritis with masitinib

2003
- 2003-03-19 US US10/392,195 patent/US6962940B2/en not_active Expired - Lifetime
- 2003-03-20 AU AU2003224729A patent/AU2003224729C1/en active Active
- 2003-03-20 ES ES09003138.6T patent/ES2608495T3/es not_active Expired - Lifetime
- 2003-03-20 CN CN200910181158A patent/CN101683334A/zh active Pending
- 2003-03-20 EP EP11176719.0A patent/EP2420490B1/de not_active Expired - Lifetime
- 2003-03-20 KR KR1020117003333A patent/KR20110022736A/ko not_active Ceased
- 2003-03-20 DK DK10186086.4T patent/DK2295055T3/en active
- 2003-03-20 HU HUE15177140A patent/HUE043539T2/hu unknown
- 2003-03-20 KR KR1020137004997A patent/KR101383845B1/ko not_active Expired - Lifetime
- 2003-03-20 AT AT03721414T patent/ATE440599T1/de active
- 2003-03-20 EP EP10186076.5A patent/EP2311453B1/de not_active Expired - Lifetime
- 2003-03-20 PT PT101860864T patent/PT2295055T/pt unknown
- 2003-03-20 DK DK10162653.9T patent/DK2223687T3/en active
- 2003-03-20 DK DK03721414T patent/DK1485087T3/da active
- 2003-03-20 CA CA2756798A patent/CA2756798A1/en not_active Abandoned
- 2003-03-20 DE DE60328974T patent/DE60328974D1/de not_active Expired - Lifetime
- 2003-03-20 DK DK10162667.9T patent/DK2223688T3/da active
- 2003-03-20 EP EP10162653.9A patent/EP2223687B1/de not_active Revoked
- 2003-03-20 ES ES10162653.9T patent/ES2635361T3/es not_active Expired - Lifetime
- 2003-03-20 MX MXPA04009075A patent/MXPA04009075A/es active IP Right Grant
- 2003-03-20 HU HUE11176719A patent/HUE029682T2/en unknown
- 2003-03-20 CN CNB038110938A patent/CN100427085C/zh not_active Expired - Lifetime
- 2003-03-20 ES ES10186076.5T patent/ES2637547T3/es not_active Expired - Lifetime
- 2003-03-20 EP EP15177140.9A patent/EP2962690B1/de not_active Revoked
- 2003-03-20 NZ NZ535798A patent/NZ535798A/en not_active IP Right Cessation
- 2003-03-20 IL IL16414703A patent/IL164147A0/xx unknown
- 2003-03-20 CA CA2479666A patent/CA2479666C/en not_active Expired - Fee Related
- 2003-03-20 SI SI200331659T patent/SI1485087T1/sl unknown
- 2003-03-20 KR KR1020107003988A patent/KR101104991B1/ko not_active Expired - Lifetime
- 2003-03-20 HU HUE10186086A patent/HUE034348T2/hu unknown
- 2003-03-20 ES ES10186086.4T patent/ES2637509T3/es not_active Expired - Lifetime
- 2003-03-20 ES ES10162667T patent/ES2742729T3/es not_active Expired - Lifetime
- 2003-03-20 EP EP10162667.9A patent/EP2223688B1/de not_active Revoked
- 2003-03-20 ES ES03721414T patent/ES2331991T3/es not_active Expired - Lifetime
- 2003-03-20 EP EP10186086.4A patent/EP2295055B1/de not_active Expired - Lifetime
- 2003-03-20 PT PT15177140T patent/PT2962690T/pt unknown
- 2003-03-20 PT PT111767190T patent/PT2420490T/pt unknown
- 2003-03-20 PT PT03721414T patent/PT1485087E/pt unknown
- 2003-03-20 KR KR1020137021411A patent/KR20130100219A/ko not_active Ceased
- 2003-03-20 EP EP09003138.6A patent/EP2074995B1/de not_active Revoked
- 2003-03-20 SI SI200332591T patent/SI2962690T1/sl unknown
- 2003-03-20 DK DK15177140.9T patent/DK2962690T3/en active
- 2003-03-20 SI SI200332599T patent/SI2223688T1/sl unknown
- 2003-03-20 KR KR1020127000230A patent/KR101263786B1/ko not_active Expired - Lifetime
- 2003-03-20 PT PT10162667T patent/PT2223688T/pt unknown
- 2003-03-20 JP JP2003577877A patent/JP2005525386A/ja active Pending
- 2003-03-20 HU HUE10162667A patent/HUE045489T2/hu unknown
- 2003-03-20 EP EP19151685.5A patent/EP3524242A1/de not_active Withdrawn
- 2003-03-20 SI SI200332535T patent/SI2223687T1/sl unknown
- 2003-03-20 EP EP03721414A patent/EP1485087B1/de not_active Revoked
- 2003-03-20 WO PCT/US2003/008738 patent/WO2003080049A1/en not_active Ceased
- 2003-03-20 ES ES11176719.0T patent/ES2595375T3/es not_active Expired - Lifetime
- 2003-03-20 DK DK11176719.0T patent/DK2420490T3/en active
- 2003-03-20 ES ES15177140T patent/ES2717517T3/es not_active Expired - Lifetime
- 2003-03-20 KR KR1020047015190A patent/KR100997001B1/ko not_active Ceased
- 2003-03-20 PT PT101626539T patent/PT2223687T/pt unknown
- 2003-03-20 SI SI200332539T patent/SI2295055T1/sl unknown
- 2003-03-20 MX MX2015010082A patent/MX366328B/es unknown
2004
- 2004-09-20 IL IL164147A patent/IL164147A/en active Protection Beyond IP Right Term
2005
- 2005-04-13 US US11/106,142 patent/US7427638B2/en active Active
- 2005-06-28 US US11/170,308 patent/US7358272B2/en not_active Expired - Lifetime
2007
- 2007-06-29 US US11/824,523 patent/US7507759B2/en not_active Expired - Lifetime
2008
- 2008-02-08 US US12/069,282 patent/US7659302B2/en not_active Expired - Lifetime
- 2008-04-04 US US12/098,379 patent/US7659303B2/en not_active Expired - Lifetime
2009
- 2009-09-18 CY CY20091100967T patent/CY1109380T1/el unknown
- 2009-12-03 US US12/630,788 patent/US8455536B2/en not_active Expired - Fee Related
- 2009-12-28 JP JP2009297650A patent/JP2010106033A/ja active Pending
2010
- 2010-07-22 IL IL207149A patent/IL207149A/en active IP Right Review Request
2012
- 2012-11-02 JP JP2012242868A patent/JP5936521B2/ja not_active Expired - Lifetime
- 2012-11-20 US US13/682,652 patent/US8802717B2/en not_active Expired - Lifetime
2014
- 2014-06-26 US US14/316,160 patent/US9283207B2/en not_active Expired - Fee Related
- 2014-09-18 JP JP2014190477A patent/JP2015013893A/ja active Pending
2016
- 2016-02-05 US US15/016,856 patent/US9724330B2/en not_active Expired - Fee Related
2017
- 2017-06-21 US US15/629,678 patent/US10092542B2/en not_active Expired - Lifetime
- 2017-07-14 CY CY20171100748T patent/CY1119204T1/el unknown
- 2017-08-21 CY CY20171100884T patent/CY1119340T1/el unknown
2018
- 2018-09-07 US US16/125,571 patent/US10610516B2/en not_active Expired - Fee Related
2019
- 2019-04-03 CY CY20191100372T patent/CY1121720T1/el unknown
- 2019-06-14 LU LU00125C patent/LUC00125I2/fr unknown
- 2019-06-18 NL NL300994C patent/NL300994I2/nl unknown
- 2019-06-18 HU HUS1900032C patent/HUS1900032I1/hu unknown
- 2019-06-18 BE BE2019C008C patent/BE2019C008I2/nl unknown
- 2019-06-18 CY CY2019032C patent/CY2019032I2/el unknown
- 2019-07-12 FR FR19C1046C patent/FR19C1046I2/fr active Active
- 2019-08-14 CY CY20191100877T patent/CY1121888T1/el unknown
2020
- 2020-02-28 US US16/805,196 patent/US11040024B2/en not_active Expired - Fee Related
- 2020-08-26 US US17/003,238 patent/US11260046B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US8802717B2 (en)	2014-08-12
US10092542B2 (en)	2018-10-09
US7659302B2 (en)	2010-02-09
MX366328B (es)	2019-07-05
US20140371287A1 (en)	2014-12-18
US20200306226A1 (en)	2020-10-01
EP2962690B1 (de)	2019-01-16
US20050192336A1 (en)	2005-09-01
NL300994I1 (nl)	2019-06-26
JP5936521B2 (ja)	2016-06-22
HK1219049A1 (en)	2017-03-24
EP2074995B1 (de)	2016-11-02
DK2223687T3 (en)	2017-08-14
US20080207730A1 (en)	2008-08-28
PT2295055T (pt)	2017-08-29
ES2637509T3 (es)	2017-10-13
FR19C1046I2 (fr)	2022-07-08
EP2223688A1 (de)	2010-09-01
DK2420490T3 (en)	2016-10-03
KR101383845B1 (ko)	2014-04-10
NL300994I2 (nl)	2019-07-11
US20080242719A1 (en)	2008-10-02
SI2223688T1 (sl)	2019-11-29
CN101683334A (zh)	2010-03-31
US10610516B2 (en)	2020-04-07
EP3524242A1 (de)	2019-08-14
US20100160405A1 (en)	2010-06-24
ES2608495T3 (es)	2017-04-11
KR100997001B1 (ko)	2010-11-25
EP1485087A1 (de)	2004-12-15
DK2295055T3 (en)	2017-09-11
DE60328974D1 (de)	2009-10-08
US8455536B2 (en)	2013-06-04
KR101263786B1 (ko)	2013-05-13
AU2003224729C1 (en)	2025-01-23
PT2420490T (pt)	2016-10-12
WO2003080049A1 (en)	2003-10-02
US6962940B2 (en)	2005-11-08
EP2311453A1 (de)	2011-04-20
CA2479666A1 (en)	2003-10-02
JP2015013893A (ja)	2015-01-22
KR20100040938A (ko)	2010-04-21
EP2223687A1 (de)	2010-09-01
US20210023051A1 (en)	2021-01-28
MXPA04009075A (es)	2005-07-13
PT1485087E (pt)	2009-10-23
JP2005525386A (ja)	2005-08-25
DK1485087T3 (da)	2009-11-02
CY1119340T1 (el)	2018-02-14
IL164147A (en)	2010-11-30
HUS1900032I1 (hu)	2019-07-29
CY1121720T1 (el)	2020-05-29
EP2962690A1 (de)	2016-01-06
HK1103985A1 (en)	2008-01-04
US20140024695A1 (en)	2014-01-23
SI1485087T1 (sl)	2009-12-31
US20160151331A1 (en)	2016-06-02
EP2311453B1 (de)	2017-06-07
ES2742729T3 (es)	2020-02-17
CY2019032I1 (el)	2020-05-29
LUC00125I1 (de)	2019-06-18
DK2223688T3 (da)	2019-08-19
AU2003224729C9 (en)	2023-06-15
US20170281597A1 (en)	2017-10-05
US11040024B2 (en)	2021-06-22
PT2223687T (pt)	2017-07-25
SI2962690T1 (sl)	2019-05-31
PT2223688T (pt)	2019-09-05
CY2019032I2 (el)	2020-05-29
ES2637547T3 (es)	2017-10-13
ATE440599T1 (de)	2009-09-15
ES2717517T3 (es)	2019-06-21
CN100427085C (zh)	2008-10-22
IL207149A (en)	2013-12-31
SI2223687T1 (sl)	2017-10-30
EP1485087B1 (de)	2009-08-26
US20050267196A1 (en)	2005-12-01
HUE045489T2 (hu)	2019-12-30
KR20120024938A (ko)	2012-03-14
AU2003224729A1 (en)	2003-10-08
EP2223687B1 (de)	2017-05-17
US9283207B2 (en)	2016-03-15
US11260046B2 (en)	2022-03-01
JP2013047262A (ja)	2013-03-07
AU2003224729B2 (en)	2008-01-03
FR19C1046I1 (fr)	2019-08-09
CN1652772A (zh)	2005-08-10
HUE029682T2 (en)	2017-02-28
ES2635361T3 (es)	2017-10-03
HUE034348T2 (hu)	2018-02-28
HUE043539T2 (hu)	2019-08-28
ES2595375T3 (es)	2016-12-29
NZ535798A (en)	2006-04-28
CY1119204T1 (el)	2018-02-14
IL164147A0 (en)	2005-12-18
EP2420490A1 (de)	2012-02-22
KR101104991B1 (ko)	2012-01-16
EP2420490B1 (de)	2016-07-20
CY1109380T1 (el)	2014-07-02
EP2223688B1 (de)	2019-05-29
US7427638B2 (en)	2008-09-23
LUC00125I2 (de)	2019-12-24
EP2295055B1 (de)	2017-06-07
ES2331991T3 (es)	2010-01-22
US20080027123A1 (en)	2008-01-31
CA2756798A1 (en)	2003-10-02
SI2295055T1 (sl)	2017-10-30
CA2479666C (en)	2012-01-10
KR20050012722A (ko)	2005-02-02
PT2962690T (pt)	2019-04-30
JP2010106033A (ja)	2010-05-13
EP2295055A2 (de)	2011-03-16
US7659303B2 (en)	2010-02-09
KR20110022736A (ko)	2011-03-07
CY1121888T1 (el)	2020-10-14
KR20130040257A (ko)	2013-04-23
KR20130100219A (ko)	2013-09-09
US20030187052A1 (en)	2003-10-02
US9724330B2 (en)	2017-08-08
US7507759B2 (en)	2009-03-24
US20190000804A1 (en)	2019-01-03
US7358272B2 (en)	2008-04-15
HK1073426A1 (en)	2005-10-07
EP2074995A1 (de)	2009-07-01
DK2962690T3 (en)	2019-04-15
EP2295055A3 (de)	2011-03-23

Publication	Publication Date	Title
BE2019C008I2 (de)	2022-08-09
BRPI0315315B8 (de)	2021-05-25
MXPA05004778A (es)	2005-10-05	Metodos de uso y composiciones que contienen compuestos inmunomoduladores para el tratamiento y manejo de enfermedades mieloproliferativas.
TW200503784A (en)	2005-02-01	Organic compounds
WO2005105088A3 (en)	2007-04-19	Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of pulmonary hypertension
IL165264A (en)	2011-07-31	Protein kinase inhibitors, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating protein kinase-associated diseases
UA84271C2 (en)	2008-10-10	Formate salt of o-desmethyl-venlafaxine
AU2003303633A8 (en)	2004-07-29	Fast dissolving films for oral administration of drugs
MEP55308A (en)	2011-05-10	New pharmaceutical compositions containing flibanserin polymorph a
GB0109122D0 (en)	2001-05-30	Novel compounds
MY148125A (en)	2013-02-28	Compounds
AU2003243439A1 (en)	2003-12-22	Medical device for intra-lumenal delivery of pharmaceutical agents
AU2003232652A1 (en)	2004-02-02	Oral controlled-release dosage forms containing acetaminophen
MXPA06003122A (es)	2006-05-31	Composiciones farmaceuticas y procedimientos que comprenden combinaciones de derivados de 2-alquiliden-19-nor-vitamina d y un agonista/antagonista de estrogenos.
WO2004037199A3 (en)	2004-12-23	Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
MXPA05010070A (es)	2005-11-23	Combinacion farmaceutica.
UA87292C2 (ru)	2009-07-10	Применение сирамезина для лечения злокачественных опухолей
NO20053167L (no)	2005-06-28	Krystallinsk form.
AU2002950887A0 (en)	2002-09-12	Orally deliverable pharmaceutical composition containing protein pump inhibitors