BE503416A - - Google Patents

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Publication number: BE503416A
Authority: BE; Belgium
Prior art keywords: sep; antibiotic; medium; culture; days
Prior art date

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English (en)

French (fr)

Publication of BE503416A publication Critical patent/BE503416A/fr

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230000003115 biocidal effect Effects 0.000 claims description 29
238000000034 method Methods 0.000 claims description 13
239000003242 anti bacterial agent Substances 0.000 claims description 10
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
230000012010 growth Effects 0.000 claims description 6
DPEYHNFHDIXMNV-UHFFFAOYSA-N (9-amino-3-bicyclo[3.3.1]nonanyl)-(4-benzyl-5-methyl-1,4-diazepan-1-yl)methanone dihydrochloride Chemical compound Cl.Cl.CC1CCN(CCN1Cc1ccccc1)C(=O)C1CC2CCCC(C1)C2N DPEYHNFHDIXMNV-UHFFFAOYSA-N 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
238000001179 sorption measurement Methods 0.000 claims description 3
241000187389 Streptomyces lavendulae Species 0.000 claims description 2
235000015097 nutrients Nutrition 0.000 claims description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
238000005273 aeration Methods 0.000 claims 2
238000013019 agitation Methods 0.000 claims 2
238000000926 separation method Methods 0.000 claims 2
239000011260 aqueous acid Substances 0.000 claims 1
230000001376 precipitating effect Effects 0.000 claims 1
238000001291 vacuum drying Methods 0.000 claims 1
239000002609 medium Substances 0.000 description 15
230000000694 effects Effects 0.000 description 9
229940088710 antibiotic agent Drugs 0.000 description 8
239000000126 substance Substances 0.000 description 7
238000002560 therapeutic procedure Methods 0.000 description 7
229930189330 Streptothricin Natural products 0.000 description 5
239000003795 chemical substances by application Substances 0.000 description 5
210000002966 serum Anatomy 0.000 description 5
239000000243 solution Substances 0.000 description 5
NRAUADCLPJTGSF-VLSXYIQESA-N streptothricin F Chemical compound NCCC[C@H](N)CC(=O)N[C@@H]1[C@H](O)[C@@H](OC(N)=O)[C@@H](CO)O[C@H]1\N=C/1N[C@H](C(=O)NC[C@H]2O)[C@@H]2N\1 NRAUADCLPJTGSF-VLSXYIQESA-N 0.000 description 5
235000014469 Bacillus subtilis Nutrition 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
230000005764 inhibitory process Effects 0.000 description 4
239000000463 material Substances 0.000 description 4
239000000049 pigment Substances 0.000 description 4
230000000699 topical effect Effects 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
241000588724 Escherichia coli Species 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
108010010803 Gelatin Proteins 0.000 description 3
230000000844 anti-bacterial effect Effects 0.000 description 3
229920001429 chelating resin Polymers 0.000 description 3
229910000396 dipotassium phosphate Inorganic materials 0.000 description 3
239000008273 gelatin Substances 0.000 description 3
229920000159 gelatin Polymers 0.000 description 3
235000019322 gelatine Nutrition 0.000 description 3
235000011852 gelatine desserts Nutrition 0.000 description 3
230000001788 irregular Effects 0.000 description 3
244000005700 microbiome Species 0.000 description 3
239000000047 product Substances 0.000 description 3
229920005989 resin Polymers 0.000 description 3
239000011347 resin Substances 0.000 description 3
239000011734 sodium Substances 0.000 description 3
239000002689 soil Substances 0.000 description 3
229920001817 Agar Polymers 0.000 description 2
241000223600 Alternaria Species 0.000 description 2
241000193830 Bacillus <bacterium> Species 0.000 description 2
244000063299 Bacillus subtilis Species 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
241000588722 Escherichia Species 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
241000588748 Klebsiella Species 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
241000186359 Mycobacterium Species 0.000 description 2
241000588769 Proteus <enterobacteria> Species 0.000 description 2
241000589516 Pseudomonas Species 0.000 description 2
241000235070 Saccharomyces Species 0.000 description 2
240000004808 Saccharomyces cerevisiae Species 0.000 description 2
241000607142 Salmonella Species 0.000 description 2
244000061456 Solanum tuberosum Species 0.000 description 2
235000002595 Solanum tuberosum Nutrition 0.000 description 2
241000187747 Streptomyces Species 0.000 description 2
108010021006 Tyrothricin Proteins 0.000 description 2
239000008272 agar Substances 0.000 description 2
238000003556 assay Methods 0.000 description 2
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 2
235000019797 dipotassium phosphate Nutrition 0.000 description 2
238000004821 distillation Methods 0.000 description 2
239000003814 drug Substances 0.000 description 2
229940079593 drug Drugs 0.000 description 2
238000000855 fermentation Methods 0.000 description 2
230000004151 fermentation Effects 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
239000007788 liquid Substances 0.000 description 2
150000007530 organic bases Chemical class 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
241000894007 species Species 0.000 description 2
239000000725 suspension Substances 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
239000012137 tryptone Substances 0.000 description 2
201000008827 tuberculosis Diseases 0.000 description 2
GSXRBRIWJGAPDU-BBVRJQLQSA-N tyrocidine A Chemical compound C([C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCN)C(=O)N[C@H](C(N[C@H](CC=2C=CC=CC=2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N1)=O)CC(C)C)C(C)C)C1=CC=C(O)C=C1 GSXRBRIWJGAPDU-BBVRJQLQSA-N 0.000 description 2
229960003281 tyrothricin Drugs 0.000 description 2
238000002211 ultraviolet spectrum Methods 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
KEQXNNJHMWSZHK-UHFFFAOYSA-L 1,3,2,4$l^{2}-dioxathiaplumbetane 2,2-dioxide Chemical compound [Pb+2].[O-]S([O-])(=O)=O KEQXNNJHMWSZHK-UHFFFAOYSA-L 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
JKYKXTRKURYNGW-UHFFFAOYSA-N 3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(O)=C(O)C(S(O)(=O)=O)=C2 JKYKXTRKURYNGW-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
241000228212 Aspergillus Species 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
102000011632 Caseins Human genes 0.000 description 1
108010076119 Caseins Proteins 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
240000001624 Espostoa lanata Species 0.000 description 1
235000009161 Espostoa lanata Nutrition 0.000 description 1
241000233866 Fungi Species 0.000 description 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
206010020565 Hyperaemia Diseases 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
241000192041 Micrococcus Species 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
241000220317 Rosa Species 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
241000006364 Torula Species 0.000 description 1
241001467018 Typhis Species 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000003463 adsorbent Substances 0.000 description 1
230000000172 allergic effect Effects 0.000 description 1
FRHBOQMZUOWXQL-UHFFFAOYSA-L ammonium ferric citrate Chemical compound [NH4+].[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FRHBOQMZUOWXQL-UHFFFAOYSA-L 0.000 description 1
230000000843 anti-fungal effect Effects 0.000 description 1
208000010668 atopic eczema Diseases 0.000 description 1
244000052616 bacterial pathogen Species 0.000 description 1
235000013405 beer Nutrition 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000003729 cation exchange resin Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
230000001886 ciliary effect Effects 0.000 description 1
238000011109 contamination Methods 0.000 description 1
210000004087 cornea Anatomy 0.000 description 1
238000012258 culturing Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
230000003292 diminished effect Effects 0.000 description 1
229960004642 ferric ammonium citrate Drugs 0.000 description 1
SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical class O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
239000012458 free base Substances 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000013922 glutamic acid Nutrition 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
WHWDWIHXSPCOKZ-UHFFFAOYSA-N hexahydrofarnesyl acetone Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)=O WHWDWIHXSPCOKZ-UHFFFAOYSA-N 0.000 description 1
229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
238000009434 installation Methods 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
235000000011 iron ammonium citrate Nutrition 0.000 description 1
239000004313 iron ammonium citrate Substances 0.000 description 1
SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 description 1
239000008101 lactose Substances 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000012528 membrane Substances 0.000 description 1
STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 description 1
229940012189 methyl orange Drugs 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
230000004899 motility Effects 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
229920000768 polyamine Polymers 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000001057 purple pigment Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000011218 seed culture Methods 0.000 description 1
229940080237 sodium caseinate Drugs 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000020275 sunflower milk Nutrition 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
230000009897 systematic effect Effects 0.000 description 1
239000008399 tap water Substances 0.000 description 1
235000020679 tap water Nutrition 0.000 description 1
239000003860 topical agent Substances 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1
IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
230000009105 vegetative growth Effects 0.000 description 1
229920006163 vinyl copolymer Polymers 0.000 description 1

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Medicines Containing Material From Animals Or Micro-Organisms (AREA)

BE503416D BE503416A (da)

Publications (1)

Publication Number	Publication Date
BE503416A true BE503416A (da)

Family

ID=144605

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BE503416D BE503416A (da)

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BE (1)	BE503416A (da)

0
- BE BE503416D patent/BE503416A/fr unknown

Publication	Publication Date	Title
US3812011A (en)	1974-05-21	Method of converting starch to beta-cyclodextrin
FR2489819A1 (fr)	1982-03-12	Antibiotique bmg162-af2 ayant notamment une activite antitumorale et son procede de preparation a partir d'une souche du genre bacillus
BE503416A (da)
FR2459289A1 (fr)	1981-01-09	Procede de preparation de l'antibiotique cephamycine c
BE1007064A3 (fr)	1995-03-07	Enzyme de levane saccharase, procede pour sa preparation, micro-organismes qui le produisent et compositions le contenant.
CH618606A5 (da)	1980-08-15
FR2598085A1 (fr)	1987-11-06	Nouvelle substance inhibitrice de l'aldose reductase et son procede de preparation
FR2459288A1 (fr)	1981-01-09	Procede de preparation de la mildiomycine par un micro-organisme du genre streptoverticillium, dans une culture contenant un compose n-methyle
BE534771A (da)
BE531046A (da)
BE636716A (da)
BE493857A (da)
BE579844A (da)
BE555769A (da)
JPS637792A (ja)	1988-01-13	微生物によるｎ，ｎ′−ジアセチルキトビオ−スの製法
BE688834A (da)	1967-03-31
CH446615A (fr)	1967-11-15	Procédé de préparation d'un antibiotique
BE572450A (da)
JPS63198993A (ja)	1988-08-17	新規微生物および新規微生物を使用するメナキノン−４の製造法
CH314151A (fr)	1956-05-31	Procédé de fabrication d'un antibiotique
BE557870A (da)
BE477991A (da)
BE566455A (da)
CH314485A (fr)	1956-06-15	Procédé de préparation d'un nouvel antibiotique
BE511759A (da)

BE503416A - - Google Patents

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Publications (1)

Family

ID=144605

Family Applications (1)

Country Status (1)

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