BE801108A - Nouveaux composes pyridopyrrolobenzheterocycliques leur preparation et compositions pharmaceutiques les contenant - Google Patents

Nouveaux composes pyridopyrrolobenzheterocycliques leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
BE801108A
BE801108A BE132425A BE132425A BE801108A BE 801108 A BE801108 A BE 801108A BE 132425 A BE132425 A BE 132425A BE 132425 A BE132425 A BE 132425A BE 801108 A BE801108 A BE 801108A
Authority
BE
Belgium
Prior art keywords
pyridopyrrolobenzheterocyclic
compounds
preparation
new
pharmaceutical compositions
Prior art date
Application number
BE132425A
Other languages
English (en)
Inventor
P Rajagopalan
Original Assignee
Endo Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endo Lab filed Critical Endo Lab
Publication of BE801108A publication Critical patent/BE801108A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/22—Eight-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/18—Eight-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE132425A 1972-06-19 1973-06-19 Nouveaux composes pyridopyrrolobenzheterocycliques leur preparation et compositions pharmaceutiques les contenant BE801108A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26376672A 1972-06-09 1972-06-09
US357528A US3914421A (en) 1972-06-19 1973-05-07 Pyridopyrrolobenzheterocycles for combatting depression

Publications (1)

Publication Number Publication Date
BE801108A true BE801108A (fr) 1973-10-15

Family

ID=26950035

Family Applications (1)

Application Number Title Priority Date Filing Date
BE132425A BE801108A (fr) 1972-06-19 1973-06-19 Nouveaux composes pyridopyrrolobenzheterocycliques leur preparation et compositions pharmaceutiques les contenant

Country Status (7)

Country Link
US (1) US3914421A (fr)
BE (1) BE801108A (fr)
DE (1) DE2330719A1 (fr)
FR (1) FR2189048B1 (fr)
IL (1) IL42430A0 (fr)
LU (1) LU67815A1 (fr)
NL (1) NL7308525A (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183936A (en) * 1972-06-19 1980-01-15 Endo Laboratories, Inc. Pyridopyrrolobenzheterocycles
US4013652A (en) * 1972-06-19 1977-03-22 Endo Laboratories, Inc. Pyridopyrrolobenzoxazine
US4115577A (en) * 1972-06-19 1978-09-19 Endo Laboratories, Inc. Pyridopyrrolobenzheterocycles
FR2428035A1 (fr) * 1978-06-05 1980-01-04 Sankyo Co Derives de benzothiazocine et de benzothiazonine, et leur application therapeutique
US4219550A (en) * 1978-11-09 1980-08-26 E. I. Du Pont De Nemours And Company Cis- and trans- octahydropyridopyrrolobenzheterocycles
JPH02180885A (ja) * 1988-09-01 1990-07-13 Glaxo Group Ltd ラクタム誘導体
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
EP0380155A1 (fr) * 1989-01-19 1990-08-01 Duphar International Research B.V Dérivés de 1,2,3,4-tétrahydro-bêta-carboline, 8,9-annelés
US6713471B1 (en) 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
US7071186B2 (en) * 1999-06-15 2006-07-04 Bristol-Myers Squibb Pharma Co. Substituted heterocycle fused gamma-carbolines
ATE277048T1 (de) 1999-06-15 2004-10-15 Bristol Myers Squibb Pharma Co Substituierte hetercyclisch kondensierte gamma carboline
SK7042003A3 (en) * 2000-12-20 2004-07-07 Bristol Myers Squibb Co Substituted pyridoindoles as serotonin agonists and antagonists
PL366060A1 (en) 2000-12-20 2005-01-24 Bristol-Myers Squibb Pharma Company Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonists and antagonists
JP4386639B2 (ja) 2000-12-20 2009-12-16 ブリストル−マイヤーズ スクイブ カンパニー セロトニンアゴニストおよびアンタゴニストとしての置換されたピロロキノリン化合物およびピリドキノリン化合物
US6849619B2 (en) * 2000-12-20 2005-02-01 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
BR0212676A (pt) * 2001-09-21 2006-05-23 Upjohn Co compostos terapêuticos ligantes de 5-ht, composições farmacêuticas compreendendo tais compostos e seus usos
WO2004056324A2 (fr) * 2002-12-19 2004-07-08 Bristol-Myers Squibb Company Gamma-carbolines tricycliques substituees utilisees comme agonistes et antagonistes du recepteur de la serotonine
KR102107954B1 (ko) * 2007-03-12 2020-05-07 인트라-셀룰라 써래피스, 인코퍼레이티드. 치환된 헤테로환 융합 감마-카르볼린 합성
US8575186B2 (en) 2009-10-05 2013-11-05 Albany Molecular Research, Inc. Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
EP2668191A4 (fr) 2011-01-19 2014-08-20 Albany Molecular Res Inc Benzofuro[3,2-c]pyridines et analogues associés en tant que modulateurs du sous-type 6 de la sérotonine (5-ht6) pour traitement de l'obésité, du syndrome métabolique, de la cognition et de la schizophrénie
KR20140146192A (ko) 2012-04-14 2014-12-24 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
US9708322B2 (en) 2013-03-15 2017-07-18 Intra-Cellular Therapies, Inc. Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity
KR102373288B1 (ko) 2013-12-03 2022-03-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
CA2944755A1 (fr) 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Composes organiques
US10077267B2 (en) 2014-04-04 2018-09-18 Intra-Cellular Therapies, Inc. Organic compounds
PL3838274T3 (pl) 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
DK3407889T3 (da) 2016-03-25 2021-08-09 Intra Cellular Therapies Inc Organiske forbindelser og deres anvendelse til behandling og forebyggelse af lidelser i centralnervesystemet
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
EP3436455A4 (fr) 2016-03-28 2019-09-04 Intra-Cellular Therapies, Inc. Nouveaux sels et cristaux
US11014925B2 (en) 2016-03-28 2021-05-25 Intra-Cellular Therapies, Inc. Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide
EP3525763B1 (fr) 2016-10-12 2025-03-05 Intra-Cellular Therapies, Inc. Dispersions solides amorphes
EP3562484B1 (fr) 2016-12-29 2021-08-25 Intra-Cellular Therapies, Inc. Dérivés de pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline utiles dans les traitements de troubles du snc
WO2018126140A1 (fr) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Composés organiques
RU2767410C2 (ru) 2017-03-24 2022-03-17 Интра-Селлулар Терапиз, Инк. Новые композиции и способы
WO2019023062A1 (fr) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. Composés organiques
EP3658144B1 (fr) 2017-07-26 2022-01-26 Intra-Cellular Therapies, Inc. Composés pyridopyrroloquinoxalines, leurs compositions et utilisations en thérapie
CN112040940A (zh) 2018-03-23 2020-12-04 细胞内治疗公司 有机化合物
AU2019280850C1 (en) 2018-06-06 2025-02-13 Intra-Cellular Therapies, Inc. Novel salts and crystals
EP3801527B1 (fr) 2018-06-08 2025-02-19 Intra-Cellular Therapies, Inc. Gamma-carbolines fusionnées pour le traitement aigu de l'anxiété ou de la dépression
CA3240552A1 (fr) 2018-06-11 2019-12-19 Intra-Cellular Therapies, Inc. Synthese de gamma-carbolines fusionnees a heterocycles substitues
US12144808B2 (en) 2018-08-29 2024-11-19 Intra-Cellular Therapies, Inc. Compositions and methods
WO2020047408A1 (fr) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Nouvelles méthodes
BR112021003655A2 (pt) 2018-08-31 2021-05-18 Intra-Cellular Therapies, Inc. métodos novos
WO2021007245A1 (fr) 2019-07-07 2021-01-14 Intra-Cellular Therapies, Inc. Nouveaux procédés
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH307223A (de) * 1952-04-28 1955-05-15 Bayer Ag Verfahren zur Herstellung eines Derivates des Tetrahydro-y-carbolins.

Also Published As

Publication number Publication date
FR2189048B1 (fr) 1976-10-22
LU67815A1 (fr) 1973-09-26
NL7308525A (fr) 1973-12-21
FR2189048A1 (fr) 1974-01-25
DE2330719A1 (de) 1974-01-10
IL42430A0 (en) 1973-08-29
US3914421A (en) 1975-10-21

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