BE865624A - Interphenylene 8-aza-9-dioxathia-11,12-secoprostaglandines utiles comme medicaments - Google Patents

Interphenylene 8-aza-9-dioxathia-11,12-secoprostaglandines utiles comme medicaments

Info

Publication number
BE865624A
BE865624A BE186514A BE186514A BE865624A BE 865624 A BE865624 A BE 865624A BE 186514 A BE186514 A BE 186514A BE 186514 A BE186514 A BE 186514A BE 865624 A BE865624 A BE 865624A
Authority
BE
Belgium
Prior art keywords
dioxathia
secoprostaglandins
interphenylene
aza
useful
Prior art date
Application number
BE186514A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BE865624A publication Critical patent/BE865624A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BE186514A 1977-04-04 1978-04-03 Interphenylene 8-aza-9-dioxathia-11,12-secoprostaglandines utiles comme medicaments BE865624A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/783,998 US4112236A (en) 1977-04-04 1977-04-04 Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins

Publications (1)

Publication Number Publication Date
BE865624A true BE865624A (fr) 1978-10-03

Family

ID=25131052

Family Applications (1)

Application Number Title Priority Date Filing Date
BE186514A BE865624A (fr) 1977-04-04 1978-04-03 Interphenylene 8-aza-9-dioxathia-11,12-secoprostaglandines utiles comme medicaments

Country Status (16)

Country Link
US (1) US4112236A (fr)
AR (1) AR225727A1 (fr)
AU (1) AU516540B2 (fr)
BE (1) BE865624A (fr)
DE (1) DE2814321A1 (fr)
DK (1) DK146578A (fr)
ES (1) ES468510A1 (fr)
FR (1) FR2386521A1 (fr)
GB (1) GB1576688A (fr)
IE (1) IE46699B1 (fr)
IT (1) IT1103475B (fr)
LU (1) LU79356A1 (fr)
NL (1) NL7802824A (fr)
PT (1) PT67847B (fr)
SE (1) SE7803606L (fr)
ZA (1) ZA781885B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3641099A1 (de) * 1986-12-02 1988-06-09 Hoechst Ag Verfahren zur herstellung von 4-(2'-chlorethyl)benzoesaeure
WO1998027976A1 (fr) * 1996-12-20 1998-07-02 Pfizer Inc. Prevention et traitement d'affections osseuses avec des agonistes de la prostaglandine e2 selectifs du sous-type de recepteur ep2
UA59384C2 (uk) * 1996-12-20 2003-09-15 Пфайзер, Інк. Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
UA67754C2 (uk) 1997-10-10 2004-07-15 Пфайзер, Інк. Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти)
US6124314A (en) * 1997-10-10 2000-09-26 Pfizer Inc. Osteoporosis compounds
PT1132086E (pt) 2000-01-31 2006-09-29 Pfizer Prod Inc Utilizacao de agonistas selectivos para o receptor da prostaglandina (pge2) 4 (ep4) para o tratamento de falha renal aguda e cronica
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
MX2015007797A (es) 2012-12-17 2015-10-05 Parion Sciences Inc Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida.
PE20151054A1 (es) 2012-12-17 2015-08-07 Parion Sciences Inc Derivados de cloro-pirazin carboxamida con actividad bloqueadora sobre los canales de sodio epiteliales
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE410185B (sv) 1973-04-25 1979-10-01 Merck & Co Inc Forfarande for framstellning av seko - prostaglandiner med vasodilaterande och blodplettaggregationshemmande effekt
US3991106A (en) * 1974-09-13 1976-11-09 Merck & Co., Inc. 16-Ethers of 8-aza-9-dioxothia-11,12-seco-prostaglandins

Also Published As

Publication number Publication date
GB1576688A (en) 1980-10-15
FR2386521B1 (fr) 1982-11-19
IE780632L (en) 1978-10-04
LU79356A1 (fr) 1978-11-27
IE46699B1 (en) 1983-08-24
IT1103475B (it) 1985-10-14
SE7803606L (sv) 1978-10-05
IT7848626A0 (it) 1978-03-28
ZA781885B (en) 1979-06-27
ES468510A1 (es) 1979-09-16
AU3436678A (en) 1979-09-27
PT67847B (en) 1980-04-04
FR2386521A1 (fr) 1978-11-03
DE2814321A1 (de) 1978-10-05
US4112236A (en) 1978-09-05
AU516540B2 (en) 1981-06-11
AR225727A1 (es) 1982-04-30
DK146578A (da) 1978-10-05
PT67847A (en) 1978-04-01
NL7802824A (nl) 1978-10-06

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: MERCK & CO. INC.

Effective date: 19840403