IT1103475B - Interfenilen 8-aza-9-diossotia-11,12-secoprostaglandine - Google Patents

Interfenilen 8-aza-9-diossotia-11,12-secoprostaglandine

Info

Publication number
IT1103475B
IT1103475B IT48626/78A IT4862678A IT1103475B IT 1103475 B IT1103475 B IT 1103475B IT 48626/78 A IT48626/78 A IT 48626/78A IT 4862678 A IT4862678 A IT 4862678A IT 1103475 B IT1103475 B IT 1103475B
Authority
IT
Italy
Prior art keywords
secoprostaglandine
interfenilen
diossotia
aza
Prior art date
Application number
IT48626/78A
Other languages
English (en)
Other versions
IT7848626A0 (it
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IT7848626A0 publication Critical patent/IT7848626A0/it
Application granted granted Critical
Publication of IT1103475B publication Critical patent/IT1103475B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT48626/78A 1977-04-04 1978-03-28 Interfenilen 8-aza-9-diossotia-11,12-secoprostaglandine IT1103475B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/783,998 US4112236A (en) 1977-04-04 1977-04-04 Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins

Publications (2)

Publication Number Publication Date
IT7848626A0 IT7848626A0 (it) 1978-03-28
IT1103475B true IT1103475B (it) 1985-10-14

Family

ID=25131052

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48626/78A IT1103475B (it) 1977-04-04 1978-03-28 Interfenilen 8-aza-9-diossotia-11,12-secoprostaglandine

Country Status (16)

Country Link
US (1) US4112236A (it)
AR (1) AR225727A1 (it)
AU (1) AU516540B2 (it)
BE (1) BE865624A (it)
DE (1) DE2814321A1 (it)
DK (1) DK146578A (it)
ES (1) ES468510A1 (it)
FR (1) FR2386521A1 (it)
GB (1) GB1576688A (it)
IE (1) IE46699B1 (it)
IT (1) IT1103475B (it)
LU (1) LU79356A1 (it)
NL (1) NL7802824A (it)
PT (1) PT67847B (it)
SE (1) SE7803606L (it)
ZA (1) ZA781885B (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3641099A1 (de) * 1986-12-02 1988-06-09 Hoechst Ag Verfahren zur herstellung von 4-(2'-chlorethyl)benzoesaeure
WO1998027976A1 (en) 1996-12-20 1998-07-02 Pfizer Inc. Prevention and treatment of skeletal disorder with ep2 receptor subtype selective prostaglandin e2 agonists
UA59384C2 (uk) * 1996-12-20 2003-09-15 Пфайзер, Інк. Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
US6124314A (en) 1997-10-10 2000-09-26 Pfizer Inc. Osteoporosis compounds
UA67754C2 (uk) * 1997-10-10 2004-07-15 Пфайзер, Інк. Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти)
IL141120A0 (en) 2000-01-31 2002-02-10 Pfizer Prod Inc Use of prostaglandin (pge2) receptor 4 (epa) selective agonists for the treatment of acute and chronic renal failure
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
CA2895512C (en) 2012-12-17 2021-10-19 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
CN108658876A (zh) 2012-12-17 2018-10-16 帕里昂科学公司 3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE410185B (sv) 1973-04-25 1979-10-01 Merck & Co Inc Forfarande for framstellning av seko - prostaglandiner med vasodilaterande och blodplettaggregationshemmande effekt
US3991106A (en) * 1974-09-13 1976-11-09 Merck & Co., Inc. 16-Ethers of 8-aza-9-dioxothia-11,12-seco-prostaglandins

Also Published As

Publication number Publication date
BE865624A (fr) 1978-10-03
IE46699B1 (en) 1983-08-24
NL7802824A (nl) 1978-10-06
US4112236A (en) 1978-09-05
DK146578A (da) 1978-10-05
FR2386521B1 (it) 1982-11-19
AU3436678A (en) 1979-09-27
DE2814321A1 (de) 1978-10-05
AU516540B2 (en) 1981-06-11
PT67847B (en) 1980-04-04
LU79356A1 (fr) 1978-11-27
ZA781885B (en) 1979-06-27
IT7848626A0 (it) 1978-03-28
FR2386521A1 (fr) 1978-11-03
GB1576688A (en) 1980-10-15
ES468510A1 (es) 1979-09-16
IE780632L (en) 1978-10-04
SE7803606L (sv) 1978-10-05
AR225727A1 (es) 1982-04-30
PT67847A (en) 1978-04-01

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