BE866117A - Homologue de la somatostatine, ses intermediaires de preparation et son utilisation comme medicament - Google Patents

Homologue de la somatostatine, ses intermediaires de preparation et son utilisation comme medicament

Info

Publication number: BE866117A
Authority: BE; Belgium
Prior art keywords: intermediaries; somatostatin; approved; preparation; medicinal product
Prior art date: 1977-04-21

Application number

BE1008847A

Other languages

English (en)

French (fr)

Inventor

J E Shields

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-04-21

Filing date

1978-04-19

Publication date

1978-10-19

1978-04-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1978-10-19 Publication of BE866117A publication Critical patent/BE866117A/xx

Links

102000005157 Somatostatin Human genes 0.000 title 1
108010056088 Somatostatin Proteins 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
229960000553 somatostatin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

BE1008847A 1977-04-21 1978-04-19 Homologue de la somatostatine, ses intermediaires de preparation et son utilisation comme medicament BE866117A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/789,472 US4100117A (en)	1977-04-21	1977-04-21	Somatostatin analogs and intermediates thereto

Publications (1)

Publication Number	Publication Date
BE866117A true BE866117A (fr)	1978-10-19

Family

ID=25147748

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE1008847A BE866117A (fr)	1977-04-21	1978-04-19	Homologue de la somatostatine, ses intermediaires de preparation et son utilisation comme medicament

Country Status (31)

Country	Link
US (1)	US4100117A (cs)
JP (1)	JPS53132588A (cs)
AR (1)	AR221699A1 (cs)
AT (1)	AT361142B (cs)
AU (1)	AU519275B2 (cs)
BE (1)	BE866117A (cs)
BG (1)	BG28703A3 (cs)
CA (2)	CA1102315A (cs)
CH (1)	CH634039A5 (cs)
CS (1)	CS202096B2 (cs)
DD (1)	DD135900A5 (cs)
DE (1)	DE2816854A1 (cs)
DK (1)	DK174278A (cs)
ES (2)	ES469005A1 (cs)
FI (1)	FI64576C (cs)
FR (1)	FR2387941A1 (cs)
GB (1)	GB1596328A (cs)
GR (1)	GR68945B (cs)
HU (1)	HU177435B (cs)
IE (1)	IE46868B1 (cs)
IL (1)	IL54533A (cs)
IT (1)	IT1094462B (cs)
NL (1)	NL7804218A (cs)
NZ (1)	NZ187009A (cs)
PL (2)	PL114533B1 (cs)
PT (1)	PT67913B (cs)
RO (2)	RO81079A (cs)
SE (1)	SE7804397L (cs)
SU (2)	SU730295A3 (cs)
YU (1)	YU91578A (cs)
ZA (1)	ZA782247B (cs)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4202802A (en) *	1978-10-02	1980-05-13	Eli Lilly And Company	Peptides related to somatostatin
US4199501A (en) *	1978-11-20	1980-04-22	Eli Lilly And Company	Peptides related to somatostatin
US4199500A (en) *	1978-11-20	1980-04-22	Eli Lilly And Company	Peptides related to somatostatin
US4428942A (en)	1982-05-17	1984-01-31	The Salk Institute For Biological Studies	Analogs of somatostatin
GB8423431D0 (en) *	1984-09-17	1984-10-24	Sandoz Ltd	Organic compounds
SE8702550D0 (sv) *	1987-06-18	1987-06-18	Anders Grubb	Cysteinproteashemmare
NZ240214A (en)	1990-10-16	1993-02-25	Takeda Chemical Industries Ltd	Polymer compositions comprising a polylactic acid and a copolymer of glycolic acid and a hydroxycarboxylic acid; use as carrier for prolonged release pharmaceutical compositions of water soluble drugs
EP0582459B1 (en)	1992-08-07	1998-01-07	Takeda Chemical Industries, Ltd.	Production of microcapsules of water-soluble drugs
US5594091A (en) *	1994-02-21	1997-01-14	Takeda Chemical Industries, Ltd.	Matrix for sustained-release preparation
US6117455A (en) *	1994-09-30	2000-09-12	Takeda Chemical Industries, Ltd.	Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
CA2192782C (en)	1995-12-15	2008-10-14	Nobuyuki Takechi	Production of microspheres
CA2208336A1 (en) *	1996-06-20	1997-12-20	Hisamitsu Pharmaceuticals Co., Inc.	A device structure for iontophoresis
US7169889B1 (en)	1999-06-19	2007-01-30	Biocon Limited	Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6309633B1 (en)	1999-06-19	2001-10-30	Nobex Corporation	Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
ATE416784T1 (de)	2000-12-01	2008-12-15	Takeda Pharmaceutical	Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz
US6867183B2 (en) *	2001-02-15	2005-03-15	Nobex Corporation	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) *	2001-02-15	2006-06-13	Nobex Corporation	Methods of treating diabetes mellitus
US7713932B2 (en)	2001-06-04	2010-05-11	Biocon Limited	Calcitonin drug-oligomer conjugates, and uses thereof
US6835802B2 (en) *	2001-06-04	2004-12-28	Nobex Corporation	Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6858580B2 (en) *	2001-06-04	2005-02-22	Nobex Corporation	Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) *	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en)	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) *	2001-06-04	2004-03-30	Nobex Corporation	Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7196059B2 (en)	2001-09-07	2007-03-27	Biocon Limited	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) *	2001-09-07	2007-12-25	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) *	2001-09-07	2005-07-05	Nobex Corporation	Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) *	2001-09-07	2007-01-23	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7601688B2 (en) *	2002-06-13	2009-10-13	Biocon Limited	Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
MX2007000883A (es) *	2004-07-19	2007-04-02	Biocon Ltd	Conjugados de insulina-oligomero, formulaciones y usos de los mismos.
BRPI0818004B8 (pt)	2007-10-16	2021-05-25	Biocon Ltd	composição farmacêutica sólida administrável por via oral e o processo da mesma.
WO2014010586A1 (ja)	2012-07-10	2014-01-16	武田薬品工業株式会社	注射用製剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2608336A1 (de) *	1975-03-11	1976-09-30	Sandoz Ag	Neue organische verbindungen, ihre herstellung und verwendung
US4372884A (en) *	1975-08-06	1983-02-08	The Salk Institute For Biological Studies	Pharmaceutically active peptides

1977
- 1977-04-21 US US05/789,472 patent/US4100117A/en not_active Expired - Lifetime
1978
- 1978-04-17 GB GB14916/78A patent/GB1596328A/en not_active Expired
- 1978-04-18 RO RO78102194A patent/RO81079A/ro unknown
- 1978-04-18 IL IL54533A patent/IL54533A/xx unknown
- 1978-04-18 NZ NZ187009A patent/NZ187009A/xx unknown
- 1978-04-18 PT PT67913A patent/PT67913B/pt unknown
- 1978-04-18 JP JP4621378A patent/JPS53132588A/ja active Pending
- 1978-04-18 FI FI781184A patent/FI64576C/fi not_active IP Right Cessation
- 1978-04-18 DE DE19782816854 patent/DE2816854A1/de not_active Withdrawn
- 1978-04-18 SE SE7804397A patent/SE7804397L/xx unknown
- 1978-04-18 AR AR271820A patent/AR221699A1/es active
- 1978-04-18 RO RO7893835A patent/RO76054A/ro unknown
- 1978-04-18 YU YU00915/78A patent/YU91578A/xx unknown
- 1978-04-19 AU AU35253/78A patent/AU519275B2/en not_active Expired
- 1978-04-19 FR FR7811580A patent/FR2387941A1/fr active Granted
- 1978-04-19 ZA ZA00782247A patent/ZA782247B/xx unknown
- 1978-04-19 CA CA301,500A patent/CA1102315A/en not_active Expired
- 1978-04-19 IE IE765/78A patent/IE46868B1/en unknown
- 1978-04-19 GR GR56030A patent/GR68945B/el unknown
- 1978-04-19 BE BE1008847A patent/BE866117A/xx not_active IP Right Cessation
- 1978-04-20 NL NL7804218A patent/NL7804218A/xx not_active Application Discontinuation
- 1978-04-20 AT AT282878A patent/AT361142B/de not_active IP Right Cessation
- 1978-04-20 HU HU78EI790A patent/HU177435B/hu unknown
- 1978-04-20 CH CH425778A patent/CH634039A5/de not_active IP Right Cessation
- 1978-04-20 DK DK174278A patent/DK174278A/da active IP Right Grant
- 1978-04-20 ES ES469005A patent/ES469005A1/es not_active Expired
- 1978-04-20 IT IT22552/78A patent/IT1094462B/it active
- 1978-04-20 SU SU782607708A patent/SU730295A3/ru active
- 1978-04-21 CS CS782580A patent/CS202096B2/cs unknown
- 1978-04-21 PL PL1978206280A patent/PL114533B1/pl unknown
- 1978-04-21 PL PL1978217479A patent/PL115827B1/pl unknown
- 1978-04-21 BG BG039503A patent/BG28703A3/xx unknown
- 1978-04-21 DD DD78204957A patent/DD135900A5/xx unknown
1979
- 1979-01-05 SU SU792705047A patent/SU904519A3/ru active
- 1979-01-16 ES ES476901A patent/ES476901A1/es not_active Expired
1980
- 1980-12-08 CA CA366,345A patent/CA1113928A/en not_active Expired

Also Published As

Publication number	Publication date
NZ187009A (en)	1981-04-24
FI64576B (fi)	1983-08-31
RO81079A (ro)	1983-06-01
HU177435B (en)	1981-10-28
SU730295A3 (ru)	1980-04-25
US4100117A (en)	1978-07-11
YU91578A (en)	1983-01-21
SU904519A3 (ru)	1982-02-07
GR68945B (cs)	1982-03-29
ES469005A1 (es)	1979-09-01
IL54533A0 (en)	1978-07-31
CS202096B2 (en)	1980-12-31
CH634039A5 (de)	1983-01-14
AU3525378A (en)	1979-10-25
PL115827B1 (en)	1981-05-30
GB1596328A (en)	1981-08-26
ZA782247B (en)	1979-12-27
SE7804397L (sv)	1978-10-22
RO76054A (ro)	1981-08-17
CA1113928A (en)	1981-12-08
ES476901A1 (es)	1979-10-16
FR2387941B1 (cs)	1983-06-10
RO81079B (ro)	1983-05-30
IL54533A (en)	1982-11-30
PT67913B (en)	1979-11-14
AR221699A1 (es)	1981-03-13
AU519275B2 (en)	1981-11-19
FI64576C (fi)	1983-12-12
PL206280A1 (cs)	1980-01-02
NL7804218A (nl)	1978-10-24
FR2387941A1 (fr)	1978-11-17
IE780765L (en)	1978-10-21
JPS53132588A (en)	1978-11-18
PT67913A (en)	1978-05-01
ATA282878A (de)	1980-07-15
IT7822552A0 (it)	1978-04-20
DD135900A5 (de)	1979-06-06
DK174278A (da)	1978-10-22
DE2816854A1 (de)	1978-11-02
BG28703A3 (bg)	1980-06-16
CA1102315A (en)	1981-06-02
IT1094462B (it)	1985-08-02
IE46868B1 (en)	1983-10-19
AT361142B (de)	1981-02-25
PL114533B1 (en)	1981-02-28
FI781184A7 (fi)	1978-10-22

Legal Events

Date

Code

Title

Description

1986-10-31

RE

Patent lapsed

Owner name: ELI LILLY AND CY

Effective date: 19860430

Publication	Publication Date	Title
BE866117A (fr)	1978-10-19	Homologue de la somatostatine, ses intermediaires de preparation et son utilisation comme medicament
DE2962051D1 (en)	1982-03-11	Benzimidazoles, their preparation and pharmaceutical compositions containing them
IL54560A0 (en)	1978-07-31	Novel cyclohexane derivatives, their preparation and their use as heribicides
BE879918A (fr)	1980-05-08	Distributeur de medicament
DE2860574D1 (en)	1981-04-23	Substituted phenoxybenzyloxycarbonyl derivatives, their preparation and their use as insecticides and acaricides
JPS5359293A (en)	1978-05-27	Medical respirator
BE881351A (fr)	1980-05-16	Preparation medicale
IL56405A0 (en)	1979-03-12	Novel substituted n-pehnyl-n'-(2-chloro-6-fluoro-benzoyl)-ureas, their preparation and their use as insecticides
FR2511003B1 (fr)	1986-12-05	Alacaloides ergopeptidiques, leur preparation et leur utilisation comme medicaments
AU3918678A (en)	1980-02-28	Fowl cholera vaccine
DE2860270D1 (en)	1981-02-05	Novel derivatives of substituted 2-benzoyl-4-chloro-glycinanilides, their preparation and their use as medicines.
BE865624A (fr)	1978-10-03	Interphenylene 8-aza-9-dioxathia-11,12-secoprostaglandines utiles comme medicaments
DE2960024D1 (en)	1981-01-22	Substituted diphenylmethyl-imidazoles, their preparation and medicaments containing them
IL53739A0 (en)	1978-04-30	Novel phenylcarbamoyl-pyrazolines, their preparation and ttheir use as insecticides
IL53740A0 (en)	1978-04-30	Novel phenylcarbamoyl-2-pyrazolines, their preparation and their use as insecticides
BE865404A (fr)	1978-09-29	3-amino-6,7-dialcoxy-1h-1,2,4-benzothiadiazine-1-oxydes 1-substitues et leur utilisation comme medicaments
BE862971A (fr)	1978-07-17	4'-desoxyvincristine et composes apparentes, et leur utilisation comme medicaments
IL57230A0 (en)	1979-09-30	Substituted alkanyl-azolyl oxime-carbamates,their preparation and their use as insecticides,acaricides and nematocides
JPS53107424A (en)	1978-09-19	Antiiinflammatory medical preparation
FR2530634B1 (fr)	1986-11-14	Derives du carbapeneme, leur preparation et leur utilisation comme medicaments
IL65142A0 (en)	1982-05-31	Carbamate derivatives,their preparation and their use as insecticides,miticides and nematodicides
LU78914A1 (fr)	1978-09-28	Nouvelles arylenedioxy-bis-dicetones,leur preparation et leur utilisation comme medicaments
IL57203A0 (en)	1979-09-30	N,n-dimethyl-o-pyrazolyl-carbamic esters,their preparation and their use as insecticides
JPS5437397A (en)	1979-03-19	Artificial respirator
GB2030860B (en)	1982-08-18	Surgical dressings