BE876040A - Nouvelles piperazines substituees, leur preparation et leur utilisation - Google Patents

Nouvelles piperazines substituees, leur preparation et leur utilisation

Info

Publication number
BE876040A
BE876040A BE0/194992A BE194992A BE876040A BE 876040 A BE876040 A BE 876040A BE 0/194992 A BE0/194992 A BE 0/194992A BE 194992 A BE194992 A BE 194992A BE 876040 A BE876040 A BE 876040A
Authority
BE
Belgium
Prior art keywords
preparation
new substituted
substituted piperazines
piperazines
new
Prior art date
Application number
BE0/194992A
Other languages
English (en)
Inventor
J Mccall
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BE876040A publication Critical patent/BE876040A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE0/194992A 1978-05-05 1979-05-04 Nouvelles piperazines substituees, leur preparation et leur utilisation BE876040A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/903,200 US4159331A (en) 1978-05-05 1978-05-05 Antihypertensive 4-aminoquinolines

Publications (1)

Publication Number Publication Date
BE876040A true BE876040A (fr) 1979-11-05

Family

ID=25417100

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/194992A BE876040A (fr) 1978-05-05 1979-05-04 Nouvelles piperazines substituees, leur preparation et leur utilisation

Country Status (9)

Country Link
US (1) US4159331A (fr)
JP (1) JPS54145684A (fr)
AU (1) AU521589B2 (fr)
BE (1) BE876040A (fr)
DE (1) DE2914491A1 (fr)
FR (1) FR2424918A1 (fr)
GB (1) GB2021568B (fr)
IT (1) IT1113369B (fr)
NL (1) NL7903510A (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871843A (en) * 1983-10-18 1989-10-03 Dropic-Societe Civile De Gestion De Droits De Propriete Industrielle Cyclic benzenesulfonamides, process for their preparation and their use as active substance of pharmaceutical compositions
FR2553414B1 (fr) * 1983-10-18 1986-08-14 Choay Sa Nouveaux benzenesulfonamides n-cyclises, leur procede de preparation et leur utilisation comme substance active de compositions pharmaceutiques
GB8424979D0 (en) * 1984-10-03 1984-11-07 Wyeth John & Brother Ltd Benzenesulphonamide derivatives
EP0215902A1 (fr) * 1985-03-13 1987-04-01 The Upjohn Company Procede de preparation de 4-amino quinolines
US5149700A (en) * 1990-05-30 1992-09-22 American Home Products Corporation Substituted arylsulfonamides and benzamides
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
JP2002538121A (ja) * 1999-03-03 2002-11-12 メルク エンド カムパニー インコーポレーテッド プレニルタンパク質トランスフェラーゼの阻害剤
AU2006326540A1 (en) * 2005-12-14 2007-06-21 Amgen Inc. Diaza heterocyclic sulfonamide derivatives and their uses
EP1994022A2 (fr) * 2006-03-15 2008-11-26 Wyeth a Corporation of the State of Delaware Azacyclylamines avec substitution n en tant qu'antagonistes de l'histamine-3
EP2027086B1 (fr) * 2006-05-19 2011-11-16 Wyeth LLC N-benzoyl-pyrrolidin-3-yl amines comme antagonistes de l'histamine-3
PE20081152A1 (es) * 2006-10-06 2008-08-10 Wyeth Corp Azaciclilaminas n-sustituidas como antagonistas de histamina-3
KR20100020487A (ko) * 2007-05-24 2010-02-22 와이어쓰 엘엘씨 히스타민-3 길항제로서 아자시클릴벤즈아미드 유도체
WO2009012252A1 (fr) * 2007-07-16 2009-01-22 Wyeth Dérivés d'aminoalkylazole en tant qu'antagonistes d'histamine-3
TW200918062A (en) * 2007-09-12 2009-05-01 Wyeth Corp Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists
WO2009036144A1 (fr) * 2007-09-12 2009-03-19 Wyeth Dérivés d'isoquinolinyle et d'isoindolinyle convenant comme antagonistes de l'histamine-3
SG11201509194SA (en) 2013-05-07 2015-12-30 Univ California Radiomitigating pharmaceutical formulations
GEAP201814266A (en) * 2014-02-14 2018-05-10 Takeda Pharmaceuticals Co Pyrazines modulators of gpr6
AU2019359823B2 (en) 2018-10-17 2025-07-10 Duke University Quinone reductase 2 inhibitors for use as neuroprotective agents
US11358964B2 (en) * 2019-08-24 2022-06-14 BCN Biosciences L.L.C. Methods of treatment using BCN057 and BCN512

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
FR2229413A1 (en) 1973-05-17 1974-12-13 Upjohn Co Para-4-quinolyl amino benzene sulphonamides - from a 4-chloro quinoline and a p-amino benzene sulphonamide, hypotensives etc.
US3992382A (en) * 1973-06-15 1976-11-16 The Upjohn Company Quinolylaminobenzoylpiperazine-1-oxides

Also Published As

Publication number Publication date
NL7903510A (nl) 1979-11-07
FR2424918A1 (fr) 1979-11-30
GB2021568A (en) 1979-12-05
IT1113369B (it) 1986-01-20
AU4667279A (en) 1979-11-08
FR2424918B1 (fr) 1983-01-14
JPS54145684A (en) 1979-11-14
IT7922089A0 (it) 1979-04-23
AU521589B2 (en) 1982-04-22
GB2021568B (en) 1982-08-04
DE2914491A1 (de) 1979-11-08
US4159331A (en) 1979-06-26

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: THE UPJOHN CY

Effective date: 19870531