BE900563A - Composition pharmaceutique pour le traitement d'etats d'insuffisance renale aigue. - Google Patents
Composition pharmaceutique pour le traitement d'etats d'insuffisance renale aigue.Info
- Publication number
- BE900563A BE900563A BE0/213640A BE213640A BE900563A BE 900563 A BE900563 A BE 900563A BE 0/213640 A BE0/213640 A BE 0/213640A BE 213640 A BE213640 A BE 213640A BE 900563 A BE900563 A BE 900563A
- Authority
- BE
- Belgium
- Prior art keywords
- treatment
- pharmaceutical composition
- acute kidney
- kidney deficiency
- administration
- Prior art date
Links
- 230000001154 acute effect Effects 0.000 title 1
- 230000007812 deficiency Effects 0.000 title 1
- 210000003734 kidney Anatomy 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000009304 Acute Kidney Injury Diseases 0.000 abstract 1
- 208000033626 Renal failure acute Diseases 0.000 abstract 1
- 208000034841 Thrombotic Microangiopathies Diseases 0.000 abstract 1
- JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 231100000749 chronicity Toxicity 0.000 abstract 1
- 229960004120 defibrotide Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'admistration d'un médicament, contenant du défibrotide comme substance active, dans le cas d'insuffisances rénales aigues accompagnées de microangiopathies thrombotiques, permet d'arreter l'évolution de la situation clinique vers la chronicité et, dans un grand nombre de cas, d0obtenir une rémission complèe. L'administration peut se faire soit par voie intraveineuse ou intramusculaire soit par voie orale.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22856/83A IT1170215B (it) | 1983-09-12 | 1983-09-12 | Composizione farmaceutica per il trattamento di stati di insufficienza renale acuta |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE900563A true BE900563A (fr) | 1985-01-02 |
Family
ID=11201234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/213640A BE900563A (fr) | 1983-09-12 | 1984-09-12 | Composition pharmaceutique pour le traitement d'etats d'insuffisance renale aigue. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4649134A (fr) |
| EP (1) | EP0137542B1 (fr) |
| JP (1) | JPH0647546B2 (fr) |
| AT (1) | ATE65696T1 (fr) |
| BE (1) | BE900563A (fr) |
| CH (1) | CH661871A5 (fr) |
| DE (1) | DE3433329A1 (fr) |
| IT (1) | IT1170215B (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1170214B (it) * | 1983-09-12 | 1987-06-03 | Crinos Industria Farmaco | Composizione farmaceutica per la cura delle arteriopatie periferiche |
| IT1190313B (it) * | 1986-04-17 | 1988-02-16 | Crinos Industria Farmaco | Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante |
| US5223609A (en) * | 1986-04-17 | 1993-06-29 | Crinos Industria Farmacobiologica S.P.A. | Process for obtaining chemically defined and reproducible polydeoxyribonucleotides |
| IT1223322B (it) * | 1987-10-23 | 1990-09-19 | Crinos Industria Farmaco | Metodo per prevenire la formazione di coaguli sanguigni nel circuito extracorporeo di apparecchi di dialisi a composizione utile per esso |
| IT1231509B (it) * | 1989-09-07 | 1991-12-07 | Crinos Industria Farmaco | Composizione farmceutica ad uso topico per la terapia della fragilita' capillare. |
| US5624912A (en) * | 1991-08-21 | 1997-04-29 | Burcoglu; Arsinur | Method of treating HIV infection and related secondary infections with defibrotide |
| US6699985B2 (en) * | 1991-08-21 | 2004-03-02 | Arsinur Burcoglu | Method of treating HIV infection and related secondary infections thereof |
| US5977083A (en) * | 1991-08-21 | 1999-11-02 | Burcoglu; Arsinur | Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states |
| EP0678029A1 (fr) * | 1993-01-13 | 1995-10-25 | BURCOGLU, Arsinur | Procede d'utilisation de polynucleotides, d'oligonucleotides et de leurs derives pour traiter divers etats pathologiques |
| EP1202750A4 (fr) * | 1997-04-28 | 2002-10-16 | Arsinur Burcoglu | Traitement de l'infection par vih et de ses infections opportunistes |
| EP1325962A1 (fr) * | 2001-12-17 | 2003-07-09 | Gentium S.p.A. | Procédé pour la détermination de l'activité biologique de la defibrotide |
| EP1872787A1 (fr) * | 2006-06-27 | 2008-01-02 | Gentium S.p.A. | Utilisation de defibrotide pour l'inhibition de l'heparanase |
| EP1982722A1 (fr) * | 2007-04-16 | 2008-10-22 | Gentium S.p.A. | Utilisation de oligotide pour le traitement de maladies rénales |
| US8515557B2 (en) | 2007-11-19 | 2013-08-20 | Cochlear Limited | Electrode array for a cochlear implant |
| EP2103689A1 (fr) * | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Oligonucléotides phosphodiesters synthétiques et leurs utilisations thérapeutiques |
| IT1406068B1 (it) | 2010-07-22 | 2014-02-06 | Medestea Int Spa | Polidesossiribonucleotidi (pdrn) per l'impiego nel trattamento di condizioni di acidosi e composizioni a base di polidesossiribonucleotidi per il suddetto impiego |
| ES2694239T3 (es) | 2010-11-12 | 2018-12-19 | Gentium S.R.L. | Defibrótido para su uso en profilaxis y/o tratamiento de la enfermedad de Injerto contra huésped (GVHD) |
| RU2627177C2 (ru) * | 2012-06-22 | 2017-08-03 | Джентиум С.Р.Л. | Способ определения биологической активности дефибротида, основанный на применении эуглобулина |
| EP3026122A1 (fr) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Procédé à base cellulaire pour déterminer la puissance de défibrotide |
| RU2766143C2 (ru) * | 2017-07-26 | 2022-02-08 | Джентиум С.Р.Л. | Жидкая композиция дефибротида для лечения и профилактики веноокклюзионной болезни |
| WO2019028340A1 (fr) * | 2017-08-03 | 2019-02-07 | Jazz Pharmaceuticals Ireland Limited | Formulations comprenant un acide nucléique à haute concentration |
| US11571440B2 (en) | 2018-04-12 | 2023-02-07 | Jazz Pharmaceuticals Ireland Limited | Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion |
| WO2021212055A1 (fr) | 2020-04-17 | 2021-10-21 | Jazz Pharmaceuticals Ireland Limited | Traitement de défibrotide pour la prévention d'un rejet et d'une lésion d'organe |
| TW202308659A (zh) | 2021-05-06 | 2023-03-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB879622A (en) * | 1959-07-13 | 1961-10-11 | Farmaceutici Italia | Steroids |
| DE1202439B (de) * | 1959-11-24 | 1965-10-07 | Cediap Centrale De Destributio | Verfahren zur Herstellung von Praeparaten mit hohem Gehalt an freien Desoxyribonucleinsaeuren aus Fischmilch |
| FR2575M (fr) * | 1962-03-19 | 1964-06-08 | Cediap Centrale De Distrib D A | Procédé de préparation d'un médicament a base d'adn (acide désoxyribonucléique) en milieu vital d'origine et produit nouveau en résultant. |
| US3899481A (en) * | 1970-11-03 | 1975-08-12 | Crinos Industria Farmaco | Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs |
| DE2154279A1 (de) * | 1970-11-03 | 1972-05-25 | Crinos Industria Farmaco | Medikamente für das fibrinolytische System |
| IT1043823B (it) * | 1970-11-03 | 1980-02-29 | Prephar | Procedimento per l estrazione di acidi nucleici da organi animali |
-
1983
- 1983-09-12 IT IT22856/83A patent/IT1170215B/it active
-
1984
- 1984-09-07 EP EP84201286A patent/EP0137542B1/fr not_active Expired - Lifetime
- 1984-09-07 CH CH4281/84A patent/CH661871A5/it not_active IP Right Cessation
- 1984-09-07 AT AT84201286T patent/ATE65696T1/de not_active IP Right Cessation
- 1984-09-10 US US06/649,069 patent/US4649134A/en not_active Expired - Fee Related
- 1984-09-11 DE DE19843433329 patent/DE3433329A1/de active Granted
- 1984-09-12 JP JP59191390A patent/JPH0647546B2/ja not_active Expired - Lifetime
- 1984-09-12 BE BE0/213640A patent/BE900563A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE65696T1 (de) | 1991-08-15 |
| EP0137542A2 (fr) | 1985-04-17 |
| JPH0647546B2 (ja) | 1994-06-22 |
| EP0137542A3 (en) | 1987-09-02 |
| IT1170215B (it) | 1987-06-03 |
| DE3433329C2 (fr) | 1993-07-22 |
| DE3433329A1 (de) | 1985-03-28 |
| EP0137542B1 (fr) | 1991-07-31 |
| IT8322856A0 (it) | 1983-09-12 |
| CH661871A5 (it) | 1987-08-31 |
| JPS6084224A (ja) | 1985-05-13 |
| US4649134A (en) | 1987-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: CRINOS INDUSTRIA FARMACOBIOLOGICA S.P.A. Effective date: 19970930 |