OA08617A - Inhibiteurs de métalloendopeptidase neutre dans le traitement de l'hypertention. - Google Patents

Inhibiteurs de métalloendopeptidase neutre dans le traitement de l'hypertention.

Info

Publication number
OA08617A
OA08617A OA59144A OA59144A OA08617A OA 08617 A OA08617 A OA 08617A OA 59144 A OA59144 A OA 59144A OA 59144 A OA59144 A OA 59144A OA 08617 A OA08617 A OA 08617A
Authority
OA
OAPI
Prior art keywords
hypertention
treatment
neutral metalloendopeptidase
metalloendopeptidase inhibitors
inhibitors
Prior art date
Application number
OA59144A
Other languages
English (en)
Inventor
Martin F Haslanger
Edmund J Sybertz
Bernard R Neustadt
Elizabeth M Smith
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/876,610 external-priority patent/US4749688A/en
Priority claimed from US07032153 external-priority patent/US4801609B1/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of OA08617A publication Critical patent/OA08617A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
OA59144A 1986-06-20 1987-06-18 Inhibiteurs de métalloendopeptidase neutre dans le traitement de l'hypertention. OA08617A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/876,610 US4749688A (en) 1986-06-20 1986-06-20 Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
US07032153 US4801609B1 (en) 1987-03-27 1987-03-27 Mercapto-acylamino acid antihypertensives

Publications (1)

Publication Number Publication Date
OA08617A true OA08617A (fr) 1988-11-30

Family

ID=26708050

Family Applications (1)

Application Number Title Priority Date Filing Date
OA59144A OA08617A (fr) 1986-06-20 1987-06-18 Inhibiteurs de métalloendopeptidase neutre dans le traitement de l'hypertention.

Country Status (14)

Country Link
US (1) US5061710A (fr)
EP (1) EP0254032A3 (fr)
JP (3) JP2542620B2 (fr)
KR (1) KR940001769B1 (fr)
AU (1) AU636423B2 (fr)
DK (1) DK313887A (fr)
FI (1) FI872720A7 (fr)
HU (1) HU208952B (fr)
IL (1) IL82908A (fr)
MY (1) MY100641A (fr)
NO (1) NO872589L (fr)
NZ (1) NZ220753A (fr)
OA (1) OA08617A (fr)
PT (1) PT85124B (fr)

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WO1990001940A1 (fr) * 1988-08-18 1990-03-08 California Biotechnology Inc. Inhibiteurs de l'elimination de peptides natriuretiques atriaux
FR2651229B1 (fr) * 1989-08-24 1991-12-13 Inst Nat Sante Rech Med Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique.
CA2069312A1 (fr) * 1989-10-13 1991-04-14 Martin F. Haslanger Inhibiteurs d'endopeptidases a base de dipeptide de carboxyalkyle
FI922867A7 (fi) * 1991-06-21 1992-12-22 Tanabe Seiyaku Co Dikarbonsyraderivat och foerfarande foer framstaellning av dem
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US5629343A (en) * 1992-10-02 1997-05-13 Merck & Co., Inc. N-(mercaptoacyl) peptidyl derivatives as antidegenerative agents
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JPH06199850A (ja) * 1992-12-28 1994-07-19 Tanabe Seiyaku Co Ltd インドール含有ペプチド及びその製法
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
EP0870762B1 (fr) * 1995-03-07 2004-04-28 Santen Pharmaceutical Co., Ltd. Nouveaux derives aminoacides ayant un groupe n,n-dialkylaminophenyle
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
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EP1469875A1 (fr) * 2002-01-29 2004-10-27 Wyeth Compositions et procedes de modulation des demi-canaux de connexines
WO2004050620A2 (fr) * 2002-12-03 2004-06-17 Enobia Pharma Derives d'acides succinique et glutarique et leurs analogues utilises comme inhibiteurs de phex
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EA200501715A1 (ru) * 2003-04-30 2006-06-30 ДЗЕ ИНСТИТЬЮТС ФОР ФАРМАСЬЮТИКАЛ ДИСКАВЕРИ, ЭлЭлСи Замещённые аминокарбоновые кислоты в качестве ингибиторов протеинтирозинфосфатазы-1в
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US7875268B2 (en) 2004-04-06 2011-01-25 L'oreal S.A. Dimercaptoamides, compositions comprising them as reducing agents, and processes for permanently reshaping keratin fibers therewith
MX2007006279A (es) 2004-12-15 2007-06-14 Solvay Pharm Gmbh Composiciones farmaceuticas que comprenden inhibidores de nep, inhibidores del sistema de produccion de endotelina endogena, e inhibidores de hmg coa-reductasa.
SG170767A1 (en) 2005-12-23 2011-05-30 Zealand Pharma As Modified lysine-mimetic compounds
EP2468724B1 (fr) 2006-12-21 2015-11-18 Zealand Pharma A/S Synthèse de composés de pyrrolidine
WO2009138437A1 (fr) * 2008-05-13 2009-11-19 Genmedica Therapeutics Sl Conjugués de salicylés utiles pour le traitement de troubles métaboliques
US8575217B2 (en) * 2009-03-16 2013-11-05 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
US20100239552A1 (en) * 2009-03-16 2010-09-23 Genmedica Therapeutics Sl Combination Therapies for Treating Metabolic Disorders
US8993631B2 (en) * 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
KR20160102210A (ko) 2013-12-27 2016-08-29 노버스 인터내쇼날 인코포레이티드 에톡시화 계면활성제
WO2018202865A1 (fr) 2017-05-05 2018-11-08 Zealand Pharma A/S Modulateurs de la communication intercellulaire par les jonctions lacunaires et leur utilisation pour le traitement d'une maladie oculaire diabétique
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
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Also Published As

Publication number Publication date
AU602701B2 (en) 1990-10-25
IL82908A0 (en) 1987-12-20
KR880000103A (ko) 1988-03-23
AU7445887A (en) 1987-12-24
KR940001769B1 (ko) 1994-03-05
NO872589D0 (no) 1987-06-19
JP2542620B2 (ja) 1996-10-09
EP0254032A3 (fr) 1990-09-05
JP2609443B2 (ja) 1997-05-14
PT85124B (pt) 1990-08-31
JPS6339855A (ja) 1988-02-20
DK313887A (da) 1987-12-21
HUT44940A (en) 1988-05-30
JPH08176100A (ja) 1996-07-09
NO872589L (no) 1987-12-21
FI872720L (fi) 1987-12-21
AU6851790A (en) 1991-07-18
PT85124A (en) 1987-07-01
EP0254032A2 (fr) 1988-01-27
FI872720A7 (fi) 1987-12-21
HU208952B (en) 1994-02-28
DK313887D0 (da) 1987-06-19
AU636423B2 (en) 1993-04-29
JPH08283153A (ja) 1996-10-29
FI872720A0 (fi) 1987-06-18
MY100641A (en) 1990-12-29
IL82908A (en) 1991-09-16
NZ220753A (en) 1992-02-25
US5061710A (en) 1991-10-29

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